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Name	Group	Epoch	Country	Sex	Year from	Year to	Haplogroup	Sequence source	Avg. coverage	Reference	Download	Pathologies
I5207	LBK	Neolithic	Austria	M	-5500	-4500	H67	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
DA125	IAST	Iron Age	Kazakhstan	M	140	160	U2e2a1	bam	126.93	de Barros Damgaard et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
RISE507	BARu	Bronze Age	Russia	F	-3322	-2923	U5a1a1	bam	<NA>	Allentoft et al. 2015 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15924G (MT-TT): LIMM (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I3596	BBC	Copper Age	Germany	M	-2300	-2150	H+16129	bam	119.37	Olalde et al. 2018 Data	FASTA Metadata	16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I6590	BBC	Copper Age	Germany	F	-2500	-2000	X2c1	bam	509.04	Olalde et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 16183C (MT-CR): Melanoma patients (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I5208	LBK	Neolithic	Austria	F	-5500	-4500	K1b1a	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I5834	BBC	Copper Age	Germany	F	-2500	-2000	W5	bam	275.62	Olalde et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
I5373	BABI	Bronze Age	Great Britain	M	-2194	-1980	X2b+226	bam	214.55	Olalde et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 15927A (MT-TT): LHON / Multiple Sclerosis / DEAF1555 increased penetrance / CHD (Reported) 16183C (MT-CR): Melanoma patients (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 8393T (MT-ATP8): Reversible brain pseudoatrophy (Reported)
I1496	LBK	Neolithic	Hungary	M	-5211	-4992	K1a3a3	bam	<NA>	Gamba et al. 2014 Data	FASTA Metadata
I1707	PPNE	Neolithic	Jordan	M	-7722	-7541	R0a	bam	20.30	Lazaridis et al. 2016 Data	FASTA Metadata
RISE508	BARu	Bronze Age	Russia	F	-3331	-2935	U5a1a1	bam	<NA>	Allentoft et al. 2015 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15924G (MT-TT): LIMM (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I2601	BABI	Bronze Age	Great Britain	F	-1955	-1750	U5a1b1a	bam	19.73	Olalde et al. 2018 Data	FASTA Metadata	12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I0708	NENE	Neolithic	Turkey	M	-6500	-6200	N1b1a	bam	<NA>	Mathieson et al. 2015 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 16390A (MT-CR): POAG - potential for association (Reported) 8836G (MT-ATP6): LHON (Reported)
DA126	MAKa	Middle Ages	Kazakhstan	M	901	920	F2c1	bam	216.48	de Barros Damgaard et al. 2018 Data	FASTA Metadata	1005C (MT-RNR1): DEAF (Unclear) 11150A (MT-ND4): Found in a Multiple Sclerosis patient (Reported) 12338C (MT-ND5): DEAF1555 increased penetrance / LHON (Conflicting reports) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 16183C (MT-CR): Melanoma patients (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 4440A (MT-TM): Mitochondrial myopathy (Reported)
I3607	BBC	Copper Age	Germany	M	-2350	-2250	W3a1	bam	15.11	Olalde et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15784C (MT-CYB): POAG - potential for association (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
I1710	PPNE	Neolithic	Jordan	M	-7733	-7526	T1a2	bam	48.50	Lazaridis et al. 2016 Data	FASTA Metadata
I0746	NENE	Neolithic	Turkey	M	-6067	-5892	K1a or K1a1	bam	<NA>	Mathieson et al. 2015 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I2602	BABI	Bronze Age	Great Britain	M	-1892	-1699	U5b2b	bam	112.84	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 12634G (MT-ND5): Thyroid Cancer Cell Line (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16270T (MT-CR): Melanoma patients (Reported)
I2463	BABI	Bronze Age	Great Britain	F	-1925	-1700	J1c3+189	bam	250.88	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
I1495	LDN	Neolithic	Hungary	M	-4491	-4357	N1a1a1a	bam	<NA>	Gamba et al. 2014 Data	FASTA Metadata
I4914	HGS	Mesolithic	Serbia	M	-6355	-5990	U5a1c1	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I2462	BABI	Bronze Age	Great Britain	F	-2128	-1891	U5a1d2a	bam	274.64	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I4665	HGS	Mesolithic	Serbia	F	-6205	-5907	J2b1	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I1099	NENE	Neolithic	Turkey	M	-6500	-6200	T2b	bam	<NA>	Mathieson et al. 2015 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I4666	HGS	Mesolithic	Serbia	M	-6222	-5912	H40	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I2612	BABI	Bronze Age	Great Britain	F	-2464	-2208	U5b2b2	bam	373.29	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 12634G (MT-ND5): Thyroid Cancer Cell Line (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I1102	NENE	Neolithic	Turkey	M	-6500	-6200	K1a3a	bam	<NA>	Mathieson et al. 2015 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I1704	PPNE	Neolithic	Jordan	F	-7446	-7058	T	bam	21.70	Lazaridis et al. 2016 Data	FASTA Metadata
I5405	HGS	Mesolithic	Serbia	F	-5836	-5632	HV	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I5658	BBC	Copper Age	Germany	F	-2500	-2000	T2b+152	bam	514.19	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I1416	PPNE	Neolithic	Jordan	M	-8300	-7900	None	<NA>	<NA>	Lazaridis et al. 2016 Data	Metadata
I1581	NENE	Neolithic	Turkey	F	-6500	-6200	U3	bam	<NA>	Mathieson et al. 2015 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I12650	MAIB	Middle Ages	Spain	M	1100	1300	H1e1a	bam	16.99	Olalde et al. 2019 Data	FASTA Metadata
DA127	IAKa	Iron Age	Kazakhstan	M	252	304	D4b1a2a1	bam	119.94	de Barros Damgaard et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 14668T (MT-ND6): Depressive Disorder associated (Reported) 15043A (MT-CYB): MDD-associated (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 15951G (MT-TT): LHON / LHON modulator (Conflicting reports) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4883T (MT-ND2): Glaucoma (Conflicting reports) 489C (MT-CR): Low VO2max response (Reported) 8414T (MT-ATP8): Increased risk of T2DM and high altitude polycythemia (HAPC) in haplogroup D4 / Longevity (Reported)
I2421	BABI	Bronze Age	Great Britain	M	-1930	-1759	U5a1a2a	bam	232.06	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I0723	NENE	Neolithic	Turkey	M	-6400	-5600	X2m2	bam	<NA>	Mathieson et al. 2015 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I2609	BABI	Bronze Age	Great Britain	F	-2022	-1771	K2a	bam	163.71	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I2037	LBK	Neolithic	Germany	M	-5210	-5002	H1e	bam	<NA>	Lipson et al. 2017 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
I7497	MAIB	Middle Ages	Spain	F	1000	1100	H20a	bam	114.00	Olalde et al. 2019 Data	FASTA Metadata
I7630	BABI	Bronze Age	Great Britain	M	-1879	-1691	U5a	bam	4.57	Olalde et al. 2018 Data	FASTA Metadata	12372A (MT-ND5): Altered brain pH / sCJD patients (Reported)
I7499	MAIB	Middle Ages	Spain	F	1000	1100	H5	bam	83.40	Olalde et al. 2019 Data	FASTA Metadata
I1727	PPNE	Neolithic	Jordan	M	-8300	-7900	T1a2	bam	8.89	Lazaridis et al. 2016 Data	FASTA Metadata
DA128	MAKa	Middle Ages	Kazakhstan	F	1230	1230	D4o2a	bam	303.74	de Barros Damgaard et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 14668T (MT-ND6): Depressive Disorder associated (Reported) 15043A (MT-CYB): MDD-associated (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4883T (MT-ND2): Glaucoma (Conflicting reports) 489C (MT-CR): Low VO2max response (Reported) 8414T (MT-ATP8): Increased risk of T2DM and high altitude polycythemia (HAPC) in haplogroup D4 / Longevity (Reported)
DA130	IAKa	Iron Age	Kazakhstan	M	-357	-284	G2a1	bam	57.70	de Barros Damgaard et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 489C (MT-CR): Low VO2max response (Reported)
I5661	BBC	Copper Age	Germany	M	-2500	-2000	K1b1b1	bam	83.32	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 14063C (MT-ND5): Potentially functional variant cosegregating with LHON3635A (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5913A (MT-CO1): Prostate Cancer / hypertension (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I1109	NEBA	Neolithic	Bulgaria	F	-5800	-5400	J2b1	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I1415	PPNE	Neolithic	Jordan	M	-8197	-7653	T1a2	bam	23.44	Lazaridis et al. 2016 Data	FASTA Metadata
I5441	BABI	Bronze Age	Great Britain	M	-1938	-1744	H1+16239	bam	199.01	Olalde et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported)
I0014	HGN	Mesolithic	Sweden	F	-5877	-5629	U5a2d	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I5663	BBC	Copper Age	Germany	M	-2500	-2000	U5a2+16294	bam	283.20	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I0551	SMC	Neolithic	Germany	M	-3400	-3025	U3a1	bam	<NA>	Mathieson et al. 2015 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16390A (MT-CR): POAG - potential for association (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported)
I1295	NEBA	Neolithic	Bulgaria	M	-5800	-5400	J1c	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I2461	BABI	Bronze Age	Great Britain	F	-2500	-2140	H5c	bam	357.81	Olalde et al. 2018 Data	FASTA Metadata
I8570	BAIB	Bronze Age	Spain	M	-1800	-1000	J1c3	bam	31.10	Olalde et al. 2019 Data	FASTA Metadata
I0559	BAC	Neolithic	Germany	M	-3654	-3527	HV	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I1296	NEBA	Neolithic	Bulgaria	M	-5800	-5400	U5a2	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I2637	NEBI	Neolithic	Great Britain	M	-3629	-3370	K1b1a1	bam	172.64	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13967T (MT-ND5): Possible LHON factor (Reported) 15257A (MT-CYB): LHON (Conflicting reports) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5913A (MT-CO1): Prostate Cancer / hypertension (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I2618	BABI	Bronze Age	Great Britain	M	-2134	-1950	H1bs	bam	706.46	Olalde et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I0103	CWC	Neolithic	Germany	F	-2578	-2468	W6a	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 16192T (MT-CR): Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
I2216	NEBA	Neolithic	Bulgaria	F	-5800	-5400	J2b1	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I5377	BABI	Bronze Age	Great Britain	M	-1894	-1694	T2b	bam	243.84	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I5383	BABI	Bronze Age	Great Britain	F	-1090	-900	J1c5f	bam	137.67	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 15924G (MT-TT): LIMM (Reported) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
I7639	BABI	Bronze Age	Great Britain	F	-2031	-1665	U5a1	bam	1.56	Olalde et al. 2018 Data	FASTA Metadata
I3879	NEBA	Neolithic	Bulgaria	M	-5800	-5400	H	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
DA134	IAST	Iron Age	Russia	M	0	100	I1	bam	66.88	de Barros Damgaard et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 15924G (MT-TT): LIMM (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 9966A (MT-CO3): LHON possible helper variant (Reported)
I2639	BABI	Bronze Age	Great Britain	F	-1600	-1430	T2e1a	bam	1051.40	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I2796	NEBI	Neolithic	Great Britain	M	-3705	-3535	H3	bam	232.16	Olalde et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I7570	BABI	Bronze Age	Great Britain	M	-1735	-1531	T2b4+152	bam	88.74	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
RISE61	NESC	Neolithic	Denmark	M	-2851	-2492	J1c4	<NA>	<NA>	Allentoft et al. 2015 Data	Metadata
Rev5	NEGr	Neolithic	Greece	F	-6438	-6264	X2b	bam	<NA>	Hofmanova et al. 2016 Data	FASTA Metadata
I8571	BAIB	Bronze Age	Spain	M	-1800	-1000	K1a2c	bam	48.50	Olalde et al. 2019 Data	FASTA Metadata
I5656	BBC	Copper Age	Germany	U	-2500	-2000	T2g2	bam	214.36	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I7575	BABI	Bronze Age	Great Britain	M	-1263	-1043	U5a1d1	bam	163.31	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I7577	BABI	Bronze Age	Great Britain	M	-1386	-1123	U5a1a1	bam	146.15	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15924G (MT-TT): LIMM (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I3708	NEGr	Neolithic	Greece	F	-5500	-3700	T1a	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I1701	PPNE	Neolithic	Jordan	F	-7750	-7569	K1a18	bam	14.82	Lazaridis et al. 2016 Data	FASTA Metadata
I3709	NEGr	Neolithic	Greece	F	-3990	-3804	K1b1a	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I3920	NEGr	Neolithic	Greece	F	-3933	-3706	H	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
DA136	IAST	Iron Age	Russia	M	0	100	A+152+16362	<NA>	64.28	de Barros Damgaard et al. 2018 Data	Metadata
I7580	BABI	Bronze Age	Great Britain	F	-1256	-1018	U5b2a1a	bam	217.86	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16192T (MT-CR): Melanoma patients (Reported)
RISE392	BARu	Bronze Age	Russia	M	-2126	-1896	J2b1a2a	bam	<NA>	Allentoft et al. 2015 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 15257A (MT-CYB): LHON (Conflicting reports) 15812A (MT-CYB): LHON (Reported / Secondary) 295T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
I3604	BBC	Copper Age	Germany	M	-2350	-2250	HV9	bam	11.45	Olalde et al. 2018 Data	FASTA Metadata
I2318	NEGr	Neolithic	Greece	F	-4043	-3947	H2	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I1926	TRP	Neolithic	Ukraine	M	-3931	-3640	H5a	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
RISE577	UNC	Bronze Age	Czech Republic	F	-2300	-1800	T2b	bam	<NA>	Allentoft et al. 2015 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I5401	HGS	Mesolithic	Serbia	M	-7076	-6699	U5a1	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 16390A (MT-CR): POAG - potential for association (Reported)
I7626	BABI	Bronze Age	Great Britain	F	-1395	-1130	T2b	bam	165.27	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I2111	TRP	Neolithic	Ukraine	M	-3758	-3636	HV	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
RISE349	BAHu	Bronze Age	Hungary	F	-2034	-1784	T2b3	bam	<NA>	Allentoft et al. 2015 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I6561	NEUk	Neolithic	Ukraine	M	-4045	-3974	H2a1a	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I0048	LBK	Neolithic	Germany	M	-5210	-5002	K1a26	bam	<NA>	Lipson et al. 2017 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I7627	BABI	Bronze Age	Great Britain	F	-1410	-1222	U4a2	bam	226.03	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 499A (MT-CR): Endometriosis (Reported)
I5882	NEUk	Neolithic	Ukraine	F	-3264	-2929	U5a2a	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I5523	BBC	Copper Age	Germany	F	-2500	-2000	K1b1a1+199	bam	113.04	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13967T (MT-ND5): Possible LHON factor (Reported) 15257A (MT-CYB): LHON (Conflicting reports) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5913A (MT-CO1): Prostate Cancer / hypertension (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I5019	BBC	Copper Age	Germany	F	-2500	-2000	K1b1a1	bam	68.25	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13967T (MT-ND5): Possible LHON factor (Reported) 15257A (MT-CYB): LHON (Conflicting reports) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 5913A (MT-CO1): Prostate Cancer / hypertension (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I7628	BABI	Bronze Age	Great Britain	M	-1208	-978	T1a1	bam	26.04	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I5884	NEUk	Neolithic	Ukraine	M	-2890	-2696	U5a2b	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I12208	BAIB	Bronze Age	Spain	F	-1368	-1211	K1a1b1	bam	389.40	Olalde et al. 2019 Data	FASTA Metadata
I7579	BABI	Bronze Age	Great Britain	F	-1496	-1300	U5b2a1a	bam	182.54	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16192T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I5885	NEUk	Neolithic	Ukraine	F	-6392	-5927	U5b2b	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I3082	BABI	Bronze Age	Great Britain	M	-1498	-1394	H1an1a	bam	199.91	Olalde et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4454C (MT-TM): Possible contributor to mito dysfunction / hypertension (Reported)
DA141	IAST	Iron Age	Russia	M	0	100	A+152+16362	bam	65.40	de Barros Damgaard et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 8414T (MT-ATP8): Increased risk of T2DM and high altitude polycythemia (HAPC) in haplogroup D4 / Longevity (Reported)
I1733	HGE	Mesolithic	Ukraine	F	-9000	-7500	U4b	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I5524	BBC	Copper Age	Germany	F	-2500	-2000	H72	bam	300.85	Olalde et al. 2018 Data	FASTA Metadata	16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 15927A (MT-TT): LHON / Multiple Sclerosis / DEAF1555 increased penetrance / CHD (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I7574	BABI	Bronze Age	Great Britain	F	-1406	-1230	H1a3	bam	203.88	Olalde et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I1734	HGE	Mesolithic	Ukraine	M	-7446	-7058	U5b2	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
MA1	HGE	Upper Paleolithic	Russia	M	-22570	-22140	None	bam	<NA>	Raghavan et al. 2014 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported)
I4305	MLN	Neolithic	France	F	-4825	-4616	T2b3+151	bam	277.19	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I4308	MLN	Neolithic	France	F	-3501	-3112	U3a1	bam	16.06	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 16390A (MT-CR): POAG - potential for association (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported)
I1737	HGE	Mesolithic	Ukraine	F	-8540	-8301	U5a2	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I3717	NEUk	Neolithic	Ukraine	M	-5460	-5218	U5a2a	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
RISE374	BAHu	Bronze Age	Hungary	M	-1866	-1619	T2b	bam	<NA>	Allentoft et al. 2015 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I5526	BBC	Copper Age	Germany	F	-2500	-2000	H72	bam	751.70	Olalde et al. 2018 Data	FASTA Metadata	16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 15927A (MT-TT): LHON / Multiple Sclerosis / DEAF1555 increased penetrance / CHD (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I7571	BABI	Bronze Age	Great Britain	M	-1448	-1259	J1c1	bam	117.06	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 3394C (MT-ND1): LHON / Diabetes / CPTdeficiency / high altitude adaptation (Reported / Population-dependent) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
I1709	PPNE	Neolithic	Jordan	M	-8300	-7900	U8b1a	bam	1.62	Lazaridis et al. 2016 Data	FASTA Metadata
I3718	NEUk	Neolithic	Ukraine	M	-5345	-5215	U5a1b	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I0013	HGN	Mesolithic	Sweden	M	-5964	-5638	U5a1	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
I4081	HGS	Mesolithic	Romania	M	-7580	-7190	H13	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I7572	BABI	Bronze Age	Great Britain	M	-1510	-1302	H13a1a	bam	52.42	Olalde et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I5020	BBC	Copper Age	Germany	F	-2457	-2205	H2a1e	bam	151.53	Allentoft et al. 2015 Data	FASTA Metadata
I0518	NEBI	Neolithic	Great Britain	M	-3360	-3100	K1a3a1	bam	25.79	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I5037	EBACz	Bronze Age	Czech Republic	M	-2300	-1900	K1a+150	bam	50.19	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
DA142	MAST	Middle Ages	Russia	M	0	100	J1c5a1	bam	312.57	de Barros Damgaard et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
I12209	BAIB	Bronze Age	Spain	M	-1368	-1211	H1ah	bam	656.00	Olalde et al. 2019 Data	FASTA Metadata
I4111	NEUk	Neolithic	Ukraine	F	-4722	-4548	U4d	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I5044	EBACz	Bronze Age	Czech Republic	F	-2300	-1900	K1b1a	bam	197.62	Allentoft et al. 2015 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15257A (MT-CYB): LHON (Conflicting reports) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 5913A (MT-CO1): Prostate Cancer / hypertension (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I0519	NEBI	Neolithic	Great Britain	M	-3360	-3100	X2b+226	bam	441.62	Olalde et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 15927A (MT-TT): LHON / Multiple Sclerosis / DEAF1555 increased penetrance / CHD (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 8393T (MT-ATP8): Reversible brain pseudoatrophy (Reported)
I4114	NEUk	Neolithic	Ukraine	M	-5473	-5329	U5a1	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I5875	NEUk	Neolithic	Ukraine	M	-5291	-5060	U4a1	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I3068	NEBI	Neolithic	Great Britain	M	-3692	-3522	T2c1d1	bam	541.45	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported) 6261A (MT-CO1): Prostate Cancer / LHON (Reported)
I5883	NEUk	Neolithic	Ukraine	M	-5208	-5003	U4a	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I4582	HGS	Mesolithic	Romania	F	-7021	-6473	K1	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I0432	BARu	Bronze Age	Russia	M	-2925	-2491	U5a1c	bam	<NA>	Mathieson et al. 2015 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I5116	CAHu	Copper Age	Hungary	F	-3400	-3000	W	bam	9.19	Olalde et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
I2605	NEBI	Neolithic	Great Britain	F	-3631	-2944	J1c6	bam	291.74	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 15927A (MT-TT): LHON / Multiple Sclerosis / DEAF1555 increased penetrance / CHD (Reported) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
I5890	NEUk	Neolithic	Ukraine	M	-5286	-5062	U5a1b	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
DA143	IAST	Iron Age	Russia	F	0	100	U4b1a4	bam	80.56	de Barros Damgaard et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 499A (MT-CR): Endometriosis (Reported) 663G (MT-RNR1): Coronary atherosclerosis risk (Reported)
I5891	NEUk	Neolithic	Ukraine	M	-5465	-5310	U4d	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I5892	NEUk	Neolithic	Ukraine	M	-5301	-4982	U4a1	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I5118	CAHu	Copper Age	Hungary	M	-3400	-3000	H+16129	bam	259.05	Olalde et al. 2018 Data	FASTA Metadata	16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I2606	NEBI	Neolithic	Great Britain	M	-3330	-2900	K1a+195	bam	93.66	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I0433	YAM	Bronze Age	Russia	M	-5200	-4000	U5a1i	bam	<NA>	Mathieson et al. 2015 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9058G (MT-ATP6): Patients with (1) LVNC cardiomyopathy / (2) autism / intellectual disability / epilepsy (Reported as (1) possible association or as (2) benign)
E09538	BBC	Copper Age	Germany	M	-2464	-2210	J1c	<NA>	<NA>	Olalde et al. 2018 Data	Metadata
I6751	NEBI	Neolithic	Great Britain	F	-3755	-3660	U5b1+16189+@16192	bam	417.88	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16183C (MT-CR): Melanoma patients (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I6759	NEBI	Neolithic	Great Britain	M	-3650	-3522	J1c1	bam	491.39	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 3394C (MT-ND1): LHON / Diabetes / CPTdeficiency / high altitude adaptation (Reported / Population-dependent) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported) 6150A (MT-CO1): Prostate Cancer / enriched in POAG cohort (Reported)
I2472	BAIB	Bronze Age	Spain	M	-1605	-1425	K1a+195	bam	321.00	Olalde et al. 2019 Data	FASTA Metadata
I5893	NEUk	Neolithic	Ukraine	M	-5374	-5226	U5a2a	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I6762	NEBI	Neolithic	Great Britain	M	-4000	-3300	K1a1b1	bam	165.31	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 114T (MT-CR): BD-associated (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 15924G (MT-TT): LIMM (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
E09569	BBC	Copper Age	Germany	M	-2396	-2148	J1c2	<NA>	<NA>	Olalde et al. 2018 Data	Metadata
I1736	NEUk	Neolithic	Ukraine	F	-6248	-6070	U5b2b1	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I6761	NEBI	Neolithic	Great Britain	F	-3650	-3400	K1a+195	bam	186.26	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I5515	BABI	Bronze Age	Great Britain	M	-2034	-1775	H3+16311	bam	44.57	Olalde et al. 2018 Data	FASTA Metadata
I3713	NEUk	Neolithic	Ukraine	M	-5190	-4911	U4b1a	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I7042	BAHu	Bronze Age	Hungary	M	-2500	-2200	H	bam	503.18	Olalde et al. 2018 Data	FASTA Metadata	16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 3236G (MT-TL1): Sporadic bilateral optic neuropathy (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I3715	NEUk	Neolithic	Ukraine	M	-5636	-5521	U2e1	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I1679	PPNE	Neolithic	Jordan	F	-6900	-6800	R	bam	2.18	Lazaridis et al. 2016 Data	FASTA Metadata
I5868	NEUk	Neolithic	Ukraine	M	-5467	-5315	U4d	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I5473	BABI	Bronze Age	Great Britain	M	-2400	-2100	U5b	bam	1.66	Olalde et al. 2018 Data	FASTA Metadata	16270T (MT-CR): Melanoma patients (Reported)
I6482	BBC	Copper Age	Germany	F	-2500	-2000	U4d2	bam	4.38	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 5567C (MT-TW): Myopathy (Reported)
I0358	SRU	Bronze Age	Russia	F	-1906	-1631	H6a1a	bam	<NA>	Mathieson et al. 2015 Data	FASTA Metadata	11253C (MT-ND4): LHON PD (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I6133	NEUk	Neolithic	Ukraine	F	-6500	-4000	U5b2a1a	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported)
I1732	NEUk	Neolithic	Ukraine	F	-5364	-5213	U4b	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 499A (MT-CR): Endometriosis (Reported)
I5516	BABI	Bronze Age	Great Britain	M	-1866	-1615	T2a1b1a1b	bam	79.93	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 14687G (MT-TE): Mito myopathy w respiratory failure / intellectual disability (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I1738	NEUk	Neolithic	Ukraine	M	-5473	-5326	U5a2	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
DA144	IAST	Iron Age	Russia	M	0	100	H28	bam	81.39	de Barros Damgaard et al. 2018 Data	FASTA Metadata	16192T (MT-CR): Melanoma patients (Reported)
I6481	BBC	Copper Age	Germany	M	-2500	-2000	U5a1a1	bam	82.94	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15924G (MT-TT): LIMM (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I2470	BAIB	Bronze Age	Spain	M	-1411	-1231	J2a1a1	bam	1401.59	Olalde et al. 2019 Data	FASTA Metadata
I5530	BBC	Copper Age	Germany	M	-2500	-2000	K1b1a1	bam	62.23	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13967T (MT-ND5): Possible LHON factor (Reported) 15257A (MT-CYB): LHON (Conflicting reports) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5913A (MT-CO1): Prostate Cancer / hypertension (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I2567	BABI	Bronze Age	Great Britain	M	-2275	-1884	U4a1a	bam	372.89	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 499A (MT-CR): Endometriosis (Reported) 961C (MT-RNR1): DEAF / possibly LVNC-associated (Unclear)
I1407	CACA	Copper Age	Armenia	M	-4350	-3500	H	bam	554.00	Lazaridis et al. 2016 Data	FASTA Metadata
I7203	UNC	Bronze Age	Czech Republic	M	-2200	-1700	H1	bam	13.12	Olalde et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported)
I0047	UNC	Bronze Age	Germany	F	-2111	-1891	V9	bam	<NA>	Lipson et al. 2017 Data	FASTA Metadata	14841G (MT-CYB): LHON helper mut. (Reported)
I2569	BABI	Bronze Age	Great Britain	M	-2139	-1915	K1a3a	bam	220.51	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 3316A (MT-ND1): Diabetes / LHON / PEO (Unclear) 9055A (MT-ATP6): PD protective factor (Reported)
ANI160	CABA	Copper Age	Bulgaria	M	-4685	-4499	H1ag	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 3310T (MT-ND1): Diabetes / HCM (Reported)
ANI163	CABA	Copper Age	Bulgaria	F	-4711	-4542	H7a1	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
DA145	IAST	Iron Age	Russia	M	0	100	U2e1h	bam	26.93	de Barros Damgaard et al. 2018 Data	FASTA Metadata	12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 15043A (MT-CYB): MDD-associated (Reported)
I5469	BABI	Bronze Age	Great Britain	F	-1642	-1503	H5'36	bam	3.25	Olalde et al. 2018 Data	FASTA Metadata
RISE154	UNC	Bronze Age	Poland	F	-1925	-1765	K1a4a1	bam	<NA>	Allentoft et al. 2015 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I2860	BABI	Bronze Age	Great Britain	M	-969	-815	H5a1	bam	1659.05	Olalde et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4336C (MT-TQ): ADPD / Hearing Loss & Migraine / autism spectrum / intellectual disability (Unclear)
I10892	MAIB	Middle Ages	Spain	F	770	1200	H1e1a3	bam	232.00	Olalde et al. 2019 Data	FASTA Metadata
I1409	CACA	Copper Age	Armenia	F	-4229	-3985	U4a	bam	22.20	Lazaridis et al. 2016 Data	FASTA Metadata
LICOL1	LONG	Middle Ages	Italy	U	570	800	None	<NA>	<NA>	Vai et al. 2019	Metadata
I2859	BABI	Bronze Age	Great Britain	M	-910	-809	K1a2c	bam	1521.11	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 9055A (MT-ATP6): PD protective factor (Reported)
RISE480	BAHu	Bronze Age	Hungary	F	-1700	-1500	U5a2a	bam	<NA>	Allentoft et al. 2015 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
Villabruna	HGS	Epigravettian	Italy	M	-12230	-11830	U5b2b	bam	14.80	Fu et al. 2016 Data	FASTA Metadata	12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 12634G (MT-ND5): Thyroid Cancer Cell Line (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16270T (MT-CR): Melanoma patients (Reported)
DA146	IACA	Iron Age	Russia	F	300	1400	HV2a1	bam	44.95	de Barros Damgaard et al. 2018 Data	FASTA Metadata	16217C (MT-CR): Endometriosis (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported)
I3130	BABI	Bronze Age	Great Britain	F	-977	-829	U5a1c	bam	970.75	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 7080C (MT-CO1): Prostate Cancer (Reported)
I2364	BBC	Copper Age	Hungary	M	-2468	-2063	U5a2b	bam	119.70	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I3499	CABA	Copper Age	Croatia	M	-2884	-2666	T2e	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I3528	BBC	Copper Age	Hungary	M	-2559	-2301	HV4a1+16291	bam	219.38	Olalde et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I0634	NEBA	Neolithic	Serbia	M	-4710	-4504	K1a4	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I2792	CABA	Copper Age	Croatia	M	-2872	-2582	T2c2	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 3394C (MT-ND1): LHON / Diabetes / CPTdeficiency / high altitude adaptation (Reported / Population-dependent) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported) 6261A (MT-CO1): Prostate Cancer / LHON (Reported)
I4175	CABA	Copper Age	Croatia	F	-3000	-2700	U4a	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 3316A (MT-ND1): Diabetes / LHON / PEO (Unclear) 499A (MT-CR): Endometriosis (Reported)
I10895	MAIB	Middle Ages	Spain	M	777	981	H1ap1	bam	304.20	Olalde et al. 2019 Data	FASTA Metadata
I2656	BABI	Bronze Age	Great Britain	M	-1278	-979	H2a2a2	bam	115.72	Olalde et al. 2018 Data	FASTA Metadata	16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
BerryAuBac1	HGW	Mesolithic	France	M	-5370	-5220	U5b1a	bam	<NA>	Fu et al. 2016 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16270T (MT-CR): Melanoma patients (Reported)
I1875	HGS	Mesolithic	Croatia	F	-7308	-7027	U5b2b	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 12634G (MT-ND5): Thyroid Cancer Cell Line (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16270T (MT-CR): Melanoma patients (Reported)
DA160	IACA	Iron Age	Russia	F	300	1400	U4d3	bam	247.76	de Barros Damgaard et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 14577C (MT-ND6): MIDM (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 16183C (MT-CR): Melanoma patients (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 499A (MT-CR): Endometriosis (Reported)
I5376	BBC	Bronze Age	Great Britain	F	-2454	-2141	H6a1b	bam	19.19	Olalde et al. 2018 Data	FASTA Metadata
I2653	BABI	Bronze Age	Great Britain	M	-1500	-1300	H2a1a	bam	102.47	Olalde et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I2105	YAM	Bronze Age	Ukraine	F	-3300	-2700	T1a1	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
DA161	IACA	Iron Age	Russia	M	300	1400	X2f	bam	33.98	de Barros Damgaard et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported)
I1631	CACA	Copper Age	Armenia	F	-4250	-4050	K1a8	bam	468.00	Lazaridis et al. 2016 Data	FASTA Metadata
RISE546	YAM	Bronze Age	Russia	M	-3000	-2400	U5a1d2b	bam	<NA>	Allentoft et al. 2015 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I2654	BABI	Bronze Age	Great Britain	F	-1500	-1300	U5b3	bam	76.42	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 228A (MT-CR): Low VO2max response (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
RISE552	YAM	Bronze Age	Russia	M	-2849	-2143	T2a1a	bam	<NA>	Allentoft et al. 2015 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 14687G (MT-TE): Mito myopathy w respiratory failure / intellectual disability (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I0261	BBC	Copper Age	Spain	M	-2850	-2250	U5b1i	bam	273.49	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I0823	BBC	Copper Age	Spain	F	-2850	-2250	H1	bam	88.67	Olalde et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I3141	YAM	Bronze Age	Ukraine	F	-3300	-2700	H15b1	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	6253C (MT-CO1): Prostate Cancer / enriched in POAG cohort (Reported)
I2655	BABI	Bronze Age	Great Britain	M	-1441	-1272	H6a1b2	bam	1123.99	Olalde et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I1632	CACA	Copper Age	Armenia	M	-4230	-4000	K	bam	267.00	Lazaridis et al. 2016 Data	FASTA Metadata
I0444	YAM	Bronze Age	Russia	M	-3335	-2882	H6a1b	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I1917	YAM	Bronze Age	Ukraine	F	-3095	-2915	R0a1	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	827G (MT-RNR1): DEAF (Conflicting reports)
I2660	NEBI	Neolithic	Great Britain	M	-3513	-3352	U5a2+16194	bam	110.18	Olalde et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
I2691	NEBI	Neolithic	Great Britain	M	-3700	-3639	J1c1	bam	479.83	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 3394C (MT-ND1): LHON / Diabetes / CPTdeficiency / high altitude adaptation (Reported / Population-dependent) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
I1298	NEBA	Neolithic	Bulgaria	F	-6032	-5837	K1a	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
DA162	IACA	Iron Age	Russia	M	300	1400	H13a2c	bam	772.73	de Barros Damgaard et al. 2018 Data	FASTA Metadata
Denisova3	HGE	Upper Paleolithic	Russia	F	-48000	-30000	L	bam	<NA>	Krause et al. 2010 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12311C (MT-TL2): CPEO (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 12477C (MT-ND5): possible HCM susceptibility (Reported) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 13276G (MT-ND5): MIDD+retinopathy (Conflicting reports) 13528G (MT-ND5): LHON-like / LHON / MELAS (Reported) 14693G (MT-TE): MELAS / LHON / DEAF / hypertension helper (Reported) 15043A (MT-CYB): MDD-associated (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16081G (MT-CR): Cyclic Vomiting Syndrome (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 3277A (MT-TL1): Poss. hypertension factor (Reported) 3290C (MT-TL1): Poss. hypertension factor (Reported) 3421A (MT-ND1): MIDD (Reported) 3496T (MT-ND1): LHON (Reported / Secondary) 4456T (MT-TM): Poss. hypertension factor (Reported) 4659A (MT-ND2): possible PD risk factor / LHON (Reported) 5821A (MT-TC): DEAF helper mut. (Reported) 6150A (MT-CO1): Prostate Cancer / enriched in POAG cohort (Reported) 7868T (MT-CO2): LHON (Possibly synergistic) 827G (MT-RNR1): DEAF (Conflicting reports) 8021G (MT-CO2): Asthenozoospermia (Reported) 9966A (MT-CO3): LHON possible helper variant (Reported)
LICOL13	LONG	Middle Ages	Italy	U	570	800	None	<NA>	<NA>	Vai et al. 2019	Metadata
KZ1	LDN	Neolithic	Poland	F	-4332	-4066	U5b2a1a	fasta	<NA>	Juras et al. 2017a Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16192T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I0443	YAM	Bronze Age	Russia	M	-3300	-2700	W3a1a	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15784C (MT-CYB): POAG - potential for association (Reported) 15951G (MT-TT): LHON / LHON modulator (Conflicting reports) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
I1634	CACA	Copper Age	Armenia	M	-4330	-4060	H2a1	bam	482.00	Lazaridis et al. 2016 Data	FASTA Metadata
I2650	NEBI	Neolithic	Great Britain	M	-3638	-3380	T2c1d1	bam	205.35	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported) 6261A (MT-CO1): Prostate Cancer / LHON (Reported)
I1541	CWC	Neolithic	Germany	M	-2500	-2050	U2e1a1	bam	<NA>	Mathieson et al. 2015 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported)
I1635	BACA	Bronze Age	Armenia	M	-2619	-2465	X2f	bam	483.00	Lazaridis et al. 2016 Data	FASTA Metadata
KZ2	LDN	Neolithic	Poland	F	-4331	-4057	K1c	fasta	<NA>	Juras et al. 2017a Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
KZ4	LDN	Neolithic	Poland	F	-4329	-3997	K1a4	fasta	<NA>	Juras et al. 2017a Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
DA164	IACA	Iron Age	Russia	F	300	1400	H5	bam	229.50	de Barros Damgaard et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5549A (MT-TW): DEMCHO (Reported)
I2176	BABA	Bronze Age	Bulgaria	M	-3338	-3025	U1a1	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported)
I0257	BBC	Copper Age	Spain	M	-2572	-2348	H1ax	bam	319.79	Olalde et al. 2018 Data	FASTA Metadata	146C (MT-CR): Absence of Endometriosis (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported)
I0360	SRU	Bronze Age	Russia	M	-1850	-1200	U5a1	bam	<NA>	Mathieson et al. 2015 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 3398C (MT-ND1): DMDF+HCM / GDM / possibly LVNC cardiomyopathy-associated (Reported) 9966A (MT-CO3): LHON possible helper variant (Reported)
I0826	BBC	Copper Age	Spain	M	-2834	-2482	H1t	bam	107.57	Olalde et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I2630	NEBI	Neolithic	Great Britain	M	-2580	-2463	K1a4	bam	158.66	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 6663G (MT-CO1): Prostate Cancer (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
SCY300	SCU	Iron Age	Moldova	F	-400	-200	H5b	reconstructed	<NA>	Juras et al. 2017b Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I0175	LDN	Neolithic	Hungary	U	-4900	-4500	N1a1a1	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 3336C (MT-ND1): Carotid atherosclerosis risk (Reported) 669C (MT-RNR1): DEAF (Reported)
I0166	LDN	Neolithic	Germany	U	-5500	-4775	V1a	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata
I2405	GAC	Bronze Age	Poland	M	-3335	-3020	W5	fasta	17.05	Tassi et al. 2017 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
I2932	NEBI	Neolithic	Great Britain	M	-2570	-2347	H5	bam	780.40	Olalde et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
SCY305	SCU	Iron Age	Moldova	U	-400	-200	U5a2b	reconstructed	<NA>	Juras et al. 2017b Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I10851	MAIB	Middle Ages	Spain	F	887	1013	H3	bam	71.19	Olalde et al. 2019 Data	FASTA Metadata
SCY308	SCU	Iron Age	Moldova	U	-400	-200	F1d	reconstructed	<NA>	Juras et al. 2017b Data	FASTA Metadata	146C (MT-CR): Absence of Endometriosis (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports) 5628C (MT-TA): CPEO / DEAF enhancer / gout (Reported) 6962A (MT-CO1): Possible helper variant for 15927A (Reported)
I0165	LDN	Neolithic	Germany	U	-4625	-4250	U5b1b	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I2933	NEBI	Neolithic	Great Britain	M	-3010	-2885	J1c2	bam	432.32	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
I1656	BACA	Bronze Age	Armenia	F	-1501	-1402	T1a2	bam	404.00	Lazaridis et al. 2016 Data	FASTA Metadata
I0556	BAC	Neolithic	Germany	U	-3950	-3400	U8a1	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported)
I6582	BBC	Copper Age	Poland	F	-2343	-2057	U5a2b	bam	339.39	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I0102	LBK	Neolithic	Germany	U	-5030	-4948	N1a1a1a3	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 3336C (MT-ND1): Carotid atherosclerosis risk (Reported) 669C (MT-RNR1): DEAF (Reported)
I0796	LBK	Neolithic	Germany	U	-5500	-4775	H	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata
SCY311	SCU	Iron Age	Moldova	F	-400	-200	T2b	reconstructed	<NA>	Juras et al. 2017b Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I10852	MAIB	Middle Ages	Spain	F	973	1150	H6c	bam	213.80	Olalde et al. 2019 Data	FASTA Metadata
I0799	SCG	Neolithic	Germany	U	-4100	-3950	H1e	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
I2418	BBC	Bronze Age	Great Britain	F	-2455	-2200	K1a4a1	bam	752.01	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I2934	NEBI	Neolithic	Great Britain	F	-3338	-3022	U5a2c3	bam	452.01	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I0820	LBK	Neolithic	Germany	U	-5298	-5247	W1c'i	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
I2935	NEBI	Neolithic	Great Britain	M	-3335	-3011	U8b1b	bam	610.26	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16183C (MT-CR): Melanoma patients (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
SCY334	SCU	Iron Age	Moldova	U	-400	-200	H5b	reconstructed	<NA>	Juras et al. 2017b Data	FASTA Metadata	228A (MT-CR): Low VO2max response (Reported)
DA179	MAST	Middle Ages	Kazakhstan	M	1200	1400	D4	bam	317.38	de Barros Damgaard et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 14668T (MT-ND6): Depressive Disorder associated (Reported) 15043A (MT-CYB): MDD-associated (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4440A (MT-TM): Mitochondrial myopathy (Reported) 4454C (MT-TM): Possible contributor to mito dysfunction / hypertension (Reported) 4883T (MT-ND2): Glaucoma (Conflicting reports) 489C (MT-CR): Low VO2max response (Reported) 8414T (MT-ATP8): Increased risk of T2DM and high altitude polycythemia (HAPC) in haplogroup D4 / Longevity (Reported)
I3085	NEBI	Neolithic	Great Britain	F	-3338	-3026	K1a+195	bam	607.89	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
SCY002	SCU	Iron Age	Ukraine	U	-400	-400	J1c2	reconstructed	<NA>	Juras et al. 2017b Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
DA189	MAST	Middle Ages	Russia	M	700	1000	J1b4	bam	167.46	de Barros Damgaard et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 295T (MT-CR): Low VO2max response (Reported) 3290C (MT-TL1): Poss. hypertension factor (Reported) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
I0024	LBK	Neolithic	Germany	U	-5500	-4800	W1c'i	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
I2977	NEBI	Neolithic	Great Britain	M	-3008	-2763	H1	bam	619.04	Olalde et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I6581	BBC	Copper Age	Poland	M	-2455	-2145	H6a1a	bam	186.09	Olalde et al. 2018 Data	FASTA Metadata	11253C (MT-ND4): LHON PD (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
DA191	SCHu	Iron Age	Hungary	F	-536	-526	H2a2	bam	3.33	de Barros Damgaard et al. 2018 Data	FASTA Metadata
I2629	NEBI	Neolithic	Great Britain	M	-3180	-2780	J1c1b	bam	1.82	Olalde et al. 2018 Data	FASTA Metadata	13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports)
SCY006	SCU	Iron Age	Ukraine	F	-700	-700	D4j2	reconstructed	<NA>	Juras et al. 2017b Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11696A (MT-ND4): LHON / LDYT / DEAF / hypertension helper mut. (Reported - possibly synergistic) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 14668T (MT-ND6): Depressive Disorder associated (Reported) 15043A (MT-CYB): MDD-associated (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 4883T (MT-ND2): Glaucoma (Conflicting reports) 489C (MT-CR): Low VO2max response (Reported) 5178A (MT-ND2): Longevity / Extraversion / diabetes / AMS protection / blood iron metabolism / correlation with myocardial infarction / atherosclerosis (Reported) 8414T (MT-ATP8): Increased risk of T2DM and high altitude polycythemia (HAPC) in haplogroup D4 / Longevity (Reported)
I2978	NEBI	Neolithic	Great Britain	M	-3335	-3023	K1b1a1	bam	637.85	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13967T (MT-ND5): Possible LHON factor (Reported) 15257A (MT-CYB): LHON (Conflicting reports) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5913A (MT-CO1): Prostate Cancer / hypertension (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I2441	GAC	Bronze Age	Poland	M	-3400	-2800	K1b1a1	fasta	244.58	Tassi et al. 2017 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13967T (MT-ND5): Possible LHON factor (Reported) 15257A (MT-CYB): LHON (Conflicting reports) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 5913A (MT-CO1): Prostate Cancer / hypertension (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
SCY011	SCU	Iron Age	Ukraine	F	-400	-400	A	reconstructed	<NA>	Juras et al. 2017b Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 663G (MT-RNR1): Coronary atherosclerosis risk (Reported) 8794T (MT-ATP6): Exercise Endurance / Coronary Atherosclerosis risk (Reported)
I10853	MAIB	Middle Ages	Spain	M	989	1153	U4a1	bam	326.10	Olalde et al. 2019 Data	FASTA Metadata
I2565	BBC	Bronze Age	Great Britain	M	-2457	-2147	W1+119	bam	44.65	Olalde et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
I4253	BBC	Copper Age	Poland	M	-2456	-2207	U5a2c	bam	1073.95	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I2631	NEBI	Neolithic	Great Britain	M	-3097	-2906	H5	bam	887.83	Olalde et al. 2018 Data	FASTA Metadata
I3133	NEBI	Neolithic	Great Britain	M	-3631	-3377	K1a+195	bam	659.83	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 7158G (MT-CO1): Prostate Cancer (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
SCY009	SCU	Iron Age	Ukraine	M	-700	-700	J2b1a6	reconstructed	<NA>	Juras et al. 2017b Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 15257A (MT-CYB): LHON (Conflicting reports) 15662G (MT-CYB): Complex mitochondriopathy-associated (Reported) 15812A (MT-CYB): LHON (Reported / Secondary) 295T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported) 9016G (MT-ATP6): LHON (Reported)
I3134	NEBI	Neolithic	Great Britain	M	-3633	-3377	T2f4	bam	482.12	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I0111	BBC	Copper Age	Germany	F	-2475	-2204	H3ao	bam	188.26	Haak et al. 2015 Data	FASTA Metadata
DA195	SCHu	Iron Age	Hungary	F	-756	-727	H+16311	bam	130.03	de Barros Damgaard et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I6774	BBC	Bronze Age	Great Britain	M	-2287	-2044	H4a1a1a	bam	93.45	Olalde et al. 2018 Data	FASTA Metadata	10044G (MT-TG): SIDS (Unclear) 14582G (MT-ND6): LHON synergistic combo 14258A + 14582G (Reported: individually neutral variants causing LHON in combination) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I2459	BBC	Bronze Age	Great Britain	F	-2455	-2150	T2a1a	bam	340.09	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 14687G (MT-TE): Mito myopathy w respiratory failure / intellectual disability (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
SCY005	SCU	Iron Age	Ukraine	F	-300	-200	H	reconstructed	<NA>	Juras et al. 2017b Data	FASTA Metadata	7697A (MT-CO2): Possible HCM susceptibility / high altitude adaptation (Reported)
I3135	NEBI	Neolithic	Great Britain	M	-3640	-3383	U5b2a	bam	825.83	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
Sam1	LBK	Neolithic	Poland	F	-5500	-4800	N1a1a1a	reconstructed	<NA>	Chyleński et al. 2017 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 3336C (MT-ND1): Carotid atherosclerosis risk (Reported) 669C (MT-RNR1): DEAF (Reported)
