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Name	Group	Epoch	Country	Sex	Year from	Year to	Haplogroup	Sequence source	Avg. coverage	Reference	Download	Pathologies
I3596	BBC	Copper Age	Germany	M	-2300	-2150	H+16129	bam	119.37	Olalde et al. 2018 Data	FASTA Metadata	16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I6590	BBC	Copper Age	Germany	F	-2500	-2000	X2c1	bam	509.04	Olalde et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 16183C (MT-CR): Melanoma patients (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I5373	BABI	Bronze Age	Great Britain	M	-2194	-1980	X2b+226	bam	214.55	Olalde et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 15927A (MT-TT): LHON / Multiple Sclerosis / DEAF1555 increased penetrance / CHD (Reported) 16183C (MT-CR): Melanoma patients (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 8393T (MT-ATP8): Reversible brain pseudoatrophy (Reported)
I5834	BBC	Copper Age	Germany	F	-2500	-2000	W5	bam	275.62	Olalde et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
I2601	BABI	Bronze Age	Great Britain	F	-1955	-1750	U5a1b1a	bam	19.73	Olalde et al. 2018 Data	FASTA Metadata	12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I3607	BBC	Copper Age	Germany	M	-2350	-2250	W3a1	bam	15.11	Olalde et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15784C (MT-CYB): POAG - potential for association (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
I2602	BABI	Bronze Age	Great Britain	M	-1892	-1699	U5b2b	bam	112.84	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 12634G (MT-ND5): Thyroid Cancer Cell Line (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16270T (MT-CR): Melanoma patients (Reported)
I2463	BABI	Bronze Age	Great Britain	F	-1925	-1700	J1c3+189	bam	250.88	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
I2462	BABI	Bronze Age	Great Britain	F	-2128	-1891	U5a1d2a	bam	274.64	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I2612	BABI	Bronze Age	Great Britain	F	-2464	-2208	U5b2b2	bam	373.29	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 12634G (MT-ND5): Thyroid Cancer Cell Line (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I5658	BBC	Copper Age	Germany	F	-2500	-2000	T2b+152	bam	514.19	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I2421	BABI	Bronze Age	Great Britain	M	-1930	-1759	U5a1a2a	bam	232.06	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I2609	BABI	Bronze Age	Great Britain	F	-2022	-1771	K2a	bam	163.71	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I7630	BABI	Bronze Age	Great Britain	M	-1879	-1691	U5a	bam	4.57	Olalde et al. 2018 Data	FASTA Metadata	12372A (MT-ND5): Altered brain pH / sCJD patients (Reported)
I5661	BBC	Copper Age	Germany	M	-2500	-2000	K1b1b1	bam	83.32	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 14063C (MT-ND5): Potentially functional variant cosegregating with LHON3635A (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5913A (MT-CO1): Prostate Cancer / hypertension (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I5441	BABI	Bronze Age	Great Britain	M	-1938	-1744	H1+16239	bam	199.01	Olalde et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported)
I5663	BBC	Copper Age	Germany	M	-2500	-2000	U5a2+16294	bam	283.20	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I2461	BABI	Bronze Age	Great Britain	F	-2500	-2140	H5c	bam	357.81	Olalde et al. 2018 Data	FASTA Metadata
I2618	BABI	Bronze Age	Great Britain	M	-2134	-1950	H1bs	bam	706.46	Olalde et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I2637	NEBI	Neolithic	Great Britain	M	-3629	-3370	K1b1a1	bam	172.64	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13967T (MT-ND5): Possible LHON factor (Reported) 15257A (MT-CYB): LHON (Conflicting reports) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5913A (MT-CO1): Prostate Cancer / hypertension (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I5377	BABI	Bronze Age	Great Britain	M	-1894	-1694	T2b	bam	243.84	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I7639	BABI	Bronze Age	Great Britain	F	-2031	-1665	U5a1	bam	1.56	Olalde et al. 2018 Data	FASTA Metadata
I5383	BABI	Bronze Age	Great Britain	F	-1090	-900	J1c5f	bam	137.67	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 15924G (MT-TT): LIMM (Reported) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
I2796	NEBI	Neolithic	Great Britain	M	-3705	-3535	H3	bam	232.16	Olalde et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I2639	BABI	Bronze Age	Great Britain	F	-1600	-1430	T2e1a	bam	1051.40	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I7570	BABI	Bronze Age	Great Britain	M	-1735	-1531	T2b4+152	bam	88.74	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I5656	BBC	Copper Age	Germany	U	-2500	-2000	T2g2	bam	214.36	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I7575	BABI	Bronze Age	Great Britain	M	-1263	-1043	U5a1d1	bam	163.31	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I7577	BABI	Bronze Age	Great Britain	M	-1386	-1123	U5a1a1	bam	146.15	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15924G (MT-TT): LIMM (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I7580	BABI	Bronze Age	Great Britain	F	-1256	-1018	U5b2a1a	bam	217.86	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16192T (MT-CR): Melanoma patients (Reported)
I3604	BBC	Copper Age	Germany	M	-2350	-2250	HV9	bam	11.45	Olalde et al. 2018 Data	FASTA Metadata
I7626	BABI	Bronze Age	Great Britain	F	-1395	-1130	T2b	bam	165.27	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I7627	BABI	Bronze Age	Great Britain	F	-1410	-1222	U4a2	bam	226.03	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 499A (MT-CR): Endometriosis (Reported)
I5019	BBC	Copper Age	Germany	F	-2500	-2000	K1b1a1	bam	68.25	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13967T (MT-ND5): Possible LHON factor (Reported) 15257A (MT-CYB): LHON (Conflicting reports) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 5913A (MT-CO1): Prostate Cancer / hypertension (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I5523	BBC	Copper Age	Germany	F	-2500	-2000	K1b1a1+199	bam	113.04	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13967T (MT-ND5): Possible LHON factor (Reported) 15257A (MT-CYB): LHON (Conflicting reports) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5913A (MT-CO1): Prostate Cancer / hypertension (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I7628	BABI	Bronze Age	Great Britain	M	-1208	-978	T1a1	bam	26.04	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I7579	BABI	Bronze Age	Great Britain	F	-1496	-1300	U5b2a1a	bam	182.54	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16192T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I3082	BABI	Bronze Age	Great Britain	M	-1498	-1394	H1an1a	bam	199.91	Olalde et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4454C (MT-TM): Possible contributor to mito dysfunction / hypertension (Reported)
I5524	BBC	Copper Age	Germany	F	-2500	-2000	H72	bam	300.85	Olalde et al. 2018 Data	FASTA Metadata	16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 15927A (MT-TT): LHON / Multiple Sclerosis / DEAF1555 increased penetrance / CHD (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I7574	BABI	Bronze Age	Great Britain	F	-1406	-1230	H1a3	bam	203.88	Olalde et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I4305	MLN	Neolithic	France	F	-4825	-4616	T2b3+151	bam	277.19	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I4308	MLN	Neolithic	France	F	-3501	-3112	U3a1	bam	16.06	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 16390A (MT-CR): POAG - potential for association (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported)
I7571	BABI	Bronze Age	Great Britain	M	-1448	-1259	J1c1	bam	117.06	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 3394C (MT-ND1): LHON / Diabetes / CPTdeficiency / high altitude adaptation (Reported / Population-dependent) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
I5526	BBC	Copper Age	Germany	F	-2500	-2000	H72	bam	751.70	Olalde et al. 2018 Data	FASTA Metadata	16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 15927A (MT-TT): LHON / Multiple Sclerosis / DEAF1555 increased penetrance / CHD (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I7572	BABI	Bronze Age	Great Britain	M	-1510	-1302	H13a1a	bam	52.42	Olalde et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I0518	NEBI	Neolithic	Great Britain	M	-3360	-3100	K1a3a1	bam	25.79	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I5037	EBACz	Bronze Age	Czech Republic	M	-2300	-1900	K1a+150	bam	50.19	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I0519	NEBI	Neolithic	Great Britain	M	-3360	-3100	X2b+226	bam	441.62	Olalde et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 15927A (MT-TT): LHON / Multiple Sclerosis / DEAF1555 increased penetrance / CHD (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 8393T (MT-ATP8): Reversible brain pseudoatrophy (Reported)
