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Name	Group	Epoch	Country	Sex	Year from	Year to	Haplogroup	Sequence source	Avg. coverage	Reference	Download	Pathologies
I5207	LBK	Neolithic	Austria	M	-5500	-4500	H67	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
DA125	IAST	Iron Age	Kazakhstan	M	140	160	U2e2a1	bam	126.93	de Barros Damgaard et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
RISE507	BARu	Bronze Age	Russia	F	-3322	-2923	U5a1a1	bam	<NA>	Allentoft et al. 2015 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15924G (MT-TT): LIMM (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I3596	BBC	Copper Age	Germany	M	-2300	-2150	H+16129	bam	119.37	Olalde et al. 2018 Data	FASTA Metadata	16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I6590	BBC	Copper Age	Germany	F	-2500	-2000	X2c1	bam	509.04	Olalde et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 16183C (MT-CR): Melanoma patients (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I5208	LBK	Neolithic	Austria	F	-5500	-4500	K1b1a	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I5834	BBC	Copper Age	Germany	F	-2500	-2000	W5	bam	275.62	Olalde et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
I5373	BABI	Bronze Age	Great Britain	M	-2194	-1980	X2b+226	bam	214.55	Olalde et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 15927A (MT-TT): LHON / Multiple Sclerosis / DEAF1555 increased penetrance / CHD (Reported) 16183C (MT-CR): Melanoma patients (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 8393T (MT-ATP8): Reversible brain pseudoatrophy (Reported)
I1496	LBK	Neolithic	Hungary	M	-5211	-4992	K1a3a3	bam	<NA>	Gamba et al. 2014 Data	FASTA Metadata
RISE508	BARu	Bronze Age	Russia	F	-3331	-2935	U5a1a1	bam	<NA>	Allentoft et al. 2015 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15924G (MT-TT): LIMM (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I2601	BABI	Bronze Age	Great Britain	F	-1955	-1750	U5a1b1a	bam	19.73	Olalde et al. 2018 Data	FASTA Metadata	12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I0708	NENE	Neolithic	Turkey	M	-6500	-6200	N1b1a	bam	<NA>	Mathieson et al. 2015 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 16390A (MT-CR): POAG - potential for association (Reported) 8836G (MT-ATP6): LHON (Reported)
DA126	MAKa	Middle Ages	Kazakhstan	M	901	920	F2c1	bam	216.48	de Barros Damgaard et al. 2018 Data	FASTA Metadata	1005C (MT-RNR1): DEAF (Unclear) 11150A (MT-ND4): Found in a Multiple Sclerosis patient (Reported) 12338C (MT-ND5): DEAF1555 increased penetrance / LHON (Conflicting reports) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 16183C (MT-CR): Melanoma patients (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 4440A (MT-TM): Mitochondrial myopathy (Reported)
I3607	BBC	Copper Age	Germany	M	-2350	-2250	W3a1	bam	15.11	Olalde et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15784C (MT-CYB): POAG - potential for association (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
I3494	BAIB	Bronze Age	Spain	M	-1920	-1753	J1c1b	bam	641.00	Olalde et al. 2019 Data	Metadata
I0746	NENE	Neolithic	Turkey	M	-6067	-5892	K1a or K1a1	bam	<NA>	Mathieson et al. 2015 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I2602	BABI	Bronze Age	Great Britain	M	-1892	-1699	U5b2b	bam	112.84	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 12634G (MT-ND5): Thyroid Cancer Cell Line (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16270T (MT-CR): Melanoma patients (Reported)
I11303	NEIB	Neolithic	Spain	F	-3400	-2500	H1j	bam	28.10	Olalde et al. 2019 Data	Metadata
I2463	BABI	Bronze Age	Great Britain	F	-1925	-1700	J1c3+189	bam	250.88	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
I1495	LDN	Neolithic	Hungary	M	-4491	-4357	N1a1a1a	bam	<NA>	Gamba et al. 2014 Data	FASTA Metadata
I4914	HGS	Mesolithic	Serbia	M	-6355	-5990	U5a1c1	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I2462	BABI	Bronze Age	Great Britain	F	-2128	-1891	U5a1d2a	bam	274.64	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I4665	HGS	Mesolithic	Serbia	F	-6205	-5907	J2b1	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I1099	NENE	Neolithic	Turkey	M	-6500	-6200	T2b	bam	<NA>	Mathieson et al. 2015 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I4666	HGS	Mesolithic	Serbia	M	-6222	-5912	H40	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I2612	BABI	Bronze Age	Great Britain	F	-2464	-2208	U5b2b2	bam	373.29	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 12634G (MT-ND5): Thyroid Cancer Cell Line (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I1102	NENE	Neolithic	Turkey	M	-6500	-6200	K1a3a	bam	<NA>	Mathieson et al. 2015 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I5405	HGS	Mesolithic	Serbia	F	-5836	-5632	HV	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I5658	BBC	Copper Age	Germany	F	-2500	-2000	T2b+152	bam	514.19	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I1416	PPNE	Neolithic	Jordan	M	-8300	-7900	None	<NA>	<NA>	Lazaridis et al. 2016 Data	Metadata
I1581	NENE	Neolithic	Turkey	F	-6500	-6200	U3	bam	<NA>	Mathieson et al. 2015 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I1699	PPNE	Neolithic	Jordan	F	-6800	-6700	R0a2	<NA>	<NA>	Lazaridis et al. 2016 Data	Metadata
DA127	IAKa	Iron Age	Kazakhstan	M	252	304	D4b1a2a1	bam	119.94	de Barros Damgaard et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 14668T (MT-ND6): Depressive Disorder associated (Reported) 15043A (MT-CYB): MDD-associated (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 15951G (MT-TT): LHON / LHON modulator (Conflicting reports) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4883T (MT-ND2): Glaucoma (Conflicting reports) 489C (MT-CR): Low VO2max response (Reported) 8414T (MT-ATP8): Increased risk of T2DM and high altitude polycythemia (HAPC) in haplogroup D4 / Longevity (Reported)
I2421	BABI	Bronze Age	Great Britain	M	-1930	-1759	U5a1a2a	bam	232.06	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I0723	NENE	Neolithic	Turkey	M	-6400	-5600	X2m2	bam	<NA>	Mathieson et al. 2015 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I2609	BABI	Bronze Age	Great Britain	F	-2022	-1771	K2a	bam	163.71	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I2037	LBK	Neolithic	Germany	M	-5210	-5002	H1e	bam	<NA>	Lipson et al. 2017 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
I1709	PPNE	Neolithic	Jordan	M	-8300	-7900	U8b1a	<NA>	<NA>	Lazaridis et al. 2016 Data	Metadata
I7630	BABI	Bronze Age	Great Britain	M	-1879	-1691	U5a	bam	4.57	Olalde et al. 2018 Data	FASTA Metadata	12372A (MT-ND5): Altered brain pH / sCJD patients (Reported)
I1710	PPNE	Neolithic	Jordan	M	-7733	-7526	T1a2	<NA>	<NA>	Lazaridis et al. 2016 Data	Metadata
I3997	BAIB	Bronze Age	Spain	M	-1864	-1618	K1a2b	bam	29.70	Olalde et al. 2019 Data	Metadata
I1727	PPNE	Neolithic	Jordan	M	-8300	-7900	T1a2	<NA>	<NA>	Lazaridis et al. 2016 Data	Metadata
DA128	MAKa	Middle Ages	Kazakhstan	F	1230	1230	D4o2a	bam	303.74	de Barros Damgaard et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 14668T (MT-ND6): Depressive Disorder associated (Reported) 15043A (MT-CYB): MDD-associated (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4883T (MT-ND2): Glaucoma (Conflicting reports) 489C (MT-CR): Low VO2max response (Reported) 8414T (MT-ATP8): Increased risk of T2DM and high altitude polycythemia (HAPC) in haplogroup D4 / Longevity (Reported)
DA130	IAKa	Iron Age	Kazakhstan	M	-357	-284	G2a1	bam	57.70	de Barros Damgaard et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 489C (MT-CR): Low VO2max response (Reported)
I5661	BBC	Copper Age	Germany	M	-2500	-2000	K1b1b1	bam	83.32	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 14063C (MT-ND5): Potentially functional variant cosegregating with LHON3635A (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5913A (MT-CO1): Prostate Cancer / hypertension (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I1109	NEBA	Neolithic	Bulgaria	F	-5800	-5400	J2b1	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I5441	BABI	Bronze Age	Great Britain	M	-1938	-1744	H1+16239	bam	199.01	Olalde et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported)
I0014	HGN	Mesolithic	Sweden	F	-5877	-5629	U5a2d	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I5663	BBC	Copper Age	Germany	M	-2500	-2000	U5a2+16294	bam	283.20	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I0551	SMC	Neolithic	Germany	M	-3400	-3025	U3a1	bam	<NA>	Mathieson et al. 2015 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16390A (MT-CR): POAG - potential for association (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported)