I0112	BBC	Copper Age	Germany	F	-2457	-2142	H13a1a2	bam	227.67	Haak et al. 2015 Data	FASTA Metadata
I3137	NEBI	Neolithic	Great Britain	M	-3800	-3200	HV0+195	bam	81.92	Olalde et al. 2018 Data	FASTA Metadata	195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
KM1	LDN	Neolithic	Poland	F	-4700	-3800	U5b1b	reconstructed	<NA>	Chyleński et al. 2017 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I10897	MAIB	Middle Ages	Spain	F	1033	1204	I1c	bam	244.40	Olalde et al. 2019 Data	FASTA Metadata
I3138	NEBI	Neolithic	Great Britain	F	-3263	-2923	K1a4a1	bam	797.42	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I5757	BBC	Copper Age	Switzerland	M	-2469	-1984	H3af	bam	209.07	Olalde et al. 2018 Data	FASTA Metadata	16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported)
I0113	BBC	Copper Age	Germany	F	-2346	-2033	J1c5	bam	8.43	Haak et al. 2015 Data	FASTA Metadata
KZ6	LDN	Neolithic	Poland	F	-4400	-4000	N1a1a1a3	reconstructed	<NA>	Chyleński et al. 2017 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 3336C (MT-ND1): Carotid atherosclerosis risk (Reported) 669C (MT-RNR1): DEAF (Reported)
I3041	NEBI	Neolithic	Great Britain	M	-3942	-3037	K1a3a	bam	445.11	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I10854	MAIB	Middle Ages	Spain	M	973	1150	H1n+146	bam	78.40	Olalde et al. 2019 Data	FASTA Metadata
I3948	NEBA	Neolithic	Croatia	M	-6005	-5814	N1a1	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 3336C (MT-ND1): Carotid atherosclerosis risk (Reported) 669C (MT-RNR1): DEAF (Reported)
I5370	NEBI	Neolithic	Great Britain	F	-4000	-3300	K1a+195	bam	19.19	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
R18_1	LDN	Neolithic	Poland	F	-5364	-5398	K2a	reconstructed	<NA>	Chyleński et al. 2017 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
DA198	SCHu	Iron Age	Hungary	M	-508	-498	H7a1	bam	74.71	de Barros Damgaard et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I4872	HGS	Mesolithic	Serbia	F	-7100	-5900	U5a1c	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I2634	NEBI	Neolithic	Great Britain	M	-3703	-3534	U2+152	bam	179.11	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 3394C (MT-ND1): LHON / Diabetes / CPTdeficiency / high altitude adaptation (Reported / Population-dependent)
PCA0001	MAPl	Middle Ages	Poland	M	80	260	W	<NA>	<NA>	Stolarek et al. 2018 Data	Metadata
I4229	BBC	Copper Age	Portugal	M	-2336	-2063	U5a2+16362	bam	346.16	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I2633	NEBI	Neolithic	Great Britain	F	-3765	-3641	T2e1	bam	432.82	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I0806	BBC	Copper Age	Germany	M	-2431	-2150	H1	bam	268.00	Haak et al. 2015 Data	FASTA Metadata
I7554	NEBI	Neolithic	Great Britain	M	-3366	-3103	J1c9	bam	137.01	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
I1775	BABI	Bronze Age	Great Britain	M	-1730	-1532	I3	bam	693.67	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 15924G (MT-TT): LIMM (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I2574	BABI	Bronze Age	Great Britain	F	-1414	-1227	U5a1a2b	bam	985.86	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I0405	NEIB	Neolithic	Spain	M	-3900	-3600	K1a1b1	bam	419.75	Haak et al. 2015 Data	FASTA Metadata
PCA0003	MAPl	Middle Ages	Poland	F	80	260	H5a1	<NA>	<NA>	Stolarek et al. 2018 Data	Metadata
I6466	BBC	Copper Age	Portugal	M	-2700	-2300	K1b1a1	bam	30.22	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13967T (MT-ND5): Possible LHON factor (Reported) 15257A (MT-CYB): LHON (Conflicting reports) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 5913A (MT-CO1): Prostate Cancer / hypertension (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I5358	NEBI	Neolithic	Great Britain	F	-3080	-2904	K1a1	bam	82.21	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 114T (MT-CR): BD-associated (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
PCA0004	MAPl	Middle Ages	Poland	F	80	260	U3a1a1	bam	<NA>	Stolarek et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12300A (MT-TL2): 3243 suppressor mutant (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 14258A (MT-ND6): LHON synergistic combo 10680A + 12033G + 14258A also combo 14258A + 14582G (Reported: individually neutral variants causing LHON in combination) 15024A (MT-CYB): Possible DEAF modifier (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 15153A (MT-CYB): Suspected mito disease (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 3460A (MT-ND1): LHON (Cfrm)
DA199	MAHu	Middle Ages	Hungary	F	1224	1264	H1ba	bam	68.65	de Barros Damgaard et al. 2018 Data	FASTA Metadata	16270T (MT-CR): Melanoma patients (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported)
PCA0006	MAPl	Middle Ages	Poland	F	80	120	U5a1d1	bam	<NA>	Stolarek et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 14459A (MT-ND6): LDYT / Leigh Disease / dystonia / carotid atherosclerosis risk (Cfrm) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 4320T (MT-TI): Mitochondrial Encephalocardiomyopathy (Reported) 4327C (MT-TI): Ataxia+ / with RRF and COX deficiency (Reported) 5532A (MT-TW): Gastrointestinal Syndrome (Reported)
PCA0015	MAPl	Middle Ages	Poland	M	80	260	H1f1a	<NA>	<NA>	Stolarek et al. 2018 Data	Metadata
PCA0007	MAPl	Middle Ages	Poland	F	80	260	W1	bam	<NA>	Stolarek et al. 2018 Data	FASTA Metadata	3635A (MT-ND1): LHON (Cfrm) 4450A (MT-TM): Myopathy / MELAS / Leigh Syndrome (Cfrm) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
I0406	NEIB	Neolithic	Spain	M	-3900	-3600	H1	bam	527.10	Haak et al. 2015 Data	FASTA Metadata
I5359	NEBI	Neolithic	Great Britain	M	-3800	-3600	H5	bam	100.37	Olalde et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I5367	BBC	Bronze Age	Great Britain	F	-2467	-2232	V10	bam	374.63	Olalde et al. 2018 Data	FASTA Metadata	16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
DA201	IAKa	Iron Age	Kazakhstan	F	-171	-88	C4a1a+195	bam	111.11	de Barros Damgaard et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 3552A (MT-ND1): Resistance to high altitude pulmonary edema (HAPE) (Reported /hg C marker) 489C (MT-CR): Low VO2max response (Reported)
I4882	HGS	Mesolithic	Serbia	M	-6200	-5900	U4b1b1	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13528G (MT-ND5): LHON-like / LHON / MELAS (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 499A (MT-CR): Endometriosis (Reported)
I7250	BBC	Copper Age	Czech Republic	F	-2500	-2200	R1a1a	bam	43.66	Olalde et al. 2018 Data	FASTA Metadata	1391C (MT-RNR1): found in 1 HCM patient (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
PCA0026	MAPl	Middle Ages	Poland	F	80	260	T2b16	bam	<NA>	Stolarek et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 1310T (MT-RNR1): DEAF-associated (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I3875	BBC	Copper Age	France	M	-2133	-1946	H1e	bam	423.99	Olalde et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
I4607	HGS	Mesolithic	Romania	M	-7340	-6640	U5a2	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 8481T (MT-ATP8): Tetralogy of Fallot patient (Reported)
I4067	BBC	Copper Age	The Netherlands	F	-1946	-1690	R1b1	bam	135.49	Olalde et al. 2018 Data	FASTA Metadata	1095C (MT-RNR1): SNHL (Unclear) 1391C (MT-RNR1): found in 1 HCM patient (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I0462	BBC	Copper Age	Spain	F	-2566	-2345	K1a+195	bam	240.45	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I7279	CWC	Neolithic	Czech Republic	M	-2900	-2200	H7d	bam	118.87	Olalde et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
DA202	IAST	Iron Age	Kazakhstan	F	-733	-690	U5a1	bam	20.96	de Barros Damgaard et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I7275	BBC	Copper Age	Czech Republic	M	-2500	-2200	U5b2c	bam	309.84	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
I1549	BBC	Copper Age	Germany	F	-2500	-2050	W1c1	bam	163.00	Mathieson et al. 2015 Data	FASTA Metadata
I5042	EBACz	Bronze Age	Czech Republic	M	-2300	-1900	I4a	bam	168.65	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 15924G (MT-TT): LIMM (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 8519A (MT-ATP8): Susceptibility to bullous pemphigoid (Reported)
I6476	BBC	Copper Age	Czech Republic	F	-2500	-1900	U5a1b1	bam	596.50	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
PCA0030	MAPl	Middle Ages	Poland	F	110	160	H2a2b	bam	<NA>	Stolarek et al. 2018 Data	FASTA Metadata
I1530	BBC	Copper Age	Germany	M	-2458	-2140	H3ao	bam	148.84	Mathieson et al. 2015 Data	FASTA Metadata
I5043	EBACz	Bronze Age	Czech Republic	M	-2300	-1900	U4c1a	bam	672.69	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 499A (MT-CR): Endometriosis (Reported)
I5665	BBC	Copper Age	Spain	M	-2280	-1984	K1a24a	bam	480.15	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I4946	BBC	Copper Age	Czech Republic	F	-2296	-2146	I4a	bam	397.00	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 15924G (MT-TT): LIMM (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 8519A (MT-ATP8): Susceptibility to bullous pemphigoid (Reported)
PCA0031	MAPl	Middle Ages	Poland	F	10	375	K2a	<NA>	<NA>	Stolarek et al. 2018 Data	Metadata
I0407	NEIB	Neolithic	Spain	F	-3900	-3600	K1b1a1	bam	363.22	Haak et al. 2015 Data	FASTA Metadata
I7195	UNC	Bronze Age	Czech Republic	F	-2200	-1700	H3v+16093	bam	303.35	Olalde et al. 2018 Data	FASTA Metadata	16093C (MT-CR): Cyclic Vomiting Syndrome (Reported)
I4655	HGS	Mesolithic	Romania	M	-7060	-6570	K1	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I4947	BBC	Copper Age	Czech Republic	M	-2500	-2000	H17a	bam	602.04	Olalde et al. 2018 Data	FASTA Metadata	16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
DA203	MAST	Middle Ages	Kazakhstan	M	950	1250	G2a2	bam	139.30	de Barros Damgaard et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 4833G (MT-ND2): Diabetes helper mutation AD / PD (Reported) 489C (MT-CR): Low VO2max response (Reported)
PCA0036	MAPl	Middle Ages	Poland	M	80	260	U5b1d1	bam	<NA>	Stolarek et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 869T (MT-RNR1): found in 1 HCM patient (Reported)
I4247	BBC	Copper Age	Spain	F	-2464	-2210	T2b3	bam	87.29	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I7196	UNC	Bronze Age	Czech Republic	M	-2200	-1700	K1a+195	bam	294.60	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I7197	UNC	Bronze Age	Czech Republic	M	-2200	-1700	X2b6	bam	323.64	Olalde et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 15927A (MT-TT): LHON / Multiple Sclerosis / DEAF1555 increased penetrance / CHD (Reported) 16183C (MT-CR): Melanoma patients (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 8393T (MT-ATP8): Reversible brain pseudoatrophy (Reported)
PCA0041	MAPl	Middle Ages	Poland	M	80	260	N	<NA>	<NA>	Stolarek et al. 2018 Data	Metadata
I7199	UNC	Bronze Age	Czech Republic	M	-2200	-1700	J1c3a	bam	297.14	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
I4889	BBC	Copper Age	Czech Republic	M	-2281	-2062	U4a2	bam	127.62	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 499A (MT-CR): Endometriosis (Reported)
I7201	UNC	Bronze Age	Czech Republic	F	-2200	-1700	U5a1a2b	bam	168.25	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
PCA0044	MAPl	Middle Ages	Poland	F	80	260	H5a1	bam	<NA>	Stolarek et al. 2018 Data	FASTA Metadata	2835T (MT-RNR2): Rett Syndrome (Reported) 4336C (MT-TQ): ADPD / Hearing Loss & Migraine / autism spectrum / intellectual disability (Unclear)
I4884	EBACz	Bronze Age	Czech Republic	M	-1882	-1745	H4a1a1a	bam	101.12	Olalde et al. 2018 Data	FASTA Metadata	10044G (MT-TG): SIDS (Unclear) 14582G (MT-ND6): LHON synergistic combo 14258A + 14582G (Reported: individually neutral variants causing LHON in combination) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
PCA0045	MAPl	Middle Ages	Poland	F	80	260	U5b1d1	<NA>	<NA>	Stolarek et al. 2018 Data	Metadata
I5237	HGS	Mesolithic	Serbia	M	-9500	-6200	U5a2a	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 228A (MT-CR): Low VO2max response (Reported)
I5236	HGS	Mesolithic	Serbia	M	-8290	-7825	U5a2d	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I5411	HGS	Mesolithic	Romania	M	-7000	-6300	U5a1c1	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I5239	HGS	Mesolithic	Serbia	F	-8535	-8230	U5a2d	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I7211	BBC	Copper Age	Czech Republic	F	-2500	-2200	U5b3	bam	319.75	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16270T (MT-CR): Melanoma patients (Reported) 228A (MT-CR): Low VO2max response (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
DA205	MAST	Middle Ages	Kazakhstan	F	950	1250	J1c	bam	206.67	de Barros Damgaard et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 15924G (MT-TT): LIMM (Reported) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
I0408	NEIB	Neolithic	Spain	F	-3893	-3661	U5b1+16189+@16192	bam	513.62	Haak et al. 2015 Data	FASTA Metadata
PCA0046	MAPl	Middle Ages	Poland	M	110	160	U8a1a1b	bam	<NA>	Stolarek et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported)
I4892	EBACz	Bronze Age	Czech Republic	F	-1881	-1701	T1a1	bam	152.98	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I4893	NECz	Neolithic	Czech Republic	M	-4449	-4348	U5b1b1	bam	205.24	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I0171	LNEGe	Neolithic	Germany	F	-2287	-2041	U5a1a2a	bam	160.01	Haak et al. 2015 Data	FASTA Metadata
PCA0047	MAPl	Middle Ages	Poland	F	80	260	H5a1	bam	<NA>	Stolarek et al. 2018 Data	FASTA Metadata	4336C (MT-TQ): ADPD / Hearing Loss & Migraine / autism spectrum / intellectual disability (Unclear)
I7286	BBC	Copper Age	Czech Republic	M	-2500	-2200	I4a	bam	223.85	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 15924G (MT-TT): LIMM (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 6480A (MT-CO1): Prostate Cancer / enriched in POAG cohort (Reported) 8519A (MT-ATP8): Susceptibility to bullous pemphigoid (Reported)
I4894	NECz	Neolithic	Czech Republic	F	-4488	-4368	U8b1b1	bam	202.73	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16183C (MT-CR): Melanoma patients (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I4303	MLN	Neolithic	France	M	-4778	-4586	H3	bam	396.49	Olalde et al. 2018 Data	FASTA Metadata
Sarretudvari-Hizofold/9/anc11	MAHu	Middle Ages	Hungary	M	900	970	T2b	bam	25.00	Neparáczki et al. 2018 Data	Metadata
I7212	BBC	Copper Age	Czech Republic	M	-2500	-2200	K1b1a1+199	bam	265.78	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13967T (MT-ND5): Possible LHON factor (Reported) 15257A (MT-CYB): LHON (Conflicting reports) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5913A (MT-CO1): Prostate Cancer / hypertension (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
PCA0049	MAPl	Middle Ages	Poland	F	110	160	H1a	bam	<NA>	Stolarek et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported)
I4304	MLN	Neolithic	France	M	-4787	-4589	T2c1d+152	bam	456.91	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported) 6261A (MT-CO1): Prostate Cancer / LHON (Reported)
I6480	BBC	Copper Age	Czech Republic	M	-2500	-1900	U4a2	bam	153.39	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 499A (MT-CR): Endometriosis (Reported)
I7040	BAHu	Bronze Age	Hungary	F	-2500	-2200	K1a4b	bam	522.38	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I1381	BBC	Copper Age	France	M	-2400	-1900	H	bam	599.16	Olalde et al. 2018 Data	FASTA Metadata
PCA0051	MAPl	Middle Ages	Poland	F	110	160	K2a	<NA>	<NA>	Stolarek et al. 2018 Data	Metadata
I7043	BAHu	Bronze Age	Hungary	M	-2500	-2200	H1b1	bam	455.99	Olalde et al. 2018 Data	FASTA Metadata	16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 3796G (MT-ND1): Adult-Onset Dystonia (Reported) 6267A (MT-CO1): Prostate Cancer (Reported)
DA207	MEST	Modern Era	Kazakhstan	M	1650	1850	H2a	bam	4.04	de Barros Damgaard et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I7041	BAHu	Bronze Age	Hungary	M	-2500	-2200	H1b1	bam	458.69	Olalde et al. 2018 Data	FASTA Metadata	16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 3796G (MT-ND1): Adult-Onset Dystonia (Reported) 6267A (MT-CO1): Prostate Cancer (Reported)
I4070	BANl	Bronze Age	The Netherlands	M	-1880	-1657	U5a1b1a	bam	138.93	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
PCA0054	MAPl	Middle Ages	Poland	F	80	260	U3a1a	bam	<NA>	Stolarek et al. 2018 Data	FASTA Metadata	12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16390A (MT-CR): POAG - potential for association (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 6285A (MT-CO1): Prostate Cancer (Reported) 8328A (MT-TK): Mito Encephalopathy / EXIT with myopathy and ptosis (Reported)
I5409	HGS	Mesolithic	Serbia	F	-9500	-6200	U5a1c	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported)
I5436	HGS	Mesolithic	Romania	F	-7451	-6698	U5a2	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
PCA0056	MAPl	Middle Ages	Poland	F	80	260	T2b6a	bam	<NA>	Stolarek et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I10277	NEIB	Neolithic	Spain	M	-3400	-2500	X2c1	bam	57.60	Olalde et al. 2019 Data	FASTA Metadata
I4071	BANl	Bronze Age	The Netherlands	F	-1883	-1664	H6a1a	bam	259.20	Olalde et al. 2018 Data	FASTA Metadata	11253C (MT-ND4): LHON PD (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
DA208	MEST	Modern Era	Kazakhstan	M	1650	1850	H1	bam	8.24	de Barros Damgaard et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported)
PCA0057	MAPl	Middle Ages	Poland	F	110	160	J1c7a	bam	<NA>	Stolarek et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
I6531	EBAPl	Bronze Age	Poland	M	-2286	-2038	U5b2b1a1	bam	267.70	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 12634G (MT-ND5): Thyroid Cancer Cell Line (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 15497A (MT-CYB): EXIT / Obesity (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I6579	EBAPl	Bronze Age	Poland	F	-2335	-2046	K1a4a1g	bam	321.42	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I2008	LBK	Neolithic	Germany	F	-5212	-4992	N1a1a1	bam	<NA>	Lipson et al. 2017 Data	FASTA Metadata
I2026	LBK	Neolithic	Germany	M	-5500	-4850	N1a1a1a3	bam	<NA>	Lipson et al. 2017 Data	FASTA Metadata
ANI153	CABA	Copper Age	Bulgaria	M	-4551	-4374	U4	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	12063T (MT-ND4): Recurrent pregnancy loss (Reported) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported)
ANI152	CABA	Copper Age	Bulgaria	M	-4683	-4406	U2	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 3275T (MT-TL1): Metabolic syndrome and polycystic ovary syndrome (Reported)
I3589	BBC	Copper Age	Germany	M	-2300	-2150	U4d1	bam	561.05	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 499A (MT-CR): Endometriosis (Reported)
I3599	BBC	Copper Age	Germany	M	-2300	-2150	H1e1a	bam	54.63	Olalde et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports) 8821G (MT-ATP6): Possible LHON helper variant (Reported)
I10278	NEIB	Neolithic	Spain	M	-3400	-2500	U5b1	bam	495.00	Olalde et al. 2019 Data	FASTA Metadata
Ust_Ishim	HGE	Upper Paleolithic	Russia	M	-45530	-40610	R*	bam	<NA>	Fu et al. 2014 Data	FASTA Metadata
PCA0060	MAPl	Middle Ages	Poland	M	80	260	U5b1d1	bam	<NA>	Stolarek et al. 2018 Data	FASTA Metadata	12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I3593	BBC	Copper Age	Germany	F	-2397	-2145	H1	bam	236.53	Olalde et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I10280	NEIB	Neolithic	Spain	M	-3400	-2500	J1c1	bam	123.00	Olalde et al. 2019 Data	FASTA Metadata
DA220	IAKa	Iron Age	Kazakhstan	M	-350	-50	HV6	bam	111.75	de Barros Damgaard et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I10283	NEIB	Neolithic	Spain	M	-3400	-2500	H	bam	39.40	Olalde et al. 2019 Data	FASTA Metadata
PCA0061	MAPl	Middle Ages	Poland	U	80	260	H1ak	bam	<NA>	Stolarek et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported)
I6475	BBC	Copper Age	Spain	F	-2500	-2000	U5b3	bam	407.07	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 15909G (MT-TT): Hypertension (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 228A (MT-CR): Low VO2max response (Reported)
I2029	LBK	Neolithic	Germany	F	-5295	-5057	K1	bam	<NA>	Lipson et al. 2017 Data	FASTA Metadata
I1553	BBC	Copper Age	Spain	F	-2850	-2250	pre-H103	bam	10.62	Olalde et al. 2018 Data	FASTA Metadata
E09613_d	BBC	Copper Age	Germany	F	-2289	-2140	H1	<NA>	<NA>	Olalde et al. 2018 Data	Metadata
DA221	IAKa	Iron Age	Kazakhstan	M	-790	-747	J1b1a1	bam	1184.38	de Barros Damgaard et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 295T (MT-CR): Low VO2max response (Reported) 2158C (MT-RNR2): Reduced risk PD (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
PCA0063	MAPl	Middle Ages	Poland	M	10	375	H2a5	bam	<NA>	Stolarek et al. 2018 Data	FASTA Metadata	13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports)
DA223	IAKa	Iron Age	Kazakhstan	M	-403	-374	J1c5a	bam	740.55	de Barros Damgaard et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
DA224	MAST	Middle Ages	Kazakhstan	M	264	273	H	bam	6.92	de Barros Damgaard et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
Gyvakarai1	CWC	Neolithic	Lithuania	M	-2690	-2470	K1b2a	fasta	7.56	Mittnik et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 5913A (MT-CO1): Prostate Cancer / hypertension (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I0262	BBC	Copper Age	Spain	F	-2850	-2250	U5b3	bam	275.01	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16270T (MT-CR): Melanoma patients (Reported) 228A (MT-CR): Low VO2max response (Reported)
I0258	BBC	Copper Age	Spain	F	-2850	-2250	H1q	bam	110.39	Olalde et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
DA227	IAKa	Iron Age	Kazakhstan	F	-350	-50	U5b2c	bam	11.45	de Barros Damgaard et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
DA228	MAST	Middle Ages	Kazakhstan	M	550	850	A15c	bam	24.16	de Barros Damgaard et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 4440A (MT-TM): Mitochondrial myopathy (Reported) 5650A (MT-TA): Myopathy (Cfrm) 663G (MT-RNR1): Coronary atherosclerosis risk (Reported)
I10284	NEIB	Neolithic	Spain	M	-3400	-2500	U5b1	bam	22.30	Olalde et al. 2019 Data	FASTA Metadata
RISE1	CWC	Neolithic	Poland	U	-2865	-2578	K1b1a1	<NA>	<NA>	Allentoft et al. 2015 Data	Metadata
I2032	LBK	Neolithic	Germany	F	-5500	-4850	J1c	bam	<NA>	Lipson et al. 2017 Data	FASTA Metadata
I2478	BBC	Copper Age	Italy	M	-2194	-1939	K1a2a	bam	251.09	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I1378	NEUk	Neolithic	Ukraine	M	-4519	-4343	U4b	bam	<NA>	Jones et al. 2017 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 499A (MT-CR): Endometriosis (Reported)
I4936	BBC	Copper Age	Italy	F	-2500	-1900	K1a	bam	2.97	Olalde et al. 2018 Data	FASTA Metadata	12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
DA229	IAST	Iron Age	Kazakhstan	M	-250	250	A8a1	bam	3.84	de Barros Damgaard et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 4440A (MT-TM): Mitochondrial myopathy (Reported) 663G (MT-RNR1): Coronary atherosclerosis risk (Reported) 6962A (MT-CO1): Possible helper variant for 15927A (Reported)
I0585	HGW	Mesolithic	Spain	M	-5983	-5747	U5b2c	bam	<NA>	Olalde et al. 2014 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
DA230	MAKa	Middle Ages	Kazakhstan	M	750	950	F1b1e	bam	837.11	de Barros Damgaard et al. 2018 Data	FASTA Metadata	16183C (MT-CR): Melanoma patients (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 6962A (MT-CO1): Possible helper variant for 15927A (Reported)
I2036	LBK	Neolithic	Germany	F	-5500	-4850	V1	bam	<NA>	Lipson et al. 2017 Data	FASTA Metadata
I2038	LBK	Neolithic	Germany	F	-5350	-5000	T2b	bam	<NA>	Lipson et al. 2017 Data	FASTA Metadata
RISE145	UNC	Bronze Age	Poland	M	-2188	-1958	H6a1b	<NA>	<NA>	Allentoft et al. 2015 Data	Metadata
RISE493	BARu	Bronze Age	Russia	M	-1531	-1427	C4a1c	<NA>	<NA>	Allentoft et al. 2015 Data	Metadata
DA231	BAKa	Bronze Age	Kazakhstan	F	-1592	-1591	U2e1h	bam	248.30	de Barros Damgaard et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 14674C (MT-TE): Reversible COX deficiency myopathy (Cfrm) 16183C (MT-CR): Melanoma patients (Reported) 228A (MT-CR): Low VO2max response (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I2158	HGS	Epigravettian	Italy	F	-14776	-9873	U2'3'4'7'8'9	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports)
I2016	LBK	Neolithic	Germany	F	-5500	-4850	V1	bam	<NA>	Lipson et al. 2017 Data	FASTA Metadata
I10285	NEIB	Neolithic	Spain	F	-3400	-2500	T2b	bam	116.00	Olalde et al. 2019 Data	FASTA Metadata
DA243	IACA	Iron Age	Russia	M	300	400	W1	bam	829.81	de Barros Damgaard et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4454C (MT-TM): Possible contributor to mito dysfunction / hypertension (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
I4875	HGS	Mesolithic	Serbia	F	-6615	-6400	U5b1d1a	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16270T (MT-CR): Melanoma patients (Reported)
RISE494	BARu	Bronze Age	Russia	M	-1416	-1268	I4a1	<NA>	<NA>	Allentoft et al. 2015 Data	Metadata
I10286	NEIB	Neolithic	Spain	M	-3400	-2500	U5b1	bam	10.60	Olalde et al. 2019 Data	FASTA Metadata
I11248	NEIB	Neolithic	Spain	M	-3400	-3000	J2a1a1a	bam	991.30	Olalde et al. 2019 Data	FASTA Metadata
I4073	BBC	Copper Age	The Netherlands	M	-2195	-1905	U5a2b3	bam	238.71	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I2021	LBK	Neolithic	Germany	M	-5500	-4850	T2b	bam	<NA>	Lipson et al. 2017 Data	FASTA Metadata
RISE497	BARu	Bronze Age	Russia	M	-1414	-1261	A+152+16362	<NA>	<NA>	Allentoft et al. 2015 Data	Metadata
I11249	NEIB	Neolithic	Spain	M	-3400	-3000	U5b1	bam	629.40	Olalde et al. 2019 Data	FASTA Metadata
LICOL48	LONG	Middle Ages	Italy	U	570	800	None	<NA>	<NA>	Vai et al. 2019	Metadata
RISE499	BARu	Bronze Age	Russia	F	-1496	-1306	H5a1	<NA>	<NA>	Allentoft et al. 2015 Data	Metadata
DA343	BASI	Bronze Age	Russia	M	-2647	-1776	D4j4	bam	899.55	de Barros Damgaard et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11696A (MT-ND4): LHON / LDYT / DEAF / hypertension helper mut. (Reported - possibly synergistic) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 14668T (MT-ND6): Depressive Disorder associated (Reported) 15043A (MT-CYB): MDD-associated (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4883T (MT-ND2): Glaucoma (Conflicting reports) 489C (MT-CR): Low VO2max response (Reported) 8414T (MT-ATP8): Increased risk of T2DM and high altitude polycythemia (HAPC) in haplogroup D4 / Longevity (Reported)
I0118	LNEGe	Neolithic	Germany	F	-2471	-2246	H+16311	bam	231.95	Haak et al. 2015 Data	FASTA Metadata
RISE515	BARu	Bronze Age	Russia	F	-2340	-2145	A8a	<NA>	<NA>	Allentoft et al. 2015 Data	Metadata
RISE516	BARu	Bronze Age	Russia	F	-2201	-2036	H6a1b	<NA>	<NA>	Allentoft et al. 2015 Data	Metadata
I11300	NEIB	Neolithic	Spain	F	-3400	-3000	J2a1a1a	bam	74.29	Olalde et al. 2019 Data	FASTA Metadata
RISE525	BARu	Bronze Age	Russia	U	-1598	-1398	I5c	<NA>	<NA>	Allentoft et al. 2015 Data	Metadata
I6612	CAIB	Copper Age	Spain	F	-2479	-1945	J1c3	bam	26.76	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
I0550	CWC	Neolithic	Germany	F	-2570	-2471	T1a1	bam	201.00	Haak et al. 2015 Data	FASTA Metadata
DA353	BASI	Bronze Age	Russia	M	-2647	-1776	A+152+16362+16189	bam	97.02	de Barros Damgaard et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 663G (MT-RNR1): Coronary atherosclerosis risk (Reported) 8078A (MT-CO2): DEAF (Reported)
I6613	CAIB	Copper Age	Spain	F	-2479	-1945	U5b1	bam	393.22	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
PCA0002	MAPl	Middle Ages	Poland	M	10	375	H28a1	bam	<NA>	Stolarek et al. 2018 Data	FASTA Metadata	5698A (MT-TN): CPEO / MM (Reported) 5703A (MT-TN): CPEO / MM (Cfrm) 6150A (MT-CO1): Prostate Cancer / enriched in POAG cohort (Reported) 7453A (MT-TS1): Fatal neonatal lactic acidosis / Neonatal lactic acidosis / exercise intolerance / mild ID (Reported)
I5771	HGS	Mesolithic	Serbia	M	-6500	-6250	U5a1c1	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
AED_106	MAGe	Middle Ages	Germany	M	480	510	V3	bam	232.41	Veeramah et al. 2018 Data	FASTA Metadata	195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I11301	NEIB	Neolithic	Spain	F	-3341	-3030	H1j8	bam	421.00	Olalde et al. 2019 Data	FASTA Metadata
I6630	CAIB	Copper Age	Spain	F	-2900	-2300	J2a1a1	bam	37.17	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 11253C (MT-ND4): LHON PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 15257A (MT-CYB): LHON (Conflicting reports) 195C (MT-CR): BD-associated / melanoma pts (Reported) 295T (MT-CR): Low VO2max response (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 489C (MT-CR): Low VO2max response (Reported)
AED_1119	MAGe	Middle Ages	Germany	F	510	530	W1e1a	bam	255.74	Veeramah et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
I0560	BAC	Neolithic	Germany	F	-3640	-3376	T2e1	bam	231.92	Haak et al. 2015 Data	FASTA Metadata
PCA0013	MAPl	Middle Ages	Poland	U	80	260	J1c3	bam	<NA>	Stolarek et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
I2014	LBK	Neolithic	Germany	M	-5199	-4857	N1a1a1a3	bam	<NA>	Lipson et al. 2017 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 3336C (MT-ND1): Carotid atherosclerosis risk (Reported) 669C (MT-RNR1): DEAF (Reported)
RISE598	BABL	Bronze Age	Lithuania	M	-908	-485	H2a2	<NA>	<NA>	Allentoft et al. 2015 Data	Metadata
I11303	NEIB	Neolithic	Spain	F	-3400	-2500	H1j	bam	28.10	Olalde et al. 2019 Data	FASTA Metadata
I5773	HGS	Mesolithic	Serbia	M	-8240	-7940	U4a	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I5232	HGS	Mesolithic	Serbia	M	-6061	-5841	K1a	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I7638	BABI	Bronze Age	Great Britain	M	-2286	-1778	V10b	bam	47.77	Olalde et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
AED_1135	MAGe	Middle Ages	Germany	F	480	530	H60a	bam	228.33	Veeramah et al. 2018 Data	FASTA Metadata	16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
PCA0027	MAPl	Middle Ages	Poland	M	80	120	H1a	bam	<NA>	Stolarek et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported)
AED_125	MAGe	Middle Ages	Germany	F	338	535	K1a	bam	341.24	Veeramah et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I1508	LBK	Neolithic	Hungary	F	-5710	-5570	K1a	bam	<NA>	Gamba et al. 2014 Data	FASTA Metadata
PCA0029	MAPl	Middle Ages	Poland	U	10	375	X2c1	bam	<NA>	Stolarek et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported)
I2301	GAC	Neolithic	Poland	M	-3400	-2800	H1b	fasta	12.99	Tassi et al. 2017 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported)
I11305	NEIB	Neolithic	Spain	M	-3400	-2500	J1c1b	bam	511.00	Olalde et al. 2019 Data	FASTA Metadata
AED_204	MAGe	Middle Ages	Germany	F	480	510	X2b	bam	247.91	Veeramah et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 15927A (MT-TT): LHON / Multiple Sclerosis / DEAF1555 increased penetrance / CHD (Reported) 16183C (MT-CR): Melanoma patients (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 8393T (MT-ATP8): Reversible brain pseudoatrophy (Reported)
I0172	BEC	Neolithic	Germany	M	-3360	-3086	T2b	bam	1182.46	Haak et al. 2015 Data	FASTA Metadata
AED_249	MAGe	Middle Ages	Germany	M	460	510	T2c1d1a	bam	263.83	Veeramah et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported) 5631A (MT-TA): Myopathy (Reported) 6261A (MT-CO1): Prostate Cancer / LHON (Reported)
I10939	BAIB	Bronze Age	Gibraltar	M	-1900	-1400	K1a3a	bam	84.90	Olalde et al. 2019 Data	FASTA Metadata
CB13	NEIB	Neolithic	Spain	F	-5469	-5327	K1a2a	<NA>	<NA>	Olalde et al. 2015 Data	Metadata
I2803	GAC	Neolithic	Poland	U	-3400	-2800	H	fasta	6.27	Tassi et al. 2017 Data	FASTA Metadata	16093C (MT-CR): Cyclic Vomiting Syndrome (Reported)
Theo1	HGS	Mesolithic	Greece	F	-7288	-6771	K1c	fasta	21.70	Hofmanova et al. 2016 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13967T (MT-ND5): Possible LHON factor (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
ATP9	BAIB	Bronze Age	Spain	F	-1750	-1618	U5b1b	bam	<NA>	Günther et al. 2015 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
AED_432	MAGe	Middle Ages	Germany	F	480	530	H1h1	bam	384.73	Veeramah et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I4440	HGE	Mesolithic	Latvia	M	-5220	-5039	U4a1	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
Donkalnis4	HGN	Mesolithic	Lithuania	M	-6000	-5740	U5b2c1	fasta	0.02	Mittnik et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I10941	BAIB	Bronze Age	Gibraltar	M	-1900	-1400	T2e1	bam	129.00	Olalde et al. 2019 Data	FASTA Metadata
I11306	NEIB	Neolithic	Spain	F	-3400	-2500	J2b1a2	bam	256.00	Olalde et al. 2019 Data	FASTA Metadata
I1765	BBC	Bronze Age	Great Britain	U	-2341	-2041	N1a1a1a2	bam	406.83	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 3336C (MT-ND1): Carotid atherosclerosis risk (Reported) 669C (MT-RNR1): DEAF (Reported)
PCA0032	MAPl	Middle Ages	Poland	F	80	120	T2n	bam	<NA>	Stolarek et al. 2018 Data	FASTA Metadata	13637G (MT-ND5): Possible LHON factor (Reported) 3460A (MT-ND1): LHON (Cfrm)
AED_513	MAGe	Middle Ages	Germany	F	261	535	H7a	bam	234.28	Veeramah et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
Donkalnis6	HGN	Mesolithic	Lithuania	F	-4720	-4530	U5a2e	fasta	6.03	Mittnik et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
AED_92	MAGe	Middle Ages	Germany	M	480	510	Ua4	bam	380.15	Veeramah et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 499A (MT-CR): Endometriosis (Reported) 961C (MT-RNR1): DEAF / possibly LVNC-associated (Unclear)
I0070	MIC	Bronze Age	Greece	M	-2400	-1700	H13a1a	bam	962.75	Lazaridis et al. 2017 Data	FASTA Metadata
PCA0034	MAPl	Middle Ages	Poland	F	80	260	K2a	bam	<NA>	Stolarek et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
LICOL65	LONG	Middle Ages	Italy	U	570	800	None	<NA>	<NA>	Vai et al. 2019	Metadata
AEH_I	MAGe	Middle Ages	Germany	F	346	529	H5	bam	322.38	Veeramah et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
Donkalnis7	HGN	Mesolithic	Lithuania	M	-5460	-4940	U5a2d1	fasta	0.76	Mittnik et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I7635	BABI	Bronze Age	Great Britain	F	-2193	-1978	H1c	bam	79.20	Olalde et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
Kivutkalns164	BABL	Bronze Age	Latvia	M	-730	-390	U5a2a1	fasta	0.09	Mittnik et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
Kivutkalns153	BABL	Bronze Age	Latvia	M	-800	-545	U5a1a1	fasta	0.33	Mittnik et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15924G (MT-TT): LIMM (Reported) 16270T (MT-CR): Melanoma patients (Reported)
Alh_1	MAGe	Middle Ages	Germany	M	200	600	J2a2b	bam	196.55	Veeramah et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 15924G (MT-TT): LIMM (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 9966A (MT-CO3): LHON possible helper variant (Reported)
I4595	HGE	Mesolithic	Latvia	F	-5728	-5646	U2e1	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I7569	BABI	Bronze Age	Great Britain	F	-1619	-1457	K1a1b1	bam	9.67	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 114T (MT-CR): BD-associated (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 15924G (MT-TT): LIMM (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
Kivutkalns194	BABL	Bronze Age	Latvia	M	-800	-545	T1a1b	fasta	0.15	Mittnik et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
Alh_10	MAGe	Middle Ages	Germany	F	387	535	I1	bam	160.80	Veeramah et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 15924G (MT-TT): LIMM (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9966A (MT-CO3): LHON possible helper variant (Reported)
I7576	BABI	Bronze Age	Great Britain	M	-1206	-1003	J1c2	bam	108.49	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
I3214	NEIB	Neolithic	Spain	M	-3400	-2500	V3	bam	13.62	Olalde et al. 2019 Data	FASTA Metadata
Matojo	CAIB	Copper Age	Spain	M	-3010	-3879	H3c3	bam	<NA>	Günther et al. 2015 Data	FASTA Metadata
rath1	BABI	Bronze Age	Ireland	M	-2026	-1885	U5a1b1e	<NA>	<NA>	Cassidy et al. 2016 Data	Metadata
Kivutkalns207	BABL	Bronze Age	Latvia	F	-730	-390	H1b2	fasta	7.21	Mittnik et al. 2018 Data	FASTA Metadata	16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported)
Alh_2	MAGe	Middle Ages	Germany	F	260	535	H2a2a1	bam	252.11	Veeramah et al. 2018 Data	FASTA Metadata
Kivutkalns209	BABL	Bronze Age	Latvia	M	-450	-230	J1b1a1	fasta	2.24	Mittnik et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 295T (MT-CR): Low VO2max response (Reported) 2158C (MT-RNR2): Reduced risk PD (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
Kivutkalns215	BABL	Bronze Age	Latvia	F	-790	-535	H1c	fasta	2.73	Mittnik et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported)
I4630	HGE	Mesolithic	Latvia	M	-7465	-7078	U5a2c	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
BIM_33	MAGe	Middle Ages	Germany	F	349	542	U5b1b	bam	189.41	Veeramah et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16183C (MT-CR): Melanoma patients (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
rath2	BABI	Bronze Age	Ireland	M	-2024	-1741	U5b2a2	<NA>	<NA>	Cassidy et al. 2016 Data	Metadata
rath3	BABI	Bronze Age	Ireland	M	-1736	-1534	J2b1a	<NA>	<NA>	Cassidy et al. 2016 Data	Metadata
Kivutkalns25	BABL	Bronze Age	Latvia	M	-800	-545	H28a	fasta	1.57	Mittnik et al. 2018 Data	FASTA Metadata	146C (MT-CR): Absence of Endometriosis (Reported)
I0071	MIC	Bronze Age	Greece	F	-2400	-1700	U5a1	bam	552.00	Lazaridis et al. 2017 Data	FASTA Metadata
BIM_37	MAGe	Middle Ages	Germany	M	580	620	T2b16	bam	183.41	Veeramah et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I7640	BABI	Bronze Age	Great Britain	M	-1430	-1282	U5a2c2	bam	136.79	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I7547	NEIB	Neolithic	Spain	F	-4300	-3700	K1a+195	bam	17.60	Olalde et al. 2019 Data	FASTA Metadata
Kivutkalns42	BABL	Bronze Age	Latvia	F	-810	-560	H1b1	fasta	1.10	Mittnik et al. 2018 Data	FASTA Metadata	16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 3796G (MT-ND1): Adult-Onset Dystonia (Reported) 9861C (MT-CO3): AD (Reported)
I1975	CAIB	Copper Age	Spain	M	-3090	-2894	J1c	bam	20.10	Lipson et al. 2017 Data	FASTA Metadata
PCA0035	MAPl	Middle Ages	Poland	M	80	120	J2b1a5	bam	<NA>	Stolarek et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 15812A (MT-CYB): LHON (Reported / Secondary) 295T (MT-CR): Low VO2max response (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 489C (MT-CR): Low VO2max response (Reported)
Kretuonas2	NEBL	Neolithic	Lithuania	M	-5500	-2900	U5b2b	fasta	1.28	Mittnik et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 12634G (MT-ND5): Thyroid Cancer Cell Line (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16270T (MT-CR): Melanoma patients (Reported)
I0073	MIC	Bronze Age	Greece	M	-2400	-1700	H	bam	563.16	Lazaridis et al. 2017 Data	FASTA Metadata
ARS005	LBAMo	Bronze Age	Mongolia	M	-1255	-925	D4e1	<NA>	0.78	Jeong et al. 2018 Data	Metadata
NW_255	MAGe	Middle Ages	Germany	F	417	536	H18b	bam	238.12	Veeramah et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
PCA0037	MAPl	Middle Ages	Poland	M	10	375	T2e	bam	<NA>	Stolarek et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 1624T (MT-TV): Leigh Syndrome (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported)
I0520	NEBI	Neolithic	Great Britain	M	-3360	-3100	U5a2c	bam	44.27	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 6340T (MT-CO1): Prostate Cancer (Reported)
I5385	BBC	Bronze Age	Great Britain	F	-2455	-2147	H5	bam	278.46	Olalde et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I7249	BBC	Copper Age	Czech Republic	M	-2500	-2200	I2	bam	343.33	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 15924G (MT-TT): LIMM (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I4554	HGE	Mesolithic	Latvia	F	-4042	-3956	U4d1	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I5366	NEBI	Neolithic	Great Britain	F	-3643	-3383	X2b+226	bam	338.22	Olalde et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 15927A (MT-TT): LHON / Multiple Sclerosis / DEAF1555 increased penetrance / CHD (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 8393T (MT-ATP8): Reversible brain pseudoatrophy (Reported)
Kretuonas4	NEBL	Neolithic	Lithuania	F	-5500	-2900	U5b1b1a	fasta	8.79	Mittnik et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 3391A (MT-ND1): LHON (Reported)
NW_54	MAGe	Middle Ages	Germany	F	388	532	C4a1a	bam	198.90	Veeramah et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 3552A (MT-ND1): Resistance to high altitude pulmonary edema (HAPE) (Reported /hg C marker) 489C (MT-CR): Low VO2max response (Reported)
Kretuonas5	NEBL	Neolithic	Lithuania	M	-4450	-4340	U5b2b	fasta	0.20	Mittnik et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 12634G (MT-ND5): Thyroid Cancer Cell Line (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16270T (MT-CR): Melanoma patients (Reported)
I6750	NEBI	Neolithic	Great Britain	M	-3755	-3660	K1a+195	bam	129.02	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
PCA0040	MAPl	Middle Ages	Poland	M	80	260	I4a	bam	<NA>	Stolarek et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 15924G (MT-TT): LIMM (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 8519A (MT-ATP8): Susceptibility to bullous pemphigoid (Reported)
STR_220	MAGe	Middle Ages	Germany	F	480	530	U5b2b	bam	229.69	Veeramah et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 12634G (MT-ND5): Thyroid Cancer Cell Line (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16270T (MT-CR): Melanoma patients (Reported)
Motala1913	HGN	Mesolithic	Sweden	F	-5722	-5564	U5a2d	<NA>	0.05	Mittnik et al. 2018	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I7549	NEIB	Neolithic	Spain	F	-4300	-3700	K1a4a1	bam	34.90	Olalde et al. 2019 Data	FASTA Metadata
N22	BKG	Neolithic	Poland	F	-4442	-4240	U5a1c	bam	46.00	Fernandes et al 2018 Data	FASTA Metadata
I5374	NEBI	Neolithic	Great Britain	M	-2830	-2460	H1c	bam	243.93	Olalde et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported)
STR_228	MAGe	Middle Ages	Germany	F	382	546	T2b21	bam	242.38	Veeramah et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
Olsund	NESC	Neolithic	Sweden	M	-2573	-2140	U4c2a	fasta	2.22	Mittnik et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 499A (MT-CR): Endometriosis (Reported)
I1658	BACA	Bronze Age	Armenia	F	-3347	-3092	U3a2a	bam	596.00	Lazaridis et al. 2016 Data	FASTA Metadata
STR_266	MAGe	Middle Ages	Germany	F	510	530	J1cH	bam	557.68	Veeramah et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12316A (MT-TL2): CPEO (Cfrm) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
PCA0053	MAPl	Middle Ages	Poland	F	80	260	K1b2a	bam	<NA>	Stolarek et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 5913A (MT-CO1): Prostate Cancer / hypertension (Reported)
N25	BKG	Neolithic	Poland	F	4600	4000	K2a	bam	57.00	Fernandes et al 2018 Data	FASTA Metadata
I2988	NEBI	Neolithic	Great Britain	F	-3516	-3361	U5b2a3	bam	554.05	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I0074	MIC	Bronze Age	Greece	F	-2400	-1700	H5	bam	933.50	Lazaridis et al. 2017 Data	FASTA Metadata
STR_310	MAGe	Middle Ages	Germany	F	510	530	H7	bam	232.36	Veeramah et al. 2018 Data	FASTA Metadata
I2659	NEBI	Neolithic	Great Britain	F	-3761	-3643	H1c	bam	115.72	Olalde et al. 2018 Data	FASTA Metadata	16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
Plinkaigalis241	CWC	Neolithic	Lithuania	F	-2860	-2410	I2	fasta	0.21	Mittnik et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 15924G (MT-TT): LIMM (Reported)
I5068	LBK	Neolithic	Austria	M	-5500	-4775	T2b23	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
Plinkaigalis242	CWC	Neolithic	Lithuania	F	-3260	-2630	W6a	fasta	2.57	Mittnik et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 16192T (MT-CR): Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
I5470	BABI	Bronze Age	Great Britain	U	-1620	-1449	H15a1	bam	2.98	Olalde et al. 2018 Data	FASTA Metadata
I2981	BABI	Bronze Age	Great Britain	F	-1950	-1496	T2a1b1a	bam	1116.11	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 14687G (MT-TE): Mito myopathy w respiratory failure / intellectual disability (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
STR_328	MAGe	Middle Ages	Germany	F	350	530	U5a1h	bam	192.33	Veeramah et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I7550	NEIB	Neolithic	Spain	F	-4300	-3700	K1b1a	bam	49.80	Olalde et al. 2019 Data	FASTA Metadata
I2861	BABI	Bronze Age	Great Britain	F	-976	-828	I2a1	bam	995.09	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 15924G (MT-TT): LIMM (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
Popovo2	HGN	Mesolithic	Russia	M	-7500	-5000	U4d	fasta	0.06	Mittnik et al. 2018 Data	FASTA Metadata	12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 499A (MT-CR): Endometriosis (Reported)
STR_355	MAGe	Middle Ages	Germany	F	510	530	T2b	bam	257.87	Veeramah et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I5069	LBK	Neolithic	Austria	F	-5500	-4775	N1a1	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
N26	BKG	Neolithic	Poland	M	-4334	-4068	T2b30	bam	53.00	Fernandes et al 2018 Data	FASTA Metadata
Saxtorp5164	FBC	Neolithic	Sweden	F	-3945	-3647	T2b	fasta	0.59	Mittnik et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
STR_360	MAGe	Middle Ages	Germany	F	510	530	H5	<NA>	226.47	Veeramah et al. 2018 Data	Metadata
I2573	BABI	Bronze Age	Great Britain	F	-1500	-1301	H3+16311	bam	68.06	Olalde et al. 2018 Data	FASTA Metadata
N27	BKG	Neolithic	Poland	M	4600	4000	V14	bam	51.00	Fernandes et al 2018 Data	FASTA Metadata
STR_486	MAGe	Middle Ages	Germany	M	460	530	T2b	bam	399.05	Veeramah et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
STR_393	MAGe	Middle Ages	Germany	M	460	530	H5a1	bam	395.41	Veeramah et al. 2018 Data	FASTA Metadata	4336C (MT-TQ): ADPD / Hearing Loss & Migraine / autism spectrum / intellectual disability (Unclear)
PCA0062	MAPl	Middle Ages	Poland	M	80	260	U4a2	bam	<NA>	Stolarek et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 499A (MT-CR): Endometriosis (Reported)
LICOL90	LONG	Middle Ages	Italy	U	570	800	None	<NA>	<NA>	Vai et al. 2019	Metadata
Spiginas1	NESC	Neolithic	Lithuania	M	-4440	-4240	H11a	fasta	6.11	Mittnik et al. 2018 Data	FASTA Metadata	195C (MT-CR): BD-associated / melanoma pts (Reported) 961G (MT-RNR1): Possibly DEAF-associated (Unclear)
I2636	NEBI	Neolithic	Great Britain	F	-3519	-3361	V	bam	720.33	Olalde et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
STR_502	MAGe	Middle Ages	Germany	F	430	647	T1	<NA>	212.69	Veeramah et al. 2018 Data	Metadata
I9005	MIC	Bronze Age	Greece	F	-2400	-1700	H	bam	<NA>	Lazaridis et al. 2017 Data	FASTA Metadata
I2651	NEBI	Neolithic	Great Britain	F	-3360	-3098	K1a1b1	bam	116.55	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 114T (MT-CR): BD-associated (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 15924G (MT-TT): LIMM (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
N28	BKG	Neolithic	Poland	M	-4251	-3996	T2b	bam	54.00	Fernandes et al 2018 Data	FASTA Metadata
Spiginas2	CWC	Neolithic	Lithuania	M	-2130	-1750	I4a	fasta	3.16	Mittnik et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 15924G (MT-TT): LIMM (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 8519A (MT-ATP8): Susceptibility to bullous pemphigoid (Reported)
I9127	MIC	Bronze Age	Greece	F	-2210	-1680	J2b1a1	bam	<NA>	Lazaridis et al. 2017 Data	FASTA Metadata
Spiginas4	HGN	Mesolithic	Lithuania	F	-6440	-6230	U4a2	fasta	1.12	Mittnik et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 499A (MT-CR): Endometriosis (Reported)