I3068	NEBI	Neolithic	Great Britain	M	-3692	-3522	T2c1d1	bam	541.45	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported) 6261A (MT-CO1): Prostate Cancer / LHON (Reported)
I5116	CAHu	Copper Age	Hungary	F	-3400	-3000	W	bam	9.19	Olalde et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
I2605	NEBI	Neolithic	Great Britain	F	-3631	-2944	J1c6	bam	291.74	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 15927A (MT-TT): LHON / Multiple Sclerosis / DEAF1555 increased penetrance / CHD (Reported) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
I5118	CAHu	Copper Age	Hungary	M	-3400	-3000	H+16129	bam	259.05	Olalde et al. 2018 Data	FASTA Metadata	16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I2606	NEBI	Neolithic	Great Britain	M	-3330	-2900	K1a+195	bam	93.66	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I6751	NEBI	Neolithic	Great Britain	F	-3755	-3660	U5b1+16189+@16192	bam	417.88	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16183C (MT-CR): Melanoma patients (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I6759	NEBI	Neolithic	Great Britain	M	-3650	-3522	J1c1	bam	491.39	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 3394C (MT-ND1): LHON / Diabetes / CPTdeficiency / high altitude adaptation (Reported / Population-dependent) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported) 6150A (MT-CO1): Prostate Cancer / enriched in POAG cohort (Reported)
E09538	BBC	Copper Age	Germany	M	-2464	-2210	J1c	<NA>	<NA>	Olalde et al. 2018 Data	Metadata
I6762	NEBI	Neolithic	Great Britain	M	-4000	-3300	K1a1b1	bam	165.31	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 114T (MT-CR): BD-associated (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 15924G (MT-TT): LIMM (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
E09569	BBC	Copper Age	Germany	M	-2396	-2148	J1c2	<NA>	<NA>	Olalde et al. 2018 Data	Metadata
I6761	NEBI	Neolithic	Great Britain	F	-3650	-3400	K1a+195	bam	186.26	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I7042	BAHu	Bronze Age	Hungary	M	-2500	-2200	H	bam	503.18	Olalde et al. 2018 Data	FASTA Metadata	16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 3236G (MT-TL1): Sporadic bilateral optic neuropathy (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I5515	BABI	Bronze Age	Great Britain	M	-2034	-1775	H3+16311	bam	44.57	Olalde et al. 2018 Data	FASTA Metadata
I5473	BABI	Bronze Age	Great Britain	M	-2400	-2100	U5b	bam	1.66	Olalde et al. 2018 Data	FASTA Metadata	16270T (MT-CR): Melanoma patients (Reported)
I6482	BBC	Copper Age	Germany	F	-2500	-2000	U4d2	bam	4.38	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 5567C (MT-TW): Myopathy (Reported)
I5516	BABI	Bronze Age	Great Britain	M	-1866	-1615	T2a1b1a1b	bam	79.93	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 14687G (MT-TE): Mito myopathy w respiratory failure / intellectual disability (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I2567	BABI	Bronze Age	Great Britain	M	-2275	-1884	U4a1a	bam	372.89	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 499A (MT-CR): Endometriosis (Reported) 961C (MT-RNR1): DEAF / possibly LVNC-associated (Unclear)
I5530	BBC	Copper Age	Germany	M	-2500	-2000	K1b1a1	bam	62.23	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13967T (MT-ND5): Possible LHON factor (Reported) 15257A (MT-CYB): LHON (Conflicting reports) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5913A (MT-CO1): Prostate Cancer / hypertension (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I6481	BBC	Copper Age	Germany	M	-2500	-2000	U5a1a1	bam	82.94	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15924G (MT-TT): LIMM (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I2569	BABI	Bronze Age	Great Britain	M	-2139	-1915	K1a3a	bam	220.51	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 3316A (MT-ND1): Diabetes / LHON / PEO (Unclear) 9055A (MT-ATP6): PD protective factor (Reported)
I7203	UNC	Bronze Age	Czech Republic	M	-2200	-1700	H1	bam	13.12	Olalde et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported)
I5469	BABI	Bronze Age	Great Britain	F	-1642	-1503	H5'36	bam	3.25	Olalde et al. 2018 Data	FASTA Metadata
I2860	BABI	Bronze Age	Great Britain	M	-969	-815	H5a1	bam	1659.05	Olalde et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4336C (MT-TQ): ADPD / Hearing Loss & Migraine / autism spectrum / intellectual disability (Unclear)
I2859	BABI	Bronze Age	Great Britain	M	-910	-809	K1a2c	bam	1521.11	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 9055A (MT-ATP6): PD protective factor (Reported)
I3130	BABI	Bronze Age	Great Britain	F	-977	-829	U5a1c	bam	970.75	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 7080C (MT-CO1): Prostate Cancer (Reported)
I3528	BBC	Copper Age	Hungary	M	-2559	-2301	HV4a1+16291	bam	219.38	Olalde et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I2364	BBC	Copper Age	Hungary	M	-2468	-2063	U5a2b	bam	119.70	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I2656	BABI	Bronze Age	Great Britain	M	-1278	-979	H2a2a2	bam	115.72	Olalde et al. 2018 Data	FASTA Metadata	16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I5376	BBC	Bronze Age	Great Britain	F	-2454	-2141	H6a1b	bam	19.19	Olalde et al. 2018 Data	FASTA Metadata
I2653	BABI	Bronze Age	Great Britain	M	-1500	-1300	H2a1a	bam	102.47	Olalde et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I0261	BBC	Copper Age	Spain	M	-2850	-2250	U5b1i	bam	273.49	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I2654	BABI	Bronze Age	Great Britain	F	-1500	-1300	U5b3	bam	76.42	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 228A (MT-CR): Low VO2max response (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
I0823	BBC	Copper Age	Spain	F	-2850	-2250	H1	bam	88.67	Olalde et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I2655	BABI	Bronze Age	Great Britain	M	-1441	-1272	H6a1b2	bam	1123.99	Olalde et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I2660	NEBI	Neolithic	Great Britain	M	-3513	-3352	U5a2+16194	bam	110.18	Olalde et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
I2691	NEBI	Neolithic	Great Britain	M	-3700	-3639	J1c1	bam	479.83	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 3394C (MT-ND1): LHON / Diabetes / CPTdeficiency / high altitude adaptation (Reported / Population-dependent) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
I2650	NEBI	Neolithic	Great Britain	M	-3638	-3380	T2c1d1	bam	205.35	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported) 6261A (MT-CO1): Prostate Cancer / LHON (Reported)
I0257	BBC	Copper Age	Spain	M	-2572	-2348	H1ax	bam	319.79	Olalde et al. 2018 Data	FASTA Metadata	146C (MT-CR): Absence of Endometriosis (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported)
I0826	BBC	Copper Age	Spain	M	-2834	-2482	H1t	bam	107.57	Olalde et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I2630	NEBI	Neolithic	Great Britain	M	-2580	-2463	K1a4	bam	158.66	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 6663G (MT-CO1): Prostate Cancer (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I2932	NEBI	Neolithic	Great Britain	M	-2570	-2347	H5	bam	780.40	Olalde et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I2933	NEBI	Neolithic	Great Britain	M	-3010	-2885	J1c2	bam	432.32	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
I6582	BBC	Copper Age	Poland	F	-2343	-2057	U5a2b	bam	339.39	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I2418	BBC	Bronze Age	Great Britain	F	-2455	-2200	K1a4a1	bam	752.01	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I2934	NEBI	Neolithic	Great Britain	F	-3338	-3022	U5a2c3	bam	452.01	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I2935	NEBI	Neolithic	Great Britain	M	-3335	-3011	U8b1b	bam	610.26	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16183C (MT-CR): Melanoma patients (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I3085	NEBI	Neolithic	Great Britain	F	-3338	-3026	K1a+195	bam	607.89	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I2977	NEBI	Neolithic	Great Britain	M	-3008	-2763	H1	bam	619.04	Olalde et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I6581	BBC	Copper Age	Poland	M	-2455	-2145	H6a1a	bam	186.09	Olalde et al. 2018 Data	FASTA Metadata	11253C (MT-ND4): LHON PD (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I2629	NEBI	Neolithic	Great Britain	M	-3180	-2780	J1c1b	bam	1.82	Olalde et al. 2018 Data	FASTA Metadata	13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports)