I1295	NEBA	Neolithic	Bulgaria	M	-5800	-5400	J1c	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I2461	BABI	Bronze Age	Great Britain	F	-2500	-2140	H5c	bam	357.81	Olalde et al. 2018 Data	FASTA Metadata
I0559	BAC	Neolithic	Germany	M	-3654	-3527	HV	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I1296	NEBA	Neolithic	Bulgaria	M	-5800	-5400	U5a2	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I2637	NEBI	Neolithic	Great Britain	M	-3629	-3370	K1b1a1	bam	172.64	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13967T (MT-ND5): Possible LHON factor (Reported) 15257A (MT-CYB): LHON (Conflicting reports) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5913A (MT-CO1): Prostate Cancer / hypertension (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I2618	BABI	Bronze Age	Great Britain	M	-2134	-1950	H1bs	bam	706.46	Olalde et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I0103	CWC	Neolithic	Germany	F	-2578	-2468	W6a	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 16192T (MT-CR): Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
I2216	NEBA	Neolithic	Bulgaria	F	-5800	-5400	J2b1	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I5377	BABI	Bronze Age	Great Britain	M	-1894	-1694	T2b	bam	243.84	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I5383	BABI	Bronze Age	Great Britain	F	-1090	-900	J1c5f	bam	137.67	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 15924G (MT-TT): LIMM (Reported) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
I8571	BAIB	Bronze Age	Spain	M	-1800	-1000	K1a2c	bam	48.50	Olalde et al. 2019 Data	Metadata
I7639	BABI	Bronze Age	Great Britain	F	-2031	-1665	U5a1	bam	1.56	Olalde et al. 2018 Data	FASTA Metadata
I3879	NEBA	Neolithic	Bulgaria	M	-5800	-5400	H	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I0070	MIC	Bronze Age	Greece	M	-2400	-1700	H13a1a	<NA>	<NA>	Lazaridis et al. 2017 Data	Metadata
DA134	IAST	Iron Age	Russia	M	0	100	I1	bam	66.88	de Barros Damgaard et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 15924G (MT-TT): LIMM (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 9966A (MT-CO3): LHON possible helper variant (Reported)
I2639	BABI	Bronze Age	Great Britain	F	-1600	-1430	T2e1a	bam	1051.40	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I2796	NEBI	Neolithic	Great Britain	M	-3705	-3535	H3	bam	232.16	Olalde et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I7570	BABI	Bronze Age	Great Britain	M	-1735	-1531	T2b4+152	bam	88.74	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
RISE61	NESC	Neolithic	Denmark	M	-2851	-2492	J1c4	<NA>	<NA>	Allentoft et al. 2015 Data	Metadata
Rev5	NEGr	Neolithic	Greece	F	-6438	-6264	X2b	bam	<NA>	Hofmanova et al. 2016 Data	FASTA Metadata
I5656	BBC	Copper Age	Germany	U	-2500	-2000	T2g2	bam	214.36	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I7575	BABI	Bronze Age	Great Britain	M	-1263	-1043	U5a1d1	bam	163.31	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I7577	BABI	Bronze Age	Great Britain	M	-1386	-1123	U5a1a1	bam	146.15	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15924G (MT-TT): LIMM (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I3708	NEGr	Neolithic	Greece	F	-5500	-3700	T1a	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I3709	NEGr	Neolithic	Greece	F	-3990	-3804	K1b1a	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I3920	NEGr	Neolithic	Greece	F	-3933	-3706	H	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
DA136	IAST	Iron Age	Russia	M	0	100	A+152+16362	<NA>	64.28	de Barros Damgaard et al. 2018 Data	Metadata
I7580	BABI	Bronze Age	Great Britain	F	-1256	-1018	U5b2a1a	bam	217.86	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16192T (MT-CR): Melanoma patients (Reported)
RISE392	BARu	Bronze Age	Russia	M	-2126	-1896	J2b1a2a	bam	<NA>	Allentoft et al. 2015 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 15257A (MT-CYB): LHON (Conflicting reports) 15812A (MT-CYB): LHON (Reported / Secondary) 295T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
I3604	BBC	Copper Age	Germany	M	-2350	-2250	HV9	bam	11.45	Olalde et al. 2018 Data	FASTA Metadata
I2318	NEGr	Neolithic	Greece	F	-4043	-3947	H2	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I1926	TRP	Neolithic	Ukraine	M	-3931	-3640	H5a	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I7688	BAIB	Bronze Age	Portugal	F	-1200	-700	H3ap	bam	49.60	Olalde et al. 2019 Data	Metadata
RISE577	UNC	Bronze Age	Czech Republic	F	-2300	-1800	T2b	bam	<NA>	Allentoft et al. 2015 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I5401	HGS	Mesolithic	Serbia	M	-7076	-6699	U5a1	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 16390A (MT-CR): POAG - potential for association (Reported)
I7626	BABI	Bronze Age	Great Britain	F	-1395	-1130	T2b	bam	165.27	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I2111	TRP	Neolithic	Ukraine	M	-3758	-3636	HV	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
RISE349	BAHu	Bronze Age	Hungary	F	-2034	-1784	T2b3	bam	<NA>	Allentoft et al. 2015 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I6561	NEUk	Neolithic	Ukraine	M	-4045	-3974	H2a1a	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I0048	LBK	Neolithic	Germany	M	-5210	-5002	K1a26	bam	<NA>	Lipson et al. 2017 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I7627	BABI	Bronze Age	Great Britain	F	-1410	-1222	U4a2	bam	226.03	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 499A (MT-CR): Endometriosis (Reported)
I5882	NEUk	Neolithic	Ukraine	F	-3264	-2929	U5a2a	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I5523	BBC	Copper Age	Germany	F	-2500	-2000	K1b1a1+199	bam	113.04	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13967T (MT-ND5): Possible LHON factor (Reported) 15257A (MT-CYB): LHON (Conflicting reports) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5913A (MT-CO1): Prostate Cancer / hypertension (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I5019	BBC	Copper Age	Germany	F	-2500	-2000	K1b1a1	bam	68.25	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13967T (MT-ND5): Possible LHON factor (Reported) 15257A (MT-CYB): LHON (Conflicting reports) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 5913A (MT-CO1): Prostate Cancer / hypertension (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I7628	BABI	Bronze Age	Great Britain	M	-1208	-978	T1a1	bam	26.04	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I5884	NEUk	Neolithic	Ukraine	M	-2890	-2696	U5a2b	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I7579	BABI	Bronze Age	Great Britain	F	-1496	-1300	U5b2a1a	bam	182.54	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16192T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I7687	BAIB	Bronze Age	Portugal	M	-1200	-700	V	bam	44.70	Olalde et al. 2019 Data	Metadata
I5885	NEUk	Neolithic	Ukraine	F	-6392	-5927	U5b2b	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I3082	BABI	Bronze Age	Great Britain	M	-1498	-1394	H1an1a	bam	199.91	Olalde et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4454C (MT-TM): Possible contributor to mito dysfunction / hypertension (Reported)
DA141	IAST	Iron Age	Russia	M	0	100	A+152+16362	bam	65.40	de Barros Damgaard et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 8414T (MT-ATP8): Increased risk of T2DM and high altitude polycythemia (HAPC) in haplogroup D4 / Longevity (Reported)
I1733	HGE	Mesolithic	Ukraine	F	-9000	-7500	U4b	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I5524	BBC	Copper Age	Germany	F	-2500	-2000	H72	bam	300.85	Olalde et al. 2018 Data	FASTA Metadata	16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 15927A (MT-TT): LHON / Multiple Sclerosis / DEAF1555 increased penetrance / CHD (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I7574	BABI	Bronze Age	Great Britain	F	-1406	-1230	H1a3	bam	203.88	Olalde et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I1734	HGE	Mesolithic	Ukraine	M	-7446	-7058	U5b2	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
MA1	HGE	Upper Paleolithic	Russia	M	-22570	-22140	None	bam	<NA>	Raghavan et al. 2014 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported)
I4305	MLN	Neolithic	France	F	-4825	-4616	T2b3+151	bam	277.19	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I4308	MLN	Neolithic	France	F	-3501	-3112	U3a1	bam	16.06	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 16390A (MT-CR): POAG - potential for association (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported)
I1737	HGE	Mesolithic	Ukraine	F	-8540	-8301	U5a2	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I3717	NEUk	Neolithic	Ukraine	M	-5460	-5218	U5a2a	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