I7594	NEIB	Neolithic	Spain	F	-3519	-3370	U5b2b	bam	15.40	Olalde et al. 2019 Data	FASTA Metadata
STR_535	MAGe	Middle Ages	Germany	F	348	538	HV9	bam	224.42	Veeramah et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 593C (MT-TF): Nonsyndromic hearing loss (Reported)
I9129	MIC	Bronze Age	Greece	F	-2210	-1680	H+163	bam	<NA>	Lazaridis et al. 2017 Data	FASTA Metadata
Tamula1	NEBL	Neolithic	Estonia	F	-3630	-3360	U5a1d2b	fasta	0.17	Mittnik et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
LICOL92	LONG	Middle Ages	Italy	U	570	800	H35	fasta	28.46	Vai et al. 2019 Data	FASTA Metadata
ARS008	LBAMo	Bronze Age	Mongolia	M	-1389	-1055	C4a2c	bam	3.56	Jeong et al. 2018 Data	Metadata
I9130	MIC	Bronze Age	Greece	M	-2210	-1680	U3b3	bam	<NA>	Lazaridis et al. 2017 Data	FASTA Metadata
Tamula3	NEBL	Neolithic	Estonia	F	-3800	-3640	U4d2	fasta	0.16	Mittnik et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 12662G (MT-ND5): Recurrent pregnancy loss (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 499A (MT-CR): Endometriosis (Reported) 5567C (MT-TW): Myopathy (Reported)
FN_2	MAGe	Middle Ages	Germany	M	300	500	H3	bam	169.61	Veeramah et al. 2018 Data	FASTA Metadata
Turlojiske1932	TRC	Bronze Age	Lithuania	F	-1230	-920	U5a2a1	fasta	0.08	Mittnik et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
N31	BKG	Neolithic	Poland	F	-4323	-4052	H26	bam	52.00	Fernandes et al 2018 Data	FASTA Metadata
I2979	NEBI	Neolithic	Great Britain	M	-3333	-2941	K1a+195	bam	659.77	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 3644C (MT-ND1): BD-associated (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I2657	NEBI	Neolithic	Great Britain	M	-3951	-3780	W1+119	bam	110.18	Olalde et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
KER_1	MAUk	Middle Ages	Ukraine	M	256	401	HV9a	bam	123.39	Veeramah et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
LICOL93	LONG	Middle Ages	Italy	U	570	800	J2b1a1	fasta	117.99	Vai et al. 2019 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 15257A (MT-CYB): LHON (Conflicting reports) 15812A (MT-CYB): LHON (Reported / Secondary) 195C (MT-CR): BD-associated / melanoma pts (Reported) 295T (MT-CR): Low VO2max response (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 489C (MT-CR): Low VO2max response (Reported) 6261A (MT-CO1): Prostate Cancer / LHON (Reported)
I5407	HGS	Mesolithic	Serbia	F	-8300	-7400	H13	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I9131	MIC	Bronze Age	Greece	F	-2210	-1680	K1a2	bam	<NA>	Lazaridis et al. 2017 Data	FASTA Metadata
I2980	NEBI	Neolithic	Great Britain	F	-3360	-3101	H1	bam	1528.10	Olalde et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I7598	NEIB	Neolithic	Spain	M	-3630	-3370	U5b3	bam	31.20	Olalde et al. 2019 Data	FASTA Metadata
Vim_2	MABA	Middle Ages	Serbia	M	500	600	H7	bam	283.19	Veeramah et al. 2018 Data	FASTA Metadata	15498A (MT-CYB): DEAF / Infantile histiocytoid cardiomyopathy (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
N36	BKG	Neolithic	Poland	F	4600	4000	J1c5	bam	47.00	Fernandes et al 2018 Data	FASTA Metadata
CL49	LONG	Middle Ages	Italy	M	570	880	None	<NA>	1.13	Amorim et al. 2018 Data	Metadata
Turlojiske1	TRC	Bronze Age	Lithuania	M	-930	-810	T2b	fasta	0.13	Mittnik et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I7600	NEIB	Neolithic	Spain	F	-4100	-2700	K1a2a	bam	30.30	Olalde et al. 2019 Data	FASTA Metadata
SCY001	SCU	Iron Age	Ukraine	U	-400	-400	U5a1b	reconstructed	<NA>	Juras et al. 2017b Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I3136	NEBI	Neolithic	Great Britain	F	-3520	-3365	H1+16189	bam	542.66	Olalde et al. 2018 Data	FASTA Metadata	16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I6617	CAIB	Copper Age	Spain	M	-2900	-2300	H1+16189	bam	191.63	Olalde et al. 2018 Data	FASTA Metadata	16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported)
SZ41	LONG	Middle Ages	Hungary	F	412	604	None	<NA>	0.94	Amorim et al. 2018 Data	Metadata
N42	BKG	Neolithic	Poland	F	-4231	-3979	U5b2a1a	bam	28.00	Fernandes et al 2018 Data	FASTA Metadata
CL23	LONG	Middle Ages	Italy	M	570	880	H	reconstructed	14.10	Amorim et al. 2018 Data	FASTA Metadata	150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 6261A (MT-CO1): Prostate Cancer / LHON (Reported)
I5371	NEBI	Neolithic	Great Britain	F	-4000	-3300	H4a1a2a	bam	87.35	Olalde et al. 2018 Data	FASTA Metadata	13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 14582G (MT-ND6): LHON synergistic combo 14258A + 14582G (Reported: individually neutral variants causing LHON in combination) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I2937	NEGr	Neolithic	Greece	F	-5479	-5338	K1a+195	bam	62.14	Lazaridis et al. 2017 Data	FASTA Metadata
I2635	NEBI	Neolithic	Great Britain	M	-3652	-3389	U5b1+16189+16192	bam	777.38	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16183C (MT-CR): Melanoma patients (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
N18	FBC	Neolithic	Poland	F	-3636	-3389	N1a1a1	bam	55.00	Fernandes et al 2018 Data	FASTA Metadata
I7602	NEIB	Neolithic	Spain	M	-3500	-2900	J1c1	bam	47.30	Olalde et al. 2019 Data	FASTA Metadata
I7603	NEIB	Neolithic	Spain	M	-3500	-2900	K1a2b	bam	37.70	Olalde et al. 2019 Data	FASTA Metadata
I5364	BABI	Bronze Age	Great Britain	F	-1600	-800	H5c	bam	6.50	Olalde et al. 2018 Data	FASTA Metadata
N19	FBC	Neolithic	Poland	F	-3636	-3388	V14	bam	50.00	Fernandes et al 2018 Data	FASTA Metadata
I1293	MEME	Mesolithic	Iran	M	-9100	-8600	None	<NA>	<NA>	Lazaridis et al. 2016 Data	Metadata
I7272	CWC	Neolithic	Czech Republic	M	-2900	-2200	K2a5	bam	292.87	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
Turlojiske5	TRC	Bronze Age	Lithuania	M	-2100	-600	H5	fasta	0.06	Mittnik et al. 2018 Data	FASTA Metadata
I7280	CWC	Neolithic	Czech Republic	M	-2900	-2200	W5a	bam	377.09	Olalde et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
CL25	LONG	Middle Ages	Italy	F	570	880	H	reconstructed	7.96	Amorim et al. 2018 Data	FASTA Metadata	3421A (MT-ND1): MIDD (Reported)
Turlojiske3	TRC	Bronze Age	Lithuania	M	-1010	-800	H4a1a1a3	fasta	0.67	Mittnik et al. 2018 Data	FASTA Metadata	10044G (MT-TG): SIDS (Unclear) 14582G (MT-ND6): LHON synergistic combo 14258A + 14582G (Reported: individually neutral variants causing LHON in combination)
Veibri4	NEBL	Neolithic	Estonia	F	-4900	-4720	U5b1	fasta	1.05	Mittnik et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
ARS010	LBAMo	Bronze Age	Mongolia	F	-1192	-899	None	<NA>	<NA>	Jeong et al. 2018 Data	Metadata
I7604	NEIB	Neolithic	Spain	M	-3500	-2900	H1ak	bam	29.70	Olalde et al. 2019 Data	FASTA Metadata
N20	FBC	Neolithic	Poland	M	-3636	-3388	H3t	bam	44.00	Fernandes et al 2018 Data	FASTA Metadata
I1497	BAD	Copper Age	Hungary	F	-2900	-2700	H	bam	445.00	Gamba et al. 2014 Data	FASTA Metadata
LRCMUS73A	LONG	Middle Ages	Czech Republic	U	500	600	T2e	fasta	23.15	Vai et al. 2019 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
LRCMUS69	LONG	Middle Ages	Czech Republic	U	500	600	N1b1b1	fasta	168.86	Vai et al. 2019 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 16390A (MT-CR): POAG - potential for association (Reported) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported) 8836G (MT-ATP6): LHON (Reported)
LRCMUS65	LONG	Middle Ages	Czech Republic	U	500	600	T2e	fasta	130.43	Vai et al. 2019 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
CL31	LONG	Middle Ages	Italy	M	570	880	H18	reconstructed	10.78	Amorim et al. 2018 Data	FASTA Metadata	13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports)
I7198	UNC	Bronze Age	Czech Republic	F	-2200	-1700	U5b2c	bam	284.22	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
LRCMUS71	LONG	Middle Ages	Czech Republic	U	500	600	H1c1	fasta	117.59	Vai et al. 2019 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported)
I7200	UNC	Bronze Age	Czech Republic	F	-2200	-1700	R1b1	bam	276.93	Olalde et al. 2018 Data	FASTA Metadata	1095C (MT-RNR1): SNHL (Unclear) 1391C (MT-RNR1): found in 1 HCM patient (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I7202	UNC	Bronze Age	Czech Republic	M	-2200	-1700	U5a1a2b	bam	111.60	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
LRCMUS68	LONG	Middle Ages	Czech Republic	U	500	600	V11	fasta	18.28	Vai et al. 2019 Data	FASTA Metadata
N38	GAC	Neolithic	Poland	F	-3263	-2903	T2c1-146	bam	70.00	Fernandes et al 2018 Data	FASTA Metadata
SCY010	SCU	Iron Age	Ukraine	F	-700	-700	N1b1a	reconstructed	<NA>	Juras et al. 2017b Data	FASTA Metadata	12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 16390A (MT-CR): POAG - potential for association (Reported)
CL36	LONG	Middle Ages	Italy	F	570	880	X2b	reconstructed	9.05	Amorim et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 8393T (MT-ATP8): Reversible brain pseudoatrophy (Reported)
SCY012	SCU	Iron Age	Ukraine	U	-400	-300	U5b2a1a2	reconstructed	<NA>	Juras et al. 2017b Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 15924G (MT-TT): LIMM (Reported) 5452T (MT-ND2): Progressive Encephalomyopathy (Reported)
I5035	EBACz	Bronze Age	Czech Republic	F	-2300	-1900	T2b	bam	283.43	Allentoft et al. 2015 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
LRCMUS73B	LONG	Middle Ages	Czech Republic	U	500	600	H1c1	fasta	45.45	Vai et al. 2019 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported)
I0867	PPNE	Neolithic	Israel	M	-7300	-6200	K1a4b	bam	126.83	Lazaridis et al. 2016 Data	FASTA Metadata
N44	CWC	Neolithic	Poland	F	-2570	-2340	U5a1b2	bam	53.00	Fernandes et al 2018 Data	FASTA Metadata
I7605	NEIB	Neolithic	Spain	M	-3500	-2900	H3	bam	13.60	Olalde et al. 2019 Data	FASTA Metadata
CL38	LONG	Middle Ages	Italy	M	570	880	X2	reconstructed	9.41	Amorim et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported)
LRCMUS72	LONG	Middle Ages	Czech Republic	U	500	600	None	<NA>	<NA>	Vai et al. 2019	Metadata
I1108	NEBA	Neolithic	Bulgaria	M	-5800	-5400	T2e	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
N45	CWC	Neolithic	Poland	F	-2570	-2340	H5a8	bam	80.00	Fernandes et al 2018 Data	FASTA Metadata
I7606	NEIB	Neolithic	Spain	M	-3500	-2900	U5b1+16189+@16192	bam	85.70	Olalde et al. 2019 Data	FASTA Metadata
LHSZ3	LONG	Middle Ages	Hungary	U	500	600	H2+16291	fasta	40.78	Vai et al. 2019 Data	FASTA Metadata	13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports)
CL47	LONG	Middle Ages	Italy	F	570	880	H11a	reconstructed	13.57	Amorim et al. 2018 Data	FASTA Metadata	195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 961G (MT-RNR1): Possibly DEAF-associated (Unclear)
N47	CWC	Neolithic	Poland	M	-2570	-2340	U5b2a2	bam	74.00	Fernandes et al 2018 Data	FASTA Metadata
CL57	LONG	Middle Ages	Italy	M	570	880	H24a	reconstructed	12.63	Amorim et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I7642	NEIB	Neolithic	Spain	M	-2907	-2761	J2b1a	bam	30.20	Olalde et al. 2019 Data	FASTA Metadata
I5117	CAHu	Copper Age	Hungary	M	-3400	-3000	K1a2	bam	69.88	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
AH1	NEME	Neolithic	Iran	F	-8200	-7700	R2	fasta	<NA>	Broushaki et al. 2016 Data	FASTA Metadata	150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 7543G (MT-TD): MEPR (Reported)
CL63	LONG	Middle Ages	Italy	M	570	880	H	reconstructed	10.53	Amorim et al. 2018 Data	FASTA Metadata
I1113	NEBA	Neolithic	Bulgaria	F	-5800	-5400	U5a1c	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I2369	CAHu	Copper Age	Hungary	M	-3367	-3103	J2a1a1	bam	125.00	Lipson et al. 2017 Data	FASTA Metadata
I2371	CAHu	Copper Age	Hungary	M	-3359	-3098	U5b	bam	42.00	Lipson et al. 2017 Data	FASTA Metadata
I5119	CAHu	Copper Age	Hungary	F	-3400	-3000	J1c2	bam	262.78	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
AH2	NEME	Neolithic	Iran	M	-8205	-7756	R2	fasta	<NA>	Broushaki et al. 2016 Data	FASTA Metadata	2755G (MT-RNR2): Possibly LVNC-associated (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 7554A (MT-TD): Myopathy+ataxia+nystagmus+migraines+lactic acidosis (Reported)
AH4	NEME	Neolithic	Iran	F	-8204	-7755	T2c	fasta	<NA>	Broushaki et al. 2016 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported) 7023A (MT-CO1): MELAS-like syndrome (Reported) 8932T (MT-ATP6): Prostate tumor / Neuromuscular disorder (Reported)
LHSZ5	LONG	Middle Ages	Hungary	U	500	600	J2b1	fasta	161.93	Vai et al. 2019 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 15257A (MT-CYB): LHON (Conflicting reports) 15812A (MT-CYB): LHON (Reported / Secondary) 195C (MT-CR): BD-associated / melanoma pts (Reported) 295T (MT-CR): Low VO2max response (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 489C (MT-CR): Low VO2max response (Reported) 9071T (MT-ATP6): Potentially functional variant cosegregating with LHON3635A (Reported)
WC1	NEME	Neolithic	Iran	M	-7455	-7082	J1d6	fasta	<NA>	Broushaki et al. 2016 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported) 9041G (MT-ATP6): Patient with suspected mitochondrial disease (Reported as VUS)
I1297	NEBA	Neolithic	Bulgaria	F	-5800	-5400	H5b	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
LHSZ6	LONG	Middle Ages	Hungary	U	500	600	I3	fasta	25.97	Vai et al. 2019 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 15924G (MT-TT): LIMM (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported)
LHSZ7	LONG	Middle Ages	Hungary	U	500	600	T2e1	fasta	76.14	Vai et al. 2019 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported) 961C (MT-RNR1): DEAF / possibly LVNC-associated (Unclear)
CL83	LONG	Middle Ages	Italy	F	570	880	H1	reconstructed	15.30	Amorim et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported)
I6537	EBAPl	Bronze Age	Poland	M	-2290	-2041	I1a1	bam	375.28	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 15924G (MT-TT): LIMM (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported)
I7643	NEIB	Neolithic	Spain	M	-3960	-3710	K1a1b1	bam	27.20	Olalde et al. 2019 Data	FASTA Metadata
LHSZ9	LONG	Middle Ages	Hungary	U	500	600	J1b1a1d	fasta	15.64	Vai et al. 2019 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 2158C (MT-RNR2): Reduced risk PD (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
N49	CWC	Neolithic	Poland	M	-2570	-2340	H6a1a	bam	76.00	Fernandes et al 2018 Data	FASTA Metadata
I7644	NEIB	Neolithic	Spain	M	-3640	-3380	no_data	bam	0.71	Olalde et al. 2019 Data	FASTA Metadata
I2215	NEBA	Neolithic	Bulgaria	U	-5800	-5400	T2b	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
LHSZ14	LONG	Middle Ages	Hungary	U	500	600	I3	fasta	155.92	Vai et al. 2019 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 15924G (MT-TT): LIMM (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported)
CL92	LONG	Middle Ages	Italy	M	570	880	H	reconstructed	4.80	Amorim et al. 2018 Data	FASTA Metadata
I2753	CAHu	Copper Age	Hungary	M	-3332	-2929	U5a1	bam	315.00	Lipson et al. 2017 Data	FASTA Metadata
I7646	NEIB	Neolithic	Spain	F	-3710	-3630	H1e1c	bam	21.20	Olalde et al. 2019 Data	FASTA Metadata
N17	BAPl	Bronze Age	Poland	M	-2016	-1775	J1c1b1a	bam	65.00	Fernandes et al 2018 Data	FASTA Metadata
I2754	CAHu	Copper Age	Hungary	M	-3337	-3024	J1c+16261+189	bam	71.90	Lipson et al. 2017 Data	FASTA Metadata
CL102	LONG	Middle Ages	Italy	F	570	880	H1i2	reconstructed	8.19	Amorim et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported)
CL121	LONG	Middle Ages	Italy	M	570	880	T2b	reconstructed	15.91	Amorim et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
SCY192	SCU	Iron Age	Moldova	F	-400	-200	H8c	reconstructed	<NA>	Juras et al. 2017b Data	FASTA Metadata	114T (MT-CR): BD-associated (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
LHSZ16	LONG	Middle Ages	Hungary	U	500	600	U4b1b1	fasta	53.55	Vai et al. 2019 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13528G (MT-ND5): LHON-like / LHON / MELAS (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 499A (MT-CR): Endometriosis (Reported)
CL145	LONG	Middle Ages	Italy	M	570	880	T2b	reconstructed	6.55	Amorim et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I2755	CAHu	Copper Age	Hungary	M	-3600	-3000	U8b1a1	bam	29.70	Lipson et al. 2017 Data	FASTA Metadata
LHSZ18	LONG	Middle Ages	Hungary	U	500	600	H13a1a2	fasta	137.68	Vai et al. 2019 Data	FASTA Metadata
I7647	NEIB	Neolithic	Spain	M	-4050	-3340	K1b1a	bam	5.73	Olalde et al. 2019 Data	FASTA Metadata
CL146	LONG	Middle Ages	Italy	M	570	880	T2b3	reconstructed	12.56	Amorim et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I2785	CAHu	Copper Age	Hungary	F	-3600	-3000	T2c1d1	bam	115.00	Lipson et al. 2017 Data	FASTA Metadata
Aes1	NESw	Neolithic	Switzerland	M	-3090	-2917	H1+152	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
I8134	NEIB	Neolithic	Spain	F	-4300	-3700	U5b3	bam	56.00	Olalde et al. 2019 Data	FASTA Metadata
I2366	CAHu	Copper Age	Hungary	M	-3600	-3000	H26a	bam	<NA>	Lipson et al. 2017 Data	FASTA Metadata
CL151	LONG	Middle Ages	Italy	F	570	880	T2b	reconstructed	4.54	Amorim et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported)
LHSZ22B	LONG	Middle Ages	Hungary	U	500	600	None	<NA>	<NA>	Vai et al. 2019	Metadata
LHSZ21	LONG	Middle Ages	Hungary	U	500	600	None	<NA>	<NA>	Vai et al. 2019	Metadata
LHSZ24	LONG	Middle Ages	Hungary	U	500	600	U4b1a1a1	fasta	84.96	Vai et al. 2019 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12297C (MT-TL2): Dilated Cardiomyopathy / Leigh Syndrome / Failure to Thrive & LA (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 499A (MT-CR): Endometriosis (Reported)
SZ6	LONG	Middle Ages	Hungary	M	412	604	None	<NA>	0.14	Amorim et al. 2018 Data	Metadata
LICOL146	LONG	Middle Ages	Italy	U	570	800	None	<NA>	<NA>	Vai et al. 2019	Metadata
I8568	NEIB	Neolithic	Spain	F	-3499	-3353	X2b+226	bam	157.00	Olalde et al. 2019 Data	FASTA Metadata
I7595	NEIB	Neolithic	Spain	F	-3519	-3370	U5b2b5	bam	22.00	Olalde et al. 2019 Data	FASTA Metadata
I0581	CAIB	Copper Age	Spain	M	-2900	-2679	X2b	<NA>	<NA>	Mathieson et al. 2015 Data	Metadata
SZ7	LONG	Middle Ages	Hungary	M	412	604	T2e	reconstructed	4.70	Amorim et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
SCY193	SCU	Iron Age	Moldova	M	-400	-200	U5a2a1	reconstructed	<NA>	Juras et al. 2017b Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
SZ9	LONG	Middle Ages	Hungary	F	412	604	J1b1a1d	reconstructed	19.64	Amorim et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 2158C (MT-RNR2): Reduced risk PD (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
Aes10	NESw	Neolithic	Switzerland	F	-2914	-2872	K1a+195	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
LHSZ26	LONG	Middle Ages	Hungary	U	500	600	H6a1a	fasta	21.88	Vai et al. 2019 Data	FASTA Metadata	11253C (MT-ND4): LHON PD (Reported)
SZ12	LONG	Middle Ages	Hungary	M	412	604	W6	reconstructed	6.50	Amorim et al. 2018 Data	FASTA Metadata	16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 16192T (MT-CR): Melanoma patients (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
LICOL147	LONG	Middle Ages	Italy	U	570	800	None	<NA>	<NA>	Vai et al. 2019	Metadata
Aes11	NESw	Neolithic	Switzerland	F	-3011	-2893	K1a3a	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
SZ14	LONG	Middle Ages	Hungary	M	412	604	I3	reconstructed	3.31	Amorim et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported)
I2367	CAHu	Copper Age	Hungary	M	-3600	-3000	HV	bam	<NA>	Lipson et al. 2017 Data	FASTA Metadata
I2788	CAHu	Copper Age	Hungary	M	-3910	-3650	H	bam	334.00	Lipson et al. 2017 Data	FASTA Metadata
I2030	LBK	Neolithic	Germany	F	-5500	-4850	H26	bam	<NA>	Lipson et al. 2017 Data	FASTA Metadata
LHSZ27A1	LONG	Middle Ages	Hungary	U	500	600	X2+225	fasta	18.27	Vai et al. 2019 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported)
I10287	NEIB	Neolithic	Spain	M	-3400	-2500	U2e3	bam	356.13	Olalde et al. 2019 Data	FASTA Metadata
Aes12	NESw	Neolithic	Switzerland	M	-3010	-2884	H1	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
I2789	CAHu	Copper Age	Hungary	M	-3800	-3600	J1c3b	bam	137.00	Lipson et al. 2017 Data	FASTA Metadata
SZ16	LONG	Middle Ages	Hungary	M	412	604	U4b1b	reconstructed	4.08	Amorim et al. 2018 Data	FASTA Metadata	13528G (MT-ND5): LHON-like / LHON / MELAS (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported)
LBK380	LBK	Neolithic	Germany	F	-5310	-5070	T2c1b	<NA>	<NA>	Lazaridis et al. 2014 Data	Metadata
mota	BAAF	Bronze Age	Ethiopia	M	-2575	-2469	L3x2a	<NA>	<NA>	Llorente et al. 2015 Data	Metadata
I11304	NEIB	Neolithic	Spain	M	-3400	-2500	U5a2+16294	bam	38.65	Olalde et al. 2019 Data	FASTA Metadata
Aes13	NESw	Neolithic	Switzerland	M	-3016	-2901	X2b+226	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
ATP2	CAIB	Copper Age	Spain	M	-2899	-2678	U5b3	bam	<NA>	Günther et al. 2015 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 228A (MT-CR): Low VO2max response (Reported)
SCY196	SCU	Iron Age	Moldova	U	-400	-200	W3a	reconstructed	<NA>	Juras et al. 2017b Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15784C (MT-CYB): POAG - potential for association (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
SCY197	SCU	Iron Age	Moldova	M	-400	-200	U5a1a1	reconstructed	<NA>	Juras et al. 2017b Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15924G (MT-TT): LIMM (Reported) 16270T (MT-CR): Melanoma patients (Reported)
ATP16	CAIB	Copper Age	Spain	F	-3261	-2916	X2c	bam	<NA>	Günther et al. 2015 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported)
SZ18	LONG	Middle Ages	Hungary	M	412	604	H13a1a2	reconstructed	5.20	Amorim et al. 2018 Data	FASTA Metadata
bally	NEBI	Neolithic	Ireland	F	-3343	-3020	HV0 +195	<NA>	<NA>	Cassidy et al. 2016 Data	Metadata
RISE210	BASC	Bronze Age	Sweden	M	-1432	-1292	T2a1a	<NA>	<NA>	Allentoft et al. 2015 Data	Metadata
RISE175	BASC	Bronze Age	Sweden	M	-1395	-1132	T1a1	<NA>	<NA>	Allentoft et al. 2015 Data	Metadata
RISE47	BASC	Bronze Age	Denmark	M	-1499	-1324	I	<NA>	<NA>	Allentoft et al. 2015 Data	Metadata
RISE276	BASC	Bronze Age	Denmark	M	-794	-547	T2b	<NA>	<NA>	Allentoft et al. 2015 Data	Metadata
SZ19	LONG	Middle Ages	Hungary	F	426	549	HV9c	reconstructed	13.50	Amorim et al. 2018 Data	FASTA Metadata
LIFART107-23A	LONG	Middle Ages	Italy	U	570	700	None	<NA>	<NA>	Vai et al. 2019	Metadata
RISE179	NESC	Neolithic	Sweden	M	-2010	-1776	K1a3	<NA>	<NA>	Allentoft et al. 2015 Data	Metadata
RISE71	NESC	Neolithic	Denmark	F	-2196	-2023	H3b	<NA>	<NA>	Allentoft et al. 2015 Data	Metadata
SZ22	LONG	Middle Ages	Hungary	M	412	604	N1b1b1	reconstructed	5.44	Amorim et al. 2018 Data	FASTA Metadata	16390A (MT-CR): POAG - potential for association (Reported) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported) 8836G (MT-ATP6): LHON (Reported)
I3273	CAIB	Copper Age	Spain	F	-3627	-3363	J2a1a1	bam	<NA>	Lipson et al. 2017 Data	FASTA Metadata
I2790	CAHu	Copper Age	Hungary	F	-3762	-3636	N1a1a3	bam	<NA>	Lipson et al. 2017 Data	FASTA Metadata
RISE97	NESC	Neolithic	Sweden	F	-2025	-1885	K2a5	<NA>	<NA>	Allentoft et al. 2015 Data	Metadata
RISE98	NESC	Neolithic	Sweden	M	-2275	-2032	K1b1a1	<NA>	<NA>	Allentoft et al. 2015 Data	Metadata
SZ23	LONG	Middle Ages	Hungary	M	412	604	H13a1a2	reconstructed	9.90	Amorim et al. 2018 Data	FASTA Metadata
Klei10	NEGr	Neolithic	Greece	M	-4230	-3995	K1a2	bam	<NA>	Hofmanova et al. 2016 Data	FASTA Metadata
SZ24	LONG	Middle Ages	Hungary	M	412	604	U4b	reconstructed	2.96	Amorim et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12297C (MT-TL2): Dilated Cardiomyopathy / Leigh Syndrome / Failure to Thrive & LA (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 499A (MT-CR): Endometriosis (Reported)
LHSZ27A2	LONG	Middle Ages	Hungary	U	500	600	X2+225	fasta	26.91	Vai et al. 2019 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 16183C (MT-CR): Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported)
Aes14	NESw	Neolithic	Switzerland	M	-3014	-2898	U5a1c1	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
SZ25	LONG	Middle Ages	Hungary	F	412	604	None	reconstructed	0.24	Amorim et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 3336C (MT-ND1): Carotid atherosclerosis risk (Reported)
LHSZ27B	LONG	Middle Ages	Hungary	U	500	600	N1a1a1a1	fasta	72.70	Vai et al. 2019 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 3336C (MT-ND1): Carotid atherosclerosis risk (Reported) 669C (MT-RNR1): DEAF (Reported)
Pal7	NEGr	Neolithic	Greece	F	-4452	-4350	J1c1	bam	<NA>	Hofmanova et al. 2016 Data	FASTA Metadata
LHSZ28	LONG	Middle Ages	Hungary	U	500	600	H3b5	fasta	37.87	Vai et al. 2019 Data	FASTA Metadata	16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 5911T (MT-CO1): Prostate Cancer (Reported)
AV1	MAHu	Middle Ages	Hungary	F	541	637	X2m'n	reconstructed	10.47	Amorim et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 16183C (MT-CR): Melanoma patients (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
Aes15	NESw	Neolithic	Switzerland	F	-3013	-2901	U5a1c1	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
I2791	CAHu	Copper Age	Hungary	M	-3658	-3384	U5a1c1	bam	<NA>	Lipson et al. 2017 Data	FASTA Metadata
I7679	NEIB	Neolithic	Spain	F	-4300	-3700	H	bam	4.56	Olalde et al. 2019 Data	FASTA Metadata
I1498	LBK	Neolithic	Hungary	F	-5291	-5056	H	bam	465.00	Gamba et al. 2014 Data	FASTA Metadata
SZ27B	LONG	Middle Ages	Hungary	M	412	538	N1a1a1a1	reconstructed	2.95	Amorim et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 3336C (MT-ND1): Carotid atherosclerosis risk (Reported)
LIFART40-25B	LONG	Middle Ages	Italy	U	570	700	None	<NA>	<NA>	Vai et al. 2019	Metadata
SZ28	LONG	Middle Ages	Hungary	F	412	604	H3b5	reconstructed	12.24	Amorim et al. 2018 Data	FASTA Metadata	16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported)
I1505	LBK	Neolithic	Hungary	F	-5211	-5011	J1c5	bam	142.00	Gamba et al. 2014 Data	FASTA Metadata
I1671	NEME	Neolithic	Iran	M	-5837	-5659	K1a12a	<NA>	<NA>	Lazaridis et al. 2016 Data	Metadata
SZ30	LONG	Middle Ages	Hungary	F	412	604	H13a	reconstructed	2.41	Amorim et al. 2018 Data	FASTA Metadata
Aes16	NESw	Neolithic	Switzerland	F	-3090	-2918	K1a2	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
I10282	NEIB	Neolithic	Spain	M	-3400	-2500	K1a3	bam	3.07	Olalde et al. 2019 Data	FASTA Metadata
SZ31	LONG	Middle Ages	Hungary	F	412	604	None	reconstructed	0.18	Amorim et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 499A (MT-CR): Endometriosis (Reported)
I7160	NEIB	Neolithic	Spain	F	-4039	-3804	T2c1d	bam	2.17	Olalde et al. 2019 Data	FASTA Metadata
Aes17	NESw	Neolithic	Switzerland	M	-3011	-2889	H10+(16093)	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
I5427	NEGr	Neolithic	Greece	F	-6005	-5879	K1a24	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
SZ35	LONG	Middle Ages	Hungary	F	412	604	None	reconstructed	0.01	Amorim et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I1506	LBK	Neolithic	Hungary	F	-5306	-5071	U5b2c	bam	220.00	Gamba et al. 2014 Data	FASTA Metadata
ARS017	LBAMo	Bronze Age	Mongolia	F	-1428	-1130	G2a	<NA>	1.67	Jeong et al. 2018 Data	Metadata
Bar31	NENE	Neolithic	Turkey	M	-6419	-6238	X2m	bam	<NA>	Hofmanova et al. 2016 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported)
LHSZ30	LONG	Middle Ages	Hungary	U	500	600	H13a1a4	fasta	77.00	Vai et al. 2019 Data	FASTA Metadata	8381G (MT-ATP8): MIDD / LVNC cardiomyopathy-assoc. (Reported)
Bar8	NENE	Neolithic	Turkey	F	-6212	-6030	K1a2	bam	<NA>	Hofmanova et al. 2016 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 4437T (MT-TM): Hypotonia / seizure / muscle weakness / lactic acidosis / hearing loss (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
LHSZ31	LONG	Middle Ages	Hungary	U	500	600	K1a	fasta	39.37	Vai et al. 2019 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
Aes18	NESw	Neolithic	Switzerland	F	-2914	-2876	H3	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
Bul6	BABA	Bronze Age	Bulgaria	M	-3400	-1600	None	<NA>	<NA>	Mathieson et al. 2018 Data	Metadata
Bul8	BABA	Bronze Age	Bulgaria	M	-3400	-1600	None	<NA>	<NA>	Mathieson et al. 2018 Data	Metadata
I2510	BABA	Bronze Age	Bulgaria	M	-2906	-2710	H4a1	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	14582G (MT-ND6): LHON synergistic combo 14258A + 14582G (Reported: individually neutral variants causing LHON in combination)
RISE486	BAIt	Bronze Age	Italy	M	-2134	-1773	J1c1b	<NA>	<NA>	Allentoft et al. 2015 Data	Metadata
LHSZ32	LONG	Middle Ages	Hungary	U	500	600	H74	fasta	91.92	Vai et al. 2019 Data	FASTA Metadata
SZ37	LONG	Middle Ages	Hungary	M	430	577	H66a	reconstructed	6.11	Amorim et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
F38	IAME	Iron Age	Iran	M	-971	-832	N1a3a	fasta	<NA>	Broushaki et al. 2016 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4491A (MT-ND2): High altitude pulmonary edema susceptibility (Reported) 5567C (MT-TW): Myopathy (Reported)
GOK2	FBC	Neolithic	Sweden	F	-3050	-2750	None	bam	<NA>	Skoglund et al. 2014 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported)
LIFART1-31A	LONG	Middle Ages	Italy	U	570	700	None	<NA>	<NA>	Vai et al. 2019	Metadata
LHSZ35	LONG	Middle Ages	Hungary	U	500	600	U5b3b	fasta	92.20	Vai et al. 2019 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 228A (MT-CR): Low VO2max response (Reported)
SZ38	LONG	Middle Ages	Hungary	F	412	604	HV0	reconstructed	9.08	Amorim et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
SZ40	LONG	Middle Ages	Hungary	F	412	604	T2	reconstructed	11.98	Amorim et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
SZ42	LONG	Middle Ages	Hungary	M	412	604	K2a6	reconstructed	9.74	Amorim et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
RISE487	BAIt	Bronze Age	Italy	M	-3483	-3107	H2a	<NA>	<NA>	Allentoft et al. 2015 Data	Metadata
RISE489	BAIt	Bronze Age	Italy	M	-2908	-2578	X2c1	<NA>	<NA>	Allentoft et al. 2015 Data	Metadata
Aes19	NESw	Neolithic	Switzerland	M	-3000	-2500	H1	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
I1662	CAME	Copper Age	Iran	M	-4831	-4612	K1a12a	bam	432.00	Lazaridis et al. 2016 Data	FASTA Metadata
SZ44	LONG	Middle Ages	Hungary	U	412	604	None	<NA>	<NA>	Amorim et al. 2018 Data	Metadata
I2534	NEBA	Neolithic	Romania	F	-6061	-5985	K1	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
RISE555	BARu	Bronze Age	Russia	M	-2857	-2497	N1a1a-T152C	<NA>	<NA>	Allentoft et al. 2015 Data	Metadata
LHSZ36	LONG	Middle Ages	Hungary	U	500	600	U4c2a	fasta	59.61	Vai et al. 2019 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 499A (MT-CR): Endometriosis (Reported)
I8145	MAIB	Middle Ages	Spain	M	1300	1500	H	bam	29.80	Olalde et al. 2019 Data	FASTA Metadata
LHSZ37	LONG	Middle Ages	Hungary	U	500	600	H66a	fasta	162.67	Vai et al. 2019 Data	FASTA Metadata
I2110	TRP	Neolithic	Ukraine	M	-3911	-3659	T2b	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
SZ1	LONG	Middle Ages	Hungary	M	412	604	J1b	reconstructed	132.76	Amorim et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 146C (MT-CR): Absence of Endometriosis (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
I3807	MAIB	Middle Ages	Spain	M	1500	1600	U6a	bam	301.24	Olalde et al. 2019 Data	FASTA Metadata
SZ3	LONG	Middle Ages	Hungary	M	412	604	H18	reconstructed	143.47	Amorim et al. 2018 Data	FASTA Metadata	13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports)
Aes2	NESw	Neolithic	Switzerland	F	-3011	-2893	H1	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
SZ4	LONG	Middle Ages	Hungary	M	412	604	H1c9	reconstructed	136.69	Amorim et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported)
I1665	CAME	Copper Age	Iran	F	-3956	-3796	U7a	bam	595.00	Lazaridis et al. 2016 Data	FASTA Metadata
Aes20	NESw	Neolithic	Switzerland	M	-2913	-2878	K2b1a	<NA>	<NA>	Furtwängler et al 2020 Data	Metadata
ARS020	LBAMo	Bronze Age	Mongolia	U	-1285	-1020	None	<NA>	<NA>	Jeong et al. 2018 Data	Metadata
Bon004	NENE	Neolithic	Turkey	M	-8300	-7952	N1a1a1	<NA>	<NA>	Kilinc et al. 2016 Data	Metadata
SZ5	LONG	Middle Ages	Hungary	M	412	604	J2b1	reconstructed	130.35	Amorim et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 15257A (MT-CYB): LHON (Conflicting reports) 15812A (MT-CYB): LHON (Reported / Secondary) 195C (MT-CR): BD-associated / melanoma pts (Reported) 295T (MT-CR): Low VO2max response (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 489C (MT-CR): Low VO2max response (Reported) 9071T (MT-ATP6): Potentially functional variant cosegregating with LHON3635A (Reported)
I3151	TRP	Neolithic	Ukraine	M	-4000	-3600	U8b1b	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
SZ11	LONG	Middle Ages	Hungary	M	412	604	K2a3a	reconstructed	126.81	Amorim et al. 2018 Data	FASTA Metadata	16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 16192T (MT-CR): Melanoma patients (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
Tep002	NENE	Neolithic	Turkey	F	-6680	-6590	K1a12a	<NA>	<NA>	Kilinc et al. 2016 Data	Metadata
I4110	NEUk	Neolithic	Ukraine	F	-3634	-3377	J2b1	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
SZ36	LONG	Middle Ages	Hungary	M	412	604	U4c2a	reconstructed	145.64	Amorim et al. 2018 Data	FASTA Metadata	16183C (MT-CR): Melanoma patients (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
Tep004	NENE	Neolithic	Turkey	F	-6430	-6260	N1a1a1	<NA>	<NA>	Kilinc et al. 2016 Data	Metadata
Aes21	NESw	Neolithic	Switzerland	M	-3000	-2500	U8b1b	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
SZ43	LONG	Middle Ages	Hungary	M	412	604	H1e	<NA>	140.37	Amorim et al. 2018 Data	Metadata
LHSZ38	LONG	Middle Ages	Hungary	U	500	600	HV0+195	fasta	26.01	Vai et al. 2019 Data	FASTA Metadata	195C (MT-CR): BD-associated / melanoma pts (Reported)
LHSZ39	LONG	Middle Ages	Hungary	U	500	600	H	fasta	129.28	Vai et al. 2019 Data	FASTA Metadata	16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported)
LHSZ40	LONG	Middle Ages	Hungary	U	500	600	T2	fasta	69.59	Vai et al. 2019 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
GOK4	FBC	Neolithic	Sweden	M	-3050	-2750	None	bam	<NA>	Skoglund et al. 2014 Data	FASTA Metadata
LHSZ41	LONG	Middle Ages	Hungary	U	500	600	U4a	fasta	125.47	Vai et al. 2019 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 499A (MT-CR): Endometriosis (Reported)
I5876	HGE	Mesolithic	Ukraine	M	-7040	-6703	U5a2a	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
LHSZ42	LONG	Middle Ages	Hungary	U	500	600	None	<NA>	<NA>	Vai et al. 2019	Metadata
LHSZ43	LONG	Middle Ages	Hungary	U	500	600	H1e	fasta	50.15	Vai et al. 2019 Data	FASTA Metadata	16183C (MT-CR): Melanoma patients (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
GOK5	FBC	Neolithic	Sweden	F	-3280	-2890	None	bam	<NA>	Skoglund et al. 2014 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
SZ45	LONG	Middle Ages	Hungary	M	412	604	J1c	<NA>	144.50	Amorim et al. 2018 Data	Metadata
Kudruküla2	MEBL	Mesolithic	Estonia	U	-3831	-3426	U4a	bam	10.39	Saag et al. 2017 Data	FASTA Metadata
I1670	CAME	Copper Age	Iran	F	-4839	-4617	U3a'c	bam	19.31	Lazaridis et al. 2016 Data	FASTA Metadata
I1763	HGE	Mesolithic	Ukraine	M	-8280	-7967	U5b2	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
Aes22	NESw	Neolithic	Switzerland	M	-2892	-2694	J2b1a2	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
I2175	BABA	Bronze Age	Bulgaria	M	-3328	-3015	K1c1	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
LHHEG71	LONG	Middle Ages	Hungary	U	500	600	None	<NA>	<NA>	Vai et al. 2019	Metadata
LHSZ44	LONG	Middle Ages	Hungary	U	500	600	H1a3b	fasta	161.21	Vai et al. 2019 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported)
LIFART72-40C	LONG	Middle Ages	Italy	U	570	700	None	<NA>	<NA>	Vai et al. 2019	Metadata
I1819	HGE	Mesolithic	Ukraine	M	-8825	-8561	U5b2	bam	<NA>	Jones et al. 2017 Data	FASTA Metadata
LHHEG18	LONG	Middle Ages	Hungary	U	500	600	U5b1b1+@16192	fasta	130.87	Vai et al. 2019 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
Kudruküla3	MEBL	Mesolithic	Estonia	U	-3950	-1850	U2e1	bam	14.29	Saag et al. 2017 Data	FASTA Metadata
I3808	MAIB	Middle Ages	Spain	F	1500	1600	H1	bam	368.00	Olalde et al. 2019 Data	FASTA Metadata
LHHEG30	LONG	Middle Ages	Hungary	U	500	600	U8a1a2	fasta	190.98	Vai et al. 2019 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports)
GOK7	FBC	Neolithic	Sweden	F	-3050	-2750	None	bam	<NA>	Skoglund et al. 2014 Data	FASTA Metadata
LHHEG31B	LONG	Middle Ages	Hungary	U	500	600	None	<NA>	<NA>	Vai et al. 2019	Metadata
LHHEG60	LONG	Middle Ages	Hungary	U	500	600	U5a1b	fasta	186.82	Vai et al. 2019 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
LHHEG61	LONG	Middle Ages	Hungary	U	500	600	T	fasta	12.23	Vai et al. 2019 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
Naakamäe	MEBL	Mesolithic	Estonia	F	-2941	-2538	None	<NA>	0.07	Saag et al. 2017 Data	Metadata
I5079	CABA	Copper Age	Croatia	F	-3710	-3360	J1c2	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
ARS024	LBAMo	Bronze Age	Mongolia	F	-1385	-1059	C4a1a1	<NA>	0.53	Jeong et al. 2018 Data	Metadata
I7425	MAIB	Middle Ages	Spain	F	1500	1600	W6	bam	51.10	Olalde et al. 2019 Data	FASTA Metadata
Ardu1	CWC	Neolithic	Estonia	M	-2850	-2050	T2a1a	bam	98.72	Saag et al. 2017 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 14687G (MT-TE): Mito myopathy w respiratory failure / intellectual disability (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I4112	NEUk	Neolithic	Ukraine	M	-5500	-4800	U5a2a	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
Ardu2	CWC	Neolithic	Estonia	M	-2921	-2555	U5b2c	bam	70.31	Saag et al. 2017 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
LHHEG2	LONG	Middle Ages	Hungary	U	500	600	HV1a2	fasta	42.91	Vai et al. 2019 Data	FASTA Metadata
Aes23	NESw	Neolithic	Switzerland	M	-2881	-2676	J2b1a	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
I5881	NEUk	Neolithic	Ukraine	M	-5218	-5059	U5a1b	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
arm1	BACA	Bronze Age	Armenia	U	-3000	-2800	K3	fasta	25.30	Margaryan et al. 2017 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 9055A (MT-ATP6): PD protective factor (Reported) 9478C (MT-CO3): Leigh Disease (Reported)
I1674	CAME	Copper Age	Iran	M	-3972	-3800	I1c	bam	334.00	Lazaridis et al. 2016 Data	FASTA Metadata
AfontovaGora3	HGE	Mesolithic	Russia	F	-16480	-15480	R1b	<NA>	<NA>	Fu et al. 2016 Data	Metadata
I1290	NEME	Neolithic	Iran	F	-8179	-7613	X1'2'3	bam	112.03	Lazaridis et al. 2016 Data	FASTA Metadata
I5886	NEUk	Neolithic	Ukraine	M	-5314	-5220	U4a	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
LHHEG3	LONG	Middle Ages	Hungary	U	500	600	H87	fasta	79.82	Vai et al. 2019 Data	FASTA Metadata
arm10	CLCA	Classical Age	Armenia	U	-719	-434	H13a1a2	fasta	31.10	Margaryan et al. 2017 Data	FASTA Metadata	195C (MT-CR): BD-associated / melanoma pts (Reported)
arm11	BACA	Bronze Age	Armenia	U	-1300	-1100	U3b	fasta	21.20	Margaryan et al. 2017 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 4640A (MT-ND2): LHON / Epilepsy (Reported)
I0785	CABA	Copper Age	Bulgaria	F	-4455	-4359	H7	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I5889	NEUk	Neolithic	Ukraine	F	-5310	-4785	U5a2a	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I4168	NEBA	Neolithic	Croatia	F	-4763	-4536	N1a1	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 3336C (MT-ND1): Carotid atherosclerosis risk (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports) 669C (MT-RNR1): DEAF (Reported)
Aes24	NESw	Neolithic	Switzerland	M	-2912	-2877	K2b1a	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
LICOL4	LONG	Middle Ages	Italy	U	570	800	None	<NA>	<NA>	Vai et al. 2019	Metadata
I3810	MAIB	Middle Ages	Spain	F	1500	1600	L2e1	bam	163.00	Olalde et al. 2019 Data	FASTA Metadata
LICOL23	LONG	Middle Ages	Italy	U	570	800	H2+152	fasta	115.23	Vai et al. 2019 Data	FASTA Metadata	150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 6261A (MT-CO1): Prostate Cancer / LHON (Reported)
I1944	NEME	Neolithic	Iran	F	-8000	-7700	R2+13500	bam	4.45	Lazaridis et al. 2016 Data	FASTA Metadata
I1945	NEME	Neolithic	Iran	M	-8000	-7700	J1	bam	14.21	Lazaridis et al. 2016 Data	FASTA Metadata
LICOL24	LONG	Middle Ages	Italy	U	570	800	None	<NA>	<NA>	Vai et al. 2019	Metadata
Aes25	NESw	Neolithic	Switzerland	M	-2864	-2501	X2b+226	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
LICOL30	LONG	Middle Ages	Italy	U	570	800	I1b	fasta	163.48	Vai et al. 2019 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 15924G (MT-TT): LIMM (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 9966A (MT-CO3): LHON possible helper variant (Reported)
LICOL25	LONG	Middle Ages	Italy	U	570	800	H	fasta	45.70	Vai et al. 2019 Data	FASTA Metadata
I0706	NEBA	Neolithic	Bulgaria	M	-6022	-5887	K1a4b	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I7423	MAIB	Middle Ages	Spain	M	1500	1600	H20c	bam	118.00	Olalde et al. 2019 Data	FASTA Metadata
I3712	NEUk	Neolithic	Ukraine	M	-5507	-5376	U4b1a	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
arm15	BACA	Bronze Age	Armenia	U	-1400	-1200	H15a1a1	fasta	22.50	Margaryan et al. 2017 Data	FASTA Metadata	6253C (MT-CO1): Prostate Cancer / enriched in POAG cohort (Reported)
NLHFON444	MAHu	Middle Ages	Hungary	U	500	600	H7	fasta	13.44	Vai et al. 2019 Data	Metadata
Aes3	NESw	Neolithic	Switzerland	F	-3078	-2908	H1	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
I3714	NEUk	Neolithic	Ukraine	M	-5500	-4800	U4d	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
arm16	BACA	Bronze Age	Armenia	U	-1400	-1200	K1a12a	fasta	28.60	Margaryan et al. 2017 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports) 8412C (MT-ATP8): Possible LHON helper mutation (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I3716	NEUk	Neolithic	Ukraine	M	-5469	-5328	U5b2a1a	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
LICOL31	LONG	Middle Ages	Italy	U	570	800	H	fasta	107.92	Vai et al. 2019 Data	FASTA Metadata	13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports)
Aes4	NESw	Neolithic	Switzerland	M	-3094	-2926	H3	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
I7426	MAIB	Middle Ages	Spain	M	1500	1600	H	bam	1.83	Olalde et al. 2019 Data	FASTA Metadata
I5870	NEUk	Neolithic	Ukraine	M	-5475	-5344	U4b1b1	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
LICOL36	LONG	Middle Ages	Italy	U	570	800	X2b+226	fasta	137.02	Vai et al. 2019 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 15927A (MT-TT): LHON / Multiple Sclerosis / DEAF1555 increased penetrance / CHD (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 8393T (MT-ATP8): Reversible brain pseudoatrophy (Reported)
Aes5	NESw	Neolithic	Switzerland	F	-3017	-2902	J1c3	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
I1951	NEME	Neolithic	Iran	F	-8202	-7681	HV	bam	13.10	Lazaridis et al. 2016 Data	FASTA Metadata
NLHFON468	MAHu	Middle Ages	Hungary	U	500	600	J2a1a1a	fasta	107.25	Vai et al. 2019 Data	Metadata
arm18	BACA	Bronze Age	Armenia	U	-1400	-1200	H15a1a1	fasta	62.60	Margaryan et al. 2017 Data	FASTA Metadata	6253C (MT-CO1): Prostate Cancer / enriched in POAG cohort (Reported)
Theo5	HGS	Mesolithic	Greece	U	-7605	-7529	K1c	fasta	62.74	Hofmanova et al. 2016 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13967T (MT-ND5): Possible LHON factor (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I4918	NEBA	Neolithic	Serbia	F	-6000	-5300	K1a4a1	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 9055A (MT-ATP6): PD protective factor (Reported)
I5872	NEUk	Neolithic	Ukraine	M	-5489	-5375	U5a2a	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
LICOL38	LONG	Middle Ages	Italy	U	570	800	X2	fasta	161.62	Vai et al. 2019 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 16183C (MT-CR): Melanoma patients (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported)
Aes6	NESw	Neolithic	Switzerland	M	-2905	-2759	H5	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
I3433	NEBA	Neolithic	Croatia	F	-5976	-5751	H1	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported)
I10865	CLIB	Classical Age	Spain	M	100	200	U5a1a1	bam	16.55	Olalde et al. 2019 Data	FASTA Metadata
I5873	NEUk	Neolithic	Ukraine	F	-5469	-5322	U4b	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 499A (MT-CR): Endometriosis (Reported)
arm19	BACA	Bronze Age	Armenia	U	-1400	-1200	K1a1b1e	fasta	49.30	Margaryan et al. 2017 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 114T (MT-CR): BD-associated (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 15924G (MT-TT): LIMM (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I5957	NEUk	Neolithic	Ukraine	M	-6500	-4000	T2	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
LICOL40	LONG	Middle Ages	Italy	U	570	800	None	<NA>	<NA>	Vai et al. 2019	Metadata
arm20	BACA	Bronze Age	Armenia	U	-1383	-1215	H8a1	fasta	92.20	Margaryan et al. 2017 Data	FASTA Metadata	146C (MT-CR): Absence of Endometriosis (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported)
LICOL47	LONG	Middle Ages	Italy	U	570	800	H11a	fasta	156.28	Vai et al. 2019 Data	FASTA Metadata	195C (MT-CR): BD-associated / melanoma pts (Reported) 961G (MT-RNR1): Possibly DEAF-associated (Unclear)
I0861	NAT	Epipaleolithic	Israel	M	-11840	-9760	JT	bam	5.38	Lazaridis et al. 2016 Data	FASTA Metadata
I1069	NAT	Epipaleolithic	Israel	M	-11840	-9760	HV	bam	4.63	Lazaridis et al. 2016 Data	FASTA Metadata
I3980	CAIB	Classical Age	Spain	F	432	601	H1e1c	bam	112.00	Olalde et al. 2019 Data	FASTA Metadata
LICOL49	LONG	Middle Ages	Italy	U	570	800	T2b	fasta	54.91	Vai et al. 2019 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
arm21	IACA	Iron Age	Armenia	U	-1300	-1100	HV12b1	fasta	55.50	Margaryan et al. 2017 Data	FASTA Metadata
I1690	NAT	Epipaleolithic	Israel	M	-11840	-9760	None	bam	1.94	Lazaridis et al. 2016 Data	FASTA Metadata
Aes7	NESw	Neolithic	Switzerland	M	-3000	-2500	U5b2b2	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
I3719	NEUk	Neolithic	Ukraine	M	-4949	-4799	H1	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported)
I0060	BBC	Copper Age	Germany	F	-2428	-2149	K1a2c	<NA>	<NA>	Haak et al. 2015 Data	Metadata
I1687	NAT	Epipaleolithic	Israel	F	-11520	-11110	H2a	bam	2.54	Lazaridis et al. 2016 Data	FASTA Metadata
I3981	CAIB	Classical Age	Spain	M	400	600	T2b32	bam	108.76	Olalde et al. 2019 Data	FASTA Metadata
NLHFON316	MAHu	Middle Ages	Hungary	U	500	600	None	<NA>	<NA>	Vai et al. 2019	Metadata
I3982	CAIB	Classical Age	Spain	F	200	400	HV0+195	bam	9.82	Olalde et al. 2019 Data	FASTA Metadata
I0804	UNC	Bronze Age	Germany	M	-2137	-1965	H3	bam	131.00	Haak et al. 2015 Data	FASTA Metadata
LICOL57	LONG	Middle Ages	Italy	U	570	800	H24a	fasta	156.42	Vai et al. 2019 Data	FASTA Metadata
arm22	IACA	Iron Age	Armenia	U	-1300	-1100	H2a	fasta	25.50	Margaryan et al. 2017 Data	FASTA Metadata	16093C (MT-CR): Cyclic Vomiting Syndrome (Reported)
RISE562	BBC	Copper Age	Germany	F	-2458	-2206	H2a1e	<NA>	<NA>	Allentoft et al. 2015 Data	Metadata
Bon001	NENE	Neolithic	Turkey	M	-8212	-7952	U3	<NA>	<NA>	Kilinc et al. 2016 Data	Metadata
LICOL61	LONG	Middle Ages	Italy	U	570	800	None	<NA>	<NA>	Vai et al. 2019	Metadata
Aes8	NESw	Neolithic	Switzerland	F	-2919	-2883	J1c3	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
I1499	LBK	Neolithic	Hungary	F	-5210	-5010	X2b+226	bam	320.00	Gamba et al. 2014 Data	FASTA Metadata
LICOL63	LONG	Middle Ages	Italy	U	570	800	H2+152	fasta	70.96	Vai et al. 2019 Data	FASTA Metadata
arm24	IACA	Iron Age	Armenia	U	-1300	-1100	U5a1b	fasta	21.70	Margaryan et al. 2017 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I0807	BAC	Neolithic	Germany	M	-3970	-3710	H1e1a	bam	48.90	Haak et al. 2015 Data	FASTA Metadata
Aes9	NESw	Neolithic	Switzerland	F	-2917	-2882	U5b2b5	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