I2978	NEBI	Neolithic	Great Britain	M	-3335	-3023	K1b1a1	bam	637.85	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13967T (MT-ND5): Possible LHON factor (Reported) 15257A (MT-CYB): LHON (Conflicting reports) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5913A (MT-CO1): Prostate Cancer / hypertension (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I2565	BBC	Bronze Age	Great Britain	M	-2457	-2147	W1+119	bam	44.65	Olalde et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
I4253	BBC	Copper Age	Poland	M	-2456	-2207	U5a2c	bam	1073.95	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I2631	NEBI	Neolithic	Great Britain	M	-3097	-2906	H5	bam	887.83	Olalde et al. 2018 Data	FASTA Metadata
I3133	NEBI	Neolithic	Great Britain	M	-3631	-3377	K1a+195	bam	659.83	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 7158G (MT-CO1): Prostate Cancer (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I3134	NEBI	Neolithic	Great Britain	M	-3633	-3377	T2f4	bam	482.12	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I6774	BBC	Bronze Age	Great Britain	M	-2287	-2044	H4a1a1a	bam	93.45	Olalde et al. 2018 Data	FASTA Metadata	10044G (MT-TG): SIDS (Unclear) 14582G (MT-ND6): LHON synergistic combo 14258A + 14582G (Reported: individually neutral variants causing LHON in combination) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I2459	BBC	Bronze Age	Great Britain	F	-2455	-2150	T2a1a	bam	340.09	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 14687G (MT-TE): Mito myopathy w respiratory failure / intellectual disability (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I3135	NEBI	Neolithic	Great Britain	M	-3640	-3383	U5b2a	bam	825.83	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I3137	NEBI	Neolithic	Great Britain	M	-3800	-3200	HV0+195	bam	81.92	Olalde et al. 2018 Data	FASTA Metadata	195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I3138	NEBI	Neolithic	Great Britain	F	-3263	-2923	K1a4a1	bam	797.42	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I5757	BBC	Copper Age	Switzerland	M	-2469	-1984	H3af	bam	209.07	Olalde et al. 2018 Data	FASTA Metadata	16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported)
I3041	NEBI	Neolithic	Great Britain	M	-3942	-3037	K1a3a	bam	445.11	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I5370	NEBI	Neolithic	Great Britain	F	-4000	-3300	K1a+195	bam	19.19	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I2634	NEBI	Neolithic	Great Britain	M	-3703	-3534	U2+152	bam	179.11	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 3394C (MT-ND1): LHON / Diabetes / CPTdeficiency / high altitude adaptation (Reported / Population-dependent)
I2633	NEBI	Neolithic	Great Britain	F	-3765	-3641	T2e1	bam	432.82	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I4229	BBC	Copper Age	Portugal	M	-2336	-2063	U5a2+16362	bam	346.16	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I7554	NEBI	Neolithic	Great Britain	M	-3366	-3103	J1c9	bam	137.01	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
I1775	BABI	Bronze Age	Great Britain	M	-1730	-1532	I3	bam	693.67	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 15924G (MT-TT): LIMM (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I2574	BABI	Bronze Age	Great Britain	F	-1414	-1227	U5a1a2b	bam	985.86	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I5358	NEBI	Neolithic	Great Britain	F	-3080	-2904	K1a1	bam	82.21	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 114T (MT-CR): BD-associated (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I6466	BBC	Copper Age	Portugal	M	-2700	-2300	K1b1a1	bam	30.22	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13967T (MT-ND5): Possible LHON factor (Reported) 15257A (MT-CYB): LHON (Conflicting reports) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 5913A (MT-CO1): Prostate Cancer / hypertension (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I5359	NEBI	Neolithic	Great Britain	M	-3800	-3600	H5	bam	100.37	Olalde et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I5367	BBC	Bronze Age	Great Britain	F	-2467	-2232	V10	bam	374.63	Olalde et al. 2018 Data	FASTA Metadata	16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I3875	BBC	Copper Age	France	M	-2133	-1946	H1e	bam	423.99	Olalde et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
I7250	BBC	Copper Age	Czech Republic	F	-2500	-2200	R1a1a	bam	43.66	Olalde et al. 2018 Data	FASTA Metadata	1391C (MT-RNR1): found in 1 HCM patient (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I4067	BBC	Copper Age	The Netherlands	F	-1946	-1690	R1b1	bam	135.49	Olalde et al. 2018 Data	FASTA Metadata	1095C (MT-RNR1): SNHL (Unclear) 1391C (MT-RNR1): found in 1 HCM patient (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I7279	CWC	Neolithic	Czech Republic	M	-2900	-2200	H7d	bam	118.87	Olalde et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I0462	BBC	Copper Age	Spain	F	-2566	-2345	K1a+195	bam	240.45	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I7275	BBC	Copper Age	Czech Republic	M	-2500	-2200	U5b2c	bam	309.84	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
I5042	EBACz	Bronze Age	Czech Republic	M	-2300	-1900	I4a	bam	168.65	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 15924G (MT-TT): LIMM (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 8519A (MT-ATP8): Susceptibility to bullous pemphigoid (Reported)
I6476	BBC	Copper Age	Czech Republic	F	-2500	-1900	U5a1b1	bam	596.50	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I5043	EBACz	Bronze Age	Czech Republic	M	-2300	-1900	U4c1a	bam	672.69	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 499A (MT-CR): Endometriosis (Reported)
I4946	BBC	Copper Age	Czech Republic	F	-2296	-2146	I4a	bam	397.00	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 15924G (MT-TT): LIMM (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 8519A (MT-ATP8): Susceptibility to bullous pemphigoid (Reported)
I5665	BBC	Copper Age	Spain	M	-2280	-1984	K1a24a	bam	480.15	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I7195	UNC	Bronze Age	Czech Republic	F	-2200	-1700	H3v+16093	bam	303.35	Olalde et al. 2018 Data	FASTA Metadata	16093C (MT-CR): Cyclic Vomiting Syndrome (Reported)
I4947	BBC	Copper Age	Czech Republic	M	-2500	-2000	H17a	bam	602.04	Olalde et al. 2018 Data	FASTA Metadata	16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I7196	UNC	Bronze Age	Czech Republic	M	-2200	-1700	K1a+195	bam	294.60	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I4247	BBC	Copper Age	Spain	F	-2464	-2210	T2b3	bam	87.29	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I7197	UNC	Bronze Age	Czech Republic	M	-2200	-1700	X2b6	bam	323.64	Olalde et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 15927A (MT-TT): LHON / Multiple Sclerosis / DEAF1555 increased penetrance / CHD (Reported) 16183C (MT-CR): Melanoma patients (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 8393T (MT-ATP8): Reversible brain pseudoatrophy (Reported)
I4889	BBC	Copper Age	Czech Republic	M	-2281	-2062	U4a2	bam	127.62	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 499A (MT-CR): Endometriosis (Reported)
I7199	UNC	Bronze Age	Czech Republic	M	-2200	-1700	J1c3a	bam	297.14	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
I7201	UNC	Bronze Age	Czech Republic	F	-2200	-1700	U5a1a2b	bam	168.25	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I4884	EBACz	Bronze Age	Czech Republic	M	-1882	-1745	H4a1a1a	bam	101.12	Olalde et al. 2018 Data	FASTA Metadata	10044G (MT-TG): SIDS (Unclear) 14582G (MT-ND6): LHON synergistic combo 14258A + 14582G (Reported: individually neutral variants causing LHON in combination) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I7211	BBC	Copper Age	Czech Republic	F	-2500	-2200	U5b3	bam	319.75	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16270T (MT-CR): Melanoma patients (Reported) 228A (MT-CR): Low VO2max response (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I4892	EBACz	Bronze Age	Czech Republic	F	-1881	-1701	T1a1	bam	152.98	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I4893	NECz	Neolithic	Czech Republic	M	-4449	-4348	U5b1b1	bam	205.24	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I7286	BBC	Copper Age	Czech Republic	M	-2500	-2200	I4a	bam	223.85	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 15924G (MT-TT): LIMM (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 6480A (MT-CO1): Prostate Cancer / enriched in POAG cohort (Reported) 8519A (MT-ATP8): Susceptibility to bullous pemphigoid (Reported)
I4894	NECz	Neolithic	Czech Republic	F	-4488	-4368	U8b1b1	bam	202.73	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16183C (MT-CR): Melanoma patients (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I4303	MLN	Neolithic	France	M	-4778	-4586	H3	bam	396.49	Olalde et al. 2018 Data	FASTA Metadata