RISE374	BAHu	Bronze Age	Hungary	M	-1866	-1619	T2b	bam	<NA>	Allentoft et al. 2015 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I5526	BBC	Copper Age	Germany	F	-2500	-2000	H72	bam	751.70	Olalde et al. 2018 Data	FASTA Metadata	16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 15927A (MT-TT): LHON / Multiple Sclerosis / DEAF1555 increased penetrance / CHD (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I7571	BABI	Bronze Age	Great Britain	M	-1448	-1259	J1c1	bam	117.06	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 3394C (MT-ND1): LHON / Diabetes / CPTdeficiency / high altitude adaptation (Reported / Population-dependent) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
I3718	NEUk	Neolithic	Ukraine	M	-5345	-5215	U5a1b	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I0013	HGN	Mesolithic	Sweden	M	-5964	-5638	U5a1	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
I4081	HGS	Mesolithic	Romania	M	-7580	-7190	H13	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I7572	BABI	Bronze Age	Great Britain	M	-1510	-1302	H13a1a	bam	52.42	Olalde et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I5020	BBC	Copper Age	Germany	F	-2457	-2205	H2a1e	bam	151.53	Allentoft et al. 2015 Data	FASTA Metadata
I0518	NEBI	Neolithic	Great Britain	M	-3360	-3100	K1a3a1	bam	25.79	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I5037	EBACz	Bronze Age	Czech Republic	M	-2300	-1900	K1a+150	bam	50.19	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
DA142	MAST	Middle Ages	Russia	M	0	100	J1c5a1	bam	312.57	de Barros Damgaard et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
I8136	BAIB	Bronze Age	Spain	F	-1606	-1418	K1b1a1	bam	54.30	Olalde et al. 2019 Data	Metadata
I4111	NEUk	Neolithic	Ukraine	F	-4722	-4548	U4d	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I5044	EBACz	Bronze Age	Czech Republic	F	-2300	-1900	K1b1a	bam	197.62	Allentoft et al. 2015 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15257A (MT-CYB): LHON (Conflicting reports) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 5913A (MT-CO1): Prostate Cancer / hypertension (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I0519	NEBI	Neolithic	Great Britain	M	-3360	-3100	X2b+226	bam	441.62	Olalde et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 15927A (MT-TT): LHON / Multiple Sclerosis / DEAF1555 increased penetrance / CHD (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 8393T (MT-ATP8): Reversible brain pseudoatrophy (Reported)
I4114	NEUk	Neolithic	Ukraine	M	-5473	-5329	U5a1	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I7689	BAIB	Bronze Age	Portugal	F	-2200	-1700	H1+16311	bam	11.10	Olalde et al. 2019 Data	Metadata
I5875	NEUk	Neolithic	Ukraine	M	-5291	-5060	U4a1	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I3068	NEBI	Neolithic	Great Britain	M	-3692	-3522	T2c1d1	bam	541.45	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported) 6261A (MT-CO1): Prostate Cancer / LHON (Reported)
I5883	NEUk	Neolithic	Ukraine	M	-5208	-5003	U4a	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I4582	HGS	Mesolithic	Romania	F	-7021	-6473	K1	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I0432	BARu	Bronze Age	Russia	M	-2925	-2491	U5a1c	bam	<NA>	Mathieson et al. 2015 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I5116	CAHu	Copper Age	Hungary	F	-3400	-3000	W	bam	9.19	Olalde et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
I2605	NEBI	Neolithic	Great Britain	F	-3631	-2944	J1c6	bam	291.74	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 15927A (MT-TT): LHON / Multiple Sclerosis / DEAF1555 increased penetrance / CHD (Reported) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
I5890	NEUk	Neolithic	Ukraine	M	-5286	-5062	U5a1b	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
DA143	IAST	Iron Age	Russia	F	0	100	U4b1a4	bam	80.56	de Barros Damgaard et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 499A (MT-CR): Endometriosis (Reported) 663G (MT-RNR1): Coronary atherosclerosis risk (Reported)
I7692	BAIB	Bronze Age	Portugal	F	-2200	-1700	U5b1+16189+@16192	bam	7.89	Olalde et al. 2019 Data	Metadata
I5891	NEUk	Neolithic	Ukraine	M	-5465	-5310	U4d	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I5892	NEUk	Neolithic	Ukraine	M	-5301	-4982	U4a1	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I5118	CAHu	Copper Age	Hungary	M	-3400	-3000	H+16129	bam	259.05	Olalde et al. 2018 Data	FASTA Metadata	16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I2606	NEBI	Neolithic	Great Britain	M	-3330	-2900	K1a+195	bam	93.66	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I0433	YAM	Bronze Age	Russia	M	-5200	-4000	U5a1i	bam	<NA>	Mathieson et al. 2015 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9058G (MT-ATP6): Patients with (1) LVNC cardiomyopathy / (2) autism / intellectual disability / epilepsy (Reported as (1) possible association or as (2) benign)
E09538	BBC	Copper Age	Germany	M	-2464	-2210	J1c	<NA>	<NA>	Olalde et al. 2018 Data	Metadata
I6751	NEBI	Neolithic	Great Britain	F	-3755	-3660	U5b1+16189+@16192	bam	417.88	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16183C (MT-CR): Melanoma patients (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I6759	NEBI	Neolithic	Great Britain	M	-3650	-3522	J1c1	bam	491.39	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 3394C (MT-ND1): LHON / Diabetes / CPTdeficiency / high altitude adaptation (Reported / Population-dependent) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported) 6150A (MT-CO1): Prostate Cancer / enriched in POAG cohort (Reported)
I7691	BAIB	Bronze Age	Portugal	M	-2200	-1700	J1c1	bam	30.80	Olalde et al. 2019 Data	Metadata
I5893	NEUk	Neolithic	Ukraine	M	-5374	-5226	U5a2a	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I6762	NEBI	Neolithic	Great Britain	M	-4000	-3300	K1a1b1	bam	165.31	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 114T (MT-CR): BD-associated (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 15924G (MT-TT): LIMM (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
E09569	BBC	Copper Age	Germany	M	-2396	-2148	J1c2	<NA>	<NA>	Olalde et al. 2018 Data	Metadata
I1736	NEUk	Neolithic	Ukraine	F	-6248	-6070	U5b2b1	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I6761	NEBI	Neolithic	Great Britain	F	-3650	-3400	K1a+195	bam	186.26	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I5515	BABI	Bronze Age	Great Britain	M	-2034	-1775	H3+16311	bam	44.57	Olalde et al. 2018 Data	FASTA Metadata
I3713	NEUk	Neolithic	Ukraine	M	-5190	-4911	U4b1a	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I7042	BAHu	Bronze Age	Hungary	M	-2500	-2200	H	bam	503.18	Olalde et al. 2018 Data	FASTA Metadata	16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 3236G (MT-TL1): Sporadic bilateral optic neuropathy (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I3715	NEUk	Neolithic	Ukraine	M	-5636	-5521	U2e1	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I11306	NEIB	Neolithic	Spain	F	-3400	-2500	J2b1a2	bam	256.00	Olalde et al. 2019 Data	Metadata
I5868	NEUk	Neolithic	Ukraine	M	-5467	-5315	U4d	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
I5473	BABI	Bronze Age	Great Britain	M	-2400	-2100	U5b	bam	1.66	Olalde et al. 2018 Data	FASTA Metadata	16270T (MT-CR): Melanoma patients (Reported)
I6482	BBC	Copper Age	Germany	F	-2500	-2000	U4d2	bam	4.38	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 5567C (MT-TW): Myopathy (Reported)
I0358	SRU	Bronze Age	Russia	F	-1906	-1631	H6a1a	bam	<NA>	Mathieson et al. 2015 Data	FASTA Metadata	11253C (MT-ND4): LHON PD (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I6133	NEUk	Neolithic	Ukraine	F	-6500	-4000	U5b2a1a	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported)
I1732	NEUk	Neolithic	Ukraine	F	-5364	-5213	U4b	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 499A (MT-CR): Endometriosis (Reported)
I5516	BABI	Bronze Age	Great Britain	M	-1866	-1615	T2a1b1a1b	bam	79.93	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 14687G (MT-TE): Mito myopathy w respiratory failure / intellectual disability (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I1738	NEUk	Neolithic	Ukraine	M	-5473	-5326	U5a2	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
DA144	IAST	Iron Age	Russia	M	0	100	H28	bam	81.39	de Barros Damgaard et al. 2018 Data	FASTA Metadata	16192T (MT-CR): Melanoma patients (Reported)