ANI159	CABA	Copper Age	Bulgaria	M	-4711	-4530	T2b2b	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
arm27	IACA	Iron Age	Armenia	U	-1316	-1070	HV	fasta	99.60	Margaryan et al. 2017 Data	FASTA Metadata	15924G (MT-TT): LIMM (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported)
Bon002	NENE	Neolithic	Turkey	F	-8279	-7977	K1a	<NA>	<NA>	Kilinc et al. 2016 Data	Metadata
I5512	BBC	Bronze Age	Great Britain	F	-2500	-1800	J1c	bam	81.91	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
I1705	BANE	Bronze Age	Jordan	M	-2198	-1966	H14a	bam	671.00	Lazaridis et al. 2016 Data	FASTA Metadata
I1730	BANE	Bronze Age	Jordan	M	-2489	-2299	R0a1a	bam	470.00	Lazaridis et al. 2016 Data	FASTA Metadata
RISE569	SLV	Iron Age	Czech Republic	F	660	770	H1af	<NA>	<NA>	Allentoft et al. 2015 Data	Metadata
RISE568	SLV	Iron Age	Czech Republic	F	600	900	H44a	<NA>	<NA>	Allentoft et al. 2015 Data	Metadata
LICOL70	LONG	Middle Ages	Italy	U	570	800	H11a	fasta	16.29	Vai et al. 2019 Data	FASTA Metadata	195C (MT-CR): BD-associated / melanoma pts (Reported) 961G (MT-RNR1): Possibly DEAF-associated (Unclear)
NLHHACS 15	MAHu	Middle Ages	Hungary	U	500	600	U5a1c2a	fasta	26.36	Vai et al. 2019 Data	Metadata
arm28	BACA	Bronze Age	Armenia	U	-1400	-1200	K1a4c1	fasta	29.40	Margaryan et al. 2017 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 114T (MT-CR): BD-associated (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
MX150	NESw	Neolithic	Switzerland	M	-3244	-3102	H4a1a	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
arm3	BACA	Bronze Age	Armenia	U	-3039	-2864	K3	fasta	60.60	Margaryan et al. 2017 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 9055A (MT-ATP6): PD protective factor (Reported) 9478C (MT-CO3): Leigh Disease (Reported)
I3983	CAIB	Classical Age	Spain	M	265	427	H4a1c2	bam	76.00	Olalde et al. 2019 Data	FASTA Metadata
ILK002	GAC	Bronze Age	Ukraine	M	-2890	-2694	T2b	<NA>	<NA>	Mathieson et al. 2018 Data	Metadata
ILK003	GAC	Bronze Age	Ukraine	F	-2900	-2709	J1c	<NA>	<NA>	Mathieson et al. 2018 Data	Metadata
Bon005	NENE	Neolithic	Turkey	F	-8300	-8240	N1a1a1	<NA>	<NA>	Kilinc et al. 2016 Data	Metadata
DV16	HGC	Gravettian	Czech Republic	M	-28760	-27360	U5	bam	<NA>	Fu et al. 2016 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
arm30	BACA	Bronze Age	Armenia	U	-1500	-1300	U8b1a2b	fasta	63.10	Margaryan et al. 2017 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 14831A (MT-CYB): LHON (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
LICOL83	LONG	Middle Ages	Italy	U	570	800	H1	fasta	101.33	Vai et al. 2019 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported)
MX182	NESw	Neolithic	Switzerland	M	-3338	-3031	K1a	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
LICOL84	LONG	Middle Ages	Italy	U	570	800	H1	fasta	146.58	Vai et al. 2019 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported)
I0099	BAGe	Bronze Age	Germany	M	-1193	-979	H23	bam	<NA>	Lipson et al. 2017 Data	FASTA Metadata
arm31	BACA	Bronze Age	Armenia	U	-1400	-1200	T1a9	fasta	44.10	Margaryan et al. 2017 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 12397G (MT-ND5): PD / early onset (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I1414	PPNE	Neolithic	Jordan	M	-8300	-7900	K1a18	bam	20.33	Lazaridis et al. 2016 Data	FASTA Metadata
kum4	NENE	Neolithic	Turkey	F	-4900	-4300	None	<NA>	<NA>	Omrak et al. 2016 Data	Metadata
arm32	BACA	Bronze Age	Armenia	U	-1400	-1200	HV1a2	fasta	96.50	Margaryan et al. 2017 Data	FASTA Metadata
MX183	NESw	Neolithic	Switzerland	M	-3344	-3037	K1a+195	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
LICOL86	LONG	Middle Ages	Italy	U	570	800	None	<NA>	<NA>	Vai et al. 2019	Metadata
arm34	BACA	Bronze Age	Armenia	U	-1348	-1175	U3b	fasta	146.80	Margaryan et al. 2017 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 3398C (MT-ND1): DMDF+HCM / GDM / possibly LVNC cardiomyopathy-associated (Reported) 4640A (MT-ND2): LHON / Epilepsy (Reported)
RISE483	BAHu	Bronze Age	Hungary	F	-2000	-1500	H2a1	bam	<NA>	Allentoft et al. 2015 Data	FASTA Metadata
Chaudardes1	HGW	Mesolithic	France	M	-6410	-6100	U5b1b	<NA>	<NA>	Fu et al. 2016 Data	Metadata
arm35	BACA	Bronze Age	Armenia	U	-2000	-1800	U3b	fasta	35.70	Margaryan et al. 2017 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 3398C (MT-ND1): DMDF+HCM / GDM / possibly LVNC cardiomyopathy-associated (Reported) 4640A (MT-ND2): LHON / Epilepsy (Reported)
NLHHACS 5	MAHu	Middle Ages	Hungary	U	500	600	H1bh	fasta	176.82	Vai et al. 2019 Data	Metadata
MX184	NESw	Neolithic	Switzerland	F	-3400	-2500	J1c3	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
arm37	IACA	Iron Age	Armenia	U	-1100	-900	H	fasta	38.40	Margaryan et al. 2017 Data	FASTA Metadata
arm39	NECA	Neolithic	Armenia	U	-5925	-5717	I1	fasta	21.90	Margaryan et al. 2017 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 15924G (MT-TT): LIMM (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 9966A (MT-CO3): LHON possible helper variant (Reported)
I6492	CLIB	Classical Age	Spain	M	200	500	T2b11	bam	32.90	Olalde et al. 2019 Data	FASTA Metadata
MX187	NESw	Neolithic	Switzerland	M	-3337	-2908	K1a+195	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
LICOL87	LONG	Middle Ages	Italy	U	570	800	H1	fasta	157.55	Vai et al. 2019 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported)
Tep003	NENE	Neolithic	Turkey	M	-6635	-6475	N1b1a	<NA>	<NA>	Kilinc et al. 2016 Data	Metadata
I1700	PPNE	Neolithic	Jordan	M	-8300	-7900	T1a2	bam	14.95	Lazaridis et al. 2016 Data	FASTA Metadata
I11599	CAIB	Copper Age	Portugal	M	-3400	-2800	J2b1a2	bam	128.90	Olalde et al. 2019 Data	FASTA Metadata
LICOL94	LONG	Middle Ages	Italy	U	570	800	K1c1	fasta	133.31	Vai et al. 2019 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
RISE512	BARu	Bronze Age	Russia	M	-1446	-1298	U2e1	bam	<NA>	Allentoft et al. 2015 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported)
RISE484	BAHu	Bronze Age	Hungary	F	-2000	-1500	T1a1	bam	<NA>	Allentoft et al. 2015 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
Bichon	HGW	Mesolithic	Switzerland	M	-11820	-11610	U5b1h	<NA>	<NA>	Jones et al. 2015 Data	Metadata
LICOL97	LONG	Middle Ages	Italy	U	570	800	H2a2b1	fasta	9.19	Vai et al. 2019 Data	FASTA Metadata
arm4	CLCA	Classical Age	Armenia	U	-100	100	J1d1b1	fasta	33.60	Margaryan et al. 2017 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 16300G (MT-CR): BD-associated (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
I7158	CLIB	Classical Age	Spain	M	200	500	T2b	bam	5.47	Olalde et al. 2019 Data	FASTA Metadata
MX188	CWC	Neolithic	Switzerland	M	-2495	-2399	U2e2a1d	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
I11601	CAIB	Copper Age	Portugal	F	-3400	-2800	V	bam	17.02	Olalde et al. 2019 Data	FASTA Metadata
JK2134	CLNE	Classical Age	Egypt	M	-776	-569	J1d	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
I11605	CAIB	Copper Age	Portugal	M	-3100	-2500	HV0d	bam	266.30	Olalde et al. 2019 Data	FASTA Metadata
Tep006	NENE	Neolithic	Turkey	M	-6345	-6215	N1a1a1	<NA>	<NA>	Kilinc et al. 2016 Data	Metadata
I11614	CAIB	Copper Age	Portugal	F	-2800	-2600	H4a1a	bam	218.10	Olalde et al. 2019 Data	FASTA Metadata
arm40	BACA	Bronze Age	Armenia	U	-3449	-3091	H14b2	fasta	37.10	Margaryan et al. 2017 Data	FASTA Metadata	16093C (MT-CR): Cyclic Vomiting Syndrome (Reported)
arm42	BACA	Bronze Age	Armenia	U	-3500	-3200	T1	fasta	25.70	Margaryan et al. 2017 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 16390A (MT-CR): POAG - potential for association (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
arm43	BACA	Bronze Age	Armenia	U	-1800	-1600	U4a	fasta	25.60	Margaryan et al. 2017 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 499A (MT-CR): Endometriosis (Reported)
I5879	NEUk	Neolithic	Ukraine	M	-5500	-4800	U5a1b	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 14693G (MT-TE): MELAS / LHON / DEAF / hypertension helper (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
MX189	CWC	Neolithic	Switzerland	F	-2105	-2036	T2b	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
Bul4	YAM	Bronze Age	Bulgaria	M	-3012	-2900	None	<NA>	<NA>	Mathieson et al. 2018 Data	Metadata
RISE547	YAM	Bronze Age	Russia	M	-2887	-2634	T2a1a	<NA>	<NA>	Allentoft et al. 2015 Data	Metadata
I3432	CAIB	Copper Age	Portugal	F	-3082	-2909	U5b2b3	bam	223.00	Olalde et al. 2019 Data	FASTA Metadata
LICOL102	LONG	Middle Ages	Italy	U	570	800	H1	fasta	92.87	Vai et al. 2019 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported)
RISE548	YAM	Bronze Age	Russia	M	-3000	-2400	U4	<NA>	<NA>	Allentoft et al. 2015 Data	Metadata
LICOL110	LONG	Middle Ages	Italy	U	570	800	None	<NA>	<NA>	Vai et al. 2019	Metadata
arm44	IACA	Iron Age	Armenia	U	-743	-491	U3b3	fasta	43.90	Margaryan et al. 2017 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 4640A (MT-ND2): LHON / Epilepsy (Reported)
LICOL121	LONG	Middle Ages	Italy	U	570	800	T2b	fasta	125.43	Vai et al. 2019 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
arm45	BACA	Bronze Age	Armenia	U	-1800	-1600	T	fasta	11.70	Margaryan et al. 2017 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I2520	BABA	Bronze Age	Bulgaria	M	-3336	-3028	H	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I8338	CLIB	Classical Age	Spain	F	100	200	HV0+195	bam	107.00	Olalde et al. 2019 Data	FASTA Metadata
MX190	CWC	Neolithic	Switzerland	M	-2860	-2460	U2e2a1d	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
NLHBAL150C	MAHu	Middle Ages	Hungary	U	450	500	None	<NA>	<NA>	Vai et al. 2019	Metadata
NLHBAL112A	MAHu	Middle Ages	Hungary	U	450	500	None	<NA>	<NA>	Vai et al. 2019	Metadata
LICOL145	LONG	Middle Ages	Italy	U	570	800	T2b	fasta	141.48	Vai et al. 2019 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
NLHBAL143C	MAHu	Middle Ages	Hungary	U	450	500	None	<NA>	<NA>	Vai et al. 2019	Metadata
I5076	CAIB	Copper Age	Portugal	F	-3335	-3026	H1	bam	205.42	Olalde et al. 2019 Data	FASTA Metadata
arm46	BACA	Bronze Age	Armenia	U	-1800	-1600	HV1a1	fasta	17.90	Margaryan et al. 2017 Data	FASTA Metadata	150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 15927A (MT-TT): LHON / Multiple Sclerosis / DEAF1555 increased penetrance / CHD (Reported)
KZ3	LDN	Neolithic	Poland	U	-4400	-3900	H3d	fasta	<NA>	Juras et al. 2017a Data	FASTA Metadata
I3313	BABA	Bronze Age	Croatia	F	-805	-761	HV0e	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	195C (MT-CR): BD-associated / melanoma pts (Reported)
Kivutkalns19	BABL	Bronze Age	Latvia	M	-730	-400	H10a	fasta	5.76	Mittnik et al. 2018 Data	FASTA Metadata	4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports)
MX191	CWC	Neolithic	Switzerland	M	-2570	-2190	H3+16189	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
SCY303	SCU	Iron Age	Moldova	F	-400	-200	U5a1a2b	reconstructed	<NA>	Juras et al. 2017b Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 3796G (MT-ND1): Adult-Onset Dystonia (Reported)
NLHBAL149-B25	MAHu	Middle Ages	Hungary	U	450	500	None	<NA>	<NA>	Vai et al. 2019	Metadata
MX192	CWC	Neolithic	Switzerland	M	-2571	-2513	H11a+152	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
I5429	CAIB	Copper Age	Portugal	M	-3010	-2887	J2b1a3	bam	75.40	Olalde et al. 2019 Data	FASTA Metadata
I2163	BABA	Bronze Age	Bulgaria	M	-1750	-1625	U5a2	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 7444A (MT-CO1): LHON / SNHL / DEAF (Reported)
arm48	IACA	Iron Age	Armenia	U	-700	-500	I4	fasta	20.50	Margaryan et al. 2017 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 15043A (MT-CYB): MDD-associated (Reported) 15924G (MT-TT): LIMM (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 8519A (MT-ATP8): Susceptibility to bullous pemphigoid (Reported)
MX193	CWC	Neolithic	Switzerland	F	-2213	-2031	K1a+195	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
SCY332	SCU	Iron Age	Moldova	F	-400	-200	M10a1a1a	reconstructed	<NA>	Juras et al. 2017b Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 13135A (MT-ND5): possible HCM susceptibility (Reported) 14502C (MT-ND6): LHON (Reported - possibly synergistic) 15043A (MT-CYB): MDD-associated (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 489C (MT-CR): Low VO2max response (Reported)
I2165	BABA	Bronze Age	Bulgaria	M	-3020	-2895	T2f	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
LIFART87-34A	LONG	Middle Ages	Italy	U	570	700	None	<NA>	<NA>	Vai et al. 2019	Metadata
arm49	IACA	Iron Age	Armenia	U	-700	-500	I4	fasta	17.50	Margaryan et al. 2017 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 15043A (MT-CYB): MDD-associated (Reported) 15924G (MT-TT): LIMM (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 8519A (MT-ATP8): Susceptibility to bullous pemphigoid (Reported)
LICOL151	LONG	Middle Ages	Italy	U	570	800	T2b	fasta	70.13	Vai et al. 2019 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
Bul10	BABA	Bronze Age	Bulgaria	F	-3090	-2924	None	<NA>	<NA>	Mathieson et al. 2018 Data	Metadata
LIFART38-35B	LONG	Middle Ages	Italy	U	570	700	V	fasta	117.36	Vai et al. 2019 Data	Metadata
arm5	BACA	Bronze Age	Armenia	U	-3000	-2800	J1b1b1	fasta	41.70	Margaryan et al. 2017 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports) 9055A (MT-ATP6): PD protective factor (Reported)
NLHBAL268C	MAHu	Middle Ages	Hungary	U	450	500	None	<NA>	<NA>	Vai et al. 2019	Metadata
I8202	CLIB	Classical Age	Spain	M	100	300	K2b1	bam	77.90	Olalde et al. 2019 Data	FASTA Metadata
arm52	CACA	Copper Age	Armenia	U	-4486	-4320	U8b1a1	fasta	138.10	Margaryan et al. 2017 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 869T (MT-RNR1): found in 1 HCM patient (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
MX194	CWC	Neolithic	Switzerland	F	-2489	-2344	U2e2a1d	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
Jan1	HGC	Mesolithic	Poland	M	-5644	-5374	U5b1b1	reconstructed	<NA>	Chyleński et al. 2017 Data	FASTA Metadata	12063T (MT-ND4): Recurrent pregnancy loss (Reported) 11527T (MT-ND4): ND4 mutation set found in a Multiple Sclerosis patient (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13051A (MT-ND5): LHON (Cfrm) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 15170A (MT-CYB): EXIT (Reported) 1612T (MT-TV): LVNC (left ventricular noncompaction) (Reported (VUS)) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 3632T (MT-ND1): LHON (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports) 7520A (MT-TD): Sporadic bilateral optic neuropathy (Reported) 8078A (MT-CO2): DEAF (Reported) 9438A (MT-CO3): LHON / gout (Conflicting reports)
arm7	NECA	Neolithic	Armenia	U	-5900	-5600	H2+152	fasta	22.50	Margaryan et al. 2017 Data	FASTA Metadata
LIFART35-13A	LONG	Middle Ages	Italy	U	570	700	None	<NA>	<NA>	Vai et al. 2019	Metadata
NHP1	LDN	Neolithic	Poland	U	-4600	-3600	H5	reconstructed	<NA>	Chyleński et al. 2017 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 961C (MT-RNR1): DEAF / possibly LVNC-associated (Unclear)
LIFART45-45C	LONG	Middle Ages	Italy	U	570	700	None	<NA>	<NA>	Vai et al. 2019	Metadata
I4331	BABA	Bronze Age	Croatia	M	-1631	-1521	I1a1	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 15924G (MT-TT): LIMM (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported)
MX195	CWC	Neolithic	Switzerland	M	-2470	-2050	H11a+152	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
LIFART60-30A	LONG	Middle Ages	Italy	U	570	700	None	<NA>	<NA>	Vai et al. 2019	Metadata
LIFART82-8B	LONG	Middle Ages	Italy	U	570	700	None	<NA>	<NA>	Vai et al. 2019	Metadata
NLHFON336	MAHu	Middle Ages	Hungary	U	500	600	None	<NA>	<NA>	Vai et al. 2019	Metadata
I4332	BABA	Bronze Age	Croatia	F	-1618	-1513	W3a1	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15784C (MT-CYB): POAG - potential for association (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
arm9	NECA	Neolithic	Armenia	U	-5900	-5600	H15a1	fasta	31.70	Margaryan et al. 2017 Data	FASTA Metadata	6253C (MT-CO1): Prostate Cancer / enriched in POAG cohort (Reported)
RISE396	IACA	Iron Age	Armenia	F	-1192	-937	H6b	fasta	7.40	Allentoft et al. 2015 Data	FASTA Metadata
I7691	BAIB	Bronze Age	Portugal	M	-2200	-1700	J1c1	bam	30.80	Olalde et al. 2019 Data	FASTA Metadata
PCA0018	MAPl	Middle Ages	Poland	M	10	375	HV18	bam	<NA>	Stolarek et al. 2018 Data	FASTA Metadata	7554A (MT-TD): Myopathy+ataxia+nystagmus+migraines+lactic acidosis (Reported) 8340A (MT-TK): Myopathy / Exercise Intolerance / Eye disease+SNHL (Cfrm) 8342A (MT-TK): PEO and Myoclonus (Reported)
Kretuonas1	NEBL	Neolithic	Lithuania	F	-4460	-3820	U5b1	fasta	0.37	Mittnik et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
RISE407	IACA	Iron Age	Armenia	F	-1115	-895	H8a1	fasta	33.80	Allentoft et al. 2015 Data	FASTA Metadata	146C (MT-CR): Absence of Endometriosis (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported)
PCA0028	MAPl	Middle Ages	Poland	F	80	260	U3a1a	bam	<NA>	Stolarek et al. 2018 Data	FASTA Metadata	12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16390A (MT-CR): POAG - potential for association (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported)
RISE247	BAHu	Bronze Age	Hungary	M	-1746	-1611	H11a	bam	<NA>	Allentoft et al. 2015 Data	FASTA Metadata	961G (MT-RNR1): Possibly DEAF-associated (Unclear)
RISE408	IACA	Iron Age	Armenia	M	-1209	-1009	I5c	fasta	103.00	Allentoft et al. 2015 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 15924G (MT-TT): LIMM (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported)
I2509	BABA	Bronze Age	Bulgaria	F	-4452	-4354	K1a2	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
NLHFON469	MAHu	Middle Ages	Hungary	U	500	600	T2c1c	fasta	72.32	Vai et al. 2019 Data	Metadata
MX196	CWC	Neolithic	Switzerland	F	-2580	-2290	J1c3	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
NLIAR3	MAIt	Middle Ages	Italy	U	500	1000	None	<NA>	<NA>	Vai et al. 2019	Metadata
I2519	CABA	Copper Age	Bulgaria	F	-4337	-4246	U5b2a1a	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16192T (MT-CR): Melanoma patients (Reported)
NLHHACS 13	MAHu	Middle Ages	Hungary	U	500	600	None	<NA>	<NA>	Vai et al. 2019	Metadata
I8474	CLIB	Classical Age	Spain	F	100	200	U5a1a2b	bam	23.40	Olalde et al. 2019 Data	FASTA Metadata
PCA0038	MAPl	Middle Ages	Poland	U	80	260	H1e1a	bam	<NA>	Stolarek et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
RISE412	IACA	Iron Age	Armenia	F	-1193	-945	U4c1	fasta	268.90	Allentoft et al. 2015 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 499A (MT-CR): Endometriosis (Reported)
I0021	LBK	Neolithic	Germany	U	-5500	-4800	T2b	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
MX197	CWC	Neolithic	Switzerland	F	-2490	-2294	H11a+152	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
I2431	CABA	Copper Age	Bulgaria	M	-4725	-4605	N1b2	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 16390A (MT-CR): POAG - potential for association (Reported) 8836G (MT-ATP6): LHON (Reported)
NLHHACS 18	MAHu	Middle Ages	Hungary	U	500	600	H39	fasta	98.36	Vai et al. 2019 Data	Metadata
PCA0050	MAPl	Middle Ages	Poland	M	80	260	H1e1a	bam	<NA>	Stolarek et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
I2423	CABA	Copper Age	Bulgaria	F	-4520	-4356	H	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
RISE413	BACA	Bronze Age	Armenia	M	-1906	-1698	T2c1f	fasta	118.20	Allentoft et al. 2015 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported) 6261A (MT-CO1): Prostate Cancer / LHON (Reported)
NLHHACS1	MAHu	Middle Ages	Hungary	U	500	600	None	<NA>	<NA>	Vai et al. 2019	Metadata
PCA0052	MAPl	Middle Ages	Poland	F	110	160	U5a1a1	bam	<NA>	Stolarek et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15924G (MT-TT): LIMM (Reported) 16270T (MT-CR): Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported)
RISE416	BACA	Bronze Age	Armenia	M	-1643	-1445	K1a17a	fasta	130.30	Allentoft et al. 2015 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
MX198	CWC	Neolithic	Switzerland	F	-2900	-2300	J1c4	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
I2424	CABA	Copper Age	Bulgaria	F	-4448	-4260	U4a	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 499A (MT-CR): Endometriosis (Reported)
I7692	BAIB	Bronze Age	Portugal	F	-2200	-1700	U5b1+16189+@16192	bam	7.89	Olalde et al. 2019 Data	FASTA Metadata
PCA0059	MAPl	Middle Ages	Poland	F	110	160	K2a	bam	<NA>	Stolarek et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I2430	CABA	Copper Age	Bulgaria	M	-4545	-4450	K1a26	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
MX199	CWC	Neolithic	Switzerland	F	-2409	-2197	J2b1a	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
NLHBAL144C	MAHu	Middle Ages	Hungary	U	450	500	K1a4	fasta	51.59	Vai et al. 2019 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I7688	BAIB	Bronze Age	Portugal	F	-1200	-700	H3ap	bam	49.60	Olalde et al. 2019 Data	FASTA Metadata
I2425	CABA	Copper Age	Bulgaria	F	-4679	-4450	T2c1b	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported) 6261A (MT-CO1): Prostate Cancer / LHON (Reported)
NLHBAL148C	MAHu	Middle Ages	Hungary	U	450	500	R	fasta	6.66	Vai et al. 2019 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports)
RISE423	BACA	Bronze Age	Armenia	M	-1402	-1211	T2a3	fasta	133.20	Allentoft et al. 2015 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
PCA0066	MAPl	Middle Ages	Poland	M	80	120	H2a5	bam	<NA>	Stolarek et al. 2018 Data	FASTA Metadata	11150A (MT-ND4): Found in a Multiple Sclerosis patient (Reported) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports)
NLHBAL267B	MAHu	Middle Ages	Hungary	U	450	500	None	<NA>	<NA>	Vai et al. 2019	Metadata
RISE139	UNC	Bronze Age	Poland	F	-2135	-1923	U2e1f1	<NA>	<NA>	Allentoft et al. 2015 Data	Metadata
I10866	CLIB	Classical Age	Spain	F	-43	51	K1b2a	bam	1053.00	Olalde et al. 2019 Data	FASTA Metadata
RISE21	BASC	Bronze Age	Denmark	U	-1426	-1281	N1a1a1a2	<NA>	<NA>	Allentoft et al. 2015 Data	Metadata
RISE42	NESC	Neolithic	Denmark	M	-2191	-1972	H3v+16093	<NA>	<NA>	Allentoft et al. 2015 Data	Metadata
MX203	NESw	Neolithic	Switzerland	F	-3400	-2500	H4a1	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
RISE492	IARu	Iron Age	Russia	M	-396	-209	D4b1a2a2	<NA>	<NA>	Allentoft et al. 2015 Data	Metadata
RISE174	IASC	Iron Age	Sweden	F	427	611	W1	<NA>	<NA>	Allentoft et al. 2015 Data	Metadata
RISE207	BASC	Bronze Age	Sweden	U	-1493	-1302	J1c8a1	<NA>	<NA>	Allentoft et al. 2015 Data	Metadata
LRV_76	ROM	Classical Age	Italy	M	0	400	D4b1c	reconstructed	156.40	Emery et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 14668T (MT-ND6): Depressive Disorder associated (Reported) 15043A (MT-CYB): MDD-associated (Reported) 15951G (MT-TT): LHON / LHON modulator (Conflicting reports) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 4883T (MT-ND2): Glaucoma (Conflicting reports) 489C (MT-CR): Low VO2max response (Reported) 5178A (MT-ND2): Longevity / Extraversion / diabetes / AMS protection / blood iron metabolism / correlation with myocardial infarction / atherosclerosis (Reported) 8414T (MT-ATP8): Increased risk of T2DM and high altitude polycythemia (HAPC) in haplogroup D4 / Longevity (Reported)
LRV_77	ROM	Classical Age	Italy	F	0	400	D4b1c	reconstructed	227.60	Emery et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 14668T (MT-ND6): Depressive Disorder associated (Reported) 15043A (MT-CYB): MDD-associated (Reported) 15951G (MT-TT): LHON / LHON modulator (Conflicting reports) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 4883T (MT-ND2): Glaucoma (Conflicting reports) 489C (MT-CR): Low VO2max response (Reported) 5178A (MT-ND2): Longevity / Extraversion / diabetes / AMS protection / blood iron metabolism / correlation with myocardial infarction / atherosclerosis (Reported) 8414T (MT-ATP8): Increased risk of T2DM and high altitude polycythemia (HAPC) in haplogroup D4 / Longevity (Reported)
RISE496	BARu	Bronze Age	Russia	F	-1414	-1261	U5a1a2a	<NA>	<NA>	Allentoft et al. 2015 Data	Metadata
RISE495	BARu	Bronze Age	Russia	M	-1414	-1261	D4j1	<NA>	<NA>	Allentoft et al. 2015 Data	Metadata
I0211	HGE	Mesolithic	Russia	M	-6773	-5886	U4a	bam	23.15	Mathieson et al. 2015 Data	FASTA Metadata
RISE504	IARu	Iron Age	Russia	F	721	889	C4a1d	<NA>	<NA>	Allentoft et al. 2015 Data	Metadata
MX204	NESw	Neolithic	Switzerland	M	-3400	-2500	K1a2b	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
LRV_93	ROM	Classical Age	Italy	M	0	400	X2e2a	reconstructed	529.00	Emery et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported)
RISE502	BARu	Bronze Age	Russia	F	-1496	-1306	U5a1d	<NA>	<NA>	Allentoft et al. 2015 Data	Metadata
MX209	NESw	Neolithic	Switzerland	M	-3400	-2500	K1a+195	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
RISE524	BARu	Bronze Age	Russia	U	-1598	-1398	J2b1a	<NA>	<NA>	Allentoft et al. 2015 Data	Metadata
I2426	CABA	Copper Age	Bulgaria	M	-4450	-4264	K1	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 3254A (MT-TL1): Gestational Diabetes (GDM) (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
RISE523	BARu	Bronze Age	Russia	U	-1598	-1398	M12'G	<NA>	<NA>	Allentoft et al. 2015 Data	Metadata
LRV_95	ROM	Classical Age	Italy	U	0	400	T2j1	reconstructed	128.00	Emery et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
RISE553	BARu	Bronze Age	Russia	U	-926	-815	F1b	<NA>	<NA>	Allentoft et al. 2015 Data	Metadata
RISE554	BARu	Bronze Age	Russia	U	-1005	-844	F1b1b	<NA>	<NA>	Allentoft et al. 2015 Data	Metadata
LRV_103	ROM	Classical Age	Italy	M	0	400	H16d	reconstructed	326.20	Emery et al. 2018 Data	FASTA Metadata
LRV_102	ROM	Classical Age	Italy	M	0	400	J1b1a1 + 146	reconstructed	50.30	Emery et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 146C (MT-CR): Absence of Endometriosis (Reported) 295T (MT-CR): Low VO2max response (Reported) 2158C (MT-RNR2): Reduced risk PD (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
EHU001	CAIB	Copper Age	Spain	M	-2287	-2044	U5a1b1	bam	<NA>	Olalde et al. 2019 Data	Metadata
LHHEG11	LONG	Middle Ages	Hungary	U	500	600	T2+16189	fasta	115.72	Vai et al. 2019 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 16183C (MT-CR): Melanoma patients (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I2427	CABA	Copper Age	Bulgaria	F	-4445	-4335	H1j	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported)
NLHBAL113A	MAHu	Middle Ages	Hungary	U	450	500	None	<NA>	<NA>	Vai et al. 2019	Metadata
I2801	GAC	Neolithic	Poland	U	-3400	-2800	H1b	fasta	13.93	Tassi et al. 2017 Data	FASTA Metadata	16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported)
JK2143	CLNE	Classical Age	Egypt	M	-801	-777	T1a7	bam	32.72	Schuenemann et al. 2017 Data	Metadata
MX210	NESw	Neolithic	Switzerland	M	-3400	-2500	K1a2b	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
NLHBAL269C	MAHu	Middle Ages	Hungary	U	450	500	None	<NA>	<NA>	Vai et al. 2019	Metadata
Donkalnis1	HGN	Mesolithic	Lithuania	F	-5500	-2900	U5b1	fasta	0.05	Mittnik et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
LHHEG12	LONG	Middle Ages	Hungary	U	500	600	U8a1a2	fasta	182.08	Vai et al. 2019 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports)
I4950	BBC	Bronze Age	Great Britain	M	-2500	-1800	U5a2d1	bam	377.94	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I0101	LBK	Neolithic	Germany	U	-5500	-4775	U5a1a	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 16270T (MT-CR): Melanoma patients (Reported)
LRV_104	ROM	Classical Age	Italy	U	0	400	J1b4	reconstructed	210.20	Emery et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 3290C (MT-TL1): Poss. hypertension factor (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
I4088	CABA	Copper Age	Romania	F	-4331	-4076	K2a	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I0455	CAIB	Copper Age	Spain	M	-2904	-2667	H1	bam	130.51	Olalde et al. 2018 Data	FASTA Metadata	10237C (MT-ND3): LHON (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
NLIAR13	MAIt	Middle Ages	Italy	U	500	1000	U5a1b1	fasta	23.56	Vai et al. 2019 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
Kivisaare3	NEBL	Neolithic	Estonia	M	-4730	-4540	U4a1	fasta	0.19	Mittnik et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 499A (MT-CR): Endometriosis (Reported)
LRV_110	ROM	Classical Age	Italy	F	0	400	N1b1a2	reconstructed	30.90	Emery et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 16390A (MT-CR): POAG - potential for association (Reported) 8836G (MT-ATP6): LHON (Reported)
NLIAR14	MAIt	Middle Ages	Italy	U	500	1000	None	<NA>	<NA>	Vai et al. 2019	Metadata
HUGO_167	BBC	Bronze Age	Germany	M	-2270	-2039	U5b2b3a	reconstructed	195.80	Knipper et al. 2017 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 12634G (MT-ND5): Thyroid Cancer Cell Line (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 2755G (MT-RNR2): Possibly LVNC-associated (Reported) 16270T (MT-CR): Melanoma patients (Reported)
LRV_112	ROM	Classical Age	Italy	F	0	400	H50	reconstructed	275.60	Emery et al. 2018 Data	FASTA Metadata	14831A (MT-CYB): LHON (Reported)
I4089	CABA	Copper Age	Romania	M	-3761	-3645	J1c	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
MX211	NESw	Neolithic	Switzerland	M	-3100	-2928	K1a+195	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
I4246	CAIB	Copper Age	Spain	M	-2473	-2030	M1a1b1	bam	13.06	Olalde et al. 2019 Data	FASTA Metadata
I0781	CABA	Copper Age	Bulgaria	F	-4528	-4371	K1a	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
MX212	NESw	Neolithic	Switzerland	M	-3323	-2581	H1	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
I8216	CLIB	Classical Age	Spain	M	57	208	H1	bam	32.50	Olalde et al. 2019 Data	FASTA Metadata
HUGO_168	BBC	Bronze Age	Germany	F	-2289	-2141	H1	reconstructed	620.10	Knipper et al. 2017 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported)
LRV_119	ROM	Classical Age	Italy	M	0	400	H5′36	reconstructed	123.70	Emery et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 16390A (MT-CR): POAG - potential for association (Reported)
I2181	CABA	Copper Age	Bulgaria	M	-4550	-4455	HV15	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
POST_3	EBAGe	Bronze Age	Germany	U	-2019	-1890	None	<NA>	3.50	Knipper et al. 2017 Data	Metadata
LRV_122	ROM	Classical Age	Italy	M	0	400	K1a12a1a	reconstructed	173.10	Emery et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports) 9055A (MT-ATP6): PD protective factor (Reported)
LRV_135	ROM	Classical Age	Italy	M	0	400	H47	reconstructed	36.00	Emery et al. 2018 Data	FASTA Metadata
Kivutkalns222	BABL	Bronze Age	Latvia	M	-805	-515	U5a1c1	fasta	1.28	Mittnik et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported)
MX213	NESw	Neolithic	Switzerland	M	-3363	-2930	K1b1a	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
POST_16	EBAGe	Bronze Age	Germany	F	-2029	-1911	T2f8a	reconstructed	303.40	Knipper et al. 2017 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 3243G (MT-TL1): MELAS / Leigh Syndrome / DMDF / MIDD / SNHL / CPEO / MM / FSGS / ASD / Cardiac+multi-organ dysfunction (Cfrm) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
LRV_137	ROM	Classical Age	Italy	U	0	400	T2a1b1	reconstructed	503.10	Emery et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 14687G (MT-TE): Mito myopathy w respiratory failure / intellectual disability (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I8343	CLIB	Classical Age	Spain	M	500	600	J1c2c2	bam	171.00	Olalde et al. 2019 Data	FASTA Metadata
HUGO_169sk1	BBC	Bronze Age	Germany	M	-2562	-2345	U5a2b3	reconstructed	949.10	Knipper et al. 2017 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I5769	IABA	Iron Age	Bulgaria	F	-500	-400	H	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
POST_21	EBAGe	Bronze Age	Germany	M	-2025	-1903	None	<NA>	3.60	Knipper et al. 2017 Data	Metadata
I3498	NEBA	Neolithic	Croatia	M	-5837	-5659	U8b1b1	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16183C (MT-CR): Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I4167	NEBA	Neolithic	Croatia	M	-4790	-4558	U5b2b	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 12634G (MT-ND5): Thyroid Cancer Cell Line (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16270T (MT-CR): Melanoma patients (Reported)
POST_32	EBAGe	Bronze Age	Germany	F	-2032	-1916	T2	reconstructed	1048.10	Knipper et al. 2017 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
HUGO_169sk2	BBC	Bronze Age	Germany	F	-2461	-2211	U5a2b3	reconstructed	35.10	Knipper et al. 2017 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
MX219	NESw	Neolithic	Switzerland	M	-3330	-3216	K	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
LHSZ11	LONG	Middle Ages	Hungary	U	500	600	K2a3a	fasta	28.50	Vai et al. 2019 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I2452	BBC	Bronze Age	Great Britain	M	-2276	-1980	H1e1a	bam	890.14	Olalde et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
POST_38	EBAGe	Bronze Age	Germany	M	-2197	-2034	H1e	reconstructed	38.30	Knipper et al. 2017 Data	FASTA Metadata	16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
I2533	NEBA	Neolithic	Romania	F	-5484	-5372	J1c5	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
LRV_138	ROM	Classical Age	Italy	M	0	400	N1a1a1a	reconstructed	9.70	Emery et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 3336C (MT-ND1): Carotid atherosclerosis risk (Reported) 669C (MT-RNR1): DEAF (Reported)
HUGO_170	BBC	Bronze Age	Germany	M	-2288	-2066	U4d3	reconstructed	475.40	Knipper et al. 2017 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 14577C (MT-ND6): MIDM (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 499A (MT-CR): Endometriosis (Reported)
I2532	NEBA	Neolithic	Romania	M	-5715	-5626	K1a2	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
MX251	BAGe	Bronze Age	Germany	F	-2197	-1981	T2b3d	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
I1271	CAIB	Copper Age	Spain	F	-3363	-1903	K1a+195	bam	180.00	Mathieson et al. 2015 Data	FASTA Metadata
LRCMUS62	LONG	Middle Ages	Czech Republic	U	500	600	None	<NA>	<NA>	Vai et al. 2019	Metadata
I0704	NEBA	Neolithic	Bulgaria	F	-6034	-5843	T2b	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
HUGO_171	BBC	Bronze Age	Germany	F	-2387	-2146	U5a1a1	reconstructed	424.90	Knipper et al. 2017 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15924G (MT-TT): LIMM (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I2521	NEBA	Neolithic	Bulgaria	M	-5619	-5491	H	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
LRV_143	ROM	Classical Age	Italy	U	0	400	H2	reconstructed	8.70	Emery et al. 2018 Data	FASTA Metadata
HUGO_180sk	BBC	Bronze Age	Germany	M	-2461	-2210	U5b2b4	reconstructed	1693.00	Knipper et al. 2017 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 12634G (MT-ND5): Thyroid Cancer Cell Line (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
HUGO_180sk2	BBC	Bronze Age	Germany	M	-2463	-2235	U5b2b4	reconstructed	879.30	Knipper et al. 2017 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 12634G (MT-ND5): Thyroid Cancer Cell Line (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I0232	SRU	Bronze Age	Russia	M	-1850	-1200	U5a1f2	bam	<NA>	Mathieson et al. 2015 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
HUGO_190	BBC	Bronze Age	Germany	F	-2268	-2046	J1c3g	reconstructed	130.90	Knipper et al. 2017 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
I4055	CAIB	Classical Age	Spain	M	200	400	U3a1	bam	249.89	Olalde et al. 2019 Data	FASTA Metadata
I6491	CLIB	Classical Age	Spain	M	200	500	H4a1a	bam	7.52	Olalde et al. 2019 Data	FASTA Metadata
I0633	NEBA	Neolithic	Serbia	M	-5604	-5376	HV	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
LRV_148	ROM	Classical Age	Italy	U	0	400	X2 + 225	reconstructed	187.10	Emery et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported)
LRV_149	ROM	Classical Age	Italy	M	0	400	H5b	reconstructed	232.10	Emery et al. 2018 Data	FASTA Metadata
POST_1	EBAGe	Bronze Age	Germany	F	-2024	-1882	H2a1a	reconstructed	280.30	Knipper et al. 2017 Data	FASTA Metadata
POST_85	EBAGe	Bronze Age	Germany	U	-2120	-1921	X2b+226	reconstructed	298.90	Knipper et al. 2017 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 15927A (MT-TT): LHON / Multiple Sclerosis / DEAF1555 increased penetrance / CHD (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 8393T (MT-ATP8): Reversible brain pseudoatrophy (Reported)
POST_2	EBAGe	Bronze Age	Germany	U	-2126	-1948	None	<NA>	1.30	Knipper et al. 2017 Data	Metadata
LRCMUS63	LONG	Middle Ages	Czech Republic	U	500	600	None	<NA>	<NA>	Vai et al. 2019	Metadata
MX252	BAGe	Bronze Age	Germany	M	-1941	-1774	H83	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
POST_6	EBAGe	Bronze Age	Germany	M	-2009	-1883	U5a1a1+16362	reconstructed	233.80	Knipper et al. 2017 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15924G (MT-TT): LIMM (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I12034	MAIB	Middle Ages	Spain	F	500	600	W6a	bam	337.20	Olalde et al. 2019 Data	FASTA Metadata
I1272	CAIB	Copper Age	Spain	F	-2857	-2496	K1b1a	bam	810.00	Mathieson et al. 2015 Data	FASTA Metadata
I1131	NEBA	Neolithic	Serbia	M	-4605	-4460	H	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I0676	NEBA	Neolithic	Macedonia	M	-5979	-5735	J1c1	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 3394C (MT-ND1): LHON / Diabetes / CPTdeficiency / high altitude adaptation (Reported / Population-dependent) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
LRCMUS66	LONG	Middle Ages	Czech Republic	U	500	600	T2e	fasta	119.83	Vai et al. 2019 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
LRV_153	ROM	Classical Age	Italy	U	0	400	H2a1b	reconstructed	24.10	Emery et al. 2018 Data	FASTA Metadata
LRV_154	ROM	Classical Age	Italy	U	0	400	T2g	reconstructed	39.60	Emery et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 16390A (MT-CR): POAG - potential for association (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
LIAV_4	IAIt	Iron Age	Italy	F	-700	-300	U4b1a1a1	reconstructed	316.00	Emery et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12297C (MT-TL2): Dilated Cardiomyopathy / Leigh Syndrome / Failure to Thrive & LA (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 499A (MT-CR): Endometriosis (Reported)
LHSZ17	LONG	Middle Ages	Hungary	U	500	600	U5b2a1a1	fasta	164.40	Vai et al. 2019 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16192T (MT-CR): Melanoma patients (Reported)
I5071	NEBA	Neolithic	Croatia	F	-5670	-5571	H5a	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	4336C (MT-TQ): ADPD / Hearing Loss & Migraine / autism spectrum / intellectual disability (Unclear)
LIAV_7	IAIt	Iron Age	Italy	F	-700	-300	V18	reconstructed	753.70	Emery et al. 2018 Data	FASTA Metadata
MX254	BAGe	Bronze Age	Germany	M	-2200	-1700	H+16129	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
POST_12	EBAGe	Bronze Age	Germany	U	-2190	-2028	J1c3g	reconstructed	14.60	Knipper et al. 2017 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4435G (MT-TM): LHON modulator / hypertension / autism spectrum / intellectual disability (Reported) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
POST_137	EBAGe	Bronze Age	Germany	M	-2029	-1912	T2c1d+152	reconstructed	46.90	Knipper et al. 2017 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported) 6261A (MT-CO1): Prostate Cancer / LHON (Reported)
LHSZ4	LONG	Middle Ages	Hungary	U	500	600	None	<NA>	<NA>	Vai et al. 2019	Metadata
LHSZ2	LONG	Middle Ages	Hungary	U	500	600	T1a1	fasta	15.67	Vai et al. 2019 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
LHSZ20	LONG	Middle Ages	Hungary	U	500	600	None	<NA>	<NA>	Vai et al. 2019	Metadata
I5072	NEBA	Neolithic	Croatia	M	-5641	-5560	H7c	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
LHSZ8	LONG	Middle Ages	Hungary	U	500	600	I3	fasta	87.74	Vai et al. 2019 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 15924G (MT-TT): LIMM (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported)
JK2866	CLNE	Classical Age	Egypt	U	-395	-264	R0a2	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
LHSZ10	LONG	Middle Ages	Hungary	U	500	600	T1a1	fasta	94.63	Vai et al. 2019 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
LIAV_8	IAIt	Iron Age	Italy	M	-700	-300	H1	reconstructed	467.10	Emery et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported)
I5077	NEBA	Neolithic	Croatia	M	-5207	-4945	U5a1a2	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
POST_24	EBAGe	Bronze Age	Germany	M	-2137	-1980	H1b1	reconstructed	1314.80	Knipper et al. 2017 Data	FASTA Metadata	16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 3796G (MT-ND1): Adult-Onset Dystonia (Reported)
LHSZ12	LONG	Middle Ages	Hungary	U	500	600	W6	fasta	25.06	Vai et al. 2019 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 16192T (MT-CR): Melanoma patients (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
LHSZ13	LONG	Middle Ages	Hungary	U	500	600	N1b1b1	fasta	26.34	Vai et al. 2019 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 16390A (MT-CR): POAG - potential for association (Reported) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported) 8836G (MT-ATP6): LHON (Reported)
LHSZ15	LONG	Middle Ages	Hungary	U	500	600	H1c1	fasta	201.89	Vai et al. 2019 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported)
POST_28	EBAGe	Bronze Age	Germany	M	-2027	-1906	K2a5	reconstructed	54.90	Knipper et al. 2017 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
LIAV_11	IAIt	Iron Age	Italy	U	-700	-300	H6a1a	reconstructed	41.80	Emery et al. 2018 Data	FASTA Metadata	11253C (MT-ND4): LHON PD (Reported)
MX256	BAGe	Bronze Age	Germany	F	-2132	-1992	H+16129	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
I5078	NEBA	Neolithic	Croatia	M	-4692	-4546	H10	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	16093C (MT-CR): Cyclic Vomiting Syndrome (Reported)
LIAV_20	IAIt	Iron Age	Italy	U	-700	-300	U5b2c	reconstructed	16.10	Emery et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16270T (MT-CR): Melanoma patients (Reported) 9966A (MT-CO3): LHON possible helper variant (Reported)
UNTA58-62_67	BBC	Bronze Age	Germany	M	-2455	-2204	K1a	reconstructed	1521.50	Knipper et al. 2017 Data	FASTA Metadata
LHSZ19	LONG	Middle Ages	Hungary	U	500	600	HV	fasta	89.45	Vai et al. 2019 Data	FASTA Metadata
I12163	MAIB	Middle Ages	Spain	F	500	600	J2b1a+16311	bam	203.20	Olalde et al. 2019 Data	FASTA Metadata
LIAV_29	IAIt	Iron Age	Italy	U	-700	-300	H5'36	reconstructed	27.20	Emery et al. 2018 Data	FASTA Metadata	13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports)
LIAV_31	IAIt	Iron Age	Italy	U	-700	-300	U5a1	reconstructed	66.40	Emery et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 16270T (MT-CR): Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports) 6267A (MT-CO1): Prostate Cancer (Reported)
LHSZ23	LONG	Middle Ages	Hungary	U	500	600	H13a1a2	fasta	18.49	Vai et al. 2019 Data	FASTA Metadata
MX257	BAGe	Bronze Age	Germany	M	-1879	-1696	U4a1a	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
I1276	CAIB	Copper Age	Spain	F	-3363	-1903	H3c3	bam	365.00	Mathieson et al. 2015 Data	FASTA Metadata
LHSZ25	LONG	Middle Ages	Hungary	U	500	600	J1c2k	fasta	45.47	Vai et al. 2019 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 3866C (MT-ND1): LHON + limb claudication (Reported / synergistic?) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
I2526	NEBA	Neolithic	Bulgaria	F	-5466	-5305	T2e	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
EHU002	CAIB	Copper Age	Spain	M	-2562	-2306	K1a4a1	bam	<NA>	Olalde et al. 2019 Data	Metadata
LIAV_33	IAIt	Iron Age	Italy	U	-700	-300	H	reconstructed	5.60	Emery et al. 2018 Data	FASTA Metadata
LIAV_37	IAIt	Iron Age	Italy	M	-700	-300	U3b1b	reconstructed	111.00	Emery et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 4640A (MT-ND2): LHON / Epilepsy (Reported)
MX258	BAGe	Bronze Age	Germany	M	-2028	-1903	U5b1+16189	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
I0698	NEBA	Neolithic	Bulgaria	M	-6000	-5900	H	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
LIAV_43	IAIt	Iron Age	Italy	U	-700	-300	U2e3	reconstructed	62.20	Emery et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported)
I2529	NEBA	Neolithic	Bulgaria	M	-5726	-5575	T1a	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I1277	CAIB	Copper Age	Spain	M	-2568	-2346	H3	bam	519.00	Mathieson et al. 2015 Data	FASTA Metadata
MX259	BBC	Neolithic	Germany	M	-2456	-2203	K1a3a	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
LHSZ29	LONG	Middle Ages	Hungary	U	500	600	None	<NA>	<NA>	Vai et al. 2019	Metadata
UNTA58-62_148	EBAGe	Bronze Age	Germany	U	-2470	-1776	None	<NA>	<NA>	Knipper et al. 2017 Data	Metadata
LHSZ33	LONG	Middle Ages	Hungary	U	500	600	H5a1j	fasta	19.83	Vai et al. 2019 Data	Metadata
LIAV_45	IAIt	Iron Age	Italy	U	-700	-300	H2	reconstructed	13.50	Emery et al. 2018 Data	FASTA Metadata	16176T (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported)
MX265	IAGe	Iron Age	Germany	M	-763	-431	H1c	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
LHSZ34	LONG	Middle Ages	Hungary	U	500	600	None	<NA>	<NA>	Vai et al. 2019	Metadata
POST_35	EBAGe	Bronze Age	Germany	F	-2033	-1918	H41a	reconstructed	868.70	Knipper et al. 2017 Data	FASTA Metadata	5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
I0439	YAM	Bronze Age	Russia	M	-3321	-2921	U5a1a1	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15924G (MT-TT): LIMM (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I0644	CANE	Copper Age	Israel	F	-4500	-3900	H4	<NA>	0.87	Harney et al. 2018 Data	FASTA Metadata
POST_44	EBAGe	Bronze Age	Germany	M	-2139	-1979	K1a3a	reconstructed	684.20	Knipper et al. 2017 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I3947	NEBA	Neolithic	Croatia	M	-5986	-5786	K1b1a	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15257A (MT-CYB): LHON (Conflicting reports) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 5913A (MT-CO1): Prostate Cancer / hypertension (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I1154	CANE	Copper Age	Israel	F	-4500	-3900	T2g1a	<NA>	0.05	Harney et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
MX270	BAGe	Bronze Age	Germany	M	-2200	-1700	W3a1	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
I12164	MAIB	Middle Ages	Spain	F	500	600	C4a1a+195	bam	193.50	Olalde et al. 2019 Data	FASTA Metadata
I1155	CANE	Copper Age	Israel	M	-4500	-3900	K1a	<NA>	0.09	Harney et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I3776	MAIB	Middle Ages	Spain	F	600	700	U5a1i1	bam	189.00	Olalde et al. 2019 Data	FASTA Metadata
JK2873	CLNE	Classical Age	Egypt	U	-804	-792	T2	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
LHSZ45	LONG	Middle Ages	Hungary	U	500	600	J1c	fasta	141.57	Vai et al. 2019 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
I1160	CANE	Copper Age	Israel	M	-4500	-3900	N1a1b	<NA>	1.31	Harney et al. 2018 Data	FASTA Metadata	15043A (MT-CYB): MDD-associated (Reported)
MX275	BAGe	Bronze Age	Germany	M	-2135	-1961	W3a1	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
I1280	CAIB	Copper Age	Spain	F	-3363	-1903	J1c1	bam	563.00	Mathieson et al. 2015 Data	FASTA Metadata
I1164	CANE	Copper Age	Israel	F	-4500	-3900	J2a2d	<NA>	0.36	Harney et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 15257A (MT-CYB): LHON (Conflicting reports) 195C (MT-CR): BD-associated / melanoma pts (Reported) 295T (MT-CR): Low VO2max response (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 489C (MT-CR): Low VO2max response (Reported)