I4304	MLN	Neolithic	France	M	-4787	-4589	T2c1d+152	bam	456.91	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported) 6261A (MT-CO1): Prostate Cancer / LHON (Reported)
I7212	BBC	Copper Age	Czech Republic	M	-2500	-2200	K1b1a1+199	bam	265.78	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13967T (MT-ND5): Possible LHON factor (Reported) 15257A (MT-CYB): LHON (Conflicting reports) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5913A (MT-CO1): Prostate Cancer / hypertension (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I6480	BBC	Copper Age	Czech Republic	M	-2500	-1900	U4a2	bam	153.39	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 499A (MT-CR): Endometriosis (Reported)
I7040	BAHu	Bronze Age	Hungary	F	-2500	-2200	K1a4b	bam	522.38	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I7043	BAHu	Bronze Age	Hungary	M	-2500	-2200	H1b1	bam	455.99	Olalde et al. 2018 Data	FASTA Metadata	16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 3796G (MT-ND1): Adult-Onset Dystonia (Reported) 6267A (MT-CO1): Prostate Cancer (Reported)
I1381	BBC	Copper Age	France	M	-2400	-1900	H	bam	599.16	Olalde et al. 2018 Data	FASTA Metadata
I7041	BAHu	Bronze Age	Hungary	M	-2500	-2200	H1b1	bam	458.69	Olalde et al. 2018 Data	FASTA Metadata	16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 3796G (MT-ND1): Adult-Onset Dystonia (Reported) 6267A (MT-CO1): Prostate Cancer (Reported)
I4070	BANl	Bronze Age	The Netherlands	M	-1880	-1657	U5a1b1a	bam	138.93	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I4071	BANl	Bronze Age	The Netherlands	F	-1883	-1664	H6a1a	bam	259.20	Olalde et al. 2018 Data	FASTA Metadata	11253C (MT-ND4): LHON PD (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I6531	EBAPl	Bronze Age	Poland	M	-2286	-2038	U5b2b1a1	bam	267.70	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 12634G (MT-ND5): Thyroid Cancer Cell Line (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 15497A (MT-CYB): EXIT / Obesity (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I6579	EBAPl	Bronze Age	Poland	F	-2335	-2046	K1a4a1g	bam	321.42	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I3599	BBC	Copper Age	Germany	M	-2300	-2150	H1e1a	bam	54.63	Olalde et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports) 8821G (MT-ATP6): Possible LHON helper variant (Reported)
I3589	BBC	Copper Age	Germany	M	-2300	-2150	U4d1	bam	561.05	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 499A (MT-CR): Endometriosis (Reported)
I3593	BBC	Copper Age	Germany	F	-2397	-2145	H1	bam	236.53	Olalde et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I6475	BBC	Copper Age	Spain	F	-2500	-2000	U5b3	bam	407.07	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 15909G (MT-TT): Hypertension (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 228A (MT-CR): Low VO2max response (Reported)
E09613_d	BBC	Copper Age	Germany	F	-2289	-2140	H1	<NA>	<NA>	Olalde et al. 2018 Data	Metadata
I1553	BBC	Copper Age	Spain	F	-2850	-2250	pre-H103	bam	10.62	Olalde et al. 2018 Data	FASTA Metadata
I0258	BBC	Copper Age	Spain	F	-2850	-2250	H1q	bam	110.39	Olalde et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I0262	BBC	Copper Age	Spain	F	-2850	-2250	U5b3	bam	275.01	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16270T (MT-CR): Melanoma patients (Reported) 228A (MT-CR): Low VO2max response (Reported)
I2478	BBC	Copper Age	Italy	M	-2194	-1939	K1a2a	bam	251.09	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I4936	BBC	Copper Age	Italy	F	-2500	-1900	K1a	bam	2.97	Olalde et al. 2018 Data	FASTA Metadata	12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I4073	BBC	Copper Age	The Netherlands	M	-2195	-1905	U5a2b3	bam	238.71	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I6613	CAIB	Copper Age	Spain	F	-2479	-1945	U5b1	bam	393.22	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I6612	CAIB	Copper Age	Spain	F	-2479	-1945	J1c3	bam	26.76	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
I6630	CAIB	Copper Age	Spain	F	-2900	-2300	J2a1a1	bam	37.17	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 11253C (MT-ND4): LHON PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 15257A (MT-CYB): LHON (Conflicting reports) 195C (MT-CR): BD-associated / melanoma pts (Reported) 295T (MT-CR): Low VO2max response (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 489C (MT-CR): Low VO2max response (Reported)
I7638	BABI	Bronze Age	Great Britain	M	-2286	-1778	V10b	bam	47.77	Olalde et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I1765	BBC	Bronze Age	Great Britain	U	-2341	-2041	N1a1a1a2	bam	406.83	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 3336C (MT-ND1): Carotid atherosclerosis risk (Reported) 669C (MT-RNR1): DEAF (Reported)
I7635	BABI	Bronze Age	Great Britain	F	-2193	-1978	H1c	bam	79.20	Olalde et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I7569	BABI	Bronze Age	Great Britain	F	-1619	-1457	K1a1b1	bam	9.67	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 114T (MT-CR): BD-associated (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 15924G (MT-TT): LIMM (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I7576	BABI	Bronze Age	Great Britain	M	-1206	-1003	J1c2	bam	108.49	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
I7640	BABI	Bronze Age	Great Britain	M	-1430	-1282	U5a2c2	bam	136.79	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I5385	BBC	Bronze Age	Great Britain	F	-2455	-2147	H5	bam	278.46	Olalde et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I0520	NEBI	Neolithic	Great Britain	M	-3360	-3100	U5a2c	bam	44.27	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 6340T (MT-CO1): Prostate Cancer (Reported)
I7249	BBC	Copper Age	Czech Republic	M	-2500	-2200	I2	bam	343.33	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 15924G (MT-TT): LIMM (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I5366	NEBI	Neolithic	Great Britain	F	-3643	-3383	X2b+226	bam	338.22	Olalde et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 15927A (MT-TT): LHON / Multiple Sclerosis / DEAF1555 increased penetrance / CHD (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 8393T (MT-ATP8): Reversible brain pseudoatrophy (Reported)
I6750	NEBI	Neolithic	Great Britain	M	-3755	-3660	K1a+195	bam	129.02	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I5374	NEBI	Neolithic	Great Britain	M	-2830	-2460	H1c	bam	243.93	Olalde et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported)
I2988	NEBI	Neolithic	Great Britain	F	-3516	-3361	U5b2a3	bam	554.05	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I2659	NEBI	Neolithic	Great Britain	F	-3761	-3643	H1c	bam	115.72	Olalde et al. 2018 Data	FASTA Metadata	16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I5470	BABI	Bronze Age	Great Britain	U	-1620	-1449	H15a1	bam	2.98	Olalde et al. 2018 Data	FASTA Metadata
I2981	BABI	Bronze Age	Great Britain	F	-1950	-1496	T2a1b1a	bam	1116.11	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 14687G (MT-TE): Mito myopathy w respiratory failure / intellectual disability (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I2861	BABI	Bronze Age	Great Britain	F	-976	-828	I2a1	bam	995.09	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 15924G (MT-TT): LIMM (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I2573	BABI	Bronze Age	Great Britain	F	-1500	-1301	H3+16311	bam	68.06	Olalde et al. 2018 Data	FASTA Metadata
I2636	NEBI	Neolithic	Great Britain	F	-3519	-3361	V	bam	720.33	Olalde et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I2651	NEBI	Neolithic	Great Britain	F	-3360	-3098	K1a1b1	bam	116.55	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 114T (MT-CR): BD-associated (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 15924G (MT-TT): LIMM (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I2979	NEBI	Neolithic	Great Britain	M	-3333	-2941	K1a+195	bam	659.77	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 3644C (MT-ND1): BD-associated (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I2657	NEBI	Neolithic	Great Britain	M	-3951	-3780	W1+119	bam	110.18	Olalde et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
I2980	NEBI	Neolithic	Great Britain	F	-3360	-3101	H1	bam	1528.10	Olalde et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I3136	NEBI	Neolithic	Great Britain	F	-3520	-3365	H1+16189	bam	542.66	Olalde et al. 2018 Data	FASTA Metadata	16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I6617	CAIB	Copper Age	Spain	M	-2900	-2300	H1+16189	bam	191.63	Olalde et al. 2018 Data	FASTA Metadata	16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported)