I6481	BBC	Copper Age	Germany	M	-2500	-2000	U5a1a1	bam	82.94	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15924G (MT-TT): LIMM (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I5530	BBC	Copper Age	Germany	M	-2500	-2000	K1b1a1	bam	62.23	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13967T (MT-ND5): Possible LHON factor (Reported) 15257A (MT-CYB): LHON (Conflicting reports) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5913A (MT-CO1): Prostate Cancer / hypertension (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I2567	BABI	Bronze Age	Great Britain	M	-2275	-1884	U4a1a	bam	372.89	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 499A (MT-CR): Endometriosis (Reported) 961C (MT-RNR1): DEAF / possibly LVNC-associated (Unclear)
I3757	IAIB	Iron Age	Spain	F	-400	-300	J1c1	bam	55.10	Olalde et al. 2019 Data	Metadata
I7203	UNC	Bronze Age	Czech Republic	M	-2200	-1700	H1	bam	13.12	Olalde et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported)
I0047	UNC	Bronze Age	Germany	F	-2111	-1891	V9	bam	<NA>	Lipson et al. 2017 Data	FASTA Metadata	14841G (MT-CYB): LHON helper mut. (Reported)
I2569	BABI	Bronze Age	Great Britain	M	-2139	-1915	K1a3a	bam	220.51	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 3316A (MT-ND1): Diabetes / LHON / PEO (Unclear) 9055A (MT-ATP6): PD protective factor (Reported)
I3496	IAIB	Iron Age	Spain	M	-300	-200	H1e1a	bam	103.00	Olalde et al. 2019 Data	Metadata
ANI160	CABA	Copper Age	Bulgaria	M	-4685	-4499	H1ag	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 3310T (MT-ND1): Diabetes / HCM (Reported)
ANI163	CABA	Copper Age	Bulgaria	F	-4711	-4542	H7a1	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata
DA145	IAST	Iron Age	Russia	M	0	100	U2e1h	bam	26.93	de Barros Damgaard et al. 2018 Data	FASTA Metadata	12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 15043A (MT-CYB): MDD-associated (Reported)
I5469	BABI	Bronze Age	Great Britain	F	-1642	-1503	H5'36	bam	3.25	Olalde et al. 2018 Data	FASTA Metadata
RISE154	UNC	Bronze Age	Poland	F	-1925	-1765	K1a4a1	bam	<NA>	Allentoft et al. 2015 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I2860	BABI	Bronze Age	Great Britain	M	-969	-815	H5a1	bam	1659.05	Olalde et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4336C (MT-TQ): ADPD / Hearing Loss & Migraine / autism spectrum / intellectual disability (Unclear)
I1530	BBC	Copper Age	Germany	M	-2458	-2140	H3ao	<NA>	<NA>	Mathieson et al. 2015 Data	Metadata
LICOL1	LONG	Middle Ages	Italy	U	570	800	None	<NA>	<NA>	Vai et al. 2019	Metadata
I4556	IAIB	Iron Age	Spain	F	-700	-500	K1a12a	bam	39.62	Olalde et al. 2019 Data	Metadata
I2859	BABI	Bronze Age	Great Britain	M	-910	-809	K1a2c	bam	1521.11	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 9055A (MT-ATP6): PD protective factor (Reported)
RISE480	BAHu	Bronze Age	Hungary	F	-1700	-1500	U5a2a	bam	<NA>	Allentoft et al. 2015 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
Villabruna	HGS	Epigravettian	Italy	M	-12230	-11830	U5b2b	bam	14.80	Fu et al. 2016 Data	FASTA Metadata	12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 12634G (MT-ND5): Thyroid Cancer Cell Line (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16270T (MT-CR): Melanoma patients (Reported)
DA146	IACA	Iron Age	Russia	F	300	1400	HV2a1	bam	44.95	de Barros Damgaard et al. 2018 Data	FASTA Metadata	16217C (MT-CR): Endometriosis (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported)
I3130	BABI	Bronze Age	Great Britain	F	-977	-829	U5a1c	bam	970.75	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 7080C (MT-CO1): Prostate Cancer (Reported)
I2364	BBC	Copper Age	Hungary	M	-2468	-2063	U5a2b	bam	119.70	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I3499	CABA	Copper Age	Croatia	M	-2884	-2666	T2e	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I3528	BBC	Copper Age	Hungary	M	-2559	-2301	HV4a1+16291	bam	219.38	Olalde et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I0634	NEBA	Neolithic	Serbia	M	-4710	-4504	K1a4	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I2792	CABA	Copper Age	Croatia	M	-2872	-2582	T2c2	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 3394C (MT-ND1): LHON / Diabetes / CPTdeficiency / high altitude adaptation (Reported / Population-dependent) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported) 6261A (MT-CO1): Prostate Cancer / LHON (Reported)
I4175	CABA	Copper Age	Croatia	F	-3000	-2700	U4a	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 3316A (MT-ND1): Diabetes / LHON / PEO (Unclear) 499A (MT-CR): Endometriosis (Reported)
I3326	IAIB	Iron Age	Spain	M	-250	-200	J1c	bam	1.04	Olalde et al. 2019 Data	Metadata
I2656	BABI	Bronze Age	Great Britain	M	-1278	-979	H2a2a2	bam	115.72	Olalde et al. 2018 Data	FASTA Metadata	16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
BerryAuBac1	HGW	Mesolithic	France	M	-5370	-5220	U5b1a	bam	<NA>	Fu et al. 2016 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16270T (MT-CR): Melanoma patients (Reported)
I1875	HGS	Mesolithic	Croatia	F	-7308	-7027	U5b2b	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 12634G (MT-ND5): Thyroid Cancer Cell Line (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16270T (MT-CR): Melanoma patients (Reported)
DA160	IACA	Iron Age	Russia	F	300	1400	U4d3	bam	247.76	de Barros Damgaard et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 14577C (MT-ND6): MIDM (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 16183C (MT-CR): Melanoma patients (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 499A (MT-CR): Endometriosis (Reported)
I5376	BBC	Bronze Age	Great Britain	F	-2454	-2141	H6a1b	bam	19.19	Olalde et al. 2018 Data	FASTA Metadata
I2653	BABI	Bronze Age	Great Britain	M	-1500	-1300	H2a1a	bam	102.47	Olalde et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I2105	YAM	Bronze Age	Ukraine	F	-3300	-2700	T1a1	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
DA161	IACA	Iron Age	Russia	M	300	1400	X2f	bam	33.98	de Barros Damgaard et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported)
RISE546	YAM	Bronze Age	Russia	M	-3000	-2400	U5a1d2b	bam	<NA>	Allentoft et al. 2015 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I2654	BABI	Bronze Age	Great Britain	F	-1500	-1300	U5b3	bam	76.42	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 228A (MT-CR): Low VO2max response (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
I3324	IAIB	Iron Age	Spain	M	-360	-193	H1	bam	577.00	Olalde et al. 2019 Data	Metadata
RISE552	YAM	Bronze Age	Russia	M	-2849	-2143	T2a1a	bam	<NA>	Allentoft et al. 2015 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 14687G (MT-TE): Mito myopathy w respiratory failure / intellectual disability (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I0261	BBC	Copper Age	Spain	M	-2850	-2250	U5b1i	bam	273.49	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I0823	BBC	Copper Age	Spain	F	-2850	-2250	H1	bam	88.67	Olalde et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I3141	YAM	Bronze Age	Ukraine	F	-3300	-2700	H15b1	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	6253C (MT-CO1): Prostate Cancer / enriched in POAG cohort (Reported)
I2655	BABI	Bronze Age	Great Britain	M	-1441	-1272	H6a1b2	bam	1123.99	Olalde et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I0444	YAM	Bronze Age	Russia	M	-3335	-2882	H6a1b	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I1917	YAM	Bronze Age	Ukraine	F	-3095	-2915	R0a1	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	827G (MT-RNR1): DEAF (Conflicting reports)
I2660	NEBI	Neolithic	Great Britain	M	-3513	-3352	U5a2+16194	bam	110.18	Olalde et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
I2691	NEBI	Neolithic	Great Britain	M	-3700	-3639	J1c1	bam	479.83	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 3394C (MT-ND1): LHON / Diabetes / CPTdeficiency / high altitude adaptation (Reported / Population-dependent) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
I1298	NEBA	Neolithic	Bulgaria	F	-6032	-5837	K1a	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
DA162	IACA	Iron Age	Russia	M	300	1400	H13a2c	bam	772.73	de Barros Damgaard et al. 2018 Data	FASTA Metadata
Denisova3	HGE	Upper Paleolithic	Russia	F	-48000	-30000	L	bam	<NA>	Krause et al. 2010 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12311C (MT-TL2): CPEO (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 12477C (MT-ND5): possible HCM susceptibility (Reported) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 13276G (MT-ND5): MIDD+retinopathy (Conflicting reports) 13528G (MT-ND5): LHON-like / LHON / MELAS (Reported) 14693G (MT-TE): MELAS / LHON / DEAF / hypertension helper (Reported) 15043A (MT-CYB): MDD-associated (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16081G (MT-CR): Cyclic Vomiting Syndrome (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 3277A (MT-TL1): Poss. hypertension factor (Reported) 3290C (MT-TL1): Poss. hypertension factor (Reported) 3421A (MT-ND1): MIDD (Reported) 3496T (MT-ND1): LHON (Reported / Secondary) 4456T (MT-TM): Poss. hypertension factor (Reported) 4659A (MT-ND2): possible PD risk factor / LHON (Reported) 5821A (MT-TC): DEAF helper mut. (Reported) 6150A (MT-CO1): Prostate Cancer / enriched in POAG cohort (Reported) 7868T (MT-CO2): LHON (Possibly synergistic) 827G (MT-RNR1): DEAF (Conflicting reports) 8021G (MT-CO2): Asthenozoospermia (Reported) 9966A (MT-CO3): LHON possible helper variant (Reported)