I1281	CAIB	Copper Age	Spain	F	-2865	-2575	H1t	bam	419.00	Mathieson et al. 2015 Data	FASTA Metadata
RISE566	BBC	Copper Age	Czech Republic	M	-2279	-2033	H	<NA>	<NA>	Allentoft et al. 2015 Data	Metadata
POST_47	EBAGe	Bronze Age	Germany	M	-2134	-1956	K2a5	reconstructed	26.80	Knipper et al. 2017 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I0554	SMC	Neolithic	Germany	U	-3237	-3171	J1c	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
MX277	BAGe	Bronze Age	Germany	F	-1926	-1770	H5a1	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
I1165	CANE	Copper Age	Israel	M	-4500	-3900	HV1a’b’c’	<NA>	0.95	Harney et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
UNTA85_1334	BBC	Bronze Age	Germany	M	-2453	-2152	H15a1	reconstructed	58.40	Knipper et al. 2017 Data	FASTA Metadata	6253C (MT-CO1): Prostate Cancer / enriched in POAG cohort (Reported)
UNTA85_113	BBC	Bronze Age	Germany	M	-2456	-2155	U5b2a3	reconstructed	33.70	Knipper et al. 2017 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
UNTA85_1336	BBC	Bronze Age	Germany	F	-2465	-2300	H2a1	reconstructed	54.30	Knipper et al. 2017 Data	FASTA Metadata
POST_50	EBAGe	Bronze Age	Germany	M	-2196	-2029	T1a1	reconstructed	328.30	Knipper et al. 2017 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
MX279	BAGe	Bronze Age	Germany	M	-1882	-1745	H76a	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
I1166	CANE	Copper Age	Israel	M	-4500	-3900	H	<NA>	0.98	Harney et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 3316A (MT-ND1): Diabetes / LHON / PEO (Unclear)
UNTA85_1412	EBAGe	Bronze Age	Germany	M	-2025	-1895	H	<NA>	134.50	Knipper et al. 2017 Data	Metadata
I1168	CANE	Copper Age	Israel	F	-4500	-3900	T2+150	<NA>	1.06	Harney et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
MX280	BAGe	Bronze Age	Germany	F	-2035	-1910	U5a1	<NA>	<NA>	Furtwängler et al 2020 Data	Metadata
I3866	MAIB	Middle Ages	Spain	M	600	700	U5a1b1	bam	107.00	Olalde et al. 2019 Data	FASTA Metadata
OBKR_9B	EBAGe	Bronze Age	Germany	F	-2032	-1903	U5a1i1	reconstructed	160.00	Knipper et al. 2017 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I1170	CANE	Copper Age	Israel	M	-4500	-3900	T1a2	<NA>	0.67	Harney et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I1171	CANE	Copper Age	Israel	M	-4500	-3900	K	<NA>	0.26	Harney et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
OBKR_47	EBAGe	Bronze Age	Germany	M	-2136	-1977	J2b1a	reconstructed	511.40	Knipper et al. 2017 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12397G (MT-ND5): PD / early onset (Reported) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 15257A (MT-CYB): LHON (Conflicting reports) 15812A (MT-CYB): LHON (Reported / Secondary) 295T (MT-CR): Low VO2max response (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 489C (MT-CR): Low VO2max response (Reported)
OBKR_50	EBAGe	Bronze Age	Germany	F	-2112	-1912	HV0	reconstructed	83.80	Knipper et al. 2017 Data	FASTA Metadata
POST_84	EBAGe	Bronze Age	Germany	F	-2126	-1928	X2b+226	reconstructed	189.50	Knipper et al. 2017 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 15927A (MT-TT): LHON / Multiple Sclerosis / DEAF1555 increased penetrance / CHD (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 8393T (MT-ATP8): Reversible brain pseudoatrophy (Reported)
I1172	CANE	Copper Age	Israel	M	-4500	-3900	K1a	<NA>	0.12	Harney et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
MX283	BAGe	Bronze Age	Germany	M	-2116	-1926	H+16129	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
JK2876	CLNE	Classical Age	Egypt	U	-151	-46	T1a8a	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
I1178	CANE	Copper Age	Israel	M	-4500	-3900	16	<NA>	2.56	Harney et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 15924G (MT-TT): LIMM (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported)
I12029	MAIB	Middle Ages	Spain	M	500	600	U5a1a1d	bam	185.20	Olalde et al. 2019 Data	FASTA Metadata
OBKR_82	EBAGe	Bronze Age	Germany	F	-2023	-1894	X2b	reconstructed	184.40	Knipper et al. 2017 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 15927A (MT-TT): LHON / Multiple Sclerosis / DEAF1555 increased penetrance / CHD (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 8393T (MT-ATP8): Reversible brain pseudoatrophy (Reported)
POST_99	EBAGe	Bronze Age	Germany	F	-2130	-1930	K1a4a1	<NA>	176.70	Knipper et al. 2017 Data	Metadata
I1179	CANE	Copper Age	Israel	F	-4500	-3900	T2	<NA>	0.51	Harney et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I1181	CANE	Copper Age	Israel	F	-4500	-3900	T2	<NA>	0.09	Harney et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I3574	MAIB	Middle Ages	Spain	F	400	600	U5b1+16189+@16192	bam	131.00	Olalde et al. 2019 Data	FASTA Metadata
MX286	BAGe	Bronze Age	Germany	M	-2029	-2892	N1b1b	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
OBKR_85	EBAGe	Bronze Age	Germany	F	-2113	-1915	H27	reconstructed	520.20	Knipper et al. 2017 Data	FASTA Metadata	16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported)
POST_111	EBAGe	Bronze Age	Germany	F	-2122	-1941	U5b2b2	reconstructed	29.40	Knipper et al. 2017 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 12634G (MT-ND5): Thyroid Cancer Cell Line (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16270T (MT-CR): Melanoma patients (Reported)
RISE254	BAHu	Bronze Age	Hungary	M	-2128	-1909	J1c9	bam	<NA>	Allentoft et al. 2015 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 185A (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
MX288	BAGe	Bronze Age	Germany	M	-2199	-2028	K1a1a	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
I4951	BBC	Bronze Age	Great Britain	M	-2500	-1800	K1b1a1	bam	301.35	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13967T (MT-ND5): Possible LHON factor (Reported) 15257A (MT-CYB): LHON (Conflicting reports) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5913A (MT-CO1): Prostate Cancer / hypertension (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I1182	CANE	Copper Age	Israel	F	-4500	-3900	T1a+152	<NA>	0.63	Harney et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
MX298	NESw	Neolithic	Switzerland	M	-2620	-2448	X2b4	<NA>	<NA>	Furtwängler et al 2020 Data	Metadata
JK2881	CLNE	Classical Age	Egypt	U	-367	-212	T2c1	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
I0441	YAM	Bronze Age	Russia	F	-3010	-2622	H2b	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata
I1183	CANE	Copper Age	Israel	F	-4500	-3900	R0a	<NA>	0.45	Harney et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 3275A (MT-TL1): LHON (Reported)
MX299	NESw	Neolithic	Switzerland	M	-2910	-2679	-	<NA>	<NA>	Furtwängler et al 2020 Data	Metadata
I1282	CAIB	Copper Age	Spain	M	-3363	-1903	H3	bam	484.00	Mathieson et al. 2015 Data	FASTA Metadata
WEHR_1414	EBAGe	Bronze Age	Germany	U	-2022	-1897	K1a1b1g	reconstructed	390.80	Knipper et al. 2017 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15924G (MT-TT): LIMM (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I1184	CANE	Copper Age	Israel	F	-4500	-3900	T1a+152	<NA>	0.41	Harney et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
WEHR_1586	EBAGe	Bronze Age	Germany	F	-1951	-1779	V	reconstructed	57.80	Knipper et al. 2017 Data	FASTA Metadata
C1	IACA	Iron Age	Nepal	M	-1200	-450	D4j1b	bam	7.25	Jeong et al. 2016 Data	Metadata
MX304	NESw	Neolithic	Switzerland	M	-2866	-2601	-	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
S10	BACA	Bronze Age	Nepal	M	-200	700	M9a1a1c1b1a	bam	3.26	Jeong et al. 2016 Data	Metadata
MX310	NESw	Neolithic	Switzerland	M	-2862	-2581	-	<NA>	<NA>	Furtwängler et al 2020 Data	Metadata
poz090	CAUk	Copper Age	Ukraine	M	-3350	-3200	U2e1a1	reconstructed	6.00	Juras et al. 2018 Data	Metadata
poz094	BAB	Bronze Age	Ukraine	F	-2200	-1600	J2b1a	reconstructed	194.00	Juras et al. 2018 Data	Metadata
I3575	MAIB	Middle Ages	Spain	M	400	600	U5b1+16189+@16192	bam	53.80	Olalde et al. 2019 Data	FASTA Metadata
S41	BACA	Bronze Age	Nepal	M	-200	700	F1d	bam	2.07	Jeong et al. 2016 Data	Metadata
RA42	NESw	Neolithic	Switzerland	F	-3340	-3097	H3ap	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
JK2886	CLNE	Classical Age	Egypt	U	-398	-373	T1a7	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
POST_131	EBAGe	Bronze Age	Germany	F	-2120	-1938	T2c1d+152	reconstructed	162.10	Knipper et al. 2017 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported) 6261A (MT-CO1): Prostate Cancer / LHON (Reported)
poz220	CAT	Bronze Age	Ukraine	F	-2834	-2499	X4	reconstructed	27.00	Juras et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 16183C (MT-CR): Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 16390A (MT-CR): POAG - potential for association (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9438A (MT-CO3): LHON / gout (Conflicting reports)
RA43	NESw	Neolithic	Switzerland	F	-3330	-3216	K1a4a1a	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
poz356	BAB	Bronze Age	Ukraine	M	-1880	-1771	H1e	reconstructed	40.00	Juras et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
RA44	NESw	Neolithic	Switzerland	F	-2914	-2871	K1a+195	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
S35	BACA	Bronze Age	Nepal	M	-200	700	M9a1a	bam	3.49	Jeong et al. 2016 Data	Metadata
RA45	NESw	Neolithic	Switzerland	F	-3096	-2927	H1	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
poz225	YAM	Bronze Age	Ukraine	U	-2858	-2621	U5a1i1	reconstructed	73.00	Juras et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I3576	MAIB	Middle Ages	Spain	M	408	538	T2c1a2	bam	260.00	Olalde et al. 2019 Data	FASTA Metadata
S40	BACA	Bronze Age	Nepal	F	-200	700	F1c1a1a	bam	0.09	Jeong et al. 2016 Data	Metadata
RA54	NESw	Neolithic	Switzerland	F	-2463	-2274	J2b1a2	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
RA57	NESw	Neolithic	Switzerland	F	-2905	-2886	J2b1a2	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
poz286	CWC	Neolithic	Poland	F	-2800	-2300	H15a1	reconstructed	19.00	Juras et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 6253C (MT-CO1): Prostate Cancer / enriched in POAG cohort (Reported)
I1284	CAIB	Copper Age	Spain	M	-3363	-1903	H3	bam	178.00	Mathieson et al. 2015 Data	FASTA Metadata
NF-15c	NAMA	Middle Ages	USA	U	1150	1700	A2f1	bam	6.80	Ozga et al. 2016 Data	Metadata
NF-47c	NAMA	Middle Ages	USA	U	1150	1700	D1	bam	7.10	Ozga et al. 2016 Data	Metadata
RA58	NESw	Neolithic	Switzerland	M	-2937	-2886	H7d	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
JK2889	CLNE	Classical Age	Egypt	M	-797	-674	U7	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
NF-95c	NAMA	Middle Ages	USA	U	1150	1700	B2	bam	13.90	Ozga et al. 2016 Data	Metadata
poz235	CWC	Neolithic	Poland	F	-2800	-2300	H2a2	reconstructed	5.40	Juras et al. 2018 Data	FASTA Metadata
NF-217c	NAMA	Middle Ages	USA	U	1150	1700	A2+(64)+@153	bam	21.40	Ozga et al. 2016 Data	Metadata
I3577	MAIB	Middle Ages	Spain	F	400	600	H5b	bam	163.00	Olalde et al. 2019 Data	FASTA Metadata
I1300	CAIB	Copper Age	Spain	F	-3363	-1903	K1a2a	bam	726.00	Mathieson et al. 2015 Data	FASTA Metadata
POST_140	EBAGe	Bronze Age	Germany	M	-2114	-1926	H41a	reconstructed	21.00	Knipper et al. 2017 Data	FASTA Metadata	5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
UNTA58-62_68Sk1	BBC	Bronze Age	Germany	M	-2470	-1776	J1c	reconstructed	691.00	Knipper et al. 2017 Data	FASTA Metadata
ERS1790732	BANE	Bronze Age	Lebanon	M	-1600	-1600	HV1b1	reconstructed	109.00	Haber et al. 2017 Data	Metadata
RISE559	BBC	Copper Age	Germany	F	-2461	-2207	H46	<NA>	<NA>	Allentoft et al. 2015 Data	Metadata
RA59	NESw	Neolithic	Switzerland	F	-2898	-2861	H1+16311	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
ERS1790730	BANE	Bronze Age	Lebanon	F	-1600	-1600	K1a2	reconstructed	124.00	Haber et al. 2017 Data	Metadata
RA61	NESw	Neolithic	Switzerland	M	-2905	-2865	K1a4a1	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
RA60	NESw	Neolithic	Switzerland	M	-2905	-2865	K1a4a1	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
30900	NENE	Neolithic	Turkey	U	-6450	-6380	U	reconstructed	36.30	Chyleński et al. 2019 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported)
RISE1159	GAC	Neolithic	Poland	F	-2880	-2776	T2b	bam	2.80	Schroeder et al. 2019 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4440A (MT-TM): Mitochondrial myopathy (Reported) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
Is_2	IAPS	Iron Age	Kazakhstan	U	-900	-700	HV-CRS	bam	0.12	Unterländer et al. 2017 Data	Metadata
I3581	MAIB	Middle Ages	Spain	F	400	600	H3	bam	122.00	Olalde et al. 2019 Data	FASTA Metadata
RISE1162	GAC	Neolithic	Poland	M	-2880	-2776	K1a1b1e	bam	3.00	Schroeder et al. 2019 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 114T (MT-CR): BD-associated (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 15924G (MT-TT): LIMM (Reported) 4440A (MT-TM): Mitochondrial myopathy (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
LICOL53	LONG	Middle Ages	Italy	U	570	800	H11a	fasta	16.57	Vai et al. 2019 Data	FASTA Metadata	195C (MT-CR): BD-associated / melanoma pts (Reported) 961G (MT-RNR1): Possibly DEAF-associated (Unclear)
UNTA58-62_68Sk2	BBC	Bronze Age	Germany	F	-2470	-2310	K1a	reconstructed	641.40	Knipper et al. 2017 Data	FASTA Metadata
Is_4	IAPS	Iron Age	Kazakhstan	U	-900	-700	H2a1	bam	<NA>	Unterländer et al. 2017 Data	Metadata
RA62	NESw	Neolithic	Switzerland	M	-2921	-2886	H1+16311	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
RISE1167	GAC	Neolithic	Poland	F	-2880	-2776	J1c3f	bam	2.50	Schroeder et al. 2019 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12477C (MT-ND5): possible HCM susceptibility (Reported) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
RISE1166	GAC	Neolithic	Poland	F	-2880	-2776	J1c3f	bam	3.00	Schroeder et al. 2019 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12477C (MT-ND5): possible HCM susceptibility (Reported) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 4440A (MT-TM): Mitochondrial myopathy (Reported) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
RISE563	BBC	Copper Age	Germany	M	-2572	-2512	K1c1	<NA>	<NA>	Allentoft et al. 2015 Data	Metadata
RISE1171	GAC	Neolithic	Poland	M	-2880	-2776	J1c3f	bam	2.60	Schroeder et al. 2019 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12477C (MT-ND5): possible HCM susceptibility (Reported) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
Ze_4	IAPS	Iron Age	Kazakhstan	U	-900	-700	D4	bam	<NA>	Unterländer et al. 2017 Data	Metadata
RISE1170	GAC	Neolithic	Poland	F	-2880	-2776	K1a1b1e	bam	3.70	Schroeder et al. 2019 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 114T (MT-CR): BD-associated (Reported) 1095C (MT-RNR1): SNHL (Unclear) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 15924G (MT-TT): LIMM (Reported) 4437T (MT-TM): Hypotonia / seizure / muscle weakness / lactic acidosis / hearing loss (Reported) 5703A (MT-TN): CPEO / MM (Cfrm) 9055A (MT-ATP6): PD protective factor (Reported)
RA63	BASw	Bronze Age	Switzerland	M	-2046	-1946	H5a	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
Ze_8	IAPS	Iron Age	Kazakhstan	U	-900	-700	D4	bam	<NA>	Unterländer et al. 2017 Data	Metadata
RISE1172	GAC	Neolithic	Poland	F	-2880	-2776	HV0a	bam	3.00	Schroeder et al. 2019 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
RA64	BASw	Bronze Age	Switzerland	M	-2206	-2126	K1a1	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
LD270	CAIB	Copper Age	Portugal	F	-2564	-2578	U8a	fasta	131.10	Gonzalez-Fortes et al. 2019 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported)
SX21	NESw	Neolithic	Switzerland	F	-2462	-2299	H3	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
Ze_9	IAPS	Iron Age	Kazakhstan	U	-900	-700	D4j3	bam	<NA>	Unterländer et al. 2017 Data	Metadata
UNTA58-62_146	EBAGe	Bronze Age	Germany	U	-2009	-1881	H1c	reconstructed	852.20	Knipper et al. 2017 Data	FASTA Metadata
RISE564	BBC	Copper Age	Germany	M	-2500	-2000	H-T16311C	<NA>	<NA>	Allentoft et al. 2015 Data	Metadata
UNTA58-62_147	EBAGe	Bronze Age	Germany	F	-2031	-1900	H2a1	reconstructed	372.40	Knipper et al. 2017 Data	FASTA Metadata
A_4	IASI	Iron Age	Russia	U	-700	-600	D4b1a2a	bam	<NA>	Unterländer et al. 2017 Data	Metadata
A_5	IASI	Iron Age	Russia	U	-700	-600	C5b1	bam	<NA>	Unterländer et al. 2017 Data	Metadata
A_10	IASI	Iron Age	Russia	M	-700	-600	A	bam	0.13	Unterländer et al. 2017 Data	Metadata
A_8	IASI	Iron Age	Russia	U	-700	-600	U4a3	bam	<NA>	Unterländer et al. 2017 Data	Metadata
UNTA58-62_149	EBAGe	Bronze Age	Germany	U	-2023	-1892	K1a1b1g	reconstructed	767.10	Knipper et al. 2017 Data	FASTA Metadata
A_14	IASI	Iron Age	Russia	U	-700	-600	T1a	bam	<NA>	Unterländer et al. 2017 Data	Metadata
I3582	MAIB	Middle Ages	Spain	M	400	600	K1b1a	bam	115.00	Olalde et al. 2019 Data	FASTA Metadata
A_17	IASI	Iron Age	Russia	F	-700	-600	H	bam	0.03	Unterländer et al. 2017 Data	Metadata
SX22	NESw	Neolithic	Switzerland	F	-3036	-2923	K1a4a1	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
JK2899	CLNE	Classical Age	Egypt	M	-795	-674	T1a7	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
I3583	MAIB	Middle Ages	Spain	M	400	600	HV0f	bam	58.20	Olalde et al. 2019 Data	FASTA Metadata
UNTA58-62_150	EBAGe	Bronze Age	Germany	U	-2009	-1780	U5b1c2	reconstructed	1225.10	Knipper et al. 2017 Data	FASTA Metadata
SX23	NESw	Neolithic	Switzerland	F	-1883	-1749	X2b4	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
I1303	CAIB	Copper Age	Spain	M	-3363	-1903	U3a1	bam	234.00	Mathieson et al. 2015 Data	FASTA Metadata
DA6	IASI	Iron Age	Russia	F	-900	-600	U2e2	bam	547.17	de Barros Damgaard et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported)
KK1	HGE	Mesolithic	Georgia	M	-7940	-7600	H13c	bam	<NA>	Jones et al. 2015 Data	FASTA Metadata	16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported)
A_21	IASI	Iron Age	Russia	U	-700	-600	A4	bam	<NA>	Unterländer et al. 2017 Data	Metadata
UNTA58-62_151	EBAGe	Bronze Age	Germany	U	-1946	-1886	U5b1c2	reconstructed	64.20	Knipper et al. 2017 Data	FASTA Metadata
UNTA58-62_152	EBAGe	Bronze Age	Germany	U	-2007	-1779	U5b1c2	reconstructed	774.50	Knipper et al. 2017 Data	FASTA Metadata
BL_1	IASI	Iron Age	Russia	U	-500	-500	C5+16093	bam	<NA>	Unterländer et al. 2017 Data	Metadata
DA15	IAST	Iron Age	Kazakhstan	M	-755	-680	C4d	bam	215.25	de Barros Damgaard et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 3552A (MT-ND1): Resistance to high altitude pulmonary edema (HAPE) (Reported /hg C marker) 489C (MT-CR): Low VO2max response (Reported)
BL_4	IASI	Iron Age	Russia	U	-500	-500	C5+16093	bam	<NA>	Unterländer et al. 2017 Data	Metadata
SX8	NESw	Neolithic	Switzerland	F	-2695	-2481	U3a1	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
JK2900	CLNE	Classical Age	Egypt	U	-804	-786	HV	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
DA18	IAST	Iron Age	Kazakhstan	F	-753	-681	U5b1c2	bam	329.34	de Barros Damgaard et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 15894A (MT-TT): Gout (Reported) 16270T (MT-CR): Melanoma patients (Reported)
SX9	NESw	Neolithic	Switzerland	F	-4449	-4341	H5	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
I3584	MAIB	Middle Ages	Spain	M	400	700	H	bam	15.60	Olalde et al. 2019 Data	FASTA Metadata
DA17	IAST	Iron Age	Kazakhstan	M	-800	-773	H10	bam	123.92	de Barros Damgaard et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 14668T (MT-ND6): Depressive Disorder associated (Reported) 15043A (MT-CYB): MDD-associated (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4440A (MT-TM): Mitochondrial myopathy (Reported) 4883T (MT-ND2): Glaucoma (Conflicting reports) 489C (MT-CR): Low VO2max response (Reported) 5631A (MT-TA): Myopathy (Reported) 8414T (MT-ATP8): Increased risk of T2DM and high altitude polycythemia (HAPC) in haplogroup D4 / Longevity (Reported)
DA19	IAST	Iron Age	Kazakhstan	M	-801	-749	U7a4	bam	163.22	de Barros Damgaard et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5628C (MT-TA): CPEO / DEAF enhancer / gout (Reported) 5650A (MT-TA): Myopathy (Cfrm) 7462T (MT-TS1): DEAF (Reported)
Be_3	IAAL	Iron Age	Kazakhstan	U	-400	-300	H-CRS	bam	<NA>	Unterländer et al. 2017 Data	Metadata
I0357	YAM	Bronze Age	Russia	F	-3090	-2913	W6c	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 16192T (MT-CR): Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
SATP	HGE	Mesolithic	Georgia	M	-11430	-11180	K	<NA>	<NA>	Jones et al. 2015 Data	Metadata
SX10	NESw	Neolithic	Switzerland	M	-2695	-2481	U3a1	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
I12030	MAIB	Middle Ages	Spain	F	500	600	J1c3g	bam	87.24	Olalde et al. 2019 Data	FASTA Metadata
UNTA58-62_153	EBAGe	Bronze Age	Germany	M	-1971	-1776	R1a1a	reconstructed	267.60	Knipper et al. 2017 Data	FASTA Metadata
Be_4	IAAL	Iron Age	Kazakhstan	U	-400	-300	A	bam	<NA>	Unterländer et al. 2017 Data	Metadata
Be_9	IAAL	Iron Age	Kazakhstan	F	-400	-300	A4f	bam	0.37	Unterländer et al. 2017 Data	Metadata
SX11	NESw	Neolithic	Switzerland	M	-4458	-4362	J1c1b	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
Be_11	IAAL	Iron Age	Kazakhstan	M	-400	-300	C4a1+16129	bam	0.12	Unterländer et al. 2017 Data	Metadata
DA38	IAMo	Iron Age	Mongolia	F	-201	-148	D4b2b4	bam	900.33	de Barros Damgaard et al. 2018 Data	FASTA Metadata	195C (MT-CR): BD-associated / melanoma pts (Reported) 4440A (MT-TM): Mitochondrial myopathy (Reported)
SX17	NESw	Neolithic	Switzerland	F	-2470	-2336	U4a2f	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
I1534	CWC	Neolithic	Germany	M	-2500	-2050	K1a1b2a	<NA>	<NA>	Mathieson et al. 2015 Data	Metadata
Ta_1	IAAL	Iron Age	Kazakhstan	U	-400	-300	K2b1a	bam	<NA>	Unterländer et al. 2017 Data	Metadata
I1314	CAIB	Copper Age	Spain	M	-3363	-1903	J2a1a1	bam	119.00	Mathieson et al. 2015 Data	FASTA Metadata
Ak5_4	IAAL	Iron Age	Russia	U	-400	-300	D4b1	bam	<NA>	Unterländer et al. 2017 Data	Metadata
DA47	IAKa	Iron Age	Kazakhstan	M	-168	-83	C4	bam	244.96	de Barros Damgaard et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 3552A (MT-ND1): Resistance to high altitude pulmonary edema (HAPE) (Reported /hg C marker) 4454C (MT-TM): Possible contributor to mito dysfunction / hypertension (Reported) 489C (MT-CR): Low VO2max response (Reported) 9921A (MT-CO3): Possible LHON helper mutation (Reported)
SX18	IASw	Iron Age	Switzerland	F	-178	2	B4c1b2c2	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
DA50	IAKa	Iron Age	Kyrgyzstan	F	-550	-50	U5a1d2b	bam	162.85	de Barros Damgaard et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
Ak5_8	IAAL	Iron Age	Russia	U	-400	-300	A	bam	<NA>	Unterländer et al. 2017 Data	Metadata
DA53	IAKa	Iron Age	Kazakhstan	F	-453	-446	U5a1a1	bam	254.32	de Barros Damgaard et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15924G (MT-TT): LIMM (Reported) 16270T (MT-CR): Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported)
UzOO77	HGN	Mesolithic	Russia	F	-5500	-5000	R1b	fasta	0.73	Mittnik et al. 2018 Data	FASTA Metadata	1095C (MT-RNR1): SNHL (Unclear) 1391C (MT-RNR1): found in 1 HCM patient (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports)
I0429	YAM	Bronze Age	Russia	M	-3339	-2918	T2c1a2	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported) 6261A (MT-CO1): Prostate Cancer / LHON (Reported)
DA55	IAKa	Iron Age	Kazakhstan	M	-89	-74	HV6	bam	268.68	de Barros Damgaard et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5631A (MT-TA): Myopathy (Reported) 8249A (MT-CO2): Mitochondrial myopathy (Reported)
RISE150	UNC	Bronze Age	Poland	F	-1885	-1693	U5a1b1	bam	<NA>	Allentoft et al. 2015 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
SX20	NESw	Neolithic	Switzerland	M	-1693	-1609	K1a4a1	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
I12032	MAIB	Middle Ages	Spain	M	500	600	C4a1a+195	bam	99.01	Olalde et al. 2019 Data	FASTA Metadata
RISE509	BARu	Bronze Age	Russia	F	-2887	-2677	T2c1a2	bam	<NA>	Allentoft et al. 2015 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported) 6261A (MT-CO1): Prostate Cancer / LHON (Reported)
UNTA85_110	BBC	Bronze Age	Germany	F	-2290	-2141	J1c1b1a	reconstructed	15.40	Knipper et al. 2017 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 3394C (MT-ND1): LHON / Diabetes / CPTdeficiency / high altitude adaptation (Reported / Population-dependent) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
K_1	IAAL	Iron Age	Russia	U	-400	-300	H-CRS	bam	<NA>	Unterländer et al. 2017 Data	Metadata
I1838	CAIB	Copper Age	Spain	F	-3354	-2943	J1c3	bam	978.00	Lipson et al. 2017 Data	FASTA Metadata
VK1_1	IAAL	Iron Age	Russia	U	-400	-300	K1	bam	<NA>	Unterländer et al. 2017 Data	Metadata
I1584	CACA	Copper Age	Turkey	F	-3943	-3708	K1a17	bam	863.21	Lazaridis et al. 2016 Data	FASTA Metadata
JK2904	CLNE	Classical Age	Egypt	U	-362	-210	R0a1a	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
DA71	IAKa	Iron Age	Kazakhstan	F	252	308	A16	bam	1277.73	de Barros Damgaard et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 663G (MT-RNR1): Coronary atherosclerosis risk (Reported)
ElMiron	HGW	Mesolithic	Spain	F	-16880	-16660	U5b	<NA>	<NA>	Fu et al. 2016 Data	Metadata
Ala_2	IAAL	Iron Age	Russia	U	-400	-300	C4	bam	<NA>	Unterländer et al. 2017 Data	Metadata
SX26	NESw	Neolithic	Switzerland	F	-2461	-2295	K2b1	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
B3_1	IAAL	Iron Age	Russia	U	-400	-300	T1a1b	bam	<NA>	Unterländer et al. 2017 Data	Metadata
RISE510	BARu	Bronze Age	Russia	F	-2851	-2468	J2a2a	bam	<NA>	Allentoft et al. 2015 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 15257A (MT-CYB): LHON (Conflicting reports) 195C (MT-CR): BD-associated / melanoma pts (Reported) 295T (MT-CR): Low VO2max response (Reported)
SX29	NESw	Neolithic	Switzerland	M	-4800	-4600	T2b	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
JK2911	CLNE	Classical Age	Egypt	M	-769	-560	M1a1	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
ILK001	GAC	Bronze Age	Ukraine	M	-2899	-2706	J1c3	<NA>	<NA>	Mathieson et al. 2018 Data	Metadata
UNTA85_1343	BBC	Bronze Age	Germany	M	-2397	-2149	J1c2	reconstructed	417.00	Knipper et al. 2017 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
Bt_1	IAAL	Iron Age	Russia	U	-400	-300	T2b+@16296	bam	<NA>	Unterländer et al. 2017 Data	Metadata
I2495	BANE	Bronze Age	Turkey	M	-2558	-2295	H	bam	430.65	Lazaridis et al. 2017 Data	FASTA Metadata
RISE511	BARu	Bronze Age	Russia	F	-2909	-2679	J2a2a	bam	<NA>	Allentoft et al. 2015 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 15257A (MT-CYB): LHON (Conflicting reports) 195C (MT-CR): BD-associated / melanoma pts (Reported) 295T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
I2403	GAC	Bronze Age	Poland	M	-2870	-2575	U5b2b1	fasta	67.39	Tassi et al. 2017 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 12634G (MT-ND5): Thyroid Cancer Cell Line (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 15497A (MT-CYB): EXIT / Obesity (Reported) 16270T (MT-CR): Melanoma patients (Reported)
SX30	NESw	Neolithic	Switzerland	F	-4786	-4618	U8b1b1	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
J12_1	IAAL	Iron Age	Russia	U	-400	-300	T2b+@16296	bam	<NA>	Unterländer et al. 2017 Data	Metadata
I0707	NENE	Neolithic	Turkey	F	-6500	-6200	K1a4	bam	<NA>	Mathieson et al. 2015 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
J12_8	IAAL	Iron Age	Russia	U	-400	-300	A8	bam	<NA>	Unterländer et al. 2017 Data	Metadata
DA98	IAKy	Iron Age	Kyrgyzstan	F	61	144	J1d6	bam	271.09	de Barros Damgaard et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported) 9041G (MT-ATP6): Patient with suspected mitochondrial disease (Reported as VUS)
I1842	CAIB	Copper Age	Spain	M	-3350	-2750	H1e1a	bam	155.00	Olalde et al. 2019 Data	FASTA Metadata
J12_9	IAAL	Iron Age	Russia	U	-400	-300	G1a1	bam	<NA>	Unterländer et al. 2017 Data	Metadata
I2433	GAC	Bronze Age	Poland	F	-3100	-2900	H28	fasta	172.32	Tassi et al. 2017 Data	FASTA Metadata	16093C (MT-CR): Cyclic Vomiting Syndrome (Reported)
U1_2	IAAL	Iron Age	Russia	U	-400	-300	Z1a	bam	<NA>	Unterländer et al. 2017 Data	Metadata
UNTA85_1163	EBAGe	Bronze Age	Germany	M	-2021	-1885	H23	reconstructed	192.30	Knipper et al. 2017 Data	FASTA Metadata	1555G (MT-RNR1): DEAF / autism spectrum intellectual disability / possibly antiatherosclerotic (Cfrm)
U2_1	IAAL	Iron Age	Russia	U	-400	-300	F2a	bam	<NA>	Unterländer et al. 2017 Data	Metadata
I2434	GAC	Bronze Age	Poland	F	-3400	-2800	U5b1d1	fasta	64.79	Tassi et al. 2017 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16270T (MT-CR): Melanoma patients (Reported)
I0709	NENE	Neolithic	Turkey	M	-6500	-6200	U3	bam	<NA>	Mathieson et al. 2015 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 3396C (MT-ND1): NSHL / MIDD (Reported / Unclear)
SX32	NESw	Neolithic	Switzerland	M	-2463	-2208	N1n1n	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
SX33	NESw	Neolithic	Switzerland	M	-4766	-4601	H1	reconstructed	<NA>	Furtwängler et al 2020 Data	FASTA Metadata
DA111	BACz	Iron Age	Czech Republic	M	-836	-780	H6a1a	bam	118.07	de Barros Damgaard et al. 2018 Data	FASTA Metadata	11253C (MT-ND4): LHON PD (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I2440	GAC	Bronze Age	Poland	M	-3100	-2900	H1b	fasta	37.41	Tassi et al. 2017 Data	FASTA Metadata	146C (MT-CR): Absence of Endometriosis (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported)
U4_4	IAAL	Iron Age	Russia	U	-400	-300	K	bam	<NA>	Unterländer et al. 2017 Data	Metadata
DA118	MAKy	Middle Ages	Kyrgyzstan	F	1029	1049	F2g	bam	260.52	de Barros Damgaard et al. 2018 Data	FASTA Metadata	1005C (MT-RNR1): DEAF (Unclear) 12338C (MT-ND5): DEAF1555 increased penetrance / LHON (Conflicting reports) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports)
DA119	IASk	Iron Age	Slovakia	M	353	407	U4b3	bam	339.96	de Barros Damgaard et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 499A (MT-CR): Endometriosis (Reported)
I2499	BANE	Bronze Age	Turkey	F	-2836	-2472	K1a2	bam	22.32	Lazaridis et al. 2017 Data	FASTA Metadata
I1072	NAT	Epipaleolithic	Israel	M	-11840	-9760	N1b	bam	12.66	Lazaridis et al. 2016 Data	FASTA Metadata
I0736	NENE	Neolithic	Turkey	F	-6500	-6200	N1a1a1a	bam	<NA>	Mathieson et al. 2015 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 3336C (MT-ND1): Carotid atherosclerosis risk (Reported) 669C (MT-RNR1): DEAF (Reported)
OBKR_2	EBAGe	Bronze Age	Germany	F	-2023	-1894	K1a4a1	reconstructed	855.00	Knipper et al. 2017 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
DA129	IAKa	Iron Age	Kazakhstan	M	-427	-422	W3b	bam	320.85	de Barros Damgaard et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
I1843	CAIB	Copper Age	Spain	F	-3092	-2877	U5b1+16189+@16192	bam	702.00	Lipson et al. 2017 Data	FASTA Metadata
I1504	BAHu	Bronze Age	Hungary	M	-1270	-1110	K1a1a	bam	<NA>	Gamba et al. 2014 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 114T (MT-CR): BD-associated (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
RISE479	BAHu	Bronze Age	Hungary	M	-2000	-1500	T2b	bam	<NA>	Allentoft et al. 2015 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
DA139	IAST	Iron Age	Russia	F	0	100	U2e1h	bam	126.59	de Barros Damgaard et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16183C (MT-CR): Melanoma patients (Reported) 228A (MT-CR): Low VO2max response (Reported)
I1845	CAIB	Copper Age	Spain	M	-3014	-2877	K1a2c	bam	15.10	Olalde et al. 2019 Data	FASTA Metadata
I2683	BANE	Bronze Age	Turkey	F	-2618	-2470	T2b+152	bam	594.12	Lazaridis et al. 2017 Data	FASTA Metadata
I1502	BAHu	Bronze Age	Hungary	F	-2190	-1980	K1c1	bam	<NA>	Gamba et al. 2014 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I0744	NENE	Neolithic	Turkey	M	-6500	-6200	J1c11	bam	<NA>	Mathieson et al. 2015 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
JK2918	CLNE	Classical Age	Egypt	F	84	129	J2a2e	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
DA177	IAST	Iron Age	Kazakhstan	F	0	1000	D4j1b	bam	448.00	de Barros Damgaard et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11696A (MT-ND4): LHON / LDYT / DEAF / hypertension helper mut. (Reported - possibly synergistic) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 14668T (MT-ND6): Depressive Disorder associated (Reported) 15043A (MT-CYB): MDD-associated (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4883T (MT-ND2): Glaucoma (Conflicting reports) 489C (MT-CR): Low VO2max response (Reported) 8414T (MT-ATP8): Increased risk of T2DM and high altitude polycythemia (HAPC) in haplogroup D4 / Longevity (Reported)
OBKR_5	EBAGe	Bronze Age	Germany	U	-2113	-1917	V7	reconstructed	34.20	Knipper et al. 2017 Data	FASTA Metadata	15924G (MT-TT): LIMM (Reported) 7444A (MT-CO1): LHON / SNHL / DEAF (Reported)
DA171	IABL	Iron Age	Lithuania	M	0	1000	H2a1	bam	24.68	de Barros Damgaard et al. 2018 Data	FASTA Metadata	16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 16176T (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported)
I0745	NENE	Neolithic	Turkey	M	-6500	-6200	U8b1b1	bam	<NA>	Mathieson et al. 2015 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16183C (MT-CR): Melanoma patients (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
DA188	MAST	Middle Ages	Russia	M	776	793	I	bam	17.51	de Barros Damgaard et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15924G (MT-TT): LIMM (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported)
DA190	MAST	Middle Ages	Russia	M	649	680	U1a1c1	bam	88.42	de Barros Damgaard et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 12397G (MT-ND5): PD / early onset (Reported)
I0438	YAM	Bronze Age	Russia	M	-3021	-2635	U5a1a1	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15924G (MT-TT): LIMM (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I1846	CAIB	Copper Age	Spain	F	-3014	-2877	T2b3+151	bam	70.60	Olalde et al. 2019 Data	FASTA Metadata
DA197	SCHu	Iron Age	Hungary	M	-506	-505	H2a2a	bam	3.00	de Barros Damgaard et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 4440A (MT-TM): Mitochondrial myopathy (Reported)
I1096	NENE	Neolithic	Turkey	M	-6500	-6200	N1a1a1	bam	<NA>	Mathieson et al. 2015 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 3336C (MT-ND1): Carotid atherosclerosis risk (Reported) 669C (MT-RNR1): DEAF (Reported)
OBKR_6	EBAGe	Bronze Age	Germany	F	-2029	-1903	V7	reconstructed	854.80	Knipper et al. 2017 Data	FASTA Metadata	15924G (MT-TT): LIMM (Reported) 7444A (MT-CO1): LHON / SNHL / DEAF (Reported)
I1976	CAIB	Copper Age	Spain	M	-2571	-2347	H3	bam	110.66	Lipson et al. 2017 Data	FASTA Metadata
I1097	NENE	Neolithic	Turkey	M	-6500	-6200	W1-T119C	bam	<NA>	Mathieson et al. 2015 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
DA204	MAST	Middle Ages	Kazakhstan	M	897	925	A+152+16362+16189	bam	54.50	de Barros Damgaard et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16183C (MT-CR): Melanoma patients (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4440A (MT-TM): Mitochondrial myopathy (Reported) 663G (MT-RNR1): Coronary atherosclerosis risk (Reported)
I1098	NENE	Neolithic	Turkey	F	-6500	-6200	X2d2	bam	<NA>	Mathieson et al. 2015 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
DA206	IAST	Iron Age	Kazakhstan	M	133	254	HV13b	bam	110.29	de Barros Damgaard et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 3290C (MT-TL1): Poss. hypertension factor (Reported) 4440A (MT-TM): Mitochondrial myopathy (Reported)
OBKR_9A	EBAGe	Bronze Age	Germany	F	-2022	-1892	K1a2a	reconstructed	1004.40	Knipper et al. 2017 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I0854	NENE	Neolithic	Turkey	F	-6500	-6200	N1a1a1a	bam	<NA>	Mathieson et al. 2015 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 3336C (MT-ND1): Carotid atherosclerosis risk (Reported) 669C (MT-RNR1): DEAF (Reported)
JK2920	CLNE	Classical Age	Egypt	U	-758	-552	U8b1a1	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
I1978	CAIB	Copper Age	Spain	F	-3014	-2877	K1a4a1	bam	55.00	Olalde et al. 2019 Data	FASTA Metadata
I1981	CAIB	Copper Age	Spain	F	-3014	-2891	J1c1	bam	162.00	Lipson et al. 2017 Data	FASTA Metadata
DA226	IAST	Iron Age	Kazakhstan	F	-250	450	U2e1h	bam	122.19	de Barros Damgaard et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16183C (MT-CR): Melanoma patients (Reported) 228A (MT-CR): Low VO2max response (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
NOV_10	IACA	Iron Age	Russia	U	-300	-300	X2b	bam	<NA>	Unterländer et al. 2017 Data	Metadata
I1100	NENE	Neolithic	Turkey	F	-6500	-6200	K1a or K1a6	bam	<NA>	Mathieson et al. 2015 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16390A (MT-CR): POAG - potential for association (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
KOL_5	IASI	Iron Age	Russia	U	-500	-200	J1b1a	bam	<NA>	Unterländer et al. 2017 Data	Metadata
Pr1	IASI	Iron Age	Russia	U	-500	-200	U3	bam	<NA>	Unterländer et al. 2017 Data	Metadata
I1101	NENE	Neolithic	Turkey	M	-6500	-6200	T2b	bam	<NA>	Mathieson et al. 2015 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I2473	CAIB	Copper Age	Spain	M	-2916	-2714	H3	bam	33.57	Lipson et al. 2017 Data	FASTA Metadata
I2454	BBC	Bronze Age	Great Britain	F	-2198	-1983	R1a1a	bam	605.79	Olalde et al. 2018 Data	FASTA Metadata	1391C (MT-RNR1): found in 1 HCM patient (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
AED_1108	MAGe	Middle Ages	Germany	F	355	532	U4a2a	bam	214.59	Veeramah et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 499A (MT-CR): Endometriosis (Reported) 8843C (MT-ATP6): Patient with suspected mitochondrial disease (Reported as Likely Benign)
DA356	BASI	Bronze Age	Russia	M	-2647	-1776	C4a1a3	bam	929.43	de Barros Damgaard et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 3552A (MT-ND1): Resistance to high altitude pulmonary edema (HAPE) (Reported /hg C marker) 489C (MT-CR): Low VO2max response (Reported) 9139A (MT-ATP6): LHON (Reported - possibly synergistic)
DA361	BASI	Bronze Age	Russia	M	-2647	-1776	C4a1a3	bam	983.51	de Barros Damgaard et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 3552A (MT-ND1): Resistance to high altitude pulmonary edema (HAPE) (Reported /hg C marker) 489C (MT-CR): Low VO2max response (Reported)
Pr5	IASI	Iron Age	Russia	U	-500	-200	T	bam	<NA>	Unterländer et al. 2017 Data	Metadata
JK2923	CLNE	Classical Age	Egypt	U	-753	-544	U8b1a1	bam	56.41	Schuenemann et al. 2017 Data	Metadata
Pr6	IASI	Iron Age	Russia	U	-500	-200	F1b	bam	<NA>	Unterländer et al. 2017 Data	Metadata
I1103	NENE	Neolithic	Turkey	M	-6500	-6200	K1b1b1	bam	<NA>	Mathieson et al. 2015 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 14063C (MT-ND5): Potentially functional variant cosegregating with LHON3635A (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5913A (MT-CO1): Prostate Cancer / hypertension (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I1579	NENE	Neolithic	Turkey	F	-6500	-6200	K1a-C150T	bam	<NA>	Mathieson et al. 2015 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 3308C (MT-ND1): MELAS / DEAF enhancer / hypertension / LVNC / putative LHON (P.M.-possibly synergistic) 9055A (MT-ATP6): PD protective factor (Reported)
I3269	CAIB	Copper Age	Spain	M	-3350	-2750	U5b2b3a	bam	387.00	Lipson et al. 2017 Data	FASTA Metadata
OBKR_26	EBAGe	Bronze Age	Germany	F	-2033	-1907	HV	reconstructed	391.40	Knipper et al. 2017 Data	FASTA Metadata	16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported)
JK2950	CLNE	Classical Age	Egypt	U	-357	-206	H6b	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
JK2925	CLNE	Classical Age	Egypt	U	5	54	U7	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
OBKR_66	EBAGe	Bronze Age	Germany	F	-2028	-1903	U4a	reconstructed	319.40	Knipper et al. 2017 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 499A (MT-CR): Endometriosis (Reported)
I1580	NENE	Neolithic	Turkey	F	-6500	-6200	H5	bam	<NA>	Mathieson et al. 2015 Data	FASTA Metadata
Pr9	IASI	Iron Age	Russia	F	-500	-200	U2e2	bam	0.07	Unterländer et al. 2017 Data	Metadata
I3270	CAIB	Copper Age	Spain	F	-3350	-2750	J2a1a1	bam	827.00	Lipson et al. 2017 Data	FASTA Metadata
Alh_3	MAGe	Middle Ages	Germany	F	356	535	H2a2b	bam	279.12	Veeramah et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I1583	NENE	Neolithic	Turkey	M	-6426	-6236	K1a2	bam	<NA>	Mathieson et al. 2015 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 7023A (MT-CO1): MELAS-like syndrome (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
OBKR_67	EBAGe	Bronze Age	Germany	M	-2023	-1894	K2a5	reconstructed	147.20	Knipper et al. 2017 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
MS10612	IASp	Iron Age	Spain	U	-300	-200	H3+152	fasta	40.65	Zalloua et al. 2018 Data	FASTA Metadata
JK2956	CLNE	Classical Age	Egypt	U	-823	-785	U1a1a3	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
JK2957	CLNE	Classical Age	Egypt	M	-788	-595	J2a2c	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
I1585	NENE	Neolithic	Turkey	F	-6500	-6200	J1 or J1c	bam	<NA>	Mathieson et al. 2015 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
STR_248	MAGe	Middle Ages	Germany	F	530	560	H11a2	bam	251.39	Veeramah et al. 2018 Data	FASTA Metadata	16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 961G (MT-RNR1): Possibly DEAF-associated (Unclear)
I0108	BBC	Copper Age	Germany	F	-2575	-2299	H5a3	bam	271.81	Haak et al. 2015 Data	FASTA Metadata
I3271	CAIB	Copper Age	Spain	F	-3350	-2750	K1a4a1	bam	771.00	Lipson et al. 2017 Data	FASTA Metadata
STR_316	MAGe	Middle Ages	Germany	M	480	510	H3	<NA>	244.16	Veeramah et al. 2018 Data	Metadata
MS10613	IASp	Iron Age	Spain	U	-400	-400	U4a	fasta	5.62	Zalloua et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 499A (MT-CR): Endometriosis (Reported)
STR_300	MAGe	Middle Ages	Germany	F	510	530	J1c10	bam	235.89	Veeramah et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
MS10614	IASp	Iron Age	Spain	U	-361	-178	T2b	fasta	139.57	Zalloua et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I3272	CAIB	Copper Age	Spain	M	-3263	-2903	X2b+226	bam	45.00	Lipson et al. 2017 Data	FASTA Metadata
I3277	CAIB	Copper Age	Spain	F	-3100	-2850	U5b2b	bam	136.59	Lipson et al. 2017 Data	FASTA Metadata
MS10617	IASp	Iron Age	Spain	U	-500	-400	U5b3	fasta	12.04	Zalloua et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 228A (MT-CR): Low VO2max response (Reported)
JK2961	CLNE	Classical Age	Egypt	U	-87	1	T1a7	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
I0724	NENE	Neolithic	Turkey	M	-6400	-5600	K1a4	bam	<NA>	Mathieson et al. 2015 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
STR_480	MAGe	Middle Ages	Germany	F	510	530	J1c2o	bam	255.82	Veeramah et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
JK2965	CLNE	Classical Age	Egypt	U	-979	-914	T2c1c	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
JK2963	CLNE	Classical Age	Egypt	F	-1211	-1126	M1a1i	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
I4565	CAIB	Copper Age	Spain	M	-3020	-2909	H5	bam	509.00	Olalde et al. 2019 Data	FASTA Metadata
JK2966	CLNE	Classical Age	Egypt	U	-384	-235	T1a7	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
JK2970	CLNE	Classical Age	Egypt	U	-357	-206	U1a1	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
OBKR_73	EBAGe	Bronze Age	Germany	F	-2024	-1897	U5b2a1a1	reconstructed	3834.40	Knipper et al. 2017 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16192T (MT-CR): Melanoma patients (Reported)
I0725	NENE	Neolithic	Turkey	F	-6400	-5600	N1a1a1	bam	<NA>	Mathieson et al. 2015 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 3336C (MT-ND1): Carotid atherosclerosis risk (Reported) 669C (MT-RNR1): DEAF (Reported)
MS10619	IASp	Iron Age	Spain	U	-500	-400	H1c	fasta	17.48	Zalloua et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported)
I5838	CAIB	Copper Age	Spain	M	-2900	-2346	K1a+195	bam	261.00	Lipson et al. 2017 Data	FASTA Metadata
CL110	LONG	Middle Ages	Italy	M	570	880	None	<NA>	0.03	Amorim et al. 2018 Data	Metadata
CL97	LONG	Middle Ages	Italy	M	570	880	None	<NA>	0.39	Amorim et al. 2018 Data	Metadata
JK2974	CLNE	Classical Age	Egypt	U	-889	-803	H	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
MS10620	IASp	Iron Age	Spain	U	-400	-400	J1c3g	fasta	3.87	Zalloua et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 185A (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported) 9071T (MT-ATP6): Potentially functional variant cosegregating with LHON3635A (Reported)
I7587	CAIB	Copper Age	Spain	M	-2900	-2500	T2b3	bam	43.00	Olalde et al. 2019 Data	FASTA Metadata
MS10589	CASp	Copper Age	Spain	U	-900	-750	K1a1b1	fasta	3.55	Zalloua et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 114T (MT-CR): BD-associated (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 15924G (MT-TT): LIMM (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
JK2977	CLNE	Classical Age	Egypt	U	-389	-235	T2e	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
I8131	CAIB	Copper Age	Spain	F	-2578	-2457	J2b1	bam	3.92	Olalde et al. 2019 Data	FASTA Metadata
CL30	LONG	Middle Ages	Italy	M	570	880	I1b	reconstructed	17.07	Amorim et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 15924G (MT-TT): LIMM (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9966A (MT-CO3): LHON possible helper variant (Reported)
JK2979	CLNE	Classical Age	Egypt	U	-369	-211	HV1a2a	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
Harta-Freifelt/10/anc25	MAHu	Middle Ages	Hungary	F	900	950	H5e1a	bam	36.00	Neparáczki et al. 2018 Data	Metadata
I0726	NENE	Neolithic	Turkey	F	-6400	-5600	H or H5-C16192T	bam	<NA>	Mathieson et al. 2015 Data	FASTA Metadata	16192T (MT-CR): Melanoma patients (Reported)
I8154	CAIB	Copper Age	Spain	F	-2900	-2500	U5b1	bam	2.59	Olalde et al. 2019 Data	FASTA Metadata
Karos1/1	MAHu	Middle Ages	Hungary	M	890	950	H1b2	bam	28.00	Neparáczki et al. 2018 Data	Metadata
I1699	PPNE	Neolithic	Jordan	F	-6800	-6700	R0a2	bam	32.40	Lazaridis et al. 2016 Data	FASTA Metadata
OBKR_76	EBAGe	Bronze Age	Germany	F	-2013	-1785	K1a	reconstructed	253.90	Knipper et al. 2017 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
JK2986	CLNE	Classical Age	Egypt	F	-508	-406	HV	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
I0727	NENE	Neolithic	Turkey	M	-6400	-5600	K1a2	bam	<NA>	Mathieson et al. 2015 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
kum6	NENE	Neolithic	Turkey	F	-4846	-4618	None	bam	<NA>	Omrak et al. 2016 Data	FASTA Metadata
I8158	CAIB	Copper Age	Spain	M	-2900	-2500	H1ah	bam	38.70	Olalde et al. 2019 Data	FASTA Metadata
I8197	CAIB	Copper Age	Spain	F	-2900	-2500	H4a1	bam	140.00	Olalde et al. 2019 Data	FASTA Metadata
JK2879	CLNE	Classical Age	Egypt	U	-45	4	U3b	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
I8198	CAIB	Copper Age	Spain	F	-2900	-2500	J2b1a	bam	104.00	Olalde et al. 2019 Data	FASTA Metadata
I8199	CAIB	Copper Age	Spain	M	-2900	-2500	U5b1+16189+@16192	bam	157.00	Olalde et al. 2019 Data	FASTA Metadata
I8364	CAIB	Copper Age	Spain	M	-2706	-2569	J2b1a2a	bam	352.00	Olalde et al. 2019 Data	FASTA Metadata
I8566	CAIB	Copper Age	Spain	F	-3800	-2500	J2b1a	bam	222.00	Olalde et al. 2019 Data	FASTA Metadata
RISE500	BARu	Bronze Age	Russia	F	-1700	-1500	U4d1	bam	<NA>	Allentoft et al. 2015 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 499A (MT-CR): Endometriosis (Reported)
RISE503	BARu	Bronze Age	Russia	F	-1727	-1511	U2e2	bam	<NA>	Allentoft et al. 2015 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported)
I7588	CAIB	Copper Age	Spain	U	-2900	-2500	J1c1b	bam	133.00	Olalde et al. 2019 Data	FASTA Metadata