I5371	NEBI	Neolithic	Great Britain	F	-4000	-3300	H4a1a2a	bam	87.35	Olalde et al. 2018 Data	FASTA Metadata	13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 14582G (MT-ND6): LHON synergistic combo 14258A + 14582G (Reported: individually neutral variants causing LHON in combination) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I2635	NEBI	Neolithic	Great Britain	M	-3652	-3389	U5b1+16189+16192	bam	777.38	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16183C (MT-CR): Melanoma patients (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I5364	BABI	Bronze Age	Great Britain	F	-1600	-800	H5c	bam	6.50	Olalde et al. 2018 Data	FASTA Metadata
I7272	CWC	Neolithic	Czech Republic	M	-2900	-2200	K2a5	bam	292.87	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I7280	CWC	Neolithic	Czech Republic	M	-2900	-2200	W5a	bam	377.09	Olalde et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
I7198	UNC	Bronze Age	Czech Republic	F	-2200	-1700	U5b2c	bam	284.22	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I7200	UNC	Bronze Age	Czech Republic	F	-2200	-1700	R1b1	bam	276.93	Olalde et al. 2018 Data	FASTA Metadata	1095C (MT-RNR1): SNHL (Unclear) 1391C (MT-RNR1): found in 1 HCM patient (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I7202	UNC	Bronze Age	Czech Republic	M	-2200	-1700	U5a1a2b	bam	111.60	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I5117	CAHu	Copper Age	Hungary	M	-3400	-3000	K1a2	bam	69.88	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I5119	CAHu	Copper Age	Hungary	F	-3400	-3000	J1c2	bam	262.78	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
I6537	EBAPl	Bronze Age	Poland	M	-2290	-2041	I1a1	bam	375.28	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 15924G (MT-TT): LIMM (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported)
I5512	BBC	Bronze Age	Great Britain	F	-2500	-1800	J1c	bam	81.91	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
I4950	BBC	Bronze Age	Great Britain	M	-2500	-1800	U5a2d1	bam	377.94	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I0455	CAIB	Copper Age	Spain	M	-2904	-2667	H1	bam	130.51	Olalde et al. 2018 Data	FASTA Metadata	10237C (MT-ND3): LHON (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I2452	BBC	Bronze Age	Great Britain	M	-2276	-1980	H1e1a	bam	890.14	Olalde et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
I4951	BBC	Bronze Age	Great Britain	M	-2500	-1800	K1b1a1	bam	301.35	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13967T (MT-ND5): Possible LHON factor (Reported) 15257A (MT-CYB): LHON (Conflicting reports) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5913A (MT-CO1): Prostate Cancer / hypertension (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I2454	BBC	Bronze Age	Great Britain	F	-2198	-1983	R1a1a	bam	605.79	Olalde et al. 2018 Data	FASTA Metadata	1391C (MT-RNR1): found in 1 HCM patient (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I2455	BBC	Bronze Age	Great Britain	F	-2125	-1911	U5a2c3a	bam	2019.89	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I1770	BBC	Bronze Age	Great Britain	F	-2400	-1600	U5b1d2	bam	70.73	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I1390	BBC	Copper Age	France	M	-2480	-2210	X2b4a	bam	177.87	Olalde et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 15927A (MT-TT): LHON / Multiple Sclerosis / DEAF1555 increased penetrance / CHD (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 8393T (MT-ATP8): Reversible brain pseudoatrophy (Reported)
I1391	BBC	Copper Age	France	F	-2396	-2060	J1c4	bam	295.00	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
I2447	BBC	Bronze Age	Great Britain	M	-2115	-1910	K1a26	bam	706.72	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 16192T (MT-CR): Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I2568	BBC	Bronze Age	Great Britain	M	-2286	-2038	U5a1b1g	bam	714.76	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I3587	BBC	Copper Age	Germany	U	-2300	-2150	H1e1a	bam	182.51	Olalde et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports) 8821G (MT-ATP6): Possible LHON helper variant (Reported)
I3592	BBC	Copper Age	Germany	F	-2457	-2203	H+16129	bam	237.68	Olalde et al. 2018 Data	FASTA Metadata	16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I5519	BBC	Copper Age	Germany	M	-2500	-2000	I4a	bam	87.78	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 15924G (MT-TT): LIMM (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 8519A (MT-ATP8): Susceptibility to bullous pemphigoid (Reported)
I5657	BBC	Copper Age	Germany	M	-2500	-2000	T2b+152	bam	892.71	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I7213	BBC	Copper Age	Czech Republic	F	-2500	-2200	HV+16311	bam	270.08	Olalde et al. 2018 Data	FASTA Metadata	15773A (MT-CYB): LHON (Possibly synergistic) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I7269	BBC	Copper Age	Czech Republic	M	-2500	-2200	T2e	bam	172.07	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I7271	BBC	Copper Age	Czech Republic	M	-2500	-2200	U4a2	bam	38.39	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 499A (MT-CR): Endometriosis (Reported) 9804A (MT-CO3): LHON / MS (Reported)
I0260	BBC	Copper Age	Spain	F	-2850	-2250	K1a2a	bam	329.61	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I0263	BBC	Copper Age	Spain	F	-2850	-2250	X2b+226	bam	122.00	Olalde et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 15927A (MT-TT): LHON / Multiple Sclerosis / DEAF1555 increased penetrance / CHD (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 8393T (MT-ATP8): Reversible brain pseudoatrophy (Reported)
I0460	BBC	Copper Age	Spain	M	-2460	-2209	H45	bam	240.61	Olalde et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 8843C (MT-ATP6): Patient with suspected mitochondrial disease (Reported as Likely Benign)
I1388	BBC	Copper Age	France	M	-2455	-2134	H	bam	625.06	Olalde et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I3529	BBC	Copper Age	Hungary	F	-2500	-2200	I3a	bam	215.16	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 15924G (MT-TT): LIMM (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I3874	BBC	Copper Age	France	F	-2200	-2035	T2b3	bam	43.60	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I4075	BBC	Copper Age	The Netherlands	F	-2118	-1937	H5a1	bam	418.88	Olalde et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4336C (MT-TQ): ADPD / Hearing Loss & Migraine / autism spectrum / intellectual disability (Unclear)
I4930	BBC	Copper Age	Italy	F	-2500	-1900	H1e	bam	9.11	Olalde et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
I5015	BBC	Copper Age	Hungary	F	-2466	-2210	H1aj	bam	260.72	Olalde et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I5527	BBC	Copper Age	Germany	F	-2500	-2000	K2b1a1	bam	230.34	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13135A (MT-ND5): possible HCM susceptibility (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I5836	BBC	Copper Age	Germany	F	-2500	-2000	H1b1+16362	bam	138.79	Olalde et al. 2018 Data	FASTA Metadata	16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 3796G (MT-ND1): Adult-Onset Dystonia (Reported)
I6472	BBC	Copper Age	Spain	M	-2500	-2000	HV0b	bam	570.50	Olalde et al. 2018 Data	FASTA Metadata	195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I6542	BBC	Copper Age	Spain	M	-2500	-1750	U5b1i	bam	347.72	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I6587	BBC	Copper Age	Spain	M	-2500	-2000	K1a1b1	bam	192.85	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 15924G (MT-TT): LIMM (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I6589	BBC	Copper Age	Spain	M	-2500	-2000	K1a1b1	bam	189.80	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 114T (MT-CR): BD-associated (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 15924G (MT-TT): LIMM (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 7859A (MT-CO2): Progressive Encephalomyopathy (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I0453	CAIB	Copper Age	Spain	M	-2458	-2147	V	bam	166.65	Olalde et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I7251	BBC	Copper Age	Czech Republic	M	-2500	-2200	U2e1	bam	344.06	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16183C (MT-CR): Melanoma patients (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I2458	BABI	Bronze Age	Great Britain	F	-1492	-1287	U5b3	bam	187.08	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 12811C (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 15497A (MT-CYB): EXIT / Obesity (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 228A (MT-CR): Low VO2max response (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 8573A (MT-ATP6): Patient with suspected mitochondrial disease (Reported as Benign)