LICOL13	LONG	Middle Ages	Italy	U	570	800	None	<NA>	<NA>	Vai et al. 2019	Metadata
KZ1	LDN	Neolithic	Poland	F	-4332	-4066	U5b2a1a	fasta	<NA>	Juras et al. 2017a Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16192T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I0443	YAM	Bronze Age	Russia	M	-3300	-2700	W3a1a	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15784C (MT-CYB): POAG - potential for association (Reported) 15951G (MT-TT): LHON / LHON modulator (Conflicting reports) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
I2650	NEBI	Neolithic	Great Britain	M	-3638	-3380	T2c1d1	bam	205.35	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported) 6261A (MT-CO1): Prostate Cancer / LHON (Reported)
I1541	CWC	Neolithic	Germany	M	-2500	-2050	U2e1a1	bam	<NA>	Mathieson et al. 2015 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported)
I12410	IAIB	Iron Age	Spain	M	-515	-375	H	bam	648.40	Olalde et al. 2019 Data	Metadata
KZ2	LDN	Neolithic	Poland	F	-4331	-4057	K1c	fasta	<NA>	Juras et al. 2017a Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
KZ4	LDN	Neolithic	Poland	F	-4329	-3997	K1a4	fasta	<NA>	Juras et al. 2017a Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
DA164	IACA	Iron Age	Russia	F	300	1400	H5	bam	229.50	de Barros Damgaard et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5549A (MT-TW): DEMCHO (Reported)
I2176	BABA	Bronze Age	Bulgaria	M	-3338	-3025	U1a1	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported)
I0257	BBC	Copper Age	Spain	M	-2572	-2348	H1ax	bam	319.79	Olalde et al. 2018 Data	FASTA Metadata	146C (MT-CR): Absence of Endometriosis (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported)
I0360	SRU	Bronze Age	Russia	M	-1850	-1200	U5a1	bam	<NA>	Mathieson et al. 2015 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 3398C (MT-ND1): DMDF+HCM / GDM / possibly LVNC cardiomyopathy-associated (Reported) 9966A (MT-CO3): LHON possible helper variant (Reported)
I0826	BBC	Copper Age	Spain	M	-2834	-2482	H1t	bam	107.57	Olalde et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I2630	NEBI	Neolithic	Great Britain	M	-2580	-2463	K1a4	bam	158.66	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 6663G (MT-CO1): Prostate Cancer (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
SCY300	SCU	Iron Age	Moldova	F	-400	-200	H5b	reconstructed	<NA>	Juras et al. 2017b Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I0175	LDN	Neolithic	Hungary	U	-4900	-4500	N1a1a1	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 3336C (MT-ND1): Carotid atherosclerosis risk (Reported) 669C (MT-RNR1): DEAF (Reported)
I0166	LDN	Neolithic	Germany	U	-5500	-4775	V1a	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata
I2405	GAC	Bronze Age	Poland	M	-3335	-3020	W5	fasta	17.05	Tassi et al. 2017 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
I2932	NEBI	Neolithic	Great Britain	M	-2570	-2347	H5	bam	780.40	Olalde et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
SCY305	SCU	Iron Age	Moldova	U	-400	-200	U5a2b	reconstructed	<NA>	Juras et al. 2017b Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
SCY308	SCU	Iron Age	Moldova	U	-400	-200	F1d	reconstructed	<NA>	Juras et al. 2017b Data	FASTA Metadata	146C (MT-CR): Absence of Endometriosis (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports) 5628C (MT-TA): CPEO / DEAF enhancer / gout (Reported) 6962A (MT-CO1): Possible helper variant for 15927A (Reported)
I0165	LDN	Neolithic	Germany	U	-4625	-4250	U5b1b	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I2933	NEBI	Neolithic	Great Britain	M	-3010	-2885	J1c2	bam	432.32	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
I12877	IAIB	Iron Age	Spain	M	-515	-375	J1c1	bam	41.54	Olalde et al. 2019 Data	Metadata
I0556	BAC	Neolithic	Germany	U	-3950	-3400	U8a1	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported)
I6582	BBC	Copper Age	Poland	F	-2343	-2057	U5a2b	bam	339.39	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I0102	LBK	Neolithic	Germany	U	-5030	-4948	N1a1a1a3	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 3336C (MT-ND1): Carotid atherosclerosis risk (Reported) 669C (MT-RNR1): DEAF (Reported)
I0796	LBK	Neolithic	Germany	U	-5500	-4775	H	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata
SCY311	SCU	Iron Age	Moldova	F	-400	-200	T2b	reconstructed	<NA>	Juras et al. 2017b Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I0799	SCG	Neolithic	Germany	U	-4100	-3950	H1e	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
I2418	BBC	Bronze Age	Great Britain	F	-2455	-2200	K1a4a1	bam	752.01	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I2934	NEBI	Neolithic	Great Britain	F	-3338	-3022	U5a2c3	bam	452.01	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I0820	LBK	Neolithic	Germany	U	-5298	-5247	W1c'i	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
I2935	NEBI	Neolithic	Great Britain	M	-3335	-3011	U8b1b	bam	610.26	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16183C (MT-CR): Melanoma patients (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
SCY334	SCU	Iron Age	Moldova	U	-400	-200	H5b	reconstructed	<NA>	Juras et al. 2017b Data	FASTA Metadata	228A (MT-CR): Low VO2max response (Reported)
DA179	MAST	Middle Ages	Kazakhstan	M	1200	1400	D4	bam	317.38	de Barros Damgaard et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 14668T (MT-ND6): Depressive Disorder associated (Reported) 15043A (MT-CYB): MDD-associated (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4440A (MT-TM): Mitochondrial myopathy (Reported) 4454C (MT-TM): Possible contributor to mito dysfunction / hypertension (Reported) 4883T (MT-ND2): Glaucoma (Conflicting reports) 489C (MT-CR): Low VO2max response (Reported) 8414T (MT-ATP8): Increased risk of T2DM and high altitude polycythemia (HAPC) in haplogroup D4 / Longevity (Reported)
I3085	NEBI	Neolithic	Great Britain	F	-3338	-3026	K1a+195	bam	607.89	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
SCY002	SCU	Iron Age	Ukraine	U	-400	-400	J1c2	reconstructed	<NA>	Juras et al. 2017b Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
DA189	MAST	Middle Ages	Russia	M	700	1000	J1b4	bam	167.46	de Barros Damgaard et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 295T (MT-CR): Low VO2max response (Reported) 3290C (MT-TL1): Poss. hypertension factor (Reported) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
I0024	LBK	Neolithic	Germany	U	-5500	-4800	W1c'i	bam	<NA>	Haak et al. 2015 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
I12640	IAIB	Iron Age	Spain	M	-696	-540	H1t	bam	16.57	Olalde et al. 2019 Data	Metadata
I2977	NEBI	Neolithic	Great Britain	M	-3008	-2763	H1	bam	619.04	Olalde et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I6581	BBC	Copper Age	Poland	M	-2455	-2145	H6a1a	bam	186.09	Olalde et al. 2018 Data	FASTA Metadata	11253C (MT-ND4): LHON PD (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
DA191	SCHu	Iron Age	Hungary	F	-536	-526	H2a2	bam	3.33	de Barros Damgaard et al. 2018 Data	FASTA Metadata
I2629	NEBI	Neolithic	Great Britain	M	-3180	-2780	J1c1b	bam	1.82	Olalde et al. 2018 Data	FASTA Metadata	13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports)
SCY006	SCU	Iron Age	Ukraine	F	-700	-700	D4j2	reconstructed	<NA>	Juras et al. 2017b Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11696A (MT-ND4): LHON / LDYT / DEAF / hypertension helper mut. (Reported - possibly synergistic) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 14668T (MT-ND6): Depressive Disorder associated (Reported) 15043A (MT-CYB): MDD-associated (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 4883T (MT-ND2): Glaucoma (Conflicting reports) 489C (MT-CR): Low VO2max response (Reported) 5178A (MT-ND2): Longevity / Extraversion / diabetes / AMS protection / blood iron metabolism / correlation with myocardial infarction / atherosclerosis (Reported) 8414T (MT-ATP8): Increased risk of T2DM and high altitude polycythemia (HAPC) in haplogroup D4 / Longevity (Reported)