RISE505	BARu	Bronze Age	Russia	F	-1746	-1626	U4a1b	bam	<NA>	Allentoft et al. 2015 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 499A (MT-CR): Endometriosis (Reported)
OBKR_79	EBAGe	Bronze Age	Germany	U	-2018	-1883	H1ba	reconstructed	107.40	Knipper et al. 2017 Data	FASTA Metadata	16270T (MT-CR): Melanoma patients (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported)
I8132	CAIB	Copper Age	Spain	F	-2600	-2400	H1aq	bam	12.80	Olalde et al. 2019 Data	FASTA Metadata
I3238	CAIB	Copper Age	Spain	M	-2500	-2200	H3+152	bam	24.15	Olalde et al. 2019 Data	FASTA Metadata
CL93	LONG	Middle Ages	Italy	M	570	880	J2b1a	reconstructed	7.41	Amorim et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 15257A (MT-CYB): LHON (Conflicting reports) 195C (MT-CR): BD-associated / melanoma pts (Reported) 295T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported) 6261A (MT-CO1): Prostate Cancer / LHON (Reported)
JK2984	CLNE	Classical Age	Egypt	U	32	122	U7	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
Karos1/1438	MAHu	Middle Ages	Hungary	M	890	950	U3b1b	bam	112.00	Neparáczki et al. 2018 Data	Metadata
CL94	LONG	Middle Ages	Italy	M	570	880	K1c1	reconstructed	10.67	Amorim et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
Karos1/2	MAHu	Middle Ages	Hungary	M	890	950	H1b2	bam	55.00	Neparáczki et al. 2018 Data	Metadata
RISE94	CWC	Neolithic	Sweden	M	-2621	-2472	K1a2a	bam	<NA>	Allentoft et al. 2015 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12192A (MT-TH): MICM / possible G15927A deafness modulator (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I1633	BACA	Bronze Age	Armenia	F	-2619	-2410	H1u	bam	429.00	Lazaridis et al. 2016 Data	FASTA Metadata
I3239	CAIB	Copper Age	Spain	F	-2500	-2200	U5b1d2	bam	6.58	Olalde et al. 2019 Data	FASTA Metadata
OBKR_80	EBAGe	Bronze Age	Germany	M	-2134	-1959	K1a3	reconstructed	627.20	Knipper et al. 2017 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 9055A (MT-ATP6): PD protective factor (Reported)
SZ8	LONG	Middle Ages	Hungary	F	412	604	M5b'c	<NA>	1.41	Amorim et al. 2018 Data	Metadata
RISE560	BBC	Neolithic	Germany	M	-2500	-2000	U5a1a1	bam	<NA>	Allentoft et al. 2015 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15924G (MT-TT): LIMM (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I3243	CAIB	Copper Age	Spain	M	-2500	-2200	U5a1a2b	bam	2.88	Olalde et al. 2019 Data	FASTA Metadata
SZ13	LONG	Middle Ages	Hungary	M	422	541	N1b1b1	reconstructed	7.44	Amorim et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 16390A (MT-CR): POAG - potential for association (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported) 8836G (MT-ATP6): LHON (Reported)
I3276	CAIB	Copper Age	Spain	M	-3092	-2918	V	bam	284.10	Lipson et al. 2017 Data	FASTA Metadata
I8140_d	CAIB	Copper Age	Spain	F	-2117	-1779	K1a+195	bam	28.10	Olalde et al. 2019 Data	FASTA Metadata
Karos1/3286	MAHu	Middle Ages	Hungary	M	890	950	T2b4h	bam	51.00	Neparáczki et al. 2018 Data	Metadata
I8155	CAIB	Copper Age	Spain	F	-2900	-2500	H4a1a	bam	6.37	Olalde et al. 2019 Data	FASTA Metadata
I7672	MAIB	Middle Ages	Spain	M	785	801	T2h	bam	59.80	Olalde et al. 2019 Data	FASTA Metadata
SZ20	LONG	Middle Ages	Hungary	M	412	604	None	reconstructed	0.03	Amorim et al. 2018 Data	FASTA Metadata
I0059	BBC	Neolithic	Germany	F	-2337	-2138	H1	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata	14319C (MT-ND6): PD / early onset (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported)
Karos2/10	MAHu	Middle Ages	Hungary	M	890	950	U5a1a1h	bam	21.00	Neparáczki et al. 2018 Data	Metadata
I1546	BBC	Copper Age	Germany	F	-2500	-2050	U5a1b1	bam	195.60	Mathieson et al. 2015 Data	FASTA Metadata
Karos2/14	MAHu	Middle Ages	Hungary	U	890	950	F2a	bam	268.00	Neparáczki et al. 2018 Data	Metadata
Karos2/15	MAHu	Middle Ages	Hungary	U	890	950	U4d2	bam	248.00	Neparáczki et al. 2018 Data	Metadata
AV2	MAHu	Middle Ages	Hungary	F	548	641	X2m'n	reconstructed	12.44	Amorim et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 16183C (MT-CR): Melanoma patients (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
OBKR_81	EBAGe	Bronze Age	Germany	F	-2024	-1896	X2b	reconstructed	715.20	Knipper et al. 2017 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 15927A (MT-TT): LHON / Multiple Sclerosis / DEAF1555 increased penetrance / CHD (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 8393T (MT-ATP8): Reversible brain pseudoatrophy (Reported)
I7673	MAIB	Middle Ages	Spain	F	785	801	W1+119	bam	50.70	Olalde et al. 2019 Data	FASTA Metadata
Karos2/18	MAHu	Middle Ages	Hungary	M	890	950	T1a1	bam	21.00	Neparáczki et al. 2018 Data	Metadata
RISE00	CWC	Neolithic	Estonia	F	-2575	-2349	H5a1	bam	<NA>	Allentoft et al. 2015 Data	FASTA Metadata	4336C (MT-TQ): ADPD / Hearing Loss & Migraine / autism spectrum / intellectual disability (Unclear)
I7674	MAIB	Middle Ages	Spain	F	785	801	H42	bam	69.90	Olalde et al. 2019 Data	FASTA Metadata
SZ32	LONG	Middle Ages	Hungary	F	412	604	H74	reconstructed	14.63	Amorim et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I7675	MAIB	Middle Ages	Spain	M	785	801	U3a1	bam	214.00	Olalde et al. 2019 Data	FASTA Metadata
I0805	BBC	Copper Age	Germany	M	-2467	-2142	H1	bam	199.00	Mathieson et al. 2015 Data	FASTA Metadata
I0049	CWC	Neolithic	Germany	F	-2464	-2210	X2b4	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 15927A (MT-TT): LHON / Multiple Sclerosis / DEAF1555 increased penetrance / CHD (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 8393T (MT-ATP8): Reversible brain pseudoatrophy (Reported)
I7676	MAIB	Middle Ages	Spain	F	785	801	U5a1c	bam	27.10	Olalde et al. 2019 Data	FASTA Metadata
I12809	BAIB	Bronze Age	Spain	M	-1880	-1770	H1j	bam	14.28	Olalde et al. 2019 Data	FASTA Metadata
OBKR_84	EBAGe	Bronze Age	Germany	F	-2021	-1830	V7	reconstructed	663.10	Knipper et al. 2017 Data	FASTA Metadata	15924G (MT-TT): LIMM (Reported) 7444A (MT-CO1): LHON / SNHL / DEAF (Reported)
OBKR_86	EBAGe	Bronze Age	Germany	M	-2032	-1901	K1a3	reconstructed	210.60	Knipper et al. 2017 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 9055A (MT-ATP6): PD protective factor (Reported)
I1536	CWC	Neolithic	Germany	M	-2500	-2050	U5a1g2	bam	112.04	Mathieson et al. 2015 Data	FASTA Metadata
Karos2/21	MAHu	Middle Ages	Hungary	U	890	950	H2a1n	bam	28.00	Neparáczki et al. 2018 Data	Metadata
I0803	UNC	Bronze Age	Germany	F	-2132	-1942	H4a1a1a	bam	200.00	Haak et al. 2015 Data	FASTA Metadata
I0104	CWC	Neolithic	Germany	M	-2559	-2296	U4b1a1a1	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12297C (MT-TL2): Dilated Cardiomyopathy / Leigh Syndrome / Failure to Thrive & LA (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported)
I0106	CWC	Neolithic	Germany	F	-2464	-2210	T2a1b1	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 14687G (MT-TE): Mito myopathy w respiratory failure / intellectual disability (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I2022	LBK	Neolithic	Germany	F	-5500	-4850	T2b	bam	168.00	Lipson et al. 2017 Data	FASTA Metadata
OBKR_93	EBAGe	Bronze Age	Germany	F	-2111	-1907	K1a4a1	reconstructed	2029.00	Knipper et al. 2017 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
Karos2/22	MAHu	Middle Ages	Hungary	U	890	950	H2a1n	bam	6.00	Neparáczki et al. 2018 Data	Metadata
I2020	LBK	Neolithic	Germany	M	-5500	-4850	K1a2	bam	855.00	Lipson et al. 2017 Data	FASTA Metadata
Karos2/26	MAHu	Middle Ages	Hungary	M	890	950	T1a1	bam	20.00	Neparáczki et al. 2018 Data	Metadata
Kivisaare	NEBL	Neolithic	Estonia	U	-4411	-4286	U5a2d	<NA>	5.66	Saag et al. 2017 Data	Metadata
Kudruküla1	MEBL	Mesolithic	Estonia	U	-3831	-3426	U5b1d1	<NA>	6.73	Saag et al. 2017 Data	Metadata
I2017	LBK	Neolithic	Germany	F	-5500	-4850	K2a	bam	<NA>	Lipson et al. 2017 Data	FASTA Metadata
I1532	CWC	Neolithic	Germany	M	-2500	-2050	J1c2e	bam	<NA>	Mathieson et al. 2015 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
I1538	CWC	Neolithic	Germany	M	-2500	-2050	J1c5	bam	<NA>	Mathieson et al. 2015 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
Kunila2	CWC	Neolithic	Estonia	M	-2696	-2390	J1c3	bam	129.52	Saag et al. 2017 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
I1310	BAIB	Bronze Age	Spain	F	-1930	-1634	U5b1c	bam	63.60	Olalde et al. 2019 Data	FASTA Metadata
Karos2/27	MAHu	Middle Ages	Hungary	F	890	950	H15b1	bam	48.00	Neparáczki et al. 2018 Data	Metadata
arm13	IACA	Iron Age	Armenia	U	-1100	-900	U2e2a1	fasta	21.10	Margaryan et al. 2017 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported)
Iceman	CAIt	Copper Age	Italy	M	-3484	-3104	K1	bam	<NA>	Keller et al. 2012 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
arm12	MACA	Middle Ages	Armenia	U	728	930	J1d6	fasta	28.90	Margaryan et al. 2017 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported) 9041G (MT-ATP6): Patient with suspected mitochondrial disease (Reported as VUS)
I1539	CWC	Neolithic	Germany	F	-2625	-2291	J1c1b1a	bam	<NA>	Mathieson et al. 2015 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 3394C (MT-ND1): LHON / Diabetes / CPTdeficiency / high altitude adaptation (Reported / Population-dependent) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
I0114	CWC	Neolithic	Germany	M	-2138	-1952	I3a	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 15924G (MT-TT): LIMM (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported)
Karos2/31	MAHu	Middle Ages	Hungary	U	890	950	N1a1a1a1	bam	37.00	Neparáczki et al. 2018 Data	Metadata
arm2	BACA	Bronze Age	Armenia	U	-3000	-2800	R1a1	fasta	18.20	Margaryan et al. 2017 Data	FASTA Metadata	1391C (MT-RNR1): found in 1 HCM patient (Reported) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I0056	LBK	Neolithic	Germany	M	-5212	-5006	T2b	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I1312_d	BAIB	Bronze Age	Spain	M	-1930	-1634	HV0+195	bam	49.80	Olalde et al. 2019 Data	FASTA Metadata
I5878	NEUk	Neolithic	Ukraine	M	-5299	-5076	U4b1a1a	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12297C (MT-TL2): Dilated Cardiomyopathy / Leigh Syndrome / Failure to Thrive & LA (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 499A (MT-CR): Endometriosis (Reported)
I1540	CWC	Neolithic	Germany	M	-2500	-2050	J1c5	bam	<NA>	Mathieson et al. 2015 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported) 9152C (MT-ATP6): Patient with suspected mitochondrial disease (Reported as VUS)
arm26	IACA	Iron Age	Armenia	U	-1300	-1100	J1d1b1	fasta	24.10	Margaryan et al. 2017 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 16300G (MT-CR): BD-associated (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
I1542	CWC	Neolithic	Germany	M	-2500	-2050	J2a2a	bam	<NA>	Mathieson et al. 2015 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15257A (MT-CYB): LHON (Conflicting reports) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
arm29	BACA	Bronze Age	Armenia	U	-1400	-1200	R1b1	fasta	27.60	Margaryan et al. 2017 Data	FASTA Metadata	1095C (MT-RNR1): SNHL (Unclear) 1391C (MT-RNR1): found in 1 HCM patient (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports)
arm33	BACA	Bronze Age	Armenia	U	-1400	-1200	W3b	fasta	159.70	Margaryan et al. 2017 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
I1544	CWC	Neolithic	Germany	M	-2500	-2050	K2b2	bam	<NA>	Mathieson et al. 2015 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
I1313_d	BAIB	Bronze Age	Spain	F	-1930	-1634	V	bam	86.50	Olalde et al. 2019 Data	FASTA Metadata
Karos2/37	MAHu	Middle Ages	Hungary	F	890	950	G2a1d2	bam	44.00	Neparáczki et al. 2018 Data	Metadata
I1836	BAIB	Bronze Age	Spain	M	-1682	-1505	U	bam	45.70	Olalde et al. 2019 Data	FASTA Metadata
I2455	BBC	Bronze Age	Great Britain	F	-2125	-1911	U5a2c3a	bam	2019.89	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
arm36	BACA	Bronze Age	Armenia	U	-1500	-1300	U2e1e	fasta	60.50	Margaryan et al. 2017 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported)
I1770	BBC	Bronze Age	Great Britain	F	-2400	-1600	U5b1d2	bam	70.73	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I5888	NEUk	Neolithic	Ukraine	M	-5500	-4800	U5b2b1	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	10237C (MT-ND3): LHON (Reported) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 12634G (MT-ND5): Thyroid Cancer Cell Line (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 15497A (MT-CYB): EXIT / Obesity (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I10942	NEIB	Neolithic	Gibraltar	F	-5500	-4500	N1a1a1	bam	97.80	Olalde et al. 2019 Data	FASTA Metadata
RISE446	CWC	Neolithic	Germany	M	-2829	-2465	U5b1c2	bam	<NA>	Allentoft et al. 2015 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
OBKR_95	EBAGe	Bronze Age	Germany	F	-2027	-1901	V1a	reconstructed	461.40	Knipper et al. 2017 Data	FASTA Metadata	16390A (MT-CR): POAG - potential for association (Reported)
Karos2/48	MAHu	Middle Ages	Hungary	U	890	950	K1c1	bam	40.00	Neparáczki et al. 2018 Data	Metadata
Karos2/50	MAHu	Middle Ages	Hungary	M	890	950	U5a2a2a	bam	22.00	Neparáczki et al. 2018 Data	Metadata
I1840	BAIB	Bronze Age	Spain	M	-1660	-1454	H3ap	bam	489.00	Olalde et al. 2019 Data	FASTA Metadata
I1977	BAIB	Bronze Age	Spain	F	-1660	-1454	U5b1+16189+@16192	bam	266.00	Olalde et al. 2019 Data	FASTA Metadata
arm51	IACA	Iron Age	Armenia	U	-700	-500	U3b3	fasta	14.60	Margaryan et al. 2017 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 11150A (MT-ND4): Found in a Multiple Sclerosis patient (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 4640A (MT-ND2): LHON / Epilepsy (Reported)
I2407	GAC	Bronze Age	Poland	M	-3095	-2915	H28a	fasta	124.76	Tassi et al. 2017 Data	FASTA Metadata	16093C (MT-CR): Cyclic Vomiting Syndrome (Reported)
RISE434	CWC	Neolithic	Germany	M	-2880	-2630	U4	bam	<NA>	Allentoft et al. 2015 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 499A (MT-CR): Endometriosis (Reported)
I1982	BAIB	Bronze Age	Spain	F	-1729	-1531	X2	bam	3.06	Olalde et al. 2019 Data	FASTA Metadata
I2471	BAIB	Bronze Age	Spain	F	-1630	-1497	K1b1a	bam	29.91	Olalde et al. 2019 Data	FASTA Metadata
I3484	CAIB	Copper Age	Spain	M	-2271	-1984	J1c1	bam	18.20	Olalde et al. 2019 Data	FASTA Metadata
RISE397	IACA	Iron Age	Armenia	M	-1048	-855	T1a2	fasta	192.20	Allentoft et al. 2015 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
Karos2/53	MAHu	Middle Ages	Hungary	F	890	950	H2a1c	bam	17.00	Neparáczki et al. 2018 Data	Metadata
I3485	CAIB	Copper Age	Spain	F	-2300	-1900	K1a4a1	bam	96.50	Olalde et al. 2019 Data	FASTA Metadata
LRV_92	ROM	Classical Age	Italy	F	0	400	T2j1	reconstructed	18.00	Emery et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
Karos2/54	MAHu	Middle Ages	Hungary	F	890	950	X2l	bam	14.00	Neparáczki et al. 2018 Data	Metadata
I3486	BAIB	Bronze Age	Spain	M	-1700	-1500	H1q	bam	558.00	Olalde et al. 2019 Data	FASTA Metadata
I3487	BAIB	Bronze Age	Spain	M	-1734	-1617	H1e1a	bam	136.00	Olalde et al. 2019 Data	FASTA Metadata
I3488	BAIB	Bronze Age	Spain	M	-1700	-1500	HV0+195	bam	1430.00	Olalde et al. 2019 Data	FASTA Metadata
OBKR_96	EBAGe	Bronze Age	Germany	F	-2013	-1784	H1j2	reconstructed	113.10	Knipper et al. 2017 Data	FASTA Metadata	13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported)
I2435	GAC	Bronze Age	Poland	M	-3100	-2900	H28	fasta	21.00	Tassi et al. 2017 Data	FASTA Metadata	16093C (MT-CR): Cyclic Vomiting Syndrome (Reported)
Karos2/58	MAHu	Middle Ages	Hungary	F	890	950	U5a2b1	bam	11.00	Neparáczki et al. 2018 Data	Metadata
I9128	MIC	Bronze Age	Greece	F	-2210	-1680	I5	bam	<NA>	Lazaridis et al. 2017 Data	FASTA Metadata
OBKR_117	EBAGe	Bronze Age	Germany	M	-2019	-1883	U4a1b	reconstructed	1731.20	Knipper et al. 2017 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 499A (MT-CR): Endometriosis (Reported) 745G (MT-RNR1): DEAF-associated (Reported)
RISE435	CWC	Neolithic	Germany	F	-2863	-2498	J1b1a1	bam	<NA>	Allentoft et al. 2015 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 295T (MT-CR): Low VO2max response (Reported) 2158C (MT-RNR2): Reduced risk PD (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
WEHR_1192SkA	BBC	Bronze Age	Germany	M	-2331	-2150	K1a4a1	reconstructed	1611.30	Knipper et al. 2017 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
Karos2/67	MAHu	Middle Ages	Hungary	F	890	950	V3	bam	330.00	Neparáczki et al. 2018 Data	Metadata
I0700	NEBA	Neolithic	Bulgaria	M	-5800	-5400	T2e	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I3490	BAIB	Bronze Age	Spain	F	-1850	-1150	HV0b	bam	462.00	Olalde et al. 2019 Data	FASTA Metadata
I3491	BAIB	Bronze Age	Spain	F	-1850	-1150	T2b	bam	130.00	Olalde et al. 2019 Data	FASTA Metadata
LRV_101	ROM	Classical Age	Italy	F	0	400	H1t	reconstructed	23.80	Emery et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported)
LRV_97	ROM	Classical Age	Italy	M	0	400	N1a1a1a	reconstructed	390.00	Emery et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 3336C (MT-ND1): Carotid atherosclerosis risk (Reported) 669C (MT-RNR1): DEAF (Reported)
RISE436	CWC	Neolithic	Germany	M	-2868	-2580	U5b1c2	bam	<NA>	Allentoft et al. 2015 Data	FASTA Metadata	12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16270T (MT-CR): Melanoma patients (Reported)
LRV_105	ROM	Classical Age	Italy	M	0	400	K2a9	reconstructed	129.00	Emery et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I3492	BAIB	Bronze Age	Spain	M	-1850	-1150	U5b1+16189	bam	101.13	Olalde et al. 2019 Data	FASTA Metadata
I3494	BAIB	Bronze Age	Spain	M	-1920	-1753	J1c1b	bam	641.00	Olalde et al. 2019 Data	FASTA Metadata
I3756	BAIB	Bronze Age	Spain	M	-2014	-1781	H1	bam	264.00	Olalde et al. 2019 Data	FASTA Metadata
LRV_114	ROM	Classical Age	Italy	M	0	400	I5a2	reconstructed	553.20	Emery et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 15924G (MT-TT): LIMM (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 3335C (MT-ND1): LHON (Reported)
I3997	BAIB	Bronze Age	Spain	M	-1864	-1618	K1a2b	bam	158.36	Olalde et al. 2019 Data	FASTA Metadata
LRV_118	ROM	Classical Age	Italy	F	0	400	HV	reconstructed	586.10	Emery et al. 2018 Data	FASTA Metadata
Karos2/68	MAHu	Middle Ages	Hungary	F	890	950	U2e2a1a2	bam	17.00	Neparáczki et al. 2018 Data	Metadata
RISE431	CWC	Neolithic	Poland	M	-2286	-2048	T2e	bam	<NA>	Allentoft et al. 2015 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported)
LRV_128	ROM	Classical Age	Italy	F	0	400	H	reconstructed	9.60	Emery et al. 2018 Data	FASTA Metadata
I5241	HGS	Mesolithic	Serbia	F	-9297	-9194	U5a2a	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
LRV_146	ROM	Classical Age	Italy	U	0	400	H + 73	reconstructed	28.10	Emery et al. 2018 Data	FASTA Metadata
I2752	CAHu	Copper Age	Hungary	M	-3600	-3000	K1a	bam	56.60	Lipson et al. 2017 Data	FASTA Metadata
LRV_151	ROM	Classical Age	Italy	F	0	400	T2 + 16,189	reconstructed	12.50	Emery et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4454C (MT-TM): Possible contributor to mito dysfunction / hypertension (Reported) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
Karos2/72	MAHu	Middle Ages	Hungary	F	890	950	H1b1	bam	15.00	Neparáczki et al. 2018 Data	Metadata
I4559	BAIB	Bronze Age	Spain	M	-1700	-1500	J1c1	bam	663.10	Olalde et al. 2019 Data	FASTA Metadata
LRV_152	ROM	Classical Age	Italy	F	0	400	H5a3a	reconstructed	174.20	Emery et al. 2018 Data	FASTA Metadata	4336C (MT-TQ): ADPD / Hearing Loss & Migraine / autism spectrum / intellectual disability (Unclear)
I6470	BAIB	Bronze Age	Spain	M	-1753	-1549	J1c1	bam	1012.71	Olalde et al. 2019 Data	FASTA Metadata
I0124	HGE	Mesolithic	Russia	M	-5657	-5541	U5a1d	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
LRV_156	ROM	Classical Age	Italy	M	0	400	H15a	reconstructed	89.10	Emery et al. 2018 Data	FASTA Metadata
LIAV_12	IAIt	Iron Age	Italy	U	-700	-300	J2b1a2	reconstructed	110.60	Emery et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 15257A (MT-CYB): LHON (Conflicting reports) 15812A (MT-CYB): LHON (Reported / Secondary) 295T (MT-CR): Low VO2max response (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 489C (MT-CR): Low VO2max response (Reported)
WEHR_1192SkB	EBAGe	Bronze Age	Germany	F	-1918	-1772	U5b2a2b	reconstructed	3962.80	Knipper et al. 2017 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I5869	NEUk	Neolithic	Ukraine	M	-6500	-4000	U4b1b1	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13528G (MT-ND5): LHON-like / LHON / MELAS (Reported) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 499A (MT-CR): Endometriosis (Reported)
I2763	CAHu	Copper Age	Hungary	F	-3600	-3000	T2	bam	555.00	Lipson et al. 2017 Data	FASTA Metadata
Karos3/1	MAHu	Middle Ages	Hungary	M	890	950	B4d1	bam	22.00	Neparáczki et al. 2018 Data	Metadata
I8136	BAIB	Bronze Age	Spain	F	-1606	-1418	K1b1a1	bam	54.30	Olalde et al. 2019 Data	FASTA Metadata
LIAV_38	IAIt	Iron Age	Italy	U	-700	-300	U4a1	reconstructed	221.40	Emery et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13528G (MT-ND5): LHON-like / LHON / MELAS (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 499A (MT-CR): Endometriosis (Reported)
I0061	HGN	Mesolithic	Russia	M	-6850	-6000	C1	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 3552A (MT-ND1): Resistance to high altitude pulmonary edema (HAPE) (Reported /hg C marker) 489C (MT-CR): Low VO2max response (Reported)
Karos3/13	MAHu	Middle Ages	Hungary	M	890	950	B4d1	bam	590.00	Neparáczki et al. 2018 Data	Metadata
RISE471	CWC	Neolithic	Germany	M	-1691	-1519	J1c1b	bam	<NA>	Allentoft et al. 2015 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 3394C (MT-ND1): LHON / Diabetes / CPTdeficiency / high altitude adaptation (Reported / Population-dependent) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
Karos3/14	MAHu	Middle Ages	Hungary	M	890	950	T1a1b	bam	36.00	Neparáczki et al. 2018 Data	Metadata
I8144	BAIB	Bronze Age	Spain	F	-1877	-1636	U5b3f	bam	21.00	Olalde et al. 2019 Data	FASTA Metadata
I0421	SRU	Bronze Age	Russia	F	-1850	-1600	H3g	bam	<NA>	Mathieson et al. 2015 Data	FASTA Metadata
Karos3/17	MAHu	Middle Ages	Hungary	M	890	950	H6a1a	bam	11.00	Neparáczki et al. 2018 Data	Metadata
Karos3/18	MAHu	Middle Ages	Hungary	F	890	950	T1a10a	bam	13.00	Neparáczki et al. 2018 Data	Metadata
I7162	BAIB	Bronze Age	Spain	F	-1932	-1697	T2e	bam	27.50	Olalde et al. 2019 Data	FASTA Metadata
I1169	CANE	Copper Age	Israel	F	-4500	-3900	J2a2d	<NA>	8.29	Harney et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 15257A (MT-CYB): LHON (Conflicting reports) 195C (MT-CR): BD-associated / melanoma pts (Reported) 295T (MT-CR): Low VO2max response (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 489C (MT-CR): Low VO2max response (Reported)
Loschbour	HGW	Mesolithic	Luxembourg	F	-6220	-5990	U5b1a	bam	<NA>	Lazaridis et al. 2014 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
Karos3/19	MAHu	Middle Ages	Hungary	U	890	950	T1a10a	bam	25.00	Neparáczki et al. 2018 Data	Metadata
WEHR_1193	EBAGe	Bronze Age	Germany	F	-1945	-1777	H4a1a1a	reconstructed	936.00	Knipper et al. 2017 Data	FASTA Metadata	10044G (MT-TG): SIDS (Unclear) 14582G (MT-ND6): LHON synergistic combo 14258A + 14582G (Reported: individually neutral variants causing LHON in combination)
I1177	CANE	Copper Age	Israel	F	-4500	-3900	N1b1	<NA>	0.09	Harney et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 8836G (MT-ATP6): LHON (Reported)
GoyetQ116-1	HGW	Aurignacian	Belgium	M	-33210	-32480	M	bam	<NA>	Fu et al. 2016 Data	FASTA Metadata
I1311	BAIB	Bronze Age	Spain	M	-1930	-1634	J2b1a	bam	33.80	Olalde et al. 2019 Data	FASTA Metadata
Karos3/4	MAHu	Middle Ages	Hungary	U	890	950	J1c7a	bam	38.00	Neparáczki et al. 2018 Data	Metadata
Karos3/8	MAHu	Middle Ages	Hungary	M	890	950	U2e1b	bam	44.00	Neparáczki et al. 2018 Data	Metadata
I1500	LBK	Neolithic	Hungary	M	-5210	-4990	J1c1	bam	528.00	Gamba et al. 2014 Data	FASTA Metadata
I4915	HGS	Mesolithic	Serbia	M	-6340	-5990	U5b2b	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 12634G (MT-ND5): Thyroid Cancer Cell Line (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16270T (MT-CR): Melanoma patients (Reported) 8481T (MT-ATP8): Tetralogy of Fallot patient (Reported)
I1187	CANE	Copper Age	Israel	M	-4500	-3900	U6d	<NA>	0.12	Harney et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 14696G (MT-TE): Progressive Encephalopathy (Reported) 15784C (MT-CYB): POAG - potential for association (Reported) 16390A (MT-CR): POAG - potential for association (Reported) 3316A (MT-ND1): Diabetes / LHON / PEO (Unclear) 8836G (MT-ATP6): LHON (Reported)
I8567	NEIB	Neolithic	Spain	M	-3500	-3300	X2	bam	96.80	Olalde et al. 2019 Data	FASTA Metadata
M63	BACA	Bronze Age	Nepal	M	-450	100	M9a1a1c1b1a	bam	1.05	Jeong et al. 2016 Data	Metadata
I0410	NEIB	Neolithic	Spain	M	-5294	-5066	T2c1d+152	bam	353.21	Haak et al. 2015 Data	FASTA Metadata
M344	BACA	Bronze Age	Nepal	M	-450	100	Z3a1a	bam	0.04	Jeong et al. 2016 Data	Metadata
Kenezlo-Fazekaszug2/1027	MAHu	Middle Ages	Hungary	M	900	1000	N1a1a1a1a	bam	300.00	Neparáczki et al. 2018 Data	Metadata
M240	BACA	Bronze Age	Nepal	M	-450	100	M9a1a2	bam	0.05	Jeong et al. 2016 Data	Metadata
Kenezlo-Fazekaszug2/1031	MAHu	Middle Ages	Hungary	F	900	1000	T1a1	bam	64.00	Neparáczki et al. 2018 Data	Metadata
NF-108c	NAMA	Middle Ages	USA	U	1150	1700	A2f1	bam	21.40	Ozga et al. 2016 Data	Metadata
I0046	LBK	Neolithic	Germany	F	-5211	-4991	T2c	bam	<NA>	Lipson et al. 2017 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported) 6261A (MT-CO1): Prostate Cancer / LHON (Reported)
I1661	CAME	Copper Age	Iran	F	-4696	-4491	H29	bam	510.91	Lazaridis et al. 2016 Data	FASTA Metadata
I0412	NEIB	Neolithic	Spain	M	-5308	-5080	N1a1a1	bam	831.40	Haak et al. 2015 Data	FASTA Metadata
I0413	NEIB	Neolithic	Spain	F	-5303	-5075	V	bam	596.21	Haak et al. 2015 Data	FASTA Metadata
NF-262c	NAMA	Middle Ages	USA	U	1150	1700	B2	bam	33.80	Ozga et al. 2016 Data	Metadata
ERS1790733	BANE	Bronze Age	Lebanon	M	-1650	-1650	N1a3a	reconstructed	110.00	Haber et al. 2017 Data	Metadata
Kenezlo-Fazekaszug1/1036	MAHu	Middle Ages	Hungary	M	900	1000	H6a1b	bam	17.00	Neparáczki et al. 2018 Data	Metadata
ERS1790731	BANE	Bronze Age	Lebanon	F	-1750	-1750	R2	reconstructed	164.00	Haber et al. 2017 Data	Metadata
ERS1790729	BANE	Bronze Age	Lebanon	F	-1750	-1750	H1bc	reconstructed	53.00	Haber et al. 2017 Data	Metadata
Is_1	IAPS	Iron Age	Kazakhstan	M	-900	-700	D4h1	bam	<NA>	Unterländer et al. 2017 Data	Metadata
Kenezlo-Fazekaszug2/1042	MAHu	Middle Ages	Hungary	M	900	1000	H7	bam	62.00	Neparáczki et al. 2018 Data	Metadata
Ze_3	IAPS	Iron Age	Kazakhstan	U	-900	-700	K1	bam	<NA>	Unterländer et al. 2017 Data	Metadata
Ze_2	IAPS	Iron Age	Kazakhstan	U	-900	-700	T2b	bam	<NA>	Unterländer et al. 2017 Data	Metadata
Ze_7	IAPS	Iron Age	Kazakhstan	U	-900	-700	U4a1	bam	<NA>	Unterländer et al. 2017 Data	Metadata
Ze_5	IAPS	Iron Age	Kazakhstan	U	-900	-700	I	bam	<NA>	Unterländer et al. 2017 Data	Metadata
Ze_6	IAPS	Iron Age	Kazakhstan	F	-900	-700	C4	bam	0.28	Unterländer et al. 2017 Data	Metadata
Kenezlo-Fazekaszug1/10939	MAHu	Middle Ages	Hungary	M	900	1000	N1a1a1a1a	bam	23.00	Neparáczki et al. 2018 Data	Metadata
I1972	NEIB	Neolithic	Spain	F	-4827	-4692	K1a4a1	bam	438.00	Lipson et al. 2017 Data	FASTA Metadata
I2199	NEIB	Neolithic	Spain	F	-5216	-5031	H1	bam	273.00	Lipson et al. 2017 Data	FASTA Metadata
A_3	IASI	Iron Age	Russia	U	-700	-600	G	bam	<NA>	Unterländer et al. 2017 Data	Metadata
WEHR_1375	EBAGe	Bronze Age	Germany	U	-1953	-1781	K1a3	reconstructed	29.10	Knipper et al. 2017 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 3316A (MT-ND1): Diabetes / LHON / PEO (Unclear) 9055A (MT-ATP6): PD protective factor (Reported)
A_2	IASI	Iron Age	Russia	U	-700	-600	A8	bam	<NA>	Unterländer et al. 2017 Data	Metadata
I1949	NEME	Neolithic	Iran	M	-8241	-7962	R2b	bam	13.45	Lazaridis et al. 2016 Data	FASTA Metadata
A_7	IASI	Iron Age	Russia	U	-700	-600	Y1	bam	<NA>	Unterländer et al. 2017 Data	Metadata
A_6	IASI	Iron Age	Russia	U	-700	-600	U5a1f1	bam	<NA>	Unterländer et al. 2017 Data	Metadata
I8209	CLIB	Classical Age	Spain	M	-450	-400	U1a1a	bam	149.00	Olalde et al. 2019 Data	FASTA Metadata
A_11	IASI	Iron Age	Russia	U	-700	-600	G	bam	<NA>	Unterländer et al. 2017 Data	Metadata
Oroshaza-Gorbicstanya/2/anc3	MAHu	Middle Ages	Hungary	F	900	1000	N1a1a1a1a	bam	25.00	Neparáczki et al. 2018 Data	Metadata
A_9	IASI	Iron Age	Russia	U	-700	-600	U5a1d2b	bam	<NA>	Unterländer et al. 2017 Data	Metadata
Magyarhomorog/120/anc2	MAHu	Middle Ages	Hungary	M	900	1200	H	bam	10.00	Neparáczki et al. 2018 Data	Metadata
I8210	CLIB	Classical Age	Spain	M	-500	-350	U5b3	bam	7.00	Olalde et al. 2019 Data	FASTA Metadata
I8211	CLIB	Classical Age	Spain	M	-500	-450	HV0+195	bam	48.90	Olalde et al. 2019 Data	FASTA Metadata
A_20	IASI	Iron Age	Russia	U	-700	-600	G2a	bam	<NA>	Unterländer et al. 2017 Data	Metadata
I4916	HGS	Mesolithic	Serbia	M	-7035	-6590	U5b2b	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 12634G (MT-ND5): Thyroid Cancer Cell Line (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16270T (MT-CR): Melanoma patients (Reported)
A_19	IASI	Iron Age	Russia	U	-700	-600	C4	bam	<NA>	Unterländer et al. 2017 Data	Metadata
I1685	NAT	Epipaleolithic	Israel	M	-11840	-9760	J2a2	bam	5.25	Lazaridis et al. 2016 Data	FASTA Metadata
BL_3	IASI	Iron Age	Russia	U	-500	-500	C5+16093	bam	<NA>	Unterländer et al. 2017 Data	Metadata
BL_2	IASI	Iron Age	Russia	U	-500	-500	U5a	bam	<NA>	Unterländer et al. 2017 Data	Metadata
Be_2	IAAL	Iron Age	Kazakhstan	U	-400	-300	D4	bam	<NA>	Unterländer et al. 2017 Data	Metadata
Sarretudvari-Hizofold/103	MAHu	Middle Ages	Hungary	F	900	970	C4a1b	bam	56.00	Neparáczki et al. 2018 Data	Metadata
BL_5	IASI	Iron Age	Russia	U	-500	-500	U2e2	bam	<NA>	Unterländer et al. 2017 Data	Metadata
BL_6	IASI	Iron Age	Russia	U	-500	-500	A4	bam	<NA>	Unterländer et al. 2017 Data	Metadata
I8340	CLIB	Classical Age	Spain	F	-500	-350	K1a+195	bam	93.30	Olalde et al. 2019 Data	FASTA Metadata
Be_8	IAAL	Iron Age	Kazakhstan	U	-400	-300	D4	bam	<NA>	Unterländer et al. 2017 Data	Metadata
I0057	LBK	Neolithic	Germany	F	-5219	-5021	N1a1	bam	<NA>	Lipson et al. 2017 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 3336C (MT-ND1): Carotid atherosclerosis risk (Reported) 669C (MT-RNR1): DEAF (Reported)
Be_6	IAAL	Iron Age	Kazakhstan	U	-400	-300	A6	bam	<NA>	Unterländer et al. 2017 Data	Metadata
Be_14	IAAL	Iron Age	Kazakhstan	U	-400	-300	A6	bam	<NA>	Unterländer et al. 2017 Data	Metadata
Be_12	IAAL	Iron Age	Kazakhstan	U	-400	-300	HV2	bam	<NA>	Unterländer et al. 2017 Data	Metadata
I8341	CLIB	Classical Age	Spain	M	-500	-350	H1	bam	110.00	Olalde et al. 2019 Data	FASTA Metadata
Ak5_1	IAAL	Iron Age	Russia	U	-400	-300	C4	bam	<NA>	Unterländer et al. 2017 Data	Metadata
Ak1_1	IAAL	Iron Age	Russia	U	-400	-300	C4a1+16129	bam	<NA>	Unterländer et al. 2017 Data	Metadata
Ak4_1	IAAL	Iron Age	Russia	U	-400	-300	A	bam	<NA>	Unterländer et al. 2017 Data	Metadata
Sarretudvari-Hizofold/118/anc12	MAHu	Middle Ages	Hungary	F	900	970	T2f1a1	bam	24.00	Neparáczki et al. 2018 Data	Metadata
I8344	CLIB	Classical Age	Spain	M	-500	-400	H3	bam	178.00	Olalde et al. 2019 Data	FASTA Metadata
Ak5_7	IAAL	Iron Age	Russia	U	-400	-300	C4a1+16129	bam	<NA>	Unterländer et al. 2017 Data	Metadata
Ak5_5	IAAL	Iron Age	Russia	U	-400	-300	U2e1a	bam	<NA>	Unterländer et al. 2017 Data	Metadata
Ak5_6	IAAL	Iron Age	Russia	U	-400	-300	U2e1a	bam	<NA>	Unterländer et al. 2017 Data	Metadata
Sarretudvari-Hizofold/136	MAHu	Middle Ages	Hungary	U	900	970	HV14a	bam	131.00	Neparáczki et al. 2018 Data	Metadata
Mo_2	IAAL	Iron Age	Russia	U	-400	-300	D4h4a	bam	<NA>	Unterländer et al. 2017 Data	Metadata
I1706	BANE	Bronze Age	Jordan	F	-2490	-2300	X2n	bam	986.00	Lazaridis et al. 2016 Data	FASTA Metadata
Mo_1	IAAL	Iron Age	Russia	U	-400	-300	D4b1a2a1	bam	<NA>	Unterländer et al. 2017 Data	Metadata
Ala_1	IAAL	Iron Age	Russia	U	-400	-300	C4a1+16129	bam	<NA>	Unterländer et al. 2017 Data	Metadata
BS_1	IAAL	Iron Age	Russia	U	-400	-300	X2b	bam	<NA>	Unterländer et al. 2017 Data	Metadata
BS_2	IAAL	Iron Age	Russia	U	-400	-300	U4b1a4	bam	<NA>	Unterländer et al. 2017 Data	Metadata
Sarretudvari-Hizofold/213/anc13	MAHu	Middle Ages	Hungary	M	900	970	J1c3g	bam	34.00	Neparáczki et al. 2018 Data	Metadata
B1_2	IAAL	Iron Age	Russia	U	-400	-300	D4m2	bam	<NA>	Unterländer et al. 2017 Data	Metadata
Sarretudvari-Hizofold/5/anc10	MAHu	Middle Ages	Hungary	M	900	970	I5a1a	bam	18.00	Neparáczki et al. 2018 Data	Metadata
Ala_4	IAAL	Iron Age	Russia	U	-400	-300	T	bam	<NA>	Unterländer et al. 2017 Data	Metadata
B1_1	IAAL	Iron Age	Russia	U	-400	-300	G	bam	<NA>	Unterländer et al. 2017 Data	Metadata
D_1	IAAL	Iron Age	Russia	U	-400	-300	T1a1b	bam	<NA>	Unterländer et al. 2017 Data	Metadata
Bt_2	IAAL	Iron Age	Russia	U	-400	-300	U2e2a	bam	<NA>	Unterländer et al. 2017 Data	Metadata
I8213	CLIB	Classical Age	Spain	F	-500	-400	K2a	bam	41.50	Olalde et al. 2019 Data	FASTA Metadata
J12_7	IAAL	Iron Age	Russia	U	-400	-300	T2b+@16296	bam	<NA>	Unterländer et al. 2017 Data	Metadata
Sarretudvari-Hizofold/66	MAHu	Middle Ages	Hungary	M	900	970	H1c1	bam	512.00	Neparáczki et al. 2018 Data	Metadata
J12_3	IAAL	Iron Age	Russia	U	-400	-300	U7	bam	<NA>	Unterländer et al. 2017 Data	Metadata
J12_6	IAAL	Iron Age	Russia	U	-400	-300	Z	bam	<NA>	Unterländer et al. 2017 Data	Metadata
I8205	CLIB	Classical Age	Spain	M	-300	-100	H14a2c	bam	32.10	Olalde et al. 2019 Data	FASTA Metadata
U1_1	IAAL	Iron Age	Russia	U	-400	-300	W4a	bam	<NA>	Unterländer et al. 2017 Data	Metadata
I0100	LBK	Neolithic	Germany	F	-5202	-4852	N1a1a1a	bam	<NA>	Lipson et al. 2017 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 3336C (MT-ND1): Carotid atherosclerosis risk (Reported) 669C (MT-RNR1): DEAF (Reported)
J22_1	IAAL	Iron Age	Russia	U	-400	-300	T2b+@16296	bam	<NA>	Unterländer et al. 2017 Data	Metadata
I5428	CAIB	Copper Age	Portugal	M	-3300	-2900	U5b1+16189+@16192	bam	24.50	Olalde et al. 2019 Data	FASTA Metadata
U4_1	IAAL	Iron Age	Russia	U	-400	-300	U2e2	bam	<NA>	Unterländer et al. 2017 Data	Metadata
U2_2	IAAL	Iron Age	Russia	U	-400	-300	F2a	bam	<NA>	Unterländer et al. 2017 Data	Metadata
NOV_9	IACA	Iron Age	Russia	U	-300	-300	T2g1	bam	<NA>	Unterländer et al. 2017 Data	Metadata
NOV_5	IACA	Iron Age	Russia	U	-800	-600	H-CRS	bam	<NA>	Unterländer et al. 2017 Data	Metadata
NOV_7	IACA	Iron Age	Russia	U	-800	-600	H1c	bam	<NA>	Unterländer et al. 2017 Data	Metadata
Sarretudvari-Hizofold/81	MAHu	Middle Ages	Hungary	M	900	970	H1c	bam	441.00	Neparáczki et al. 2018 Data	Metadata
I8208	CLIB	Classical Age	Spain	M	-370	-204	H33	bam	48.30	Olalde et al. 2019 Data	FASTA Metadata
KOL_3	IASI	Iron Age	Russia	U	-500	-200	U4	bam	<NA>	Unterländer et al. 2017 Data	Metadata
Szabadkigyos-Palliget/7/anc4	MAHu	Middle Ages	Hungary	M	900	1000	N1a1a1a1	bam	19.00	Neparáczki et al. 2018 Data	Metadata
KOL_1	IAPS	Iron Age	Russia	U	-300	-300	X4	bam	<NA>	Unterländer et al. 2017 Data	Metadata
KOL_2	IAPS	Iron Age	Russia	U	-300	-300	H8c	bam	<NA>	Unterländer et al. 2017 Data	Metadata
I8203	CLIB	Classical Age	Spain	F	-300	-100	H13a1a1	bam	130.00	Olalde et al. 2019 Data	FASTA Metadata
Pr4	IASI	Iron Age	Russia	U	-500	-200	U1a´c	bam	<NA>	Unterländer et al. 2017 Data	Metadata
Pr3	IASI	Iron Age	Russia	M	-500	-200	Mt_hg	bam	0.08	Unterländer et al. 2017 Data	Metadata
I8206	CLIB	Classical Age	Spain	M	-300	-100	H7a1	bam	43.40	Olalde et al. 2019 Data	FASTA Metadata
Pr8	IASI	Iron Age	Russia	U	-500	-200	T2	bam	<NA>	Unterländer et al. 2017 Data	Metadata
WEHR_1380	EBAGe	Bronze Age	Germany	M	-2021	-1895	K1a1b1g	reconstructed	160.70	Knipper et al. 2017 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15924G (MT-TT): LIMM (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
Pr7	IASI	Iron Age	Russia	U	-500	-200	N1a1a1a1a	bam	<NA>	Unterländer et al. 2017 Data	Metadata
I8204	CLIB	Classical Age	Spain	F	-300	-100	H1e	bam	2.11	Olalde et al. 2019 Data	FASTA Metadata
Pr13	IASI	Iron Age	Russia	U	-500	-200	U5a1d2b	bam	<NA>	Unterländer et al. 2017 Data	Metadata
Pr10	IASI	Iron Age	Russia	U	-500	-200	H2a1f	bam	<NA>	Unterländer et al. 2017 Data	Metadata
Pr11	IASI	Iron Age	Russia	U	-500	-200	T1a	bam	<NA>	Unterländer et al. 2017 Data	Metadata
I7689	BAIB	Bronze Age	Portugal	F	-2200	-1700	H1+16311	bam	11.10	Olalde et al. 2019 Data	FASTA Metadata
Szegvar-Oromdulo/412/anc5	MAHu	Middle Ages	Hungary	F	900	1100	K1c1d	bam	303.00	Neparáczki et al. 2018 Data	Metadata
I4917	HGS	Mesolithic	Serbia	F	-6220	-5995	U5a1c	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 7080C (MT-CO1): Prostate Cancer (Reported)
I7687	BAIB	Bronze Age	Portugal	M	-1200	-700	V	bam	44.70	Olalde et al. 2019 Data	FASTA Metadata
I0659	LBK	Neolithic	Germany	M	-5211	-4963	N1a1a2	bam	<NA>	Lipson et al. 2017 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 3336C (MT-ND1): Carotid atherosclerosis risk (Reported) 669C (MT-RNR1): DEAF (Reported)
I3209	MEIB	Mesolithic	Spain	M	-5976	-5783	U5b1d1	bam	4.47	Olalde et al. 2019 Data	FASTA Metadata
I0821	LBK	Neolithic	Germany	M	-5201	-4850	X2d1	bam	<NA>	Lipson et al. 2017 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported)
WEHR_1415adult	EBAGe	Bronze Age	Germany	F	-2008	-1883	H13a2b2a	reconstructed	559.50	Knipper et al. 2017 Data	FASTA Metadata
I5402	HGS	Mesolithic	Serbia	M	-6361	-6050	U5a1c1	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I0843	MEIB	Mesolithic	Spain	M	6010	-5796	U5b2c1	bam	138.00	Olalde et al. 2019 Data	FASTA Metadata
I8130	MEIB	Mesolithic	Spain	M	-6061	-5934	U5b2b	bam	15.00	Olalde et al. 2019 Data	FASTA Metadata
Szegvar-Oromdulo/593/anc6	MAHu	Middle Ages	Hungary	F	900	1100	U5a2a1b	bam	23.00	Neparáczki et al. 2018 Data	Metadata
Karos1/13	MAHu	Middle Ages	Hungary	M	890	950	U5b2b3	bam	10.00	Neparáczki et al. 2018 Data	Metadata
I10899	MEIB	Mesolithic	Spain	M	-9700	-5500	U5b1	bam	112.70	Olalde et al. 2019 Data	FASTA Metadata
Karos1/10	MAHu	Middle Ages	Hungary	M	890	950	U3b1b	bam	123.00	Neparáczki et al. 2018 Data	Metadata
Karos1/12	MAHu	Middle Ages	Hungary	U	890	950	U2e1b1	bam	198.00	Neparáczki et al. 2018 Data	Metadata
I12410	IAIB	Iron Age	Spain	M	-515	-375	H	bam	648.40	Olalde et al. 2019 Data	FASTA Metadata
Karos1/3285	MAHu	Middle Ages	Hungary	F	890	950	K1c1	bam	26.00	Neparáczki et al. 2018 Data	Metadata
Karos1/3	MAHu	Middle Ages	Hungary	M	890	950	D4j12	bam	74.00	Neparáczki et al. 2018 Data	Metadata
I12640	IAIB	Iron Age	Spain	M	-696	-540	H1t	bam	16.57	Olalde et al. 2019 Data	FASTA Metadata
Karos2/1	MAHu	Middle Ages	Hungary	F	890	950	D4c2a	bam	16.00	Neparáczki et al. 2018 Data	Metadata
Karos1/5	MAHu	Middle Ages	Hungary	U	890	950	D4j12	bam	96.00	Neparáczki et al. 2018 Data	Metadata
Karos1/7	MAHu	Middle Ages	Hungary	M	890	950	Y1a1	bam	11.00	Neparáczki et al. 2018 Data	Metadata
I12641	IAIB	Iron Age	Spain	M	-791	-540	HV0d	bam	62.06	Olalde et al. 2019 Data	FASTA Metadata
Karos2/13	MAHu	Middle Ages	Hungary	U	890	950	T1a1	bam	298.00	Neparáczki et al. 2018 Data	Metadata
Karos2/11	MAHu	Middle Ages	Hungary	M	890	950	D2	bam	253.00	Neparáczki et al. 2018 Data	Metadata
Karos2/12	MAHu	Middle Ages	Hungary	U	890	950	U3b2	bam	40.00	Neparáczki et al. 2018 Data	Metadata
I12877	IAIB	Iron Age	Spain	M	-515	-375	J1c1	bam	41.54	Olalde et al. 2019 Data	FASTA Metadata
I12878	IAIB	Iron Age	Spain	F	-507	-366	H3	bam	74.15	Olalde et al. 2019 Data	FASTA Metadata
Karos2/17	MAHu	Middle Ages	Hungary	U	890	950	J1c2	bam	793.00	Neparáczki et al. 2018 Data	Metadata
Karos2/16	MAHu	Middle Ages	Hungary	M	890	950	X2l	bam	27.00	Neparáczki et al. 2018 Data	Metadata
Karos2/20	MAHu	Middle Ages	Hungary	M	890	950	C4b	bam	20.00	Neparáczki et al. 2018 Data	Metadata
I3320	IAIB	Iron Age	Spain	M	-300	-100	I1	bam	1554.92	Olalde et al. 2019 Data	FASTA Metadata
Karos2/19	MAHu	Middle Ages	Hungary	F	890	950	J1b1a1e	bam	45.00	Neparáczki et al. 2018 Data	Metadata
Karos2/2	MAHu	Middle Ages	Hungary	M	890	950	H5v	bam	71.00	Neparáczki et al. 2018 Data	Metadata
I3323	IAIB	Iron Age	Spain	M	-365	-204	X2b	bam	424.54	Olalde et al. 2019 Data	FASTA Metadata
Karos2/25	MAHu	Middle Ages	Hungary	U	890	950	F1a2	bam	31.00	Neparáczki et al. 2018 Data	Metadata
I1550	LBK	Neolithic	Germany	F	-5500	-4850	K1a2	bam	<NA>	Lipson et al. 2017 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
Karos2/23	MAHu	Middle Ages	Hungary	F	890	950	T1a1	bam	14.00	Neparáczki et al. 2018 Data	Metadata
I4556	IAIB	Iron Age	Spain	F	-700	-500	K1a12a	bam	1347.94	Olalde et al. 2019 Data	FASTA Metadata
Karos2/30	MAHu	Middle Ages	Hungary	U	890	950	K1f	bam	10.00	Neparáczki et al. 2018 Data	Metadata
Karos2/29	MAHu	Middle Ages	Hungary	M	890	950	J1b1a1e	bam	100.00	Neparáczki et al. 2018 Data	Metadata
I3758	IAIB	Iron Age	Spain	F	-365	-204	U5b1+16189+@16192	bam	34.46	Olalde et al. 2019 Data	FASTA Metadata
Karos2/36	MAHu	Middle Ages	Hungary	M	890	950	D4i2	bam	34.00	Neparáczki et al. 2018 Data	Metadata
Karos2/32	MAHu	Middle Ages	Hungary	F	890	950	T1a1	bam	27.00	Neparáczki et al. 2018 Data	Metadata
Karos2/33	MAHu	Middle Ages	Hungary	M	890	950	U4a1b1	bam	21.00	Neparáczki et al. 2018 Data	Metadata
Karos2/47	MAHu	Middle Ages	Hungary	F	890	950	U4a1b1	bam	23.00	Neparáczki et al. 2018 Data	Metadata
I3757	IAIB	Iron Age	Spain	F	-400	-300	J1c1	bam	303.53	Olalde et al. 2019 Data	FASTA Metadata
Karos2/41	MAHu	Middle Ages	Hungary	M	890	950	H35	bam	30.00	Neparáczki et al. 2018 Data	Metadata
Karos2/44	MAHu	Middle Ages	Hungary	F	890	950	H2a1n	bam	14.00	Neparáczki et al. 2018 Data	Metadata
I12642	IAIB	Iron Age	Spain	F	-731	-399	H	bam	168.00	Olalde et al. 2019 Data	FASTA Metadata
Karos2/52	MAHu	Middle Ages	Hungary	M	890	950	X2f	bam	42.00	Neparáczki et al. 2018 Data	Metadata
Karos2/51	MAHu	Middle Ages	Hungary	M	890	950	U4d2	bam	77.00	Neparáczki et al. 2018 Data	Metadata
I3324	IAIB	Iron Age	Spain	M	-360	-193	H1	bam	577.00	Olalde et al. 2019 Data	FASTA Metadata
Karos2/57	MAHu	Middle Ages	Hungary	U	890	950	T2b	bam	11.00	Neparáczki et al. 2018 Data	Metadata
I5408	HGS	Mesolithic	Romania	M	-6000	-5000	K1c	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
Karos2/56	MAHu	Middle Ages	Hungary	F	890	950	D4i2	bam	71.00	Neparáczki et al. 2018 Data	Metadata
I3326	IAIB	Iron Age	Spain	M	-250	-200	J1c	bam	34.02	Olalde et al. 2019 Data	FASTA Metadata
Karos2/61	MAHu	Middle Ages	Hungary	M	890	950	U4d2	bam	38.00	Neparáczki et al. 2018 Data	Metadata
Karos2/6	MAHu	Middle Ages	Hungary	U	890	950	H5v	bam	43.00	Neparáczki et al. 2018 Data	Metadata
Karos2/60	MAHu	Middle Ages	Hungary	M	890	950	N1a1a1a1a	bam	8.00	Neparáczki et al. 2018 Data	Metadata
I3321	IAIB	Iron Age	Spain	M	-300	-100	U3a1	bam	82.81	Olalde et al. 2019 Data	FASTA Metadata
Karos2/71	MAHu	Middle Ages	Hungary	F	890	950	H11a1	bam	45.00	Neparáczki et al. 2018 Data	Metadata
Karos2/70	MAHu	Middle Ages	Hungary	F	890	950	X2c1	bam	16.00	Neparáczki et al. 2018 Data	Metadata
I8142	CAIB	Copper Age	Spain	M	-2200	-2000	U5b1i	bam	31.50	Olalde et al. 2019 Data	Metadata
I3496	IAIB	Iron Age	Spain	M	-300	-200	H1	bam	105.28	Olalde et al. 2019 Data	FASTA Metadata
Karos2/9	MAHu	Middle Ages	Hungary	M	890	950	N1a1a1a1a	bam	20.00	Neparáczki et al. 2018 Data	Metadata
Karos2/73	MAHu	Middle Ages	Hungary	U	890	950	D4b2a	bam	10.00	Neparáczki et al. 2018 Data	Metadata
Karos2/8	MAHu	Middle Ages	Hungary	U	890	950	K1c1e	bam	60.00	Neparáczki et al. 2018 Data	Metadata
I12561	IAIB	Iron Age	Spain	M	-700	-500	H1	bam	3.15	Olalde et al. 2019 Data	FASTA Metadata
Karos3/12	MAHu	Middle Ages	Hungary	M	890	950	A12	bam	850.00	Neparáczki et al. 2018 Data	Metadata
Karos3/10	MAHu	Middle Ages	Hungary	M	890	950	H5e1	bam	14.00	Neparáczki et al. 2018 Data	Metadata
Karos3/11	MAHu	Middle Ages	Hungary	M	890	950	X2f	bam	241.00	Neparáczki et al. 2018 Data	Metadata
Karos3/16	MAHu	Middle Ages	Hungary	U	890	950	U5a1a2a	bam	24.00	Neparáczki et al. 2018 Data	Metadata
Karos3/15	MAHu	Middle Ages	Hungary	F	890	950	J2a1	bam	115.00	Neparáczki et al. 2018 Data	Metadata
Karos3/3	MAHu	Middle Ages	Hungary	M	890	950	H6a1b	bam	32.00	Neparáczki et al. 2018 Data	Metadata
I2467	CAIB	Copper Age	Spain	M	-2481	-2212	X2	bam	132.00	Lipson et al. 2017 Data	FASTA Metadata
I0795	LBK	Neolithic	Germany	M	-5217	-5041	H1 or H1au1b	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
Karos3/7	MAHu	Middle Ages	Hungary	U	890	950	U2e1b	bam	62.00	Neparáczki et al. 2018 Data	Metadata
I12514	MAIB	Middle Ages	Spain	M	1020	1155	HV0+195	bam	402.70	Olalde et al. 2019 Data	FASTA Metadata
Karos3/5	MAHu	Middle Ages	Hungary	U	890	950	B4d1	bam	100.00	Neparáczki et al. 2018 Data	Metadata
Karos3/6	MAHu	Middle Ages	Hungary	U	890	950	B4d1	bam	506.00	Neparáczki et al. 2018 Data	Metadata
Karos3/9	MAHu	Middle Ages	Hungary	F	890	950	U2e1b	bam	1452.00	Neparáczki et al. 2018 Data	Metadata
Kenezlo-Fazekaszug2/1025	MAHu	Middle Ages	Hungary	M	900	1000	G2a1	bam	95.00	Neparáczki et al. 2018 Data	Metadata
I12515	MAIB	Middle Ages	Spain	M	1000	1200	H3	bam	221.60	Olalde et al. 2019 Data	FASTA Metadata
WEHR_1415child	EBAGe	Bronze Age	Germany	M	-2021	-1893	H13a2b2a	reconstructed	2022.20	Knipper et al. 2017 Data	FASTA Metadata
I8149	CAIB	Copper Age	Spain	F	-2900	-2500	T	bam	16.00	Olalde et al. 2019 Data	FASTA Metadata
I12644	MAIB	Middle Ages	Spain	M	1100	1300	U4a2	bam	212.70	Olalde et al. 2019 Data	FASTA Metadata
Kenezlo-Fazekaszug2/1041	MAHu	Middle Ages	Hungary	F	900	1000	N1a1a1a1a	bam	142.00	Neparáczki et al. 2018 Data	Metadata
I8153	CAIB	Copper Age	Spain	M	-2900	-2500	J2b1a1	bam	46.20	Olalde et al. 2019 Data	FASTA Metadata
Kenezlo-Fazekaszug2/1044	MAHu	Middle Ages	Hungary	M	900	1000	U5a1i	bam	212.00	Neparáczki et al. 2018 Data	Metadata
Kenezlo-Fazekaszug2/1045	MAHu	Middle Ages	Hungary	M	900	1000	N1a1a1a1a	bam	164.00	Neparáczki et al. 2018 Data	Metadata
Kenezlo-Fazekaszug2/10936	MAHu	Middle Ages	Hungary	F	900	1000	C4b	bam	107.00	Neparáczki et al. 2018 Data	Metadata
I0797	LBK	Neolithic	Germany	M	-5500	-4850	H46b	bam	<NA>	Mathieson et al. 2015 Data	FASTA Metadata
I8157	CAIB	Copper Age	Spain	M	-2900	-2500	HV0+195	bam	20.30	Olalde et al. 2019 Data	FASTA Metadata
I8156	CAIB	Copper Age	Spain	M	-2900	-2500	K1a4a1	bam	24.70	Olalde et al. 2019 Data	FASTA Metadata
I8048	CAIB	Copper Age	Spain	M	-2200	-2000	U5b1	bam	17.60	Olalde et al. 2019 Data	FASTA Metadata
I5233	HGS	Mesolithic	Serbia	F	-6224	-5878	U5b1d1	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I8365	CAIB	Copper Age	Spain	M	-2706	-2569	H	bam	109.00	Olalde et al. 2019 Data	FASTA Metadata
I11592	CAIB	Copper Age	Portugal	M	-2800	-2600	U5b2b	bam	157.90	Olalde et al. 2019 Data	FASTA Metadata
I12645	MAIB	Middle Ages	Spain	F	1100	1300	U5b1f1a	bam	96.09	Olalde et al. 2019 Data	FASTA Metadata
ARS001	LBAMo	Bronze Age	Mongolia	M	-1046	-820	D4	<NA>	1.53	Jeong et al. 2018 Data	Metadata
ARS002	LBAMo	Bronze Age	Mongolia	U	-1259	-936	D4j5	<NA>	0.89	Jeong et al. 2018 Data	Metadata
I0054	LBK	Neolithic	Germany	F	-5223	-5021	J1c17	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
I8045	BAIB	Bronze Age	Portugal	F	-1700	-1300	U5b	bam	3.32	Olalde et al. 2019 Data	FASTA Metadata
I5234	HGS	Mesolithic	Serbia	F	-9500	-6200	U4a	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 499A (MT-CR): Endometriosis (Reported)
I12648	MAIB	Middle Ages	Spain	M	1100	1300	H1	bam	68.99	Olalde et al. 2019 Data	FASTA Metadata
I11604	CAIB	Copper Age	Portugal	M	-3100	-2500	K1a1	bam	142.70	Olalde et al. 2019 Data	FASTA Metadata
I8141	CAIB	Copper Age	Spain	F	-2200	-2000	K1a1b1	bam	41.60	Olalde et al. 2019 Data	FASTA Metadata
I5235	HGS	Mesolithic	Serbia	M	-9221	-8548	U5b2c	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I8148	CAIB	Copper Age	Spain	M	-2900	-2500	T2b3+151	bam	18.40	Olalde et al. 2019 Data	FASTA Metadata