I2600	BABI	Bronze Age	Great Britain	F	-2133	-1937	U5b1+16189	bam	344.51	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I2610	BABI	Bronze Age	Great Britain	F	-1935	-1745	U2e1b	bam	11.37	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 988A (MT-RNR1): Possible DEAF risk factor (Reported)
I7281	BBC	Copper Age	Czech Republic	F	-2500	-2200	H5a1g	bam	211.62	Olalde et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4336C (MT-TQ): ADPD / Hearing Loss & Migraine / autism spectrum / intellectual disability (Unclear)
I4895	BBC	Copper Age	Czech Republic	M	-2273	-2047	H1+16189	bam	153.93	Olalde et al. 2018 Data	FASTA Metadata	16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I3255	BBC	Bronze Age	Great Britain	F	-2135	-1949	T2b	bam	797.20	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I3256	BBC	Bronze Age	Great Britain	M	-2203	-2029	T2b	bam	603.66	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I2453	BBC	Bronze Age	Great Britain	M	-2288	-2040	K2a	bam	1505.93	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I3132	BABI	Bronze Age	Great Britain	M	-2118	-1887	T2a1b1a	bam	620.60	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 14687G (MT-TE): Mito myopathy w respiratory failure / intellectual disability (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I4949	NEBI	Neolithic	Great Britain	M	-3629	-3376	T2b	bam	177.37	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 1555G (MT-RNR1): DEAF / autism spectrum intellectual disability / possibly antiatherosclerotic (Cfrm) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I6601	CAIB	Copper Age	Portugal	M	-2800	-2600	H1e2	bam	369.41	Olalde et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
I6680	BABI	Bronze Age	Great Britain	M	-1876	-1625	H1+16189	bam	95.71	Olalde et al. 2018 Data	FASTA Metadata	16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I7568	BABI	Bronze Age	Great Britain	F	-1600	-1300	W1+119	bam	104.25	Olalde et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
I7573	BABI	Bronze Age	Great Britain	F	-1642	-1507	H1	bam	177.67	Olalde et al. 2018 Data	FASTA Metadata	16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported)
I7578	BABI	Bronze Age	Great Britain	F	-1225	-1013	U5a2c	bam	185.73	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 228A (MT-CR): Low VO2max response (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I6775	BBC	Bronze Age	Great Britain	M	-2400	-2000	H1	bam	216.86	Olalde et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I2450	BBC	Bronze Age	Great Britain	F	-2461	-2146	K1a1b1g	bam	1089.59	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 15924G (MT-TT): LIMM (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I2416	BBC	Bronze Age	Great Britain	M	-2455	-2151	K1b1a1	bam	421.21	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13967T (MT-ND5): Possible LHON factor (Reported) 15257A (MT-CYB): LHON (Conflicting reports) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5913A (MT-CO1): Prostate Cancer / hypertension (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I6777	BBC	Bronze Age	Great Britain	M	-2500	-1900	U4b1b2	bam	180.18	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13528G (MT-ND5): LHON-like / LHON / MELAS (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 499A (MT-CR): Endometriosis (Reported)
I6778	BBC	Bronze Age	Great Britain	F	-2500	-1900	K1a26	bam	177.80	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 16192T (MT-CR): Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I1767	BBC	Bronze Age	Great Britain	M	-2200	-1979	U5a1a1	bam	471.98	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15924G (MT-TT): LIMM (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I2566	BBC	Bronze Age	Great Britain	M	-2204	-2035	K1b1a1	bam	650.33	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13967T (MT-ND5): Possible LHON factor (Reported) 15257A (MT-CYB): LHON (Conflicting reports) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5913A (MT-CO1): Prostate Cancer / hypertension (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I2598	BBC	Bronze Age	Great Britain	M	-2135	-1953	H	bam	794.37	Olalde et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I2417	BBC	Bronze Age	Great Britain	M	-2500	-2140	J1c	bam	125.19	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
I5379	BBC	Bronze Age	Great Britain	M	-2469	-2296	HV0+195	bam	203.14	Olalde et al. 2018 Data	FASTA Metadata	195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I6679	BBC	Bronze Age	Great Britain	M	-2124	-1890	J1c1b1	bam	251.70	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 146C (MT-CR): Absence of Endometriosis (Reported) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 3394C (MT-ND1): LHON / Diabetes / CPTdeficiency / high altitude adaptation (Reported / Population-dependent) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
I5513	BBC	Bronze Age	Great Britain	M	-2500	-1800	V	bam	117.45	Olalde et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I5382	BBC	Bronze Age	Great Britain	M	-2278	-1981	T2b	bam	173.19	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I2443	BBC	Bronze Age	Great Britain	F	-2284	-2028	T2c1d+152	bam	1012.23	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported) 6261A (MT-CO1): Prostate Cancer / LHON (Reported)
I2445	BBC	Bronze Age	Great Britain	M	-2396	-1929	X2b6	bam	2027.55	Olalde et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 15927A (MT-TT): LHON / Multiple Sclerosis / DEAF1555 increased penetrance / CHD (Reported) 16183C (MT-CR): Melanoma patients (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 8393T (MT-ATP8): Reversible brain pseudoatrophy (Reported)
I2446	BBC	Bronze Age	Great Britain	F	-2455	-2139	K1b1a1	bam	55.16	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13967T (MT-ND5): Possible LHON factor (Reported) 15257A (MT-CYB): LHON (Conflicting reports) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5913A (MT-CO1): Prostate Cancer / hypertension (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I5471	BBC	Bronze Age	Great Britain	F	-2266	-2025	H1c3a	bam	80.04	Olalde et al. 2018 Data	FASTA Metadata	16176T (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I7270	BBC	Copper Age	Czech Republic	F	-2500	-2200	K1a2c	bam	9.53	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 9055A (MT-ATP6): PD protective factor (Reported)
I4896	BBC	Copper Age	Czech Republic	F	-2288	-2142	U5a2+16294	bam	114.05	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I7276	BBC	Copper Age	Czech Republic	M	-2500	-2200	H5b	bam	288.09	Olalde et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I4945	BBC	Copper Age	Czech Republic	F	-2291	-2144	H4a1c	bam	273.48	Olalde et al. 2018 Data	FASTA Metadata	14582G (MT-ND6): LHON synergistic combo 14258A + 14582G (Reported: individually neutral variants causing LHON in combination)
I7278	BBC	Copper Age	Czech Republic	M	-2500	-2200	U4a2	bam	175.83	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 499A (MT-CR): Endometriosis (Reported) 9804A (MT-CO3): LHON / MS (Reported)
I5666	BBC	Copper Age	Czech Republic	M	-2500	-1900	U4a2c	bam	248.11	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 499A (MT-CR): Endometriosis (Reported)
I5514	BBC	Copper Age	Czech Republic	M	-2500	-2000	T2b+152	bam	205.49	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I4885	BBC	Copper Age	Czech Republic	M	-2289	-2143	U5a1i	bam	93.21	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I4886	BBC	Copper Age	Czech Republic	M	-2205	-2042	H6a	bam	219.41	Olalde et al. 2018 Data	FASTA Metadata	16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I7282	BBC	Copper Age	Czech Republic	M	-2500	-2200	K1a3a3	bam	228.41	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 12811C (MT-ND5): Possible LHON factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I4888	BBC	Copper Age	Czech Republic	M	-2190	-2029	K1a2c	bam	137.03	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 9055A (MT-ATP6): PD protective factor (Reported)
I7288	BBC	Copper Age	Czech Republic	M	-2500	-2200	H1m	bam	14.98	Olalde et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported)
I7289	BBC	Copper Age	Czech Republic	M	-2500	-2200	U8b1b1	bam	193.60	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16183C (MT-CR): Melanoma patients (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I4890	BBC	Copper Age	Czech Republic	M	-2500	-2000	H	bam	13.50	Olalde et al. 2018 Data	FASTA Metadata