I2978	NEBI	Neolithic	Great Britain	M	-3335	-3023	K1b1a1	bam	637.85	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13967T (MT-ND5): Possible LHON factor (Reported) 15257A (MT-CYB): LHON (Conflicting reports) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5913A (MT-CO1): Prostate Cancer / hypertension (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I2441	GAC	Bronze Age	Poland	M	-3400	-2800	K1b1a1	fasta	244.58	Tassi et al. 2017 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13967T (MT-ND5): Possible LHON factor (Reported) 15257A (MT-CYB): LHON (Conflicting reports) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 5913A (MT-CO1): Prostate Cancer / hypertension (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I12642	IAIB	Iron Age	Spain	F	-731	-399	H	bam	168.00	Olalde et al. 2019 Data	Metadata
SCY011	SCU	Iron Age	Ukraine	F	-400	-400	A	reconstructed	<NA>	Juras et al. 2017b Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 663G (MT-RNR1): Coronary atherosclerosis risk (Reported) 8794T (MT-ATP6): Exercise Endurance / Coronary Atherosclerosis risk (Reported)
I2565	BBC	Bronze Age	Great Britain	M	-2457	-2147	W1+119	bam	44.65	Olalde et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
I4253	BBC	Copper Age	Poland	M	-2456	-2207	U5a2c	bam	1073.95	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I2631	NEBI	Neolithic	Great Britain	M	-3097	-2906	H5	bam	887.83	Olalde et al. 2018 Data	FASTA Metadata
I3133	NEBI	Neolithic	Great Britain	M	-3631	-3377	K1a+195	bam	659.83	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 7158G (MT-CO1): Prostate Cancer (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
SCY009	SCU	Iron Age	Ukraine	M	-700	-700	J2b1a6	reconstructed	<NA>	Juras et al. 2017b Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 15257A (MT-CYB): LHON (Conflicting reports) 15662G (MT-CYB): Complex mitochondriopathy-associated (Reported) 15812A (MT-CYB): LHON (Reported / Secondary) 295T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported) 9016G (MT-ATP6): LHON (Reported)
I3134	NEBI	Neolithic	Great Britain	M	-3633	-3377	T2f4	bam	482.12	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I3322	IAIB	Iron Age	Spain	F	-600	-500	H1t	bam	632.00	Olalde et al. 2019 Data	Metadata
DA195	SCHu	Iron Age	Hungary	F	-756	-727	H+16311	bam	130.03	de Barros Damgaard et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I6774	BBC	Bronze Age	Great Britain	M	-2287	-2044	H4a1a1a	bam	93.45	Olalde et al. 2018 Data	FASTA Metadata	10044G (MT-TG): SIDS (Unclear) 14582G (MT-ND6): LHON synergistic combo 14258A + 14582G (Reported: individually neutral variants causing LHON in combination) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I12561	IAIB	Iron Age	Spain	M	-700	-500	H1	bam	3.15	Olalde et al. 2019 Data	Metadata
I2459	BBC	Bronze Age	Great Britain	F	-2455	-2150	T2a1a	bam	340.09	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 14687G (MT-TE): Mito myopathy w respiratory failure / intellectual disability (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
SCY005	SCU	Iron Age	Ukraine	F	-300	-200	H	reconstructed	<NA>	Juras et al. 2017b Data	FASTA Metadata	7697A (MT-CO2): Possible HCM susceptibility / high altitude adaptation (Reported)
I3135	NEBI	Neolithic	Great Britain	M	-3640	-3383	U5b2a	bam	825.83	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
Sam1	LBK	Neolithic	Poland	F	-5500	-4800	N1a1a1a	reconstructed	<NA>	Chyleński et al. 2017 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 3336C (MT-ND1): Carotid atherosclerosis risk (Reported) 669C (MT-RNR1): DEAF (Reported)
I3137	NEBI	Neolithic	Great Britain	M	-3800	-3200	HV0+195	bam	81.92	Olalde et al. 2018 Data	FASTA Metadata	195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
KM1	LDN	Neolithic	Poland	F	-4700	-3800	U5b1b	reconstructed	<NA>	Chyleński et al. 2017 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I3138	NEBI	Neolithic	Great Britain	F	-3263	-2923	K1a4a1	bam	797.42	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I5757	BBC	Copper Age	Switzerland	M	-2469	-1984	H3af	bam	209.07	Olalde et al. 2018 Data	FASTA Metadata	16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported)
I3214	NEIB	Neolithic	Spain	M	-3400	-2500	V3	bam	11.20	Olalde et al. 2019 Data	Metadata
KZ6	LDN	Neolithic	Poland	F	-4400	-4000	N1a1a1a3	reconstructed	<NA>	Chyleński et al. 2017 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 3336C (MT-ND1): Carotid atherosclerosis risk (Reported) 669C (MT-RNR1): DEAF (Reported)
I3041	NEBI	Neolithic	Great Britain	M	-3942	-3037	K1a3a	bam	445.11	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I8210	CLIB	Classical Age	Spain	M	-500	-350	U5b3	bam	7.00	Olalde et al. 2019 Data	Metadata
I3948	NEBA	Neolithic	Croatia	M	-6005	-5814	N1a1	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 3336C (MT-ND1): Carotid atherosclerosis risk (Reported) 669C (MT-RNR1): DEAF (Reported)
I7643	NEIB	Neolithic	Spain	M	-3960	-3710	K1a1b1	bam	27.20	Olalde et al. 2019 Data	Metadata
I5370	NEBI	Neolithic	Great Britain	F	-4000	-3300	K1a+195	bam	19.19	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
R18_1	LDN	Neolithic	Poland	F	-5364	-5398	K2a	reconstructed	<NA>	Chyleński et al. 2017 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
DA198	SCHu	Iron Age	Hungary	M	-508	-498	H7a1	bam	74.71	de Barros Damgaard et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I4872	HGS	Mesolithic	Serbia	F	-7100	-5900	U5a1c	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I2634	NEBI	Neolithic	Great Britain	M	-3703	-3534	U2+152	bam	179.11	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 3394C (MT-ND1): LHON / Diabetes / CPTdeficiency / high altitude adaptation (Reported / Population-dependent)
PCA0001	MAPl	Middle Ages	Poland	M	80	260	W	<NA>	<NA>	Stolarek et al. 2018 Data	Metadata
I4229	BBC	Copper Age	Portugal	M	-2336	-2063	U5a2+16362	bam	346.16	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I2633	NEBI	Neolithic	Great Britain	F	-3765	-3641	T2e1	bam	432.82	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I7554	NEBI	Neolithic	Great Britain	M	-3366	-3103	J1c9	bam	137.01	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
I1775	BABI	Bronze Age	Great Britain	M	-1730	-1532	I3	bam	693.67	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 15924G (MT-TT): LIMM (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I2574	BABI	Bronze Age	Great Britain	F	-1414	-1227	U5a1a2b	bam	985.86	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
PCA0003	MAPl	Middle Ages	Poland	F	80	260	H5a1	<NA>	<NA>	Stolarek et al. 2018 Data	Metadata
I6466	BBC	Copper Age	Portugal	M	-2700	-2300	K1b1a1	bam	30.22	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13967T (MT-ND5): Possible LHON factor (Reported) 15257A (MT-CYB): LHON (Conflicting reports) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 5913A (MT-CO1): Prostate Cancer / hypertension (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I5358	NEBI	Neolithic	Great Britain	F	-3080	-2904	K1a1	bam	82.21	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 114T (MT-CR): BD-associated (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
PCA0004	MAPl	Middle Ages	Poland	F	80	260	U3a1a1	bam	<NA>	Stolarek et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12300A (MT-TL2): 3243 suppressor mutant (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 14258A (MT-ND6): LHON synergistic combo 10680A + 12033G + 14258A also combo 14258A + 14582G (Reported: individually neutral variants causing LHON in combination) 15024A (MT-CYB): Possible DEAF modifier (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 15153A (MT-CYB): Suspected mito disease (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 3460A (MT-ND1): LHON (Cfrm)
DA199	MAHu	Middle Ages	Hungary	F	1224	1264	H1ba	bam	68.65	de Barros Damgaard et al. 2018 Data	FASTA Metadata	16270T (MT-CR): Melanoma patients (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported)
I8341	CLIB	Classical Age	Spain	M	-500	-350	H1	bam	110.00	Olalde et al. 2019 Data	Metadata
PCA0006	MAPl	Middle Ages	Poland	F	80	120	U5a1d1	bam	<NA>	Stolarek et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 14459A (MT-ND6): LDYT / Leigh Disease / dystonia / carotid atherosclerosis risk (Cfrm) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 4320T (MT-TI): Mitochondrial Encephalocardiomyopathy (Reported) 4327C (MT-TI): Ataxia+ / with RRF and COX deficiency (Reported) 5532A (MT-TW): Gastrointestinal Syndrome (Reported)
PCA0015	MAPl	Middle Ages	Poland	M	80	260	H1f1a	<NA>	<NA>	Stolarek et al. 2018 Data	Metadata