I0022	LBK	Neolithic	Germany	F	-5500	-4850	T2e	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I8150	CAIB	Copper Age	Spain	F	-2900	-2500	J1c3	bam	8.86	Olalde et al. 2019 Data	FASTA Metadata
ARS003	LBAMo	Bronze Age	Mongolia	M	-1421	-1128	U5a2d1	<NA>	0.19	Jeong et al. 2018 Data	Metadata
ARS004	LBAMo	Bronze Age	Mongolia	M	-1207	-901	F2a	<NA>	0.57	Jeong et al. 2018 Data	Metadata
WEHR_1474	EBAGe	Bronze Age	Germany	M	-2029	-1916	V	reconstructed	1314.30	Knipper et al. 2017 Data	FASTA Metadata
I7457	MAIB	Middle Ages	Spain	M	1100	1300	H3+152	bam	201.00	Olalde et al. 2019 Data	FASTA Metadata
I7458	MAIB	Middle Ages	Spain	U	1100	1300	H3ap	bam	139.00	Olalde et al. 2019 Data	FASTA Metadata
I0025	LBK	Neolithic	Germany	F	-5500	-4850	T2b	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I3493	BAIB	Bronze Age	Spain	F	-1420	-1283	H1	bam	94.90	Olalde et al. 2019 Data	FASTA Metadata
ARS006	LBAMo	Bronze Age	Mongolia	F	-1206	-919	C4a1a+195	<NA>	1.43	Jeong et al. 2018 Data	Metadata
WEHR_1564	EBAGe	Bronze Age	Germany	M	-2020	-1892	V	reconstructed	2467.10	Knipper et al. 2017 Data	FASTA Metadata
I2469	BAIB	Bronze Age	Spain	F	-910	-840	H3an	bam	81.30	Olalde et al. 2019 Data	FASTA Metadata
I5238	HGS	Mesolithic	Serbia	F	-8265	-7820	K1c	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13967T (MT-ND5): Possible LHON factor (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
ARS007	LBAMo	Bronze Age	Mongolia	M	-1388	-1055	A+152+16362	<NA>	1.66	Jeong et al. 2018 Data	Metadata
I8569	CAIB	Copper Age	Spain	M	-2871	-2626	H1ah	bam	71.40	Olalde et al. 2019 Data	FASTA Metadata
I0026	LBK	Neolithic	Germany	F	-5500	-4850	T2b	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I7500	MAIB	Middle Ages	Spain	M	900	1100	M1b1a	bam	8.83	Olalde et al. 2019 Data	FASTA Metadata
I12646	MAIB	Middle Ages	Spain	M	1100	1300	K2b1a1	bam	132.80	Olalde et al. 2019 Data	FASTA Metadata
DA124	MAKa	Middle Ages	Kazakhstan	M	654	689	HV19	bam	116.36	de Barros Damgaard et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
VAD004	BAIB	Bronze Age	Spain	M	-1673	-1255	J1c3	bam	<NA>	Olalde et al. 2019 Data	Metadata
VAD005	BAIB	Bronze Age	Spain	M	-1742	-1546	J2b1a2	bam	<NA>	Olalde et al. 2019 Data	Metadata
I5240	HGS	Mesolithic	Serbia	M	-9140	-8570	U5a1c	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 7080C (MT-CO1): Prostate Cancer (Reported)
I4563	BAIB	Bronze Age	Spain	M	-1700	-1500	H84	bam	310.43	Olalde et al. 2019 Data	FASTA Metadata
I0176	LBK	Neolithic	Hungary	F	-5207	-4944	N1a1a1a3	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 16300G (MT-CR): BD-associated (Reported) 3336C (MT-ND1): Carotid atherosclerosis risk (Reported) 669C (MT-RNR1): DEAF (Reported)
I4562	BAIB	Bronze Age	Spain	F	-1738	-1623	H1	bam	193.00	Olalde et al. 2019 Data	FASTA Metadata
Ampack_1	BBC	Bronze Age	Germany	M	-2476	-2310	T2b33	reconstructed	1897.40	Knipper et al. 2017 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
ARS011	LBAMo	Bronze Age	Mongolia	M	-1278	-979	None	<NA>	0.11	Jeong et al. 2018 Data	Metadata
I5242	HGS	Mesolithic	Serbia	F	-8805	-8355	U5a1	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I10940	BAIB	Bronze Age	Gibraltar	M	-1900	-1400	H1e1a	bam	10.30	Olalde et al. 2019 Data	FASTA Metadata
RISE371	BAHu	Bronze Age	Hungary	F	-2136	-1941	U5a2b	bam	<NA>	Allentoft et al. 2015 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I3759	IAIB	Iron Age	Spain	M	-361	-195	H1	bam	291.00	Olalde et al. 2019 Data	FASTA Metadata
ARS012	LBAMo	Bronze Age	Mongolia	F	-1410	-1126	C4a2a1	<NA>	0.29	Jeong et al. 2018 Data	Metadata
I3327	IAIB	Iron Age	Spain	M	-250	-200	J2b1a	bam	411.17	Olalde et al. 2019 Data	FASTA Metadata
poz211	CAUk	Copper Age	Ukraine	M	-2898	-2761	U5a2b	reconstructed	11.00	Juras et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 8393T (MT-ATP8): Reversible brain pseudoatrophy (Reported)
DA92	IAST	Iron Age	Kazakhstan	M	-37	-28	J1b1a1+146	bam	313.88	de Barros Damgaard et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 146C (MT-CR): Absence of Endometriosis (Reported) 295T (MT-CR): Low VO2max response (Reported) 2158C (MT-RNR2): Reduced risk PD (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
ARS013	LBAMo	Bronze Age	Mongolia	F	-1442	-1208	C	<NA>	0.14	Jeong et al. 2018 Data	Metadata
I12879	IAIB	Iron Age	Spain	F	-728	-397	HV0+195	bam	364.70	Olalde et al. 2019 Data	FASTA Metadata
RISE373	BAHu	Bronze Age	Hungary	F	-1886	-1696	K1a2a	bam	<NA>	Allentoft et al. 2015 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I5244	HGS	Mesolithic	Serbia	F	-9115	-8555	K1f	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
ARS014	LBAMo	Bronze Age	Mongolia	F	-1412	-1127	C4a2c1	<NA>	0.36	Jeong et al. 2018 Data	Metadata
I12643	IAIB	Iron Age	Spain	F	-758	-429	J2a1a1c	bam	46.63	Olalde et al. 2019 Data	FASTA Metadata
I12560	IAIB	Iron Age	Spain	F	-700	-500	H4a1	bam	3.98	Olalde et al. 2019 Data	FASTA Metadata
I12173	IAIB	Iron Age	Spain	F	-700	-500	T2b23	bam	3.14	Olalde et al. 2019 Data	FASTA Metadata
I8212	CLIB	Classical Age	Spain	M	-500	-350	H27+16093	bam	15.40	Olalde et al. 2019 Data	FASTA Metadata
I8214	CLIB	Classical Age	Spain	F	-400	-350	H3+152	bam	98.50	Olalde et al. 2019 Data	FASTA Metadata
I8215	CLIB	Classical Age	Spain	F	-400	-350	HV11	bam	51.60	Olalde et al. 2019 Data	FASTA Metadata
I0011	HGN	Mesolithic	Sweden	F	-5721	-5516	U5a1	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
I8339	CLIB	Classical Age	Spain	F	100	200	K1a+195	bam	83.60	Olalde et al. 2019 Data	FASTA Metadata
I8475	CLIB	Classical Age	Spain	F	100	200	T2b	bam	83.70	Olalde et al. 2019 Data	FASTA Metadata
ARS015	LBAMo	Bronze Age	Mongolia	M	-1429	-1130	G3a	<NA>	0.63	Jeong et al. 2018 Data	Metadata
I6490	CLIB	Classical Age	Spain	F	200	500	K1c2	bam	132.00	Olalde et al. 2019 Data	FASTA Metadata
I4560	BAIB	Bronze Age	Spain	F	-1700	-1500	K1a3a	bam	580.57	Olalde et al. 2019 Data	FASTA Metadata
I3778	MAIB	Middle Ages	Spain	M	600	700	H4a1	bam	235.00	Olalde et al. 2019 Data	FASTA Metadata
I4657	HGS	Mesolithic	Serbia	F	-9755	-9275	K1c	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I3775	MAIB	Middle Ages	Spain	M	600	700	H3t	bam	59.90	Olalde et al. 2019 Data	FASTA Metadata
I3777	MAIB	Middle Ages	Spain	F	600	700	V17	bam	142.00	Olalde et al. 2019 Data	FASTA Metadata
DA194	SCHu	Iron Age	Hungary	F	-408	-369	H2a2a1	bam	4.33	de Barros Damgaard et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 15924G (MT-TT): LIMM (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
ARS016	LBAMo	Bronze Age	Mongolia	M	-1606	-1298	A+152+16362+16189	<NA>	3.65	Jeong et al. 2018 Data	Metadata
I12031	MAIB	Middle Ages	Spain	M	500	600	H1e2	bam	216.10	Olalde et al. 2019 Data	FASTA Metadata
I0012	HGN	Mesolithic	Sweden	M	-5714	-5575	U2e1	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported)
I12162	MAIB	Middle Ages	Spain	M	500	600	U5b1b1d	bam	134.60	Olalde et al. 2019 Data	FASTA Metadata
I12033	MAIB	Middle Ages	Spain	M	500	600	V	bam	174.70	Olalde et al. 2019 Data	FASTA Metadata
poz212	BAUk	Bronze Age	Ukraine	F	-3022	-2918	R11’B6	reconstructed	11.00	Juras et al. 2018 Data	FASTA Metadata
I12171	IAIB	Iron Age	Spain	F	-700	-500	J1c1b	bam	35.60	Olalde et al. 2019 Data	FASTA Metadata
I4660	HGS	Mesolithic	Serbia	F	-7940	-7585	U8b1b	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
DA222	MAKa	Middle Ages	Kazakhstan	M	750	950	A+152+16362	bam	586.30	de Barros Damgaard et al. 2018 Data	FASTA Metadata	1095C (MT-RNR1): SNHL (Unclear) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 663G (MT-RNR1): Coronary atherosclerosis risk (Reported)
I0409	NEIB	Neolithic	Spain	F	-5311	-5218	J1c3	bam	521.13	Haak et al. 2015 Data	FASTA Metadata
I0015	HGN	Mesolithic	Sweden	M	-5964	-5629	U5a2d	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 6480A (MT-CO1): Prostate Cancer / enriched in POAG cohort (Reported)
ARS018	LBAMo	Bronze Age	Mongolia	M	-1188	-846	B5b1	<NA>	0.11	Jeong et al. 2018 Data	Metadata
I4054	CAIB	Classical Age	Spain	M	200	400	H4a1c2	bam	98.00	Olalde et al. 2019 Data	FASTA Metadata
I3579	MAIB	Middle Ages	Spain	M	400	600	H1e1a6	bam	183.00	Olalde et al. 2019 Data	FASTA Metadata
I4870	HGS	Mesolithic	Serbia	M	-7045	-6535	K1c	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 146C (MT-CR): Absence of Endometriosis (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I3578	MAIB	Middle Ages	Spain	F	400	600	HV0f	bam	281.00	Olalde et al. 2019 Data	FASTA Metadata
I0017	HGN	Mesolithic	Sweden	M	-5721	-5631	U2e1	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported)
I3585	MAIB	Middle Ages	Spain	M	677	866	H1	bam	400.00	Olalde et al. 2019 Data	FASTA Metadata
I7498	MAIB	Middle Ages	Spain	M	1000	1100	H3a1	bam	88.50	Olalde et al. 2019 Data	FASTA Metadata
I7427	MAIB	Middle Ages	Spain	M	900	1000	H1+16189	bam	127.40	Olalde et al. 2019 Data	FASTA Metadata
poz213	BAB	Copper Age	Ukraine	F	-2117	-1950	J1c2m	reconstructed	32.00	Juras et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
I8146	MAIB	Middle Ages	Spain	F	1300	1500	H3a1	bam	120.00	Olalde et al. 2019 Data	FASTA Metadata
I8147	MAIB	Middle Ages	Spain	U	1300	1500	H1	bam	3.14	Olalde et al. 2019 Data	FASTA Metadata
I3809	MAIB	Middle Ages	Spain	M	1500	1600	U6a3b	bam	46.05	Olalde et al. 2019 Data	FASTA Metadata
I7424	MAIB	Middle Ages	Spain	F	1500	1600	U5b1+16189+@16192	bam	116.00	Olalde et al. 2019 Data	FASTA Metadata
I4871	HGS	Mesolithic	Serbia	F	-7100	-5900	U5b2a1a	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16192T (MT-CR): Melanoma patients (Reported)
I12647	MAIB	Middle Ages	Spain	F	1100	1300	H1ak1	bam	151.60	Olalde et al. 2019 Data	FASTA Metadata
I12649	MAIB	Middle Ages	Spain	M	1100	1300	H13a1a	bam	168.50	Olalde et al. 2019 Data	FASTA Metadata
I12516	MAIB	Middle Ages	Spain	F	901	1116	U5b2b2	bam	147.10	Olalde et al. 2019 Data	FASTA Metadata
I0371	BARu	Bronze Age	Russia	M	-2872	-2583	U2d2	bam	<NA>	Mathieson et al. 2015 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16183C (MT-CR): Melanoma patients (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports) 8296G (MT-TK): DMDF / MERRF / HCM / epilepsy (Reported)
CL53	LONG	Middle Ages	Italy	M	570	880	H11a	reconstructed	3.72	Amorim et al. 2018 Data	FASTA Metadata	961G (MT-RNR1): Possibly DEAF-associated (Unclear)
ARS026	LBAMo	Bronze Age	Mongolia	M	-1126	-898	C4a1a+195	bam	4.87	Jeong et al. 2018 Data	Metadata
I4873	HGS	Mesolithic	Serbia	F	-6006	-5838	U5a2a	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 16390A (MT-CR): POAG - potential for association (Reported)
CL84	LONG	Middle Ages	Italy	M	570	880	H1t	reconstructed	15.43	Amorim et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I0126	BARu	Bronze Age	Russia	M	-2867	-2486	H6a2	bam	<NA>	Mathieson et al. 2015 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
CL87	LONG	Middle Ages	Italy	F	570	880	H1	reconstructed	18.30	Amorim et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
Kunila1	CWC	Neolithic	Estonia	M	-2850	-2050	U5b1b	bam	58.67	Saag et al. 2017 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
STR_241	MAGe	Middle Ages	Germany	M	480	510	H1	bam	220.45	Veeramah et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported)
ARS025	LBAMo	Bronze Age	Mongolia	M	-1427	-1134	D4b1a2a	<NA>	0.17	Jeong et al. 2018 Data	Metadata
STR_491	MAGe	Middle Ages	Germany	M	510	530	T2b	bam	234.94	Veeramah et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I0440	BARu	Bronze Age	Russia	M	-2887	-2666	I3a	bam	<NA>	Mathieson et al. 2015 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 15924G (MT-TT): LIMM (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
JK2127	CLNE	Classical Age	Egypt	F	-358	-208	W6	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
Iboussieres25-1	HGW	Epipaleolithic	France	M	-10090	-9460	U5b2a	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I0374	BARu	Bronze Age	Russia	M	-2800	-2200	H13a1a	bam	<NA>	Mathieson et al. 2015 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I4874	HGS	Mesolithic	Serbia	F	-6636	-6476	U5b2a1a	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I4876	HGS	Mesolithic	Serbia	F	-6635	-6375	U5a2d	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
SZ2	LONG	Middle Ages	Hungary	M	412	604	T1a1	reconstructed	132.84	Amorim et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
SZ15	LONG	Middle Ages	Hungary	M	412	604	H1c1	reconstructed	143.03	Amorim et al. 2018 Data	FASTA Metadata	13528G (MT-ND5): LHON-like / LHON / MELAS (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported)
I4877	HGS	Mesolithic	Serbia	F	-6645	-6465	U5b1d1	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I0246	BARu	Bronze Age	Russia	M	-2469	-1928	C1	bam	<NA>	Mathieson et al. 2015 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 3552A (MT-ND1): Resistance to high altitude pulmonary edema (HAPE) (Reported /hg C marker) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 489C (MT-CR): Low VO2max response (Reported)
arm14	MACA	Middle Ages	Armenia	U	1700	1800	U1a1a	fasta	28.60	Margaryan et al. 2017 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 228A (MT-CR): Low VO2max response (Reported)
Sope	CWC	Neolithic	Estonia	F	-2625	-2400	H5a1	bam	90.48	Saag et al. 2017 Data	FASTA Metadata	4336C (MT-TQ): ADPD / Hearing Loss & Migraine / autism spectrum / intellectual disability (Unclear)
arm23	BACA	Bronze Age	Armenia	U	-1500	-1300	R1a1a	fasta	70.10	Margaryan et al. 2017 Data	FASTA Metadata	1391C (MT-RNR1): found in 1 HCM patient (Reported) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I4878	HGS	Mesolithic	Serbia	M	-5995	-5710	U4a	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 499A (MT-CR): Endometriosis (Reported)
I1152	CANE	Copper Age	Israel	F	-4500	-3900	J2a2d	<NA>	1.14	Harney et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 15257A (MT-CYB): LHON (Conflicting reports) 195C (MT-CR): BD-associated / melanoma pts (Reported) 295T (MT-CR): Low VO2max response (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 489C (MT-CR): Low VO2max response (Reported)
poz214	CAUk	Copper Age	Ukraine	M	-2863	-2630	H2a1	reconstructed	58.00	Juras et al. 2018 Data	FASTA Metadata	3090A (MT-RNR2): Myopathy (Reported)
I3322	IAIB	Iron Age	Spain	F	-600	-500	H1t	bam	632.00	Olalde et al. 2019 Data	FASTA Metadata
I0418	BARu	Bronze Age	Russia	F	-2125	-1769	T1a1	bam	<NA>	Mathieson et al. 2015 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I1180	CANE	Copper Age	Israel	M	-4500	-3900	T	<NA>	0.09	Harney et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
LIAV_32	IAIt	Iron Age	Italy	U	-700	-300	H	reconstructed	32.20	Emery et al. 2018 Data	FASTA Metadata	16176T (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported)
JK2128	CLNE	Classical Age	Egypt	M	-185	-107	HV21	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
I0419	BARu	Bronze Age	Russia	M	-2200	-1900	U2e1h	bam	<NA>	Mathieson et al. 2015 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16183C (MT-CR): Melanoma patients (Reported) 228A (MT-CR): Low VO2max response (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
LIAV_40	IAIt	Iron Age	Italy	U	-700	-300	H	reconstructed	37.10	Emery et al. 2018 Data	FASTA Metadata	16176T (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported)
JK2130	CLNE	Classical Age	Egypt	F	91	212	M1a1	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
I0122	YAM	Bronze Age	Russia	M	-5200	-4000	H2a1	bam	<NA>	Mathieson et al. 2015 Data	FASTA Metadata	15168A (MT-CYB): EXIT (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 3551T (MT-ND1): LHON (Reported) 602T (MT-TF): Axial myopathy with encephalopathy (Reported) 6285A (MT-CO1): Prostate Cancer (Reported)
I0050	CWC	Neolithic	Germany	U	-2800	-2050	U5a2d	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I0434	YAM	Bronze Age	Russia	M	-5200	-4000	U4a2 or U4d	bam	<NA>	Mathieson et al. 2015 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 499A (MT-CR): Endometriosis (Reported)
I4880	HGS	Mesolithic	Serbia	M	-6000	-5725	U4b1b1	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I0247	SCR	Iron Age	Russia	M	-375	-203	G2a4	bam	<NA>	Mathieson et al. 2015 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4833G (MT-ND2): Diabetes helper mutation AD / PD (Reported) 489C (MT-CR): Low VO2max response (Reported)
RISE395	BARu	Bronze Age	Russia	F	-1960	-1756	U2e1h	bam	<NA>	Allentoft et al. 2015 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16183C (MT-CR): Melanoma patients (Reported) 228A (MT-CR): Low VO2max response (Reported)
MS10622	IASp	Iron Age	Spain	U	-400	-400	H3	fasta	29.36	Zalloua et al. 2018 Data	FASTA Metadata	14577C (MT-ND6): MIDM (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports)
poz221	CAT	Bronze Age	Ukraine	F	-2548	-2348	X4	reconstructed	114.00	Juras et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 16183C (MT-CR): Melanoma patients (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 16390A (MT-CR): POAG - potential for association (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9438A (MT-CO3): LHON / gout (Conflicting reports)
I4881	HGS	Mesolithic	Serbia	M	-6570	-6255	U4b1b1	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
RISE386	BARu	Bronze Age	Russia	M	-2298	-2045	J1c1b1a	bam	<NA>	Allentoft et al. 2015 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 3394C (MT-ND1): LHON / Diabetes / CPTdeficiency / high altitude adaptation (Reported / Population-dependent) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
poz222	YAM	Bronze Age	Ukraine	F	-3023	-2911	W3a1	reconstructed	15.60	Juras et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15784C (MT-CYB): POAG - potential for association (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports) 6267A (MT-CO1): Prostate Cancer (Reported)
I5772	HGS	Mesolithic	Serbia	M	-7100	-5900	U5a2a	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
RISE394	BARu	Bronze Age	Russia	F	-1949	-1754	U2e1e	bam	<NA>	Allentoft et al. 2015 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16183C (MT-CR): Melanoma patients (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported)
JK2131	CLNE	Classical Age	Egypt	F	-749	-517	U3b	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
I1390	BBC	Copper Age	France	M	-2480	-2210	X2b4a	bam	177.87	Olalde et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 15927A (MT-TT): LHON / Multiple Sclerosis / DEAF1555 increased penetrance / CHD (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 8393T (MT-ATP8): Reversible brain pseudoatrophy (Reported)
RISE391	BAKa	Bronze Age	Kazakhstan	F	-2120	-1887	N1a1a1a1	bam	<NA>	Allentoft et al. 2015 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 3336C (MT-ND1): Carotid atherosclerosis risk (Reported) 669C (MT-RNR1): DEAF (Reported)
poz224	YAM	Bronze Age	Ukraine	U	-2847	-2574	U4c1	reconstructed	97.50	Juras et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 499A (MT-CR): Endometriosis (Reported)
I1391	BBC	Copper Age	France	F	-2396	-2060	J1c4	bam	295.00	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
I1507	LBK	Neolithic	Hungary	M	-5780	-5640	R1b1	bam	<NA>	Gamba et al. 2014 Data	FASTA Metadata
Kostenki14	HGE	Mesolithic	Russia	M	-36730	-34310	None	<NA>	<NA>	Fu et al. 2016 Data	Metadata
I0422	SRU	Bronze Age	Russia	F	-1850	-1200	T1a1	bam	<NA>	Mathieson et al. 2015 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
poz208	YAM	Bronze Age	Ukraine	U	-2882	-2698	W3a1a	reconstructed	42.00	Juras et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15784C (MT-CYB): POAG - potential for association (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
I2447	BBC	Bronze Age	Great Britain	M	-2115	-1910	K1a26	bam	706.72	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 16192T (MT-CR): Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I0679	NEBA	Neolithic	Bulgaria	F	-5718	-5626	H5	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
JK2132	CLNE	Classical Age	Egypt	M	83	208	T	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
I0234	SRU	Bronze Age	Russia	F	-1850	-1600	I1a1	bam	<NA>	Mathieson et al. 2015 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 15924G (MT-TT): LIMM (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported)
I4432	HGE	Mesolithic	Latvia	M	-6075	-5920	U5a2c	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
poz287	CWC	Neolithic	Poland	F	-2800	-2300	H6a	reconstructed	369.00	Juras et al. 2018 Data	FASTA Metadata
I4434	HGE	Mesolithic	Latvia	M	-5606	-5385	U5a2d	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I3587	BBC	Copper Age	Germany	U	-2300	-2150	H1e1a	bam	182.51	Olalde et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports) 8821G (MT-ATP6): Possible LHON helper variant (Reported)
I2568	BBC	Bronze Age	Great Britain	M	-2286	-2038	U5a1b1g	bam	714.76	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I4438	HGE	Mesolithic	Latvia	M	-5462	-5220	U4b1a2	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I3592	BBC	Copper Age	Germany	F	-2457	-2203	H+16129	bam	237.68	Olalde et al. 2018 Data	FASTA Metadata	16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I4439	HGE	Mesolithic	Latvia	M	-5763	-5633	U5b1d1	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I4132	BBC	Copper Age	Germany	M	-2500	-2000	U5a1a1	bam	187.21	Allentoft et al. 2015 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15924G (MT-TT): LIMM (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I0235	SRU	Bronze Age	Russia	F	-1850	-1600	K1b2a	bam	<NA>	Mathieson et al. 2015 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I4441	HGE	Mesolithic	Latvia	M	-4837	-4713	U5a1c	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
poz256	CWC	Neolithic	Czech Republic	U	-2600	-2200	U4b1a1a	reconstructed	71.00	Juras et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12297C (MT-TL2): Dilated Cardiomyopathy / Leigh Syndrome / Failure to Thrive & LA (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 499A (MT-CR): Endometriosis (Reported)
JK2133	CLNE	Classical Age	Egypt	U	-750	-525	X	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
I0430	SRU	Bronze Age	Russia	M	-1850	-1600	H3g	bam	<NA>	Mathieson et al. 2015 Data	FASTA Metadata
I4550	HGE	Mesolithic	Latvia	M	-6601	-6476	U5b2a1a	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
poz257	CWC	Neolithic	Czech Republic	U	-2600	-2200	I4a	reconstructed	64.00	Juras et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 15924G (MT-TT): LIMM (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 8519A (MT-ATP8): Susceptibility to bullous pemphigoid (Reported)
poz279	CWC	Neolithic	Poland	U	-2454	-2236	W5b	reconstructed	12.00	Juras et al. 2018 Data	FASTA Metadata	11696A (MT-ND4): LHON / LDYT / DEAF / hypertension helper mut. (Reported - possibly synergistic) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports) 7023A (MT-CO1): MELAS-like syndrome (Reported)
JK2135	CLNE	Classical Age	Egypt	F	-992	-923	M1a2a	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
I5519	BBC	Copper Age	Germany	M	-2500	-2000	I4a	bam	87.78	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 15924G (MT-TT): LIMM (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 8519A (MT-ATP8): Susceptibility to bullous pemphigoid (Reported)
I4551	HGE	Mesolithic	Latvia	M	-5775	-5666	U5a2c3	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
poz280	CWC	Neolithic	Poland	U	-2800	-2300	W5b	reconstructed	57.00	Juras et al. 2018 Data	FASTA Metadata	11696A (MT-ND4): LHON / LDYT / DEAF / hypertension helper mut. (Reported - possibly synergistic) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
poz281	CWC	Neolithic	Poland	U	-2800	-2300	T2e	reconstructed	79.00	Juras et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I4552	HGE	Mesolithic	Latvia	F	-5479	-5374	U5a1d	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I5657	BBC	Copper Age	Germany	M	-2500	-2000	T2b+152	bam	892.71	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
Rochedane	HGW	Epipaleolithic	France	M	-11140	-10880	U5b2b	bam	<NA>	Fu et al. 2016 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 12634G (MT-ND5): Thyroid Cancer Cell Line (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16270T (MT-CR): Melanoma patients (Reported)
RISE550	YAM	Bronze Age	Russia	M	-3334	-2635	U5a1i	bam	<NA>	Allentoft et al. 2015 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
RISE240	YAM	Bronze Age	Russia	F	-2880	-2632	U5a1d1	bam	<NA>	Allentoft et al. 2015 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I4553	HGE	Mesolithic	Latvia	M	-5482	-5375	U5a1c	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
poz282	CWC	Neolithic	Poland	U	-2800	-2300	U4a2f	reconstructed	36.00	Juras et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 12397G (MT-ND5): PD / early onset (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 499A (MT-CR): Endometriosis (Reported)
I0431	SRU	Bronze Age	Russia	F	-1850	-1600	H2b	bam	<NA>	Mathieson et al. 2015 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
poz234	CWC	Neolithic	Poland	U	-2800	-2300	H1e	reconstructed	39.00	Juras et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
I4596	HGE	Mesolithic	Latvia	M	-6061	-5990	U5a2d	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I4626	NEBL	Neolithic	Latvia	M	-5841	-5636	U2e1	bam	<NA>	Jones et al. 2017 Data	FASTA Metadata
I7213	BBC	Copper Age	Czech Republic	F	-2500	-2200	HV+16311	bam	270.08	Olalde et al. 2018 Data	FASTA Metadata	15773A (MT-CYB): LHON (Possibly synergistic) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I7269	BBC	Copper Age	Czech Republic	M	-2500	-2200	T2e	bam	172.07	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I7271	BBC	Copper Age	Czech Republic	M	-2500	-2200	U4a2	bam	38.39	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 499A (MT-CR): Endometriosis (Reported) 9804A (MT-CO3): LHON / MS (Reported)
I4628	NEBL	Neolithic	Latvia	M	-5302	-4852	U5a2d	bam	<NA>	Jones et al. 2017 Data	FASTA Metadata
JK2136	CLNE	Classical Age	Egypt	M	-405	-394	R0a2	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
I4632	HGE	Mesolithic	Latvia	F	-6467	-6249	U5a1c	bam	<NA>	Jones et al. 2017 Data	FASTA Metadata
I0260	BBC	Copper Age	Spain	F	-2850	-2250	K1a2a	bam	329.61	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I0263	BBC	Copper Age	Spain	F	-2850	-2250	X2b+226	bam	122.00	Olalde et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 15927A (MT-TT): LHON / Multiple Sclerosis / DEAF1555 increased penetrance / CHD (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 8393T (MT-ATP8): Reversible brain pseudoatrophy (Reported)
I0460	BBC	Copper Age	Spain	M	-2460	-2209	H45	bam	240.61	Olalde et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 8843C (MT-ATP6): Patient with suspected mitochondrial disease (Reported as Likely Benign)
I0359	SRU	Bronze Age	Russia	F	-1850	-1200	U5a2a1	bam	<NA>	Mathieson et al. 2015 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I4629	CWC	Neolithic	Latvia	F	-3089	-2676	U5a1b	bam	<NA>	Jones et al. 2017 Data	FASTA Metadata
JK2137	CLNE	Classical Age	Egypt	M	-164	-60	J2a2b	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
I1388	BBC	Copper Age	France	M	-2455	-2134	H	bam	625.06	Olalde et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
poz232	CWC	Neolithic	Poland	U	-3025	-2898	U5a1b	reconstructed	11.00	Juras et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 14668T (MT-ND6): Depressive Disorder associated (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 3736A (MT-ND1): LHON (Reported) 6480A (MT-CO1): Prostate Cancer / enriched in POAG cohort (Reported)
I4435	NEBL	Neolithic	Latvia	F	-4146	-3960	U4a1	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I0231	YAM	Bronze Age	Russia	M	-2921	-2762	U4a1a or U4a1d	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 499A (MT-CR): Endometriosis (Reported)
I4436	HGE	Mesolithic	Latvia	M	-4260	-4050	U4a1	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I3874	BBC	Copper Age	France	F	-2200	-2035	T2b3	bam	43.60	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I0361	SRU	Bronze Age	Russia	M	-1850	-1200	H5b	bam	<NA>	Mathieson et al. 2015 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I3529	BBC	Copper Age	Hungary	F	-2500	-2200	I3a	bam	215.16	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 15924G (MT-TT): LIMM (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I4437	HGE	Mesolithic	Latvia	F	-4329	-4067	U5a1d2	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
20810	NENE	Neolithic	Turkey	U	-6450	-6380	W1c	reconstructed	23.10	Chyleński et al. 2019 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
19727	NENE	Neolithic	Turkey	M	-6450	-6380	K	reconstructed	25.50	Chyleński et al. 2019 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I0424	SRU	Bronze Age	Russia	M	-1850	-1600	T2b4	bam	<NA>	Mathieson et al. 2015 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I4627	NEBL	Neolithic	Latvia	M	-4251	-3976	U4a1	bam	<NA>	Jones et al. 2017 Data	FASTA Metadata
I5070	LBK	Neolithic	Austria	M	-5500	-4775	K1a1a	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I5204	LBK	Neolithic	Austria	M	-5500	-4500	J1c2	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I4075	BBC	Copper Age	The Netherlands	F	-2118	-1937	H5a1	bam	418.88	Olalde et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4336C (MT-TQ): ADPD / Hearing Loss & Migraine / autism spectrum / intellectual disability (Unclear)
JK2139	CLNE	Classical Age	Egypt	U	54	124	K1a	bam	438.70	Schuenemann et al. 2017 Data	Metadata
I5206	LBK	Neolithic	Austria	F	-5500	-4500	T2b	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I5205	LBK	Neolithic	Austria	F	-5500	-4500	H	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I4930	BBC	Copper Age	Italy	F	-2500	-1900	H1e	bam	9.11	Olalde et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
JK2141	CLNE	Classical Age	Egypt	U	-358	-204	J2a2e	bam	117.53	Schuenemann et al. 2017 Data	Metadata
20832	NENE	Neolithic	Turkey	F	-6450	-6380	H+73	reconstructed	6.30	Chyleński et al. 2019 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 14668T (MT-ND6): Depressive Disorder associated (Reported) 8249A (MT-CO2): Mitochondrial myopathy (Reported)
I5527	BBC	Copper Age	Germany	F	-2500	-2000	K2b1a1	bam	230.34	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13135A (MT-ND5): possible HCM susceptibility (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I0423	SRU	Bronze Age	Russia	M	-1850	-1200	J2b1a2a	bam	<NA>	Mathieson et al. 2015 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 15257A (MT-CYB): LHON (Conflicting reports) 15812A (MT-CYB): LHON (Reported / Secondary) 295T (MT-CR): Low VO2max response (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 489C (MT-CR): Low VO2max response (Reported)
20351	NENE	Neolithic	Turkey	U	-6450	-6380	U5b2	reconstructed	18.00	Chyleński et al. 2019 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13637G (MT-ND5): Possible LHON factor (Reported)
I5015	BBC	Copper Age	Hungary	F	-2466	-2210	H1aj	bam	260.72	Olalde et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
20374	NENE	Neolithic	Turkey	U	-6450	-6380	X2b4	reconstructed	41.90	Chyleński et al. 2019 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 15927A (MT-TT): LHON / Multiple Sclerosis / DEAF1555 increased penetrance / CHD (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 8393T (MT-ATP8): Reversible brain pseudoatrophy (Reported)
I0354	SRU	Bronze Age	Russia	F	-2014	-1692	U5a1	bam	<NA>	Mathieson et al. 2015 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 3398C (MT-ND1): DMDF+HCM / GDM / possibly LVNC cardiomyopathy-associated (Reported) 9966A (MT-CO3): LHON possible helper variant (Reported)
I5836	BBC	Copper Age	Germany	F	-2500	-2000	H1b1+16362	bam	138.79	Olalde et al. 2018 Data	FASTA Metadata	16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 3796G (MT-ND1): Adult-Onset Dystonia (Reported)
20036	NENE	Neolithic	Turkey	U	-6450	-6380	U3b	reconstructed	242.30	Chyleński et al. 2019 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 4640A (MT-ND2): LHON / Epilepsy (Reported)
I6542	BBC	Copper Age	Spain	M	-2500	-1750	U5b1i	bam	347.72	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
JK2142	CLNE	Classical Age	Egypt	F	-382	-234	U6a	bam	10.97	Schuenemann et al. 2017 Data	Metadata
I6472	BBC	Copper Age	Spain	M	-2500	-2000	HV0b	bam	570.50	Olalde et al. 2018 Data	FASTA Metadata	195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I6587	BBC	Copper Age	Spain	M	-2500	-2000	K1a1b1	bam	192.85	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 15924G (MT-TT): LIMM (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
19159	NENE	Neolithic	Turkey	U	-6450	-6380	N	reconstructed	13.70	Chyleński et al. 2019 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported)
I0174	LBK	Neolithic	Hungary	M	-5702	-5536	N1a1a1	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 3336C (MT-ND1): Carotid atherosclerosis risk (Reported) 669C (MT-RNR1): DEAF (Reported)
I6589	BBC	Copper Age	Spain	M	-2500	-2000	K1a1b1	bam	189.80	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 114T (MT-CR): BD-associated (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 15924G (MT-TT): LIMM (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 7859A (MT-CO2): Progressive Encephalomyopathy (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
21981	NENE	Neolithic	Turkey	M	-6450	-6380	K1a17	reconstructed	3.80	Chyleński et al. 2019 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I0453	CAIB	Copper Age	Spain	M	-2458	-2147	V	bam	166.65	Olalde et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
20850	NENE	Neolithic	Turkey	M	-6450	-6380	H	reconstructed	11.30	Chyleński et al. 2019 Data	FASTA Metadata
JK2150	CLNE	Classical Age	Egypt	F	-759	-551	K1a4	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
RISE1160	GAC	Neolithic	Poland	M	-2880	-2776	T2b	bam	1.90	Schroeder et al. 2019 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I0115	UNC	Bronze Age	Germany	F	-1954	-1760	U5a1i	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I0116	UNC	Bronze Age	Germany	M	-2134	-1939	W3a1	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15784C (MT-CYB): POAG - potential for association (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports) 6267A (MT-CO1): Prostate Cancer (Reported)
I7251	BBC	Copper Age	Czech Republic	M	-2500	-2200	U2e1	bam	344.06	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16183C (MT-CR): Melanoma patients (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
JK2153	CLNE	Classical Age	Egypt	M	-43	15	R0a1a	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
RISE1161	GAC	Neolithic	Poland	F	-2880	-2776	H27+16093	bam	1.30	Schroeder et al. 2019 Data	FASTA Metadata	16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 4440A (MT-TM): Mitochondrial myopathy (Reported)
I2458	BABI	Bronze Age	Great Britain	F	-1492	-1287	U5b3	bam	187.08	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 12811C (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 15497A (MT-CYB): EXIT / Obesity (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 228A (MT-CR): Low VO2max response (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 8573A (MT-ATP6): Patient with suspected mitochondrial disease (Reported as Benign)
RISE1163	GAC	Neolithic	Poland	M	-2880	-2776	HV0a	bam	3.90	Schroeder et al. 2019 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4440A (MT-TM): Mitochondrial myopathy (Reported) 5650A (MT-TA): Myopathy (Cfrm)
RISE1164	GAC	Neolithic	Poland	F	-2880	-2776	K1a1b1e	bam	1.10	Schroeder et al. 2019 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 114T (MT-CR): BD-associated (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 15924G (MT-TT): LIMM (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I2600	BABI	Bronze Age	Great Britain	F	-2133	-1937	U5b1+16189	bam	344.51	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
RISE1165	GAC	Neolithic	Poland	M	-2880	-2776	HV16	bam	2.10	Schroeder et al. 2019 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I0117	UNC	Bronze Age	Germany	F	-2272	-2039	I3a	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 15924G (MT-TT): LIMM (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported)
RISE1168	GAC	Neolithic	Poland	M	-2880	-2776	HV0a	bam	2.40	Schroeder et al. 2019 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
RISE1169	GAC	Neolithic	Poland	M	-2880	-2776	HV0a	bam	1.10	Schroeder et al. 2019 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I2610	BABI	Bronze Age	Great Britain	F	-1935	-1745	U2e1b	bam	11.37	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 988A (MT-RNR1): Possible DEAF risk factor (Reported)
I7281	BBC	Copper Age	Czech Republic	F	-2500	-2200	H5a1g	bam	211.62	Olalde et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4336C (MT-TQ): ADPD / Hearing Loss & Migraine / autism spectrum / intellectual disability (Unclear)
I4895	BBC	Copper Age	Czech Republic	M	-2273	-2047	H1+16189	bam	153.93	Olalde et al. 2018 Data	FASTA Metadata	16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
JK2155	CLNE	Classical Age	Egypt	M	386	426	T	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
I0164	UNC	Bronze Age	Germany	F	-2023	-1894	U5b2a1b	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported)
I3255	BBC	Bronze Age	Great Britain	F	-2135	-1949	T2b	bam	797.20	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
RISE1173	GAC	Neolithic	Poland	M	-2880	-2776	HV0a	bam	2.90	Schroeder et al. 2019 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4440A (MT-TM): Mitochondrial myopathy (Reported)
COV20126	BAIB	Bronze Age	Spain	M	-1746	-1627	L2a1	fasta	84.70	Gonzalez-Fortes et al. 2019 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 15784C (MT-CYB): POAG - potential for association (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16390A (MT-CR): POAG - potential for association (Reported)
JK2158	CLNE	Classical Age	Egypt	U	261	382	X1c	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
RISE586	UNC	Bronze Age	Czech Republic	F	-2300	-1800	K1b1a	bam	<NA>	Allentoft et al. 2015 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15257A (MT-CYB): LHON (Conflicting reports) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
COV20125	BAIB	Bronze Age	Spain	U	-1886	-1702	U2e1	fasta	103.00	Gonzalez-Fortes et al. 2019 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported)
I3256	BBC	Bronze Age	Great Britain	M	-2203	-2029	T2b	bam	603.66	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
RISE109	UNC	Bronze Age	Poland	F	-1954	-1772	U4	bam	<NA>	Allentoft et al. 2015 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 499A (MT-CR): Endometriosis (Reported)
I2453	BBC	Bronze Age	Great Britain	M	-2288	-2040	K2a	bam	1505.93	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I3132	BABI	Bronze Age	Great Britain	M	-2118	-1887	T2a1b1a	bam	620.60	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 14687G (MT-TE): Mito myopathy w respiratory failure / intellectual disability (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I4949	NEBI	Neolithic	Great Britain	M	-3629	-3376	T2b	bam	177.37	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 1555G (MT-RNR1): DEAF / autism spectrum intellectual disability / possibly antiatherosclerotic (Cfrm) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
LU339	CAIB	Copper Age	Spain	F	-3007	-2871	H	fasta	102.20	Gonzalez-Fortes et al. 2019 Data	FASTA Metadata
JK2165	CLNE	Classical Age	Egypt	F	-364	-211	W3a1	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
LU657	CAIB	Copper Age	Spain	U	-3500	-1700	U5b1	fasta	13.50	Gonzalez-Fortes et al. 2019 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
LD1174	CAIB	Copper Age	Portugal	F	-2577	-2456	U5b2	fasta	145.60	Gonzalez-Fortes et al. 2019 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 12634G (MT-ND5): Thyroid Cancer Cell Line (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16270T (MT-CR): Melanoma patients (Reported)
JK2169	CLNE	Classical Age	Egypt	F	-355	-204	W8	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
I6601	CAIB	Copper Age	Portugal	M	-2800	-2600	H1e2	bam	369.41	Olalde et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
I6680	BABI	Bronze Age	Great Britain	M	-1876	-1625	H1+16189	bam	95.71	Olalde et al. 2018 Data	FASTA Metadata	16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
LD903	BAIB	Bronze Age	Portugal	U	-2050	-1881	U3a1	fasta	38.30	Gonzalez-Fortes et al. 2019 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16390A (MT-CR): POAG - potential for association (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported)
I7568	BABI	Bronze Age	Great Britain	F	-1600	-1300	W1+119	bam	104.25	Olalde et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
I7573	BABI	Bronze Age	Great Britain	F	-1642	-1507	H1	bam	177.67	Olalde et al. 2018 Data	FASTA Metadata	16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported)
Val05	NEIB	Neolithic	Spain	U	-3480	-3030	H1ay	fasta	125.80	Gonzalez-Fortes et al. 2019 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 9861C (MT-CO3): AD (Reported)
JK2870	CLNE	Classical Age	Egypt	M	-899	-841	R0a	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
I7578	BABI	Bronze Age	Great Britain	F	-1225	-1013	U5a2c	bam	185.73	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 228A (MT-CR): Low VO2max response (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
Iboussieres31-2	HGW	Epipaleolithic	France	M	-10090	-9460	U5b1	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
Falkenstein	HGW	Mesolithic	Germany	M	-7460	-7040	U5a2c	bam	<NA>	Fu et al. 2016 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
Val3.99	BAIB	Bronze Age	Spain	U	-1650	-1430	H3	fasta	14.40	Gonzalez-Fortes et al. 2019 Data	FASTA Metadata
Val107	BAIB	Bronze Age	Spain	U	-1650	-1430	H1bm	fasta	42.10	Gonzalez-Fortes et al. 2019 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 9055A (MT-ATP6): PD protective factor (Reported)
I0370	YAM	Bronze Age	Russia	M	-3300	-2700	H13a1a1	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
Val145	BAIB	Bronze Age	Spain	U	-1650	-1430	H1bm	fasta	33.70	Gonzalez-Fortes et al. 2019 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 9055A (MT-ATP6): PD protective factor (Reported)
JK2872	CLNE	Classical Age	Egypt	M	81	132	HV1a2a	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
JK2874	CLNE	Classical Age	Egypt	U	-151	-48	U	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
I0163	LDN	Neolithic	Germany	U	-4582	-4407	H5b	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata
Val146	BAIB	Bronze Age	Spain	U	-1650	-1430	H1bm	fasta	57.70	Gonzalez-Fortes et al. 2019 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 9055A (MT-ATP6): PD protective factor (Reported)
I6775	BBC	Bronze Age	Great Britain	M	-2400	-2000	H1	bam	216.86	Olalde et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
Eiros1	BAIB	Bronze Age	Spain	U	-1499	-1310	V	fasta	72.10	Gonzalez-Fortes et al. 2019 Data	FASTA Metadata
I0162	LDN	Neolithic	Germany	U	-4625	-4250	H16a'c'd	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata
Eiros2	NEIB	Neolithic	Spain	U	-3636	-3381	U5b3	fasta	163.80	Gonzalez-Fortes et al. 2019 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 228A (MT-CR): Low VO2max response (Reported)
Rebolal	CAIB	Copper Age	Spain	U	-3500	-3181	K2b1	fasta	72.52	Gonzalez-Fortes et al. 2019 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13135A (MT-ND5): possible HCM susceptibility (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I0557	BAC	Neolithic	Germany	U	-3950	-3400	U5b2a2	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
Pxevi	CAIB	Copper Age	Spain	U	-3354	-3090	J2a1	fasta	167.80	Gonzalez-Fortes et al. 2019 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 11253C (MT-ND4): LHON PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 15257A (MT-CYB): LHON (Conflicting reports) 195C (MT-CR): BD-associated / melanoma pts (Reported) 295T (MT-CR): Low VO2max response (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 489C (MT-CR): Low VO2max response (Reported)
I0552	SMC	Neolithic	Germany	U	-3400	-3025	H5	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata
I0558	BAC	Neolithic	Germany	U	-3700	-3620	None	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 3336C (MT-ND1): Carotid atherosclerosis risk (Reported) 669C (MT-RNR1): DEAF (Reported)
I0800	SMC	Neolithic	Germany	U	-3334	-3262	H3	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata
Pv517	CAIB	Copper Age	Spain	U	-3354	-3090	K2b1	fasta	145.60	Gonzalez-Fortes et al. 2019 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13135A (MT-ND5): possible HCM susceptibility (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
JK2875	CLNE	Classical Age	Egypt	U	340	395	N	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
I0798	SCG	Neolithic	Germany	U	-4172	-4089	H10e'f'g	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata	16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
DA2	IASI	Iron Age	Russia	M	-898	-835	N1a1a1a1	bam	224.27	de Barros Damgaard et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12280G (MT-TL2): Hypertension (Reported) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 3336C (MT-ND1): Carotid atherosclerosis risk (Reported) 669C (MT-RNR1): DEAF (Reported)
JK2878	CLNE	Classical Age	Egypt	M	-344	-126	T1a7	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
I0802	SMC	Neolithic	Germany	U	-3400	-3025	H3	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata	16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I0016	HGE	Mesolithic	Sweden	U	-5898	-5531	U5a2	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 228A (MT-CR): Low VO2max response (Reported)
DA3	IASI	Iron Age	Russia	F	-900	-600	N9a9	bam	368.29	de Barros Damgaard et al. 2018 Data	FASTA Metadata	12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I0428	YAM	Bronze Age	Russia	U	-3090	-2910	W6c	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 16192T (MT-CR): Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
I0027	LBK	Neolithic	Germany	U	-5500	-4800	H40	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata
I2450	BBC	Bronze Age	Great Britain	F	-2461	-2146	K1a1b1g	bam	1089.59	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 15924G (MT-TT): LIMM (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I2416	BBC	Bronze Age	Great Britain	M	-2455	-2151	K1b1a1	bam	421.21	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13967T (MT-ND5): Possible LHON factor (Reported) 15257A (MT-CYB): LHON (Conflicting reports) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5913A (MT-CO1): Prostate Cancer / hypertension (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I6777	BBC	Bronze Age	Great Britain	M	-2500	-1900	U4b1b2	bam	180.18	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13528G (MT-ND5): LHON-like / LHON / MELAS (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 499A (MT-CR): Endometriosis (Reported)
I0023	LBK	Neolithic	Germany	U	-5500	-4800	H	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata
JK2880	CLNE	Classical Age	Egypt	M	-770	-567	T1a2	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