I4891	BBC	Copper Age	Czech Republic	M	-2281	-2062	J2a1a2	bam	193.26	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 15257A (MT-CYB): LHON (Conflicting reports) 195C (MT-CR): BD-associated / melanoma pts (Reported) 295T (MT-CR): Low VO2max response (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 489C (MT-CR): Low VO2max response (Reported)
I1382	BBC	Copper Age	France	M	-2434	-2135	U5a2c3a	bam	126.33	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I1389	BBC	Copper Age	France	M	-2468	-2278	X2b4a	bam	133.39	Olalde et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 15927A (MT-TT): LHON / Multiple Sclerosis / DEAF1555 increased penetrance / CHD (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 8393T (MT-ATP8): Reversible brain pseudoatrophy (Reported)
I4887	BBC	Copper Age	Czech Republic	M	-2201	-2039	K1a2c	bam	232.53	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 9055A (MT-ATP6): PD protective factor (Reported)
I7205	BBC	Copper Age	Czech Republic	M	-2500	-2200	H10+(16093)	bam	206.12	Olalde et al. 2018 Data	FASTA Metadata	16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I7210	BBC	Copper Age	Czech Republic	M	-2500	-2200	H6a1b4	bam	263.89	Olalde et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I7287	BBC	Copper Age	Czech Republic	M	-2500	-2200	K1a4a1	bam	97.13	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I7290	BBC	Copper Age	Czech Republic	F	-2500	-2200	V3	bam	201.42	Olalde et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I7283	BBC	Copper Age	Czech Republic	F	-2500	-2200	K1a3a3	bam	301.46	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 12811C (MT-ND5): Possible LHON factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I7214	BBC	Copper Age	Czech Republic	F	-2500	-2200	U8b1b1	bam	227.21	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16183C (MT-CR): Melanoma patients (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I6468	BBC	Copper Age	Czech Republic	F	-2500	-1900	K2b1	bam	161.26	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I1392	BBC	Copper Age	France	F	-2833	-2475	H1+152	bam	644.76	Olalde et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported)
I3601	BBC	Copper Age	Germany	F	-2300	-2150	H10e	bam	303.69	Olalde et al. 2018 Data	FASTA Metadata	16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I3588	BBC	Copper Age	Germany	M	-2300	-2150	H1e1a	bam	350.93	Olalde et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports) 8821G (MT-ATP6): Possible LHON helper variant (Reported)
I3590	BBC	Copper Age	Germany	F	-2335	-2140	H1	bam	276.17	Olalde et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I3594	BBC	Copper Age	Germany	F	-2300	-2150	T2f	bam	726.27	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 185A (MT-CR): Low VO2max response (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I4248	BBC	Copper Age	Germany	M	-2500	-2000	T2b+152	bam	102.76	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I3602	BBC	Copper Age	Germany	F	-2300	-2150	I3a	bam	341.36	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 15924G (MT-TT): LIMM (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I3600	BBC	Copper Age	Germany	F	-2300	-2150	U5b3	bam	1229.41	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9966A (MT-CO3): LHON possible helper variant (Reported)
I3597	BBC	Copper Age	Germany	M	-2300	-2150	T2f	bam	289.27	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 185A (MT-CR): Low VO2max response (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I5520	BBC	Copper Age	Germany	F	-2500	-2000	K1b2a	bam	224.12	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5913A (MT-CO1): Prostate Cancer / hypertension (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I5521	BBC	Copper Age	Germany	F	-2500	-2000	J1b1a1	bam	213.51	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 295T (MT-CR): Low VO2max response (Reported) 2158C (MT-RNR2): Reduced risk PD (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
I5659	BBC	Copper Age	Germany	M	-2500	-2000	K1a4b	bam	677.92	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I5522	BBC	Copper Age	Germany	F	-2500	-2000	J1b1a1	bam	535.91	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 295T (MT-CR): Low VO2max response (Reported) 2158C (MT-RNR2): Reduced risk PD (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
E09568_d	BBC	Copper Age	Germany	M	-2460	-2210	U5b2b	<NA>	<NA>	Olalde et al. 2018 Data	Metadata
E09614_d	BBC	Copper Age	Germany	F	-2270	-2045	J1c3	<NA>	<NA>	Olalde et al. 2018 Data	Metadata
I4249	BBC	Copper Age	Germany	F	-2500	-2000	H5a1	bam	1142.95	Olalde et al. 2018 Data	FASTA Metadata	4336C (MT-TQ): ADPD / Hearing Loss & Migraine / autism spectrum / intellectual disability (Unclear)
I4250	BBC	Copper Age	Germany	F	-2433	-2149	U5a1a2b	bam	387.91	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9804A (MT-CO3): LHON / MS (Reported)
I5833	BBC	Copper Age	Germany	M	-2500	-2000	J1c	bam	89.89	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12477C (MT-ND5): possible HCM susceptibility (Reported) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported)
I5655	BBC	Copper Age	Germany	F	-2500	-2000	H5a1	bam	246.55	Olalde et al. 2018 Data	FASTA Metadata	4336C (MT-TQ): ADPD / Hearing Loss & Migraine / autism spectrum / intellectual disability (Unclear)
I6591	BBC	Copper Age	Germany	F	-2500	-2000	U5b2c	bam	398.98	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I6624	BBC	Copper Age	Germany	F	-2500	-2000	T1a1	bam	80.90	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I5835	BBC	Copper Age	Germany	M	-2500	-2000	J1c	bam	233.73	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
I5660	BBC	Copper Age	Germany	M	-2500	-2000	T1a1	bam	463.35	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I5525	BBC	Copper Age	Germany	F	-2500	-2000	U4b1b2	bam	307.97	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13528G (MT-ND5): LHON-like / LHON / MELAS (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 499A (MT-CR): Endometriosis (Reported)
I7044	BBC	Copper Age	Hungary	M	-2500	-2200	U5b1d1b	bam	276.86	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I7045	BBC	Copper Age	Hungary	F	-2500	-2200	T2c1d+152	bam	453.09	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported) 6261A (MT-CO1): Prostate Cancer / LHON (Reported)
I5014	BBC	Copper Age	Germany	F	-2500	-2000	V	bam	443.53	Olalde et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I5023	BBC	Copper Age	Germany	F	-2500	-2000	U2e1a1	bam	530.45	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16183C (MT-CR): Melanoma patients (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I5529	BBC	Copper Age	Germany	M	-2500	-2000	HV15	bam	158.93	Olalde et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I4252	BBC	Copper Age	Poland	M	-2285	-2138	U5a1a1	bam	117.18	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15924G (MT-TT): LIMM (Reported) 16270T (MT-CR): Melanoma patients (Reported)
E09537_d	BBC	Copper Age	Germany	F	-2471	-2298	K1a	<NA>	<NA>	Olalde et al. 2018 Data	Metadata
I5531	BBC	Copper Age	Germany	F	-2500	-2000	T2b	bam	120.03	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I2365	BBC	Copper Age	Hungary	M	-2464	-2207	V3	bam	310.06	Olalde et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I2741	BBC	Copper Age	Hungary	M	-2457	-2153	H1+16189	bam	648.16	Olalde et al. 2018 Data	FASTA Metadata	16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I2786	BBC	Copper Age	Hungary	M	-2458	-2205	I1	bam	210.54	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 15924G (MT-TT): LIMM (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9966A (MT-CO3): LHON possible helper variant (Reported)
I2787	BBC	Copper Age	Hungary	M	-2457	-2201	T2b	bam	116.25	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I4178	BBC	Copper Age	Hungary	M	-2500	-2200	J1c1b1a	bam	31.08	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 3394C (MT-ND1): LHON / Diabetes / CPTdeficiency / high altitude adaptation (Reported / Population-dependent) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
I6538	BBC	Copper Age	Poland	F	-2008	-1765	H40	bam	142.67	Olalde et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I6583	BBC	Copper Age	Poland	F	-2289	-2050	U5b1c2	bam	300.85	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I5755	BBC	Copper Age	Switzerland	M	-2469	-1984	K2b1a	bam	84.01	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13135A (MT-ND5): possible HCM susceptibility (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I6580	BBC	Copper Age	Poland	M	-2300	-2150	K1a1b2b	bam	105.69	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 114T (MT-CR): BD-associated (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 15924G (MT-TT): LIMM (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I6534	BBC	Copper Age	Poland	M	-2456	-2149	T2e1	bam	322.74	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I6535	BBC	Copper Age	Poland	M	-2463	-2205	U5a2b	bam	47.01	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported)