PCA0007	MAPl	Middle Ages	Poland	F	80	260	W1	bam	<NA>	Stolarek et al. 2018 Data	FASTA Metadata	3635A (MT-ND1): LHON (Cfrm) 4450A (MT-TM): Myopathy / MELAS / Leigh Syndrome (Cfrm) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
I5359	NEBI	Neolithic	Great Britain	M	-3800	-3600	H5	bam	100.37	Olalde et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I5367	BBC	Bronze Age	Great Britain	F	-2467	-2232	V10	bam	374.63	Olalde et al. 2018 Data	FASTA Metadata	16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
DA201	IAKa	Iron Age	Kazakhstan	F	-171	-88	C4a1a+195	bam	111.11	de Barros Damgaard et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 3552A (MT-ND1): Resistance to high altitude pulmonary edema (HAPE) (Reported /hg C marker) 489C (MT-CR): Low VO2max response (Reported)
I4882	HGS	Mesolithic	Serbia	M	-6200	-5900	U4b1b1	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13528G (MT-ND5): LHON-like / LHON / MELAS (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 499A (MT-CR): Endometriosis (Reported)
I8344	CLIB	Classical Age	Spain	M	-500	-400	H3	bam	178.00	Olalde et al. 2019 Data	Metadata
I7250	BBC	Copper Age	Czech Republic	F	-2500	-2200	R1a1a	bam	43.66	Olalde et al. 2018 Data	FASTA Metadata	1391C (MT-RNR1): found in 1 HCM patient (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
PCA0026	MAPl	Middle Ages	Poland	F	80	260	T2b16	bam	<NA>	Stolarek et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 1310T (MT-RNR1): DEAF-associated (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I3875	BBC	Copper Age	France	M	-2133	-1946	H1e	bam	423.99	Olalde et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
I4607	HGS	Mesolithic	Romania	M	-7340	-6640	U5a2	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 8481T (MT-ATP8): Tetralogy of Fallot patient (Reported)
I4067	BBC	Copper Age	The Netherlands	F	-1946	-1690	R1b1	bam	135.49	Olalde et al. 2018 Data	FASTA Metadata	1095C (MT-RNR1): SNHL (Unclear) 1391C (MT-RNR1): found in 1 HCM patient (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I0462	BBC	Copper Age	Spain	F	-2566	-2345	K1a+195	bam	240.45	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I7279	CWC	Neolithic	Czech Republic	M	-2900	-2200	H7d	bam	118.87	Olalde et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
DA202	IAST	Iron Age	Kazakhstan	F	-733	-690	U5a1	bam	20.96	de Barros Damgaard et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I7275	BBC	Copper Age	Czech Republic	M	-2500	-2200	U5b2c	bam	309.84	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
I5042	EBACz	Bronze Age	Czech Republic	M	-2300	-1900	I4a	bam	168.65	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 15924G (MT-TT): LIMM (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 8519A (MT-ATP8): Susceptibility to bullous pemphigoid (Reported)
I6476	BBC	Copper Age	Czech Republic	F	-2500	-1900	U5a1b1	bam	596.50	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I8206	CLIB	Classical Age	Spain	M	-300	-100	H7a1	bam	43.40	Olalde et al. 2019 Data	Metadata
PCA0030	MAPl	Middle Ages	Poland	F	110	160	H2a2b	bam	<NA>	Stolarek et al. 2018 Data	FASTA Metadata
I5043	EBACz	Bronze Age	Czech Republic	M	-2300	-1900	U4c1a	bam	672.69	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 499A (MT-CR): Endometriosis (Reported)
I5665	BBC	Copper Age	Spain	M	-2280	-1984	K1a24a	bam	480.15	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I4946	BBC	Copper Age	Czech Republic	F	-2296	-2146	I4a	bam	397.00	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 15924G (MT-TT): LIMM (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 8519A (MT-ATP8): Susceptibility to bullous pemphigoid (Reported)
PCA0031	MAPl	Middle Ages	Poland	F	10	375	K2a	<NA>	<NA>	Stolarek et al. 2018 Data	Metadata
I7195	UNC	Bronze Age	Czech Republic	F	-2200	-1700	H3v+16093	bam	303.35	Olalde et al. 2018 Data	FASTA Metadata	16093C (MT-CR): Cyclic Vomiting Syndrome (Reported)
I4655	HGS	Mesolithic	Romania	M	-7060	-6570	K1	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I4947	BBC	Copper Age	Czech Republic	M	-2500	-2000	H17a	bam	602.04	Olalde et al. 2018 Data	FASTA Metadata	16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
DA203	MAST	Middle Ages	Kazakhstan	M	950	1250	G2a2	bam	139.30	de Barros Damgaard et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 4833G (MT-ND2): Diabetes helper mutation AD / PD (Reported) 489C (MT-CR): Low VO2max response (Reported)
PCA0036	MAPl	Middle Ages	Poland	M	80	260	U5b1d1	bam	<NA>	Stolarek et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 869T (MT-RNR1): found in 1 HCM patient (Reported)
I4247	BBC	Copper Age	Spain	F	-2464	-2210	T2b3	bam	87.29	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I7196	UNC	Bronze Age	Czech Republic	M	-2200	-1700	K1a+195	bam	294.60	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I7197	UNC	Bronze Age	Czech Republic	M	-2200	-1700	X2b6	bam	323.64	Olalde et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 15927A (MT-TT): LHON / Multiple Sclerosis / DEAF1555 increased penetrance / CHD (Reported) 16183C (MT-CR): Melanoma patients (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 8393T (MT-ATP8): Reversible brain pseudoatrophy (Reported)
I8202	CLIB	Classical Age	Spain	M	100	300	K2b1	bam	77.90	Olalde et al. 2019 Data	Metadata
PCA0041	MAPl	Middle Ages	Poland	M	80	260	N	<NA>	<NA>	Stolarek et al. 2018 Data	Metadata
I7199	UNC	Bronze Age	Czech Republic	M	-2200	-1700	J1c3a	bam	297.14	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
I4889	BBC	Copper Age	Czech Republic	M	-2281	-2062	U4a2	bam	127.62	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 499A (MT-CR): Endometriosis (Reported)
I7201	UNC	Bronze Age	Czech Republic	F	-2200	-1700	U5a1a2b	bam	168.25	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
PCA0044	MAPl	Middle Ages	Poland	F	80	260	H5a1	bam	<NA>	Stolarek et al. 2018 Data	FASTA Metadata	2835T (MT-RNR2): Rett Syndrome (Reported) 4336C (MT-TQ): ADPD / Hearing Loss & Migraine / autism spectrum / intellectual disability (Unclear)
I4884	EBACz	Bronze Age	Czech Republic	M	-1882	-1745	H4a1a1a	bam	101.12	Olalde et al. 2018 Data	FASTA Metadata	10044G (MT-TG): SIDS (Unclear) 14582G (MT-ND6): LHON synergistic combo 14258A + 14582G (Reported: individually neutral variants causing LHON in combination) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
PCA0045	MAPl	Middle Ages	Poland	F	80	260	U5b1d1	<NA>	<NA>	Stolarek et al. 2018 Data	Metadata
I5237	HGS	Mesolithic	Serbia	M	-9500	-6200	U5a2a	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 228A (MT-CR): Low VO2max response (Reported)
I5236	HGS	Mesolithic	Serbia	M	-8290	-7825	U5a2d	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I5411	HGS	Mesolithic	Romania	M	-7000	-6300	U5a1c1	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I5239	HGS	Mesolithic	Serbia	F	-8535	-8230	U5a2d	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I7211	BBC	Copper Age	Czech Republic	F	-2500	-2200	U5b3	bam	319.75	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16270T (MT-CR): Melanoma patients (Reported) 228A (MT-CR): Low VO2max response (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
DA205	MAST	Middle Ages	Kazakhstan	F	950	1250	J1c	bam	206.67	de Barros Damgaard et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 15924G (MT-TT): LIMM (Reported) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
PCA0046	MAPl	Middle Ages	Poland	M	110	160	U8a1a1b	bam	<NA>	Stolarek et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported)
I4892	EBACz	Bronze Age	Czech Republic	F	-1881	-1701	T1a1	bam	152.98	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I4893	NECz	Neolithic	Czech Republic	M	-4449	-4348	U5b1b1	bam	205.24	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I8338	CLIB	Classical Age	Spain	F	100	200	HV0+195	bam	107.00	Olalde et al. 2019 Data	Metadata
PCA0047	MAPl	Middle Ages	Poland	F	80	260	H5a1	bam	<NA>	Stolarek et al. 2018 Data	FASTA Metadata	4336C (MT-TQ): ADPD / Hearing Loss & Migraine / autism spectrum / intellectual disability (Unclear)
I7286	BBC	Copper Age	Czech Republic	M	-2500	-2200	I4a	bam	223.85	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 15043A (MT-CYB): MDD-associated (Reported) 15924G (MT-TT): LIMM (Reported) 16129A (MT-CR): Cyclic Vomiting Syndrome with Migraine (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 6480A (MT-CO1): Prostate Cancer / enriched in POAG cohort (Reported) 8519A (MT-ATP8): Susceptibility to bullous pemphigoid (Reported)
I4894	NECz	Neolithic	Czech Republic	F	-4488	-4368	U8b1b1	bam	202.73	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16183C (MT-CR): Melanoma patients (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I4303	MLN	Neolithic	France	M	-4778	-4586	H3	bam	396.49	Olalde et al. 2018 Data	FASTA Metadata