I6778	BBC	Bronze Age	Great Britain	F	-2500	-1900	K1a26	bam	177.80	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 16192T (MT-CR): Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I1767	BBC	Bronze Age	Great Britain	M	-2200	-1979	U5a1a1	bam	471.98	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15924G (MT-TT): LIMM (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I0019	LBK	Neolithic	Germany	U	-5500	-4800	HV6'17	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata
I0020	LBK	Neolithic	Germany	U	-5500	-4800	T2e	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
DA4	IASI	Iron Age	Russia	M	-900	-600	H5a1+152	bam	255.65	de Barros Damgaard et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 14668T (MT-ND6): Depressive Disorder associated (Reported) 15043A (MT-CYB): MDD-associated (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 3290C (MT-TL1): Poss. hypertension factor (Reported) 4395G (MT-TQ): Poss. hypertension factor (Reported) 4883T (MT-ND2): Glaucoma (Conflicting reports) 489C (MT-CR): Low VO2max response (Reported) 5703A (MT-TN): CPEO / MM (Cfrm) 8414T (MT-ATP8): Increased risk of T2DM and high altitude polycythemia (HAPC) in haplogroup D4 / Longevity (Reported)
DA5	IASI	Iron Age	Russia	M	-900	-600	W1c	bam	898.81	de Barros Damgaard et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 5650A (MT-TA): Myopathy (Cfrm) 8932T (MT-ATP6): Prostate tumor / Neuromuscular disorder (Reported)
I2566	BBC	Bronze Age	Great Britain	M	-2204	-2035	K1b1a1	bam	650.33	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13967T (MT-ND5): Possible LHON factor (Reported) 15257A (MT-CYB): LHON (Conflicting reports) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5913A (MT-CO1): Prostate Cancer / hypertension (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I2598	BBC	Bronze Age	Great Britain	M	-2135	-1953	H	bam	794.37	Olalde et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
JK2884	CLNE	Classical Age	Egypt	U	-158	-54	T1a5	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
DA7	IASI	Iron Age	Russia	M	-900	-600	A8a1	bam	334.71	de Barros Damgaard et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 5650A (MT-TA): Myopathy (Cfrm)
I2417	BBC	Bronze Age	Great Britain	M	-2500	-2140	J1c	bam	125.19	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
DA8	IASI	Iron Age	Russia	F	-900	-600	U2e1h	bam	473.96	de Barros Damgaard et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5703A (MT-TN): CPEO / MM (Cfrm) 7497A (MT-TS1): MM / EXIT (Cfrm)
DA9	IASI	Iron Age	Russia	F	-900	-600	F1b1b	bam	146.86	de Barros Damgaard et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 1095C (MT-RNR1): SNHL (Unclear) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 4440A (MT-TM): Mitochondrial myopathy (Reported) 489C (MT-CR): Low VO2max response (Reported) 8414T (MT-ATP8): Increased risk of T2DM and high altitude polycythemia (HAPC) in haplogroup D4 / Longevity (Reported)
I5379	BBC	Bronze Age	Great Britain	M	-2469	-2296	HV0+195	bam	203.14	Olalde et al. 2018 Data	FASTA Metadata	195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
DA11	IAST	Iron Age	Kazakhstan	F	-766	-729	F1b1+@152	bam	282.70	de Barros Damgaard et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4454C (MT-TM): Possible contributor to mito dysfunction / hypertension (Reported) 5650A (MT-TA): Myopathy (Cfrm)
JK2885	CLNE	Classical Age	Egypt	U	-1304	-1136	R2'JT	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
DA10	IAST	Iron Age	Kazakhstan	F	-600	-400	C4a1a	bam	485.37	de Barros Damgaard et al. 2018 Data	FASTA Metadata	16270T (MT-CR): Melanoma patients (Reported) 4440A (MT-TM): Mitochondrial myopathy (Reported)
DA13	IAST	Iron Age	Kazakhstan	M	-752	-682	A+152+16362+16189	bam	525.80	de Barros Damgaard et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 4440A (MT-TM): Mitochondrial myopathy (Reported) 663G (MT-RNR1): Coronary atherosclerosis risk (Reported) 7462T (MT-TS1): DEAF (Reported)
I6679	BBC	Bronze Age	Great Britain	M	-2124	-1890	J1c1b1	bam	251.70	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 146C (MT-CR): Absence of Endometriosis (Reported) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 3394C (MT-ND1): LHON / Diabetes / CPTdeficiency / high altitude adaptation (Reported / Population-dependent) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
JK2887	CLNE	Classical Age	Egypt	M	-1388	-1311	J2a1a1	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
JK2888	CLNE	Classical Age	Egypt	U	-97	-2	U6a2	bam	567.83	Schuenemann et al. 2017 Data	Metadata
I5513	BBC	Bronze Age	Great Britain	M	-2500	-1800	V	bam	117.45	Olalde et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
DA14	IAST	Iron Age	Kazakhstan	F	-753	-681	H101	bam	734.98	de Barros Damgaard et al. 2018 Data	FASTA Metadata	7462T (MT-TS1): DEAF (Reported)
DA16	IAST	Iron Age	Kazakhstan	M	-750	-683	U2e1'2'3	bam	209.41	de Barros Damgaard et al. 2018 Data	FASTA Metadata
I5382	BBC	Bronze Age	Great Britain	M	-2278	-1981	T2b	bam	173.19	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I2443	BBC	Bronze Age	Great Britain	F	-2284	-2028	T2c1d+152	bam	1012.23	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported) 6261A (MT-CO1): Prostate Cancer / LHON (Reported)
I2445	BBC	Bronze Age	Great Britain	M	-2396	-1929	X2b6	bam	2027.55	Olalde et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 15927A (MT-TT): LHON / Multiple Sclerosis / DEAF1555 increased penetrance / CHD (Reported) 16183C (MT-CR): Melanoma patients (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 8393T (MT-ATP8): Reversible brain pseudoatrophy (Reported)
I2446	BBC	Bronze Age	Great Britain	F	-2455	-2139	K1b1a1	bam	55.16	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13967T (MT-ND5): Possible LHON factor (Reported) 15257A (MT-CYB): LHON (Conflicting reports) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5913A (MT-CO1): Prostate Cancer / hypertension (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
JK2890	CLNE	Classical Age	Egypt	U	-794	-671	I	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
I5471	BBC	Bronze Age	Great Britain	F	-2266	-2025	H1c3a	bam	80.04	Olalde et al. 2018 Data	FASTA Metadata	16176T (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
DA20	IAST	Iron Age	Kazakhstan	M	-357	-342	C4a1a+195	bam	415.40	de Barros Damgaard et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 4440A (MT-TM): Mitochondrial myopathy (Reported) 489C (MT-CR): Low VO2max response (Reported)
DA23	IAST	Middle Ages	Kazakhstan	M	1045	1095	F1b1b	bam	772.74	de Barros Damgaard et al. 2018 Data	FASTA Metadata	16183C (MT-CR): Melanoma patients (Reported) 6962A (MT-CO1): Possible helper variant for 15927A (Reported)
I7270	BBC	Copper Age	Czech Republic	F	-2500	-2200	K1a2c	bam	9.53	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 9055A (MT-ATP6): PD protective factor (Reported)
I4896	BBC	Copper Age	Czech Republic	F	-2288	-2142	U5a2+16294	bam	114.05	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
DA26	IAST	Iron Age	Kazakhstan	F	-400	-100	U4a2	bam	331.72	de Barros Damgaard et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 499A (MT-CR): Endometriosis (Reported) 8414T (MT-ATP8): Increased risk of T2DM and high altitude polycythemia (HAPC) in haplogroup D4 / Longevity (Reported)
DA27	IAST	Iron Age	Kazakhstan	M	349	368	C4b1	bam	618.31	de Barros Damgaard et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 15043A (MT-CYB): MDD-associated (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 3552A (MT-ND1): Resistance to high altitude pulmonary edema (HAPE) (Reported /hg C marker) 4440A (MT-TM): Mitochondrial myopathy (Reported) 489C (MT-CR): Low VO2max response (Reported)
I7276	BBC	Copper Age	Czech Republic	M	-2500	-2200	H5b	bam	288.09	Olalde et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
JK2893	CLNE	Classical Age	Egypt	U	-797	-771	H5	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
I4945	BBC	Copper Age	Czech Republic	F	-2291	-2144	H4a1c	bam	273.48	Olalde et al. 2018 Data	FASTA Metadata	14582G (MT-ND6): LHON synergistic combo 14258A + 14582G (Reported: individually neutral variants causing LHON in combination)
JK2895	CLNE	Classical Age	Egypt	M	25	111	K 16T	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
I7278	BBC	Copper Age	Czech Republic	M	-2500	-2200	U4a2	bam	175.83	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 499A (MT-CR): Endometriosis (Reported) 9804A (MT-CO3): LHON / MS (Reported)
I5666	BBC	Copper Age	Czech Republic	M	-2500	-1900	U4a2c	bam	248.11	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 499A (MT-CR): Endometriosis (Reported)
DA28	IAST	Middle Ages	Kazakhstan	M	1200	1400	D4m2	bam	1900.58	de Barros Damgaard et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 14668T (MT-ND6): Depressive Disorder associated (Reported) 15043A (MT-CYB): MDD-associated (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 4883T (MT-ND2): Glaucoma (Conflicting reports) 489C (MT-CR): Low VO2max response (Reported) 8414T (MT-ATP8): Increased risk of T2DM and high altitude polycythemia (HAPC) in haplogroup D4 / Longevity (Reported)
DA29	IAST	Middle Ages	Kazakhstan	M	1200	1400	I1b	bam	814.14	de Barros Damgaard et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 15924G (MT-TT): LIMM (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9133A (MT-ATP6): Patient with suspected mitochondrial disease (Reported as VUS) 9966A (MT-CO3): LHON possible helper variant (Reported)
I5514	BBC	Copper Age	Czech Republic	M	-2500	-2000	T2b+152	bam	205.49	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
DA30	IAST	Iron Age	Kazakhstan	M	-47	24	U4a2	bam	514.89	de Barros Damgaard et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 499A (MT-CR): Endometriosis (Reported)
JK2902	CLNE	Classical Age	Egypt	U	-902	-842	I	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
JK2903	CLNE	Classical Age	Egypt	U	-87	2	U5a	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
I4885	BBC	Copper Age	Czech Republic	M	-2289	-2143	U5a1i	bam	93.21	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
DA31	IACA	Iron Age	Armenia	M	-1500	-700	HV0a	bam	254.11	de Barros Damgaard et al. 2018 Data	FASTA Metadata	295T (MT-CR): Low VO2max response (Reported)
I4886	BBC	Copper Age	Czech Republic	M	-2205	-2042	H6a	bam	219.41	Olalde et al. 2018 Data	FASTA Metadata	16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I7282	BBC	Copper Age	Czech Republic	M	-2500	-2200	K1a3a3	bam	228.41	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 12811C (MT-ND5): Possible LHON factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I7288	BBC	Copper Age	Czech Republic	M	-2500	-2200	H1m	bam	14.98	Olalde et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported)
I4888	BBC	Copper Age	Czech Republic	M	-2190	-2029	K1a2c	bam	137.03	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 9055A (MT-ATP6): PD protective factor (Reported)
DA35	IACA	Iron Age	Armenia	F	-1390	-1337	J1b1a1+146	bam	1372.45	de Barros Damgaard et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 146C (MT-CR): Absence of Endometriosis (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 2158C (MT-RNR2): Reduced risk PD (Reported) 489C (MT-CR): Low VO2max response (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
I7289	BBC	Copper Age	Czech Republic	M	-2500	-2200	U8b1b1	bam	193.60	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16183C (MT-CR): Melanoma patients (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I4890	BBC	Copper Age	Czech Republic	M	-2500	-2000	H	bam	13.50	Olalde et al. 2018 Data	FASTA Metadata
I4891	BBC	Copper Age	Czech Republic	M	-2281	-2062	J2a1a2	bam	193.26	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 15257A (MT-CYB): LHON (Conflicting reports) 195C (MT-CR): BD-associated / melanoma pts (Reported) 295T (MT-CR): Low VO2max response (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 489C (MT-CR): Low VO2max response (Reported)
I1382	BBC	Copper Age	France	M	-2434	-2135	U5a2c3a	bam	126.33	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
JK2907	CLNE	Classical Age	Egypt	M	26	84	HV1a'b'c	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
I1389	BBC	Copper Age	France	M	-2468	-2278	X2b4a	bam	133.39	Olalde et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 15927A (MT-TT): LHON / Multiple Sclerosis / DEAF1555 increased penetrance / CHD (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 8393T (MT-ATP8): Reversible brain pseudoatrophy (Reported)
I4887	BBC	Copper Age	Czech Republic	M	-2201	-2039	K1a2c	bam	232.53	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 9055A (MT-ATP6): PD protective factor (Reported)
DA39	IAMo	Iron Age	Mongolia	M	-49	53	N9a2a	bam	670.32	de Barros Damgaard et al. 2018 Data	FASTA Metadata	12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4440A (MT-TM): Mitochondrial myopathy (Reported) 5153G (MT-ND2): Recurrent pregnancy loss (Reported) 9966A (MT-CO3): LHON possible helper variant (Reported) 961C (MT-RNR1): DEAF / possibly LVNC-associated (Unclear)
I7205	BBC	Copper Age	Czech Republic	M	-2500	-2200	H10+(16093)	bam	206.12	Olalde et al. 2018 Data	FASTA Metadata	16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
DA41	IAMo	Iron Age	Mongolia	M	-347	-319	G3a3	bam	494.78	de Barros Damgaard et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 16390A (MT-CR): POAG - potential for association (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 489C (MT-CR): Low VO2max response (Reported)
I7210	BBC	Copper Age	Czech Republic	M	-2500	-2200	H6a1b4	bam	263.89	Olalde et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
DA43	IAMo	Iron Age	Mongolia	M	-300	-100	D4a6	bam	439.54	de Barros Damgaard et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 14668T (MT-ND6): Depressive Disorder associated (Reported) 15043A (MT-CYB): MDD-associated (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4440A (MT-TM): Mitochondrial myopathy (Reported) 4883T (MT-ND2): Glaucoma (Conflicting reports) 489C (MT-CR): Low VO2max response (Reported) 8414T (MT-ATP8): Increased risk of T2DM and high altitude polycythemia (HAPC) in haplogroup D4 / Longevity (Reported)
JK2913	CLNE	Classical Age	Egypt	U	-895	-834	X1	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
I7287	BBC	Copper Age	Czech Republic	M	-2500	-2200	K1a4a1	bam	97.13	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
DA45	IAMo	Iron Age	Mongolia	M	-156	-134	D4b2b2b	bam	3766.24	de Barros Damgaard et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 14668T (MT-ND6): Depressive Disorder associated (Reported) 15043A (MT-CYB): MDD-associated (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 3290C (MT-TL1): Poss. hypertension factor (Reported) 4395G (MT-TQ): Poss. hypertension factor (Reported) 4883T (MT-ND2): Glaucoma (Conflicting reports) 489C (MT-CR): Low VO2max response (Reported) 5153G (MT-ND2): Recurrent pregnancy loss (Reported) 5703A (MT-TN): CPEO / MM (Cfrm) 5650A (MT-TA): Myopathy (Cfrm) 8414T (MT-ATP8): Increased risk of T2DM and high altitude polycythemia (HAPC) in haplogroup D4 / Longevity (Reported)
JK2914	CLNE	Classical Age	Egypt	U	-510	-408	T2	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
JK2916	CLNE	Classical Age	Egypt	U	-1111	-998	R0	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
I7214	BBC	Copper Age	Czech Republic	F	-2500	-2200	U8b1b1	bam	227.21	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16183C (MT-CR): Melanoma patients (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I7290	BBC	Copper Age	Czech Republic	F	-2500	-2200	V3	bam	201.42	Olalde et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I7283	BBC	Copper Age	Czech Republic	F	-2500	-2200	K1a3a3	bam	301.46	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 12811C (MT-ND5): Possible LHON factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I6468	BBC	Copper Age	Czech Republic	F	-2500	-1900	K2b1	bam	161.26	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
DA48	IAKa	Iron Age	Kazakhstan	M	-550	-50	H4d	bam	23.35	de Barros Damgaard et al. 2018 Data	FASTA Metadata
I5024	BBC	Copper Age	Czech Republic	M	-2278	-2032	H3	bam	109.65	Allentoft et al. 2015 Data	FASTA Metadata
I5025	BBC	Copper Age	Czech Republic	F	-2500	-1900	U5b2c	bam	1116.00	Allentoft et al. 2015 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
DA49	IAKa	Iron Age	Kazakhstan	M	-356	-285	T2a1	bam	762.38	de Barros Damgaard et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 14687G (MT-TE): Mito myopathy w respiratory failure / intellectual disability (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
JK2919	CLNE	Classical Age	Egypt	U	-790	-671	J2a2c	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
DA51	IAKa	Iron Age	Kazakhstan	M	-361	-349	H2a1	bam	722.72	de Barros Damgaard et al. 2018 Data	FASTA Metadata
I1392	BBC	Copper Age	France	F	-2833	-2475	H1+152	bam	644.76	Olalde et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported)
JK2921	CLNE	Classical Age	Egypt	M	35	120	R0a1	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
DA52	IAKa	Iron Age	Kazakhstan	M	403	434	G2a1d2	bam	1059.98	de Barros Damgaard et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12311C (MT-TL2): CPEO (Reported) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4833G (MT-ND2): Diabetes helper mutation AD / PD (Reported) 489C (MT-CR): Low VO2max response (Reported)
I3590	BBC	Copper Age	Germany	F	-2335	-2140	H1	bam	276.17	Olalde et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I3601	BBC	Copper Age	Germany	F	-2300	-2150	H10e	bam	303.69	Olalde et al. 2018 Data	FASTA Metadata	16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I3588	BBC	Copper Age	Germany	M	-2300	-2150	H1e1a	bam	350.93	Olalde et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports) 8821G (MT-ATP6): Possible LHON helper variant (Reported)
I3594	BBC	Copper Age	Germany	F	-2300	-2150	T2f	bam	726.27	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 185A (MT-CR): Low VO2max response (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I4248	BBC	Copper Age	Germany	M	-2500	-2000	T2b+152	bam	102.76	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I3602	BBC	Copper Age	Germany	F	-2300	-2150	I3a	bam	341.36	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 15924G (MT-TT): LIMM (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I3600	BBC	Copper Age	Germany	F	-2300	-2150	U5b3	bam	1229.41	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9966A (MT-CO3): LHON possible helper variant (Reported)
JK2922	CLNE	Classical Age	Egypt	U	-352	-200	R	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
DA54	IAKa	Iron Age	Kazakhstan	M	265	271	C4+152+16093	bam	140.36	de Barros Damgaard et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 3552A (MT-ND1): Resistance to high altitude pulmonary edema (HAPE) (Reported /hg C marker) 489C (MT-CR): Low VO2max response (Reported)
I3597	BBC	Copper Age	Germany	M	-2300	-2150	T2f	bam	289.27	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 185A (MT-CR): Low VO2max response (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
JK2951	CLNE	Classical Age	Egypt	U	-344	-169	U8b1b1	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
DA56	IAKa	Iron Age	Kazakhstan	M	-159	-132	HV6	bam	429.36	de Barros Damgaard et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
JK2952	CLNE	Classical Age	Egypt	U	-790	-603	J2a2c	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
I5520	BBC	Copper Age	Germany	F	-2500	-2000	K1b2a	bam	224.12	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5913A (MT-CO1): Prostate Cancer / hypertension (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
JK2953	CLNE	Classical Age	Egypt	F	-37	48	M1a1	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
I5521	BBC	Copper Age	Germany	F	-2500	-2000	J1b1a1	bam	213.51	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 295T (MT-CR): Low VO2max response (Reported) 2158C (MT-RNR2): Reduced risk PD (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
I5659	BBC	Copper Age	Germany	M	-2500	-2000	K1a4b	bam	677.92	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I5522	BBC	Copper Age	Germany	F	-2500	-2000	J1b1a1	bam	535.91	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 295T (MT-CR): Low VO2max response (Reported) 2158C (MT-RNR2): Reduced risk PD (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
DA57	IAKa	Iron Age	Kazakhstan	M	-169	-90	D4j8	bam	621.21	de Barros Damgaard et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11696A (MT-ND4): LHON / LDYT / DEAF / hypertension helper mut. (Reported - possibly synergistic) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 14668T (MT-ND6): Depressive Disorder associated (Reported) 15043A (MT-CYB): MDD-associated (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4883T (MT-ND2): Glaucoma (Conflicting reports) 489C (MT-CR): Low VO2max response (Reported) 5650A (MT-TA): Myopathy (Cfrm) 8414T (MT-ATP8): Increased risk of T2DM and high altitude polycythemia (HAPC) in haplogroup D4 / Longevity (Reported)
JK2955	CLNE	Classical Age	Egypt	U	-391	-260	L3	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
I5017	BBC	Copper Age	Germany	F	-2460	-2206	H46	bam	147.85	Allentoft et al. 2015 Data	FASTA Metadata	16192T (MT-CR): Melanoma patients (Reported)
JK2958	CLNE	Classical Age	Egypt	U	27	83	I	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
DA58	IAKa	Iron Age	Kazakhstan	M	-166	-89	W1c	bam	730.40	de Barros Damgaard et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
JK2960	CLNE	Classical Age	Egypt	U	-44	16	N1'5	bam	13.39	Schuenemann et al. 2017 Data	Metadata
E09568_d	BBC	Copper Age	Germany	M	-2460	-2210	U5b2b	<NA>	<NA>	Olalde et al. 2018 Data	Metadata
E09614_d	BBC	Copper Age	Germany	F	-2270	-2045	J1c3	<NA>	<NA>	Olalde et al. 2018 Data	Metadata
JK2972	CLNE	Classical Age	Egypt	U	-156	-53	T1a5	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
I4249	BBC	Copper Age	Germany	F	-2500	-2000	H5a1	bam	1142.95	Olalde et al. 2018 Data	FASTA Metadata	4336C (MT-TQ): ADPD / Hearing Loss & Migraine / autism spectrum / intellectual disability (Unclear)
I4250	BBC	Copper Age	Germany	F	-2433	-2149	U5a1a2b	bam	387.91	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9804A (MT-CO3): LHON / MS (Reported)
DA59	IAKa	Iron Age	Kazakhstan	M	-349	-313	D4j8	bam	307.45	de Barros Damgaard et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11696A (MT-ND4): LHON / LDYT / DEAF / hypertension helper mut. (Reported - possibly synergistic) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 14668T (MT-ND6): Depressive Disorder associated (Reported) 15043A (MT-CYB): MDD-associated (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4883T (MT-ND2): Glaucoma (Conflicting reports) 489C (MT-CR): Low VO2max response (Reported) 8414T (MT-ATP8): Increased risk of T2DM and high altitude polycythemia (HAPC) in haplogroup D4 / Longevity (Reported)
DA385	IAKa	Iron Age	Kazakhstan	M	397	570	H13a2a	bam	369.92	de Barros Damgaard et al. 2018 Data	FASTA Metadata	195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4440A (MT-TM): Mitochondrial myopathy (Reported)
I5833	BBC	Copper Age	Germany	M	-2500	-2000	J1c	bam	89.89	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12477C (MT-ND5): possible HCM susceptibility (Reported) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported)
DA66	IAKa	Iron Age	Kazakhstan	F	430	492	H6b2	bam	390.40	de Barros Damgaard et al. 2018 Data	FASTA Metadata	16300G (MT-CR): BD-associated (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
DA65	IAKa	Iron Age	Kazakhstan	M	382	433	N9a9	bam	116.30	de Barros Damgaard et al. 2018 Data	FASTA Metadata	12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
JK2973	CLNE	Classical Age	Egypt	U	-347	-168	U6a3	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
I5655	BBC	Copper Age	Germany	F	-2500	-2000	H5a1	bam	246.55	Olalde et al. 2018 Data	FASTA Metadata	4336C (MT-TQ): ADPD / Hearing Loss & Migraine / autism spectrum / intellectual disability (Unclear)
DA68	IAKa	Iron Age	Kazakhstan	F	557	615	M11a	bam	396.73	de Barros Damgaard et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 14340T (MT-ND6): SNHL (Reported) 15043A (MT-CYB): MDD-associated (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 489C (MT-CR): Low VO2max response (Reported) 8108G (MT-CO2): SNHL (Reported)
DA69	IAKa	Iron Age	Kazakhstan	F	349	368	U5b2a1a2	bam	329.73	de Barros Damgaard et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 15924G (MT-TT): LIMM (Reported) 5452T (MT-ND2): Progressive Encephalomyopathy (Reported)
DA70	IAKa	Iron Age	Kazakhstan	F	60	143	C4a1a+195	bam	284.87	de Barros Damgaard et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 3552A (MT-ND1): Resistance to high altitude pulmonary edema (HAPE) (Reported /hg C marker) 489C (MT-CR): Low VO2max response (Reported)
I6591	BBC	Copper Age	Germany	F	-2500	-2000	U5b2c	bam	398.98	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
JK2975	CLNE	Classical Age	Egypt	U	-43	45	R	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
DA72	IAKa	Iron Age	Kazakhstan	F	264	274	M10a1+16129	bam	367.14	de Barros Damgaard et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 14502C (MT-ND6): LHON (Reported - possibly synergistic) 146C (MT-CR): Absence of Endometriosis (Reported) 15043A (MT-CYB): MDD-associated (Reported) 3253C (MT-TL1): Maternally inherited hypertension (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4440A (MT-TM): Mitochondrial myopathy (Reported) 489C (MT-CR): Low VO2max response (Reported)
JK2978	CLNE	Classical Age	Egypt	U	-975	-905	N1a1a2	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
I6624	BBC	Copper Age	Germany	F	-2500	-2000	T1a1	bam	80.90	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I5835	BBC	Copper Age	Germany	M	-2500	-2000	J1c	bam	233.73	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
I5660	BBC	Copper Age	Germany	M	-2500	-2000	T1a1	bam	463.35	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
DA73	IAKa	Iron Age	Kazakhstan	M	255	301	G2a1	bam	493.12	de Barros Damgaard et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 4833G (MT-ND2): Diabetes helper mutation AD / PD (Reported) 489C (MT-CR): Low VO2max response (Reported)
I7044	BBC	Copper Age	Hungary	M	-2500	-2200	U5b1d1b	bam	276.86	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I5525	BBC	Copper Age	Germany	F	-2500	-2000	U4b1b2	bam	307.97	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13528G (MT-ND5): LHON-like / LHON / MELAS (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 499A (MT-CR): Endometriosis (Reported)
I7045	BBC	Copper Age	Hungary	F	-2500	-2200	T2c1d+152	bam	453.09	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported) 6261A (MT-CO1): Prostate Cancer / LHON (Reported)
DA74	IAKa	Iron Age	Kazakhstan	M	385	435	H7b	bam	442.00	de Barros Damgaard et al. 2018 Data	FASTA Metadata
I5014	BBC	Copper Age	Germany	F	-2500	-2000	V	bam	443.53	Olalde et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I5023	BBC	Copper Age	Germany	F	-2500	-2000	U2e1a1	bam	530.45	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16183C (MT-CR): Melanoma patients (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
JK2980	CLNE	Classical Age	Egypt	U	-357	-204	I	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
DA80	IAKa	Iron Age	Kazakhstan	F	257	297	A1a	bam	536.14	de Barros Damgaard et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 663G (MT-RNR1): Coronary atherosclerosis risk (Reported)
I4252	BBC	Copper Age	Poland	M	-2285	-2138	U5a1a1	bam	117.18	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15924G (MT-TT): LIMM (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I5529	BBC	Copper Age	Germany	M	-2500	-2000	HV15	bam	158.93	Olalde et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I5021	BBC	Copper Age	Germany	M	-2571	-2341	K1c1	bam	140.81	Allentoft et al. 2015 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 146C (MT-CR): Absence of Endometriosis (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
DA81	IAKa	Iron Age	Kazakhstan	M	177	190	A16	bam	1093.76	de Barros Damgaard et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4440A (MT-TM): Mitochondrial myopathy (Reported) 663G (MT-RNR1): Coronary atherosclerosis risk (Reported)
I5022	BBC	Copper Age	Germany	M	-2500	-2000	HV+16311	bam	709.38	Allentoft et al. 2015 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
E09537_d	BBC	Copper Age	Germany	F	-2471	-2298	K1a	<NA>	<NA>	Olalde et al. 2018 Data	Metadata
I5531	BBC	Copper Age	Germany	F	-2500	-2000	T2b	bam	120.03	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
JK2981	CLNE	Classical Age	Egypt	U	-399	-376	M1a1e	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
DA82	IAKa	Iron Age	Kazakhstan	F	83	177	K2a5	bam	1269.22	de Barros Damgaard et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
DA85	IAKa	Iron Age	Kazakhstan	M	170	194	U4a2	bam	1675.64	de Barros Damgaard et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 499A (MT-CR): Endometriosis (Reported)
I2365	BBC	Copper Age	Hungary	M	-2464	-2207	V3	bam	310.06	Olalde et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
JK2985	CLNE	Classical Age	Egypt	U	-352	-195	HV1a'b'c	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
I2741	BBC	Copper Age	Hungary	M	-2457	-2153	H1+16189	bam	648.16	Olalde et al. 2018 Data	FASTA Metadata	16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I2786	BBC	Copper Age	Hungary	M	-2458	-2205	I1	bam	210.54	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 15924G (MT-TT): LIMM (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9966A (MT-CO3): LHON possible helper variant (Reported)
I2787	BBC	Copper Age	Hungary	M	-2457	-2201	T2b	bam	116.25	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
DA86	MAKy	Middle Ages	Kyrgyzstan	M	424	474	C4b1	bam	337.51	de Barros Damgaard et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 15043A (MT-CYB): MDD-associated (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 3552A (MT-ND1): Resistance to high altitude pulmonary edema (HAPE) (Reported /hg C marker) 489C (MT-CR): Low VO2max response (Reported)
I6538	BBC	Copper Age	Poland	F	-2008	-1765	H40	bam	142.67	Olalde et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I4178	BBC	Copper Age	Hungary	M	-2500	-2200	J1c1b1a	bam	31.08	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 3394C (MT-ND1): LHON / Diabetes / CPTdeficiency / high altitude adaptation (Reported / Population-dependent) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
I6583	BBC	Copper Age	Poland	F	-2289	-2050	U5b1c2	bam	300.85	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I5755	BBC	Copper Age	Switzerland	M	-2469	-1984	K2b1a	bam	84.01	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13135A (MT-ND5): possible HCM susceptibility (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I6580	BBC	Copper Age	Poland	M	-2300	-2150	K1a1b2b	bam	105.69	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 114T (MT-CR): BD-associated (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 15924G (MT-TT): LIMM (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I6534	BBC	Copper Age	Poland	M	-2456	-2149	T2e1	bam	322.74	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I4251	BBC	Copper Age	Poland	M	-2431	-2150	H1	bam	59.82	Olalde et al. 2018 Data	FASTA Metadata	14502C (MT-ND6): LHON (Reported - possibly synergistic) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported)
I6535	BBC	Copper Age	Poland	M	-2463	-2205	U5a2b	bam	47.01	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported)
I0840	BBC	Copper Age	Portugal	F	-2455	-2200	U5b1i	bam	6.96	Olalde et al. 2018 Data	FASTA Metadata	12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I5759	BBC	Copper Age	Switzerland	F	-2469	-1984	U2e1c1	bam	244.82	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I0839	BBC	Copper Age	Portugal	F	-2456	-2205	-	bam	6.60	Olalde et al. 2018 Data	FASTA Metadata
DA87	MAST	Middle Ages	Kazakhstan	M	640	692	A+152+16362	bam	124.80	de Barros Damgaard et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 663G (MT-RNR1): Coronary atherosclerosis risk (Reported)
JK2987	CLNE	Classical Age	Egypt	U	-342	-117	HV1a'b'c	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
DA89	MAST	Middle Ages	Kazakhstan	M	659	712	A14	bam	173.40	de Barros Damgaard et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 663G (MT-RNR1): Coronary atherosclerosis risk (Reported) 735G (MT-RNR1): DEAF (Reported)
I1970	BBC	Copper Age	Portugal	M	-2700	-2300	X2b+226	bam	33.37	Olalde et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 15927A (MT-TT): LHON / Multiple Sclerosis / DEAF1555 increased penetrance / CHD (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 8393T (MT-ATP8): Reversible brain pseudoatrophy (Reported)
I6467	BBC	Copper Age	Portugal	F	-2700	-2300	K1a4a1	bam	134.12	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 16183C (MT-CR): Melanoma patients (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I0458	BBC	Copper Age	Spain	M	-2457	-2206	K1a1b1	bam	320.17	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 114T (MT-CR): BD-associated (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 15924G (MT-TT): LIMM (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
DA93	MAST	Middle Ages	Kazakhstan	M	727	737	D4j8	bam	200.59	de Barros Damgaard et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 1095C (MT-RNR1): SNHL (Unclear) 11696A (MT-ND4): LHON / LDYT / DEAF / hypertension helper mut. (Reported - possibly synergistic) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 14668T (MT-ND6): Depressive Disorder associated (Reported) 15043A (MT-CYB): MDD-associated (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4883T (MT-ND2): Glaucoma (Conflicting reports) 489C (MT-CR): Low VO2max response (Reported) 8414T (MT-ATP8): Increased risk of T2DM and high altitude polycythemia (HAPC) in haplogroup D4 / Longevity (Reported)
I0459	BBC	Copper Age	Spain	F	-2600	-2200	U5b2b	bam	426.97	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 12634G (MT-ND5): Thyroid Cancer Cell Line (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I0461	BBC	Copper Age	Spain	F	-2455	-2201	K1a1b1	bam	306.24	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15924G (MT-TT): LIMM (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 6261A (MT-CO1): Prostate Cancer / LHON (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
DA94	MAST	Middle Ages	Kazakhstan	M	700	900	Z1a1	bam	123.58	de Barros Damgaard et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 15784C (MT-CYB): POAG - potential for association (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 489C (MT-CR): Low VO2max response (Reported)
JK2883	CLNE	Classical Age	Egypt	U	-799	-781	T1a	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
DA95	IAST	Iron Age	Kazakhstan	M	259	282	D4b1	bam	348.10	de Barros Damgaard et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 1095C (MT-RNR1): SNHL (Unclear) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 14668T (MT-ND6): Depressive Disorder associated (Reported) 15043A (MT-CYB): MDD-associated (Reported) 15951G (MT-TT): LHON / LHON modulator (Conflicting reports) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 4883T (MT-ND2): Glaucoma (Conflicting reports) 489C (MT-CR): Low VO2max response (Reported) 8414T (MT-ATP8): Increased risk of T2DM and high altitude polycythemia (HAPC) in haplogroup D4 / Longevity (Reported)
I4245	BBC	Copper Age	Spain	F	-2460	-2291	L1b1a	bam	552.93	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 2352C (MT-RNR2): Possibly LVNC-associated (Reported) 3308C (MT-ND1): MELAS / DEAF enhancer / hypertension / LVNC / putative LHON (P.M.-possibly synergistic) 5655C (MT-TA): DEAF enhancer / Hypertension risk (Reported)
JK2896	CLNE	Classical Age	Egypt	U	-394	-239	HV1b2	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
DA96	IAKy	Iron Age	Kyrgyzstan	M	259	281	D4j5	bam	564.52	de Barros Damgaard et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11696A (MT-ND4): LHON / LDYT / DEAF / hypertension helper mut. (Reported - possibly synergistic) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 14668T (MT-ND6): Depressive Disorder associated (Reported) 15043A (MT-CYB): MDD-associated (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4883T (MT-ND2): Glaucoma (Conflicting reports) 489C (MT-CR): Low VO2max response (Reported) 8414T (MT-ATP8): Increased risk of T2DM and high altitude polycythemia (HAPC) in haplogroup D4 / Longevity (Reported)
JK2959	CLNE	Classical Age	Egypt	U	-44	16	T1a	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
I6626	BBC	Copper Age	Spain	U	-2500	-1750	H1	bam	26.38	Olalde et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported)
I6622	BBC	Copper Age	Spain	M	-2800	-1750	U5b1i	bam	6.87	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I6623	BBC	Copper Age	Spain	F	-1956	-1743	U5b1f1a	bam	220.60	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I6539	BBC	Copper Age	Spain	M	-2500	-2000	T2b3+151	bam	446.41	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I6588	BBC	Copper Age	Spain	M	-2500	-2000	U5b2b3	bam	217.08	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 12634G (MT-ND5): Thyroid Cancer Cell Line (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 2755G (MT-RNR2): Possibly LVNC-associated (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I6584	BBC	Copper Age	Spain	F	-2500	-2000	H4a1a+195	bam	185.83	Olalde et al. 2018 Data	FASTA Metadata	14582G (MT-ND6): LHON synergistic combo 14258A + 14582G (Reported: individually neutral variants causing LHON in combination) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
DA99	MAKy	Middle Ages	Kyrgyzstan	F	1161	1255	C4a2c	bam	358.12	de Barros Damgaard et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 13967T (MT-ND5): Possible LHON factor (Reported) 15043A (MT-CYB): MDD-associated (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 3394C (MT-ND1): LHON / Diabetes / CPTdeficiency / high altitude adaptation (Reported / Population-dependent) 3552A (MT-ND1): Resistance to high altitude pulmonary edema (HAPE) (Reported /hg C marker) 489C (MT-CR): Low VO2max response (Reported)
JK2962	CLNE	Classical Age	Egypt	U	-756	-545	H13c1	bam	<NA>	Schuenemann et al. 2017 Data	Metadata
I6585	BBC	Copper Age	Spain	M	-2344	-2135	K1a4a1	bam	212.65	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I6471	BBC	Copper Age	Spain	M	-2500	-2000	U5b1c1	bam	84.76	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I0825	BBC	Copper Age	Spain	M	-2474	-2298	K1a4a1	bam	114.27	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15924G (MT-TT): LIMM (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
DA100	IAKy	Iron Age	Kyrgyzstan	M	255	300	C4b1	bam	320.14	de Barros Damgaard et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 15043A (MT-CYB): MDD-associated (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 3552A (MT-ND1): Resistance to high altitude pulmonary edema (HAPE) (Reported /hg C marker) 489C (MT-CR): Low VO2max response (Reported)
I2477	BBC	Copper Age	Italy	F	-2200	-1930	T2b3+151	bam	272.51	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I1979	BBC	Copper Age	Italy	F	-2200	-1930	T2b3	bam	31.78	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
DA101	IAKy	Iron Age	Kyrgyzstan	M	214	261	U5a1b1e	bam	1806.03	de Barros Damgaard et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
DA104	IAKy	Iron Age	Kyrgyzstan	F	100	500	F1b1+@152	bam	224.03	de Barros Damgaard et al. 2018 Data	FASTA Metadata	16183C (MT-CR): Melanoma patients (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 6962A (MT-CO1): Possible helper variant for 15927A (Reported)
I4933	BBC	Copper Age	Italy	U	-2500	-1900	R0a	bam	3.33	Olalde et al. 2018 Data	FASTA Metadata
JK2982	CLNE	Classical Age	Egypt	U	-92	1	T1a5	bam	394.03	Schuenemann et al. 2017 Data	Metadata
I2575	BBC	Copper Age	France	M	-2475	-2210	K1c1	bam	71.01	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
1622BM	CLNE	Classical Age	Egypt	F	-806	-784	R0a2f	bam	35.72	Schuenemann et al. 2017 Data	Metadata
DA105	IAKy	Iron Age	Kyrgyzstan	M	134	219	F1b1+@152	bam	189.88	de Barros Damgaard et al. 2018 Data	FASTA Metadata	16183C (MT-CR): Melanoma patients (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 6962A (MT-CO1): Possible helper variant for 15927A (Reported)
I4068	BBC	Copper Age	The Netherlands	M	-2131	-1951	U5a2a1	bam	54.46	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 7444A (MT-CO1): LHON / SNHL / DEAF (Reported)
DA106	MAKy	Middle Ages	Kyrgyzstan	M	1170	1171	C4b1a	bam	693.83	de Barros Damgaard et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 15043A (MT-CYB): MDD-associated (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 3552A (MT-ND1): Resistance to high altitude pulmonary edema (HAPE) (Reported /hg C marker) 489C (MT-CR): Low VO2max response (Reported)
I4069	BBC	Copper Age	The Netherlands	M	-2188	-1887	U5a1a1	bam	150.56	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15924G (MT-TT): LIMM (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I4074	BBC	Copper Age	The Netherlands	M	-2278	-1915	H	bam	292.85	Olalde et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9041G (MT-ATP6): Patient with suspected mitochondrial disease (Reported as VUS)
I4076	BBC	Copper Age	The Netherlands	F	-1882	-1750	K1d	bam	68.07	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5592G (MT-TA): Coronary Heart Disease (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
DA112	BACz	Iron Age	Czech Republic	F	-729	-693	HV0+195	bam	362.87	de Barros Damgaard et al. 2018 Data	FASTA Metadata	195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I5750	BBC	Copper Age	The Netherlands	M	-2300	-1900	K1b1a1+199	bam	208.46	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13967T (MT-ND5): Possible LHON factor (Reported) 15257A (MT-CYB): LHON (Conflicting reports) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5913A (MT-CO1): Prostate Cancer / hypertension (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I5748	BBC	Copper Age	The Netherlands	M	-2579	-2233	X2b4	bam	99.70	Olalde et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 15927A (MT-TT): LHON / Multiple Sclerosis / DEAF1555 increased penetrance / CHD (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 8393T (MT-ATP8): Reversible brain pseudoatrophy (Reported)
DA116	MAKy	Middle Ages	Kyrgyzstan	F	1156	1224	G2a+152	bam	766.10	de Barros Damgaard et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4833G (MT-ND2): Diabetes helper mutation AD / PD (Reported) 489C (MT-CR): Low VO2max response (Reported)
I6543	CAIB	Copper Age	Spain	M	-2479	-1945	H1	bam	624.97	Olalde et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported)
I6604	CAIB	Copper Age	Spain	M	-2127	-1905	U5b1c	bam	581.00	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I6610	CAIB	Copper Age	Spain	F	-1971	-1745	K1a+195	bam	119.72	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I6605	CAIB	Copper Age	Spain	F	-2479	-2287	H1t	bam	151.86	Olalde et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I6608	CAIB	Copper Age	Spain	M	-2020	-1768	J1c1	bam	168.12	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 3394C (MT-ND1): LHON / Diabetes / CPTdeficiency / high altitude adaptation (Reported / Population-dependent) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
I6609	CAIB	Copper Age	Spain	F	-2436	-2143	U5b1e	bam	289.06	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
DA117	MEKy	Modern Era	Kyrgyzstan	M	1678	1696	H6a1b	bam	301.35	de Barros Damgaard et al. 2018 Data	FASTA Metadata	195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
DA121	IAST	Iron Age	Kazakhstan	F	264	273	H6a1a	bam	177.93	de Barros Damgaard et al. 2018 Data	FASTA Metadata	11253C (MT-ND4): LHON PD (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
DA123	MAST	Middle Ages	Kazakhstan	F	-100	800	C4a1	bam	448.88	de Barros Damgaard et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 3552A (MT-ND1): Resistance to high altitude pulmonary edema (HAPE) (Reported /hg C marker) 489C (MT-CR): Low VO2max response (Reported)
I6596	CAIB	Copper Age	Spain	M	-2900	-2300	H3	bam	335.66	Olalde et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I6629	CAIB	Copper Age	Spain	M	-2900	-2300	T2b	bam	401.49	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I6628	CAIB	Copper Age	Spain	F	-2900	-2300	H1	bam	106.80	Olalde et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported)
I2464	BABI	Bronze Age	Great Britain	M	-1745	-1614	I2	bam	79.02	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 15924G (MT-TT): LIMM (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I0457	CAIB	Copper Age	Spain	M	-2920	-2340	J1c1	bam	160.21	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 3394C (MT-ND1): LHON / Diabetes / CPTdeficiency / high altitude adaptation (Reported / Population-dependent) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
I0456	CAIB	Copper Age	Spain	F	-2920	-2340	U5b2a1a	bam	75.16	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16192T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I2457	BABI	Bronze Age	Great Britain	M	-2467	-2030	I4a	bam	542.20	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 15924G (MT-TT): LIMM (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 8519A (MT-ATP8): Susceptibility to bullous pemphigoid (Reported)
I2604	BABI	Bronze Age	Great Britain	F	-2265	-2031	H2a3	bam	166.06	Olalde et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I7601	NEIB	Neolithic	Spain	M	-3660	-3520	X2b+226	bam	21.10	Olalde et al. 2019 Data	FASTA Metadata
I2596	BABI	Bronze Age	Great Britain	M	-2273	-2034	J1c1	bam	122.49	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 3394C (MT-ND1): LHON / Diabetes / CPTdeficiency / high altitude adaptation (Reported / Population-dependent) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
I2460	BABI	Bronze Age	Great Britain	F	-2022	-1827	T2a1a	bam	308.43	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 14687G (MT-TE): Mito myopathy w respiratory failure / intellectual disability (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I2597	BABI	Bronze Age	Great Britain	M	-2269	-2033	U5a2c3a	bam	171.78	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I12855	BAIB	Bronze Age	Spain	M	-1880	-1770	K1a+195	bam	29.65	Olalde et al. 2019 Data	FASTA Metadata
I6618	BAIB	Bronze Age	Spain	M	-1879	-1693	U5b3	bam	504.09	Olalde et al. 2019 Data	FASTA Metadata
VAD001	BAIB	Bronze Age	Spain	M	-1867	-1616	U5b1	bam	<NA>	Olalde et al. 2019 Data	Metadata
VAD002	BAIB	Bronze Age	Spain	M	-1689	-1528	J2b1a2	bam	<NA>	Olalde et al. 2019 Data	Metadata
VAD003	BAIB	Bronze Age	Spain	F	-1689	-1528	HV0	bam	<NA>	Olalde et al. 2019 Data	Metadata
I7645	NEIB	Neolithic	Spain	M	-3990	-3550	HV0d	bam	7.09	Olalde et al. 2019 Data	FASTA Metadata
I7597	NEIB	Neolithic	Spain	U	-4100	-2700	J2b1	bam	11.70	Olalde et al. 2019 Data	FASTA Metadata
I4558	BAIB	Bronze Age	Spain	F	-1700	-1500	K1a3a	bam	462.17	Olalde et al. 2019 Data	FASTA Metadata
I4561	BAIB	Bronze Age	Spain	F	-1700	-1500	H84	bam	389.54	Olalde et al. 2019 Data	FASTA Metadata