I4251	BBC	Copper Age	Poland	M	-2431	-2150	H1	bam	59.82	Olalde et al. 2018 Data	FASTA Metadata	14502C (MT-ND6): LHON (Reported - possibly synergistic) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported)
I0840	BBC	Copper Age	Portugal	F	-2455	-2200	U5b1i	bam	6.96	Olalde et al. 2018 Data	FASTA Metadata	12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I5759	BBC	Copper Age	Switzerland	F	-2469	-1984	U2e1c1	bam	244.82	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I0839	BBC	Copper Age	Portugal	F	-2456	-2205	-	bam	6.60	Olalde et al. 2018 Data	FASTA Metadata
I1970	BBC	Copper Age	Portugal	M	-2700	-2300	X2b+226	bam	33.37	Olalde et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 15927A (MT-TT): LHON / Multiple Sclerosis / DEAF1555 increased penetrance / CHD (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 8393T (MT-ATP8): Reversible brain pseudoatrophy (Reported)
I6467	BBC	Copper Age	Portugal	F	-2700	-2300	K1a4a1	bam	134.12	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 16183C (MT-CR): Melanoma patients (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I0458	BBC	Copper Age	Spain	M	-2457	-2206	K1a1b1	bam	320.17	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 114T (MT-CR): BD-associated (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 15924G (MT-TT): LIMM (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I0459	BBC	Copper Age	Spain	F	-2600	-2200	U5b2b	bam	426.97	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 12634G (MT-ND5): Thyroid Cancer Cell Line (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I0461	BBC	Copper Age	Spain	F	-2455	-2201	K1a1b1	bam	306.24	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15924G (MT-TT): LIMM (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 6261A (MT-CO1): Prostate Cancer / LHON (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I4245	BBC	Copper Age	Spain	F	-2460	-2291	L1b1a	bam	552.93	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 2352C (MT-RNR2): Possibly LVNC-associated (Reported) 3308C (MT-ND1): MELAS / DEAF enhancer / hypertension / LVNC / putative LHON (P.M.-possibly synergistic) 5655C (MT-TA): DEAF enhancer / Hypertension risk (Reported)
I6626	BBC	Copper Age	Spain	U	-2500	-1750	H1	bam	26.38	Olalde et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported)
I6622	BBC	Copper Age	Spain	M	-2800	-1750	U5b1i	bam	6.87	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I6623	BBC	Copper Age	Spain	F	-1956	-1743	U5b1f1a	bam	220.60	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I6539	BBC	Copper Age	Spain	M	-2500	-2000	T2b3+151	bam	446.41	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I6588	BBC	Copper Age	Spain	M	-2500	-2000	U5b2b3	bam	217.08	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 12634G (MT-ND5): Thyroid Cancer Cell Line (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 2755G (MT-RNR2): Possibly LVNC-associated (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I6584	BBC	Copper Age	Spain	F	-2500	-2000	H4a1a+195	bam	185.83	Olalde et al. 2018 Data	FASTA Metadata	14582G (MT-ND6): LHON synergistic combo 14258A + 14582G (Reported: individually neutral variants causing LHON in combination) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I6585	BBC	Copper Age	Spain	M	-2344	-2135	K1a4a1	bam	212.65	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I6471	BBC	Copper Age	Spain	M	-2500	-2000	U5b1c1	bam	84.76	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I0825	BBC	Copper Age	Spain	M	-2474	-2298	K1a4a1	bam	114.27	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15924G (MT-TT): LIMM (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I2477	BBC	Copper Age	Italy	F	-2200	-1930	T2b3+151	bam	272.51	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I1979	BBC	Copper Age	Italy	F	-2200	-1930	T2b3	bam	31.78	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I4933	BBC	Copper Age	Italy	U	-2500	-1900	R0a	bam	3.33	Olalde et al. 2018 Data	FASTA Metadata
I2575	BBC	Copper Age	France	M	-2475	-2210	K1c1	bam	71.01	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I4068	BBC	Copper Age	The Netherlands	M	-2131	-1951	U5a2a1	bam	54.46	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 7444A (MT-CO1): LHON / SNHL / DEAF (Reported)
I4069	BBC	Copper Age	The Netherlands	M	-2188	-1887	U5a1a1	bam	150.56	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15924G (MT-TT): LIMM (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I4074	BBC	Copper Age	The Netherlands	M	-2278	-1915	H	bam	292.85	Olalde et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9041G (MT-ATP6): Patient with suspected mitochondrial disease (Reported as VUS)
I4076	BBC	Copper Age	The Netherlands	F	-1882	-1750	K1d	bam	68.07	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5592G (MT-TA): Coronary Heart Disease (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I5748	BBC	Copper Age	The Netherlands	M	-2579	-2233	X2b4	bam	99.70	Olalde et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 15927A (MT-TT): LHON / Multiple Sclerosis / DEAF1555 increased penetrance / CHD (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 8393T (MT-ATP8): Reversible brain pseudoatrophy (Reported)
I5750	BBC	Copper Age	The Netherlands	M	-2300	-1900	K1b1a1+199	bam	208.46	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13967T (MT-ND5): Possible LHON factor (Reported) 15257A (MT-CYB): LHON (Conflicting reports) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5913A (MT-CO1): Prostate Cancer / hypertension (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I6543	CAIB	Copper Age	Spain	M	-2479	-1945	H1	bam	624.97	Olalde et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported)
I6604	CAIB	Copper Age	Spain	M	-2127	-1905	U5b1c	bam	581.00	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I6605	CAIB	Copper Age	Spain	F	-2479	-2287	H1t	bam	151.86	Olalde et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I6610	CAIB	Copper Age	Spain	F	-1971	-1745	K1a+195	bam	119.72	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I6608	CAIB	Copper Age	Spain	M	-2020	-1768	J1c1	bam	168.12	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 3394C (MT-ND1): LHON / Diabetes / CPTdeficiency / high altitude adaptation (Reported / Population-dependent) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
I6609	CAIB	Copper Age	Spain	F	-2436	-2143	U5b1e	bam	289.06	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I6596	CAIB	Copper Age	Spain	M	-2900	-2300	H3	bam	335.66	Olalde et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I6628	CAIB	Copper Age	Spain	F	-2900	-2300	H1	bam	106.80	Olalde et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported)
I6629	CAIB	Copper Age	Spain	M	-2900	-2300	T2b	bam	401.49	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I2464	BABI	Bronze Age	Great Britain	M	-1745	-1614	I2	bam	79.02	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 15924G (MT-TT): LIMM (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I0457	CAIB	Copper Age	Spain	M	-2920	-2340	J1c1	bam	160.21	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 3394C (MT-ND1): LHON / Diabetes / CPTdeficiency / high altitude adaptation (Reported / Population-dependent) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
I0456	CAIB	Copper Age	Spain	F	-2920	-2340	U5b2a1a	bam	75.16	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16192T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I2457	BABI	Bronze Age	Great Britain	M	-2467	-2030	I4a	bam	542.20	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 15924G (MT-TT): LIMM (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 8519A (MT-ATP8): Susceptibility to bullous pemphigoid (Reported)
I2604	BABI	Bronze Age	Great Britain	F	-2265	-2031	H2a3	bam	166.06	Olalde et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I2596	BABI	Bronze Age	Great Britain	M	-2273	-2034	J1c1	bam	122.49	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 3394C (MT-ND1): LHON / Diabetes / CPTdeficiency / high altitude adaptation (Reported / Population-dependent) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
I2460	BABI	Bronze Age	Great Britain	F	-2022	-1827	T2a1a	bam	308.43	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 14687G (MT-TE): Mito myopathy w respiratory failure / intellectual disability (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I2597	BABI	Bronze Age	Great Britain	M	-2269	-2033	U5a2c3a	bam	171.78	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)