I8474	CLIB	Classical Age	Spain	F	100	200	U5a1a2b	bam	23.40	Olalde et al. 2019 Data	Metadata
Sarretudvari-Hizofold/9/anc11	MAHu	Middle Ages	Hungary	M	900	970	T2b	bam	25.00	Neparáczki et al. 2018 Data	Metadata
I7212	BBC	Copper Age	Czech Republic	M	-2500	-2200	K1b1a1+199	bam	265.78	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13967T (MT-ND5): Possible LHON factor (Reported) 15257A (MT-CYB): LHON (Conflicting reports) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5913A (MT-CO1): Prostate Cancer / hypertension (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
PCA0049	MAPl	Middle Ages	Poland	F	110	160	H1a	bam	<NA>	Stolarek et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported)
I4304	MLN	Neolithic	France	M	-4787	-4589	T2c1d+152	bam	456.91	Olalde et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported) 6261A (MT-CO1): Prostate Cancer / LHON (Reported)
I6480	BBC	Copper Age	Czech Republic	M	-2500	-1900	U4a2	bam	153.39	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 499A (MT-CR): Endometriosis (Reported)
I7040	BAHu	Bronze Age	Hungary	F	-2500	-2200	K1a4b	bam	522.38	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I1381	BBC	Copper Age	France	M	-2400	-1900	H	bam	599.16	Olalde et al. 2018 Data	FASTA Metadata
PCA0051	MAPl	Middle Ages	Poland	F	110	160	K2a	<NA>	<NA>	Stolarek et al. 2018 Data	Metadata
I7043	BAHu	Bronze Age	Hungary	M	-2500	-2200	H1b1	bam	455.99	Olalde et al. 2018 Data	FASTA Metadata	16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 3796G (MT-ND1): Adult-Onset Dystonia (Reported) 6267A (MT-CO1): Prostate Cancer (Reported)
DA207	MEST	Modern Era	Kazakhstan	M	1650	1850	H2a	bam	4.04	de Barros Damgaard et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I7041	BAHu	Bronze Age	Hungary	M	-2500	-2200	H1b1	bam	458.69	Olalde et al. 2018 Data	FASTA Metadata	16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 3796G (MT-ND1): Adult-Onset Dystonia (Reported) 6267A (MT-CO1): Prostate Cancer (Reported)
I4070	BANl	Bronze Age	The Netherlands	M	-1880	-1657	U5a1b1a	bam	138.93	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
PCA0054	MAPl	Middle Ages	Poland	F	80	260	U3a1a	bam	<NA>	Stolarek et al. 2018 Data	FASTA Metadata	12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16390A (MT-CR): POAG - potential for association (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 6285A (MT-CO1): Prostate Cancer (Reported) 8328A (MT-TK): Mito Encephalopathy / EXIT with myopathy and ptosis (Reported)
I5409	HGS	Mesolithic	Serbia	F	-9500	-6200	U5a1c	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported)
I5436	HGS	Mesolithic	Romania	F	-7451	-6698	U5a2	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
PCA0056	MAPl	Middle Ages	Poland	F	80	260	T2b6a	bam	<NA>	Stolarek et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 15928A (MT-TT): Multiple Sclerosis / idiopathic repeat miscarriage / AD protection (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 4917G (MT-ND2): LHON / Insulin Resistance / AMD / NRTI-PN (Reported)
I4071	BANl	Bronze Age	The Netherlands	F	-1883	-1664	H6a1a	bam	259.20	Olalde et al. 2018 Data	FASTA Metadata	11253C (MT-ND4): LHON PD (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I6491	CLIB	Classical Age	Spain	M	200	500	H4a1a	bam	7.40	Olalde et al. 2019 Data	Metadata
DA208	MEST	Modern Era	Kazakhstan	M	1650	1850	H1	bam	8.24	de Barros Damgaard et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported)
PCA0057	MAPl	Middle Ages	Poland	F	110	160	J1c7a	bam	<NA>	Stolarek et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 4216C (MT-ND1): LHON / Insulin Resistance /possible adaptive high altitude variant / miscarriage (Conflicting reports) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
I6531	EBAPl	Bronze Age	Poland	M	-2286	-2038	U5b2b1a1	bam	267.70	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 12634G (MT-ND5): Thyroid Cancer Cell Line (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 15497A (MT-CYB): EXIT / Obesity (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I2754	CAHu	Copper Age	Hungary	M	-3337	-3024	J1c	<NA>	<NA>	Lipson et al. 2017 Data	Metadata
I6579	EBAPl	Bronze Age	Poland	F	-2335	-2046	K1a4a1g	bam	321.42	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
ANI153	CABA	Copper Age	Bulgaria	M	-4551	-4374	U4	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	12063T (MT-ND4): Recurrent pregnancy loss (Reported) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported)
ANI152	CABA	Copper Age	Bulgaria	M	-4683	-4406	U2	bam	<NA>	Mathieson et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 3275T (MT-TL1): Metabolic syndrome and polycystic ovary syndrome (Reported)
I3589	BBC	Copper Age	Germany	M	-2300	-2150	U4d1	bam	561.05	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 499A (MT-CR): Endometriosis (Reported)
I3599	BBC	Copper Age	Germany	M	-2300	-2150	H1e1a	bam	54.63	Olalde et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports) 8821G (MT-ATP6): Possible LHON helper variant (Reported)
I2755	CAHu	Copper Age	Hungary	M	-3600	-3000	U8b1a1	<NA>	<NA>	Lipson et al. 2017 Data	Metadata
Ust_Ishim	HGE	Upper Paleolithic	Russia	M	-45530	-40610	R*	bam	<NA>	Fu et al. 2014 Data	FASTA Metadata
I2788	CAHu	Copper Age	Hungary	M	-3910	-3650	H	<NA>	<NA>	Lipson et al. 2017 Data	Metadata
PCA0060	MAPl	Middle Ages	Poland	M	80	260	U5b1d1	bam	<NA>	Stolarek et al. 2018 Data	FASTA Metadata	12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
I3593	BBC	Copper Age	Germany	F	-2397	-2145	H1	bam	236.53	Olalde et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
DA220	IAKa	Iron Age	Kazakhstan	M	-350	-50	HV6	bam	111.75	de Barros Damgaard et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I2789	CAHu	Copper Age	Hungary	M	-3800	-3600	J1c3b	<NA>	<NA>	Lipson et al. 2017 Data	Metadata
I8343	CLIB	Classical Age	Spain	M	500	600	J1c2c2	bam	171.00	Olalde et al. 2019 Data	Metadata
I3866	MAIB	Middle Ages	Spain	M	600	700	U5a1b1	bam	107.00	Olalde et al. 2019 Data	Metadata
PCA0061	MAPl	Middle Ages	Poland	U	80	260	H1ak	bam	<NA>	Stolarek et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported)
I2791	CAHu	Copper Age	Hungary	M	-3658	-3384	U5a1c1	<NA>	<NA>	Lipson et al. 2017 Data	Metadata
I7600	NEIB	Neolithic	Spain	F	-4100	-2700	K1a2a	bam	30.30	Olalde et al. 2019 Data	Metadata
I6475	BBC	Copper Age	Spain	F	-2500	-2000	U5b3	bam	407.07	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 15909G (MT-TT): Hypertension (Reported) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 228A (MT-CR): Low VO2max response (Reported)
I2371	CAHu	Copper Age	Hungary	M	-3359	-3098	U5b3f	<NA>	<NA>	Lipson et al. 2017 Data	Metadata
I1553	BBC	Copper Age	Spain	F	-2850	-2250	pre-H103	bam	10.62	Olalde et al. 2018 Data	FASTA Metadata
E09613_d	BBC	Copper Age	Germany	F	-2289	-2140	H1	<NA>	<NA>	Olalde et al. 2018 Data	Metadata
DA221	IAKa	Iron Age	Kazakhstan	M	-790	-747	J1b1a1	bam	1184.38	de Barros Damgaard et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 295T (MT-CR): Low VO2max response (Reported) 2158C (MT-RNR2): Reduced risk PD (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported) 5460A (MT-ND2): AD / PD / LHON (Conflicting reports)
PCA0063	MAPl	Middle Ages	Poland	M	10	375	H2a5	bam	<NA>	Stolarek et al. 2018 Data	FASTA Metadata	13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports)
DA223	IAKa	Iron Age	Kazakhstan	M	-403	-374	J1c5a	bam	740.55	de Barros Damgaard et al. 2018 Data	FASTA Metadata	11251G (MT-ND4): Reduced risk of PD (Reported) 10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 13708A (MT-ND5): LHON / Increased MS risk / higher freq in PD-ADS (Conflicting reports) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 185A (MT-CR): Low VO2max response (Reported) 295T (MT-CR): Low VO2max response (Reported) 3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 228A (MT-CR): Low VO2max response (Reported) 462T (MT-CR): Low VO2max response (Reported) 489C (MT-CR): Low VO2max response (Reported)
DA224	MAST	Middle Ages	Kazakhstan	M	264	273	H	bam	6.92	de Barros Damgaard et al. 2018 Data	FASTA Metadata	310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
I7672	MAIB	Middle Ages	Spain	M	785	801	T2h	bam	59.80	Olalde et al. 2019 Data	Metadata
Gyvakarai1	CWC	Neolithic	Lithuania	M	-2690	-2470	K1b2a	fasta	7.56	Mittnik et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 5913A (MT-CO1): Prostate Cancer / hypertension (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I1975	CAIB	Copper Age	Spain	M	-3090	-2894	J1c1	<NA>	<NA>	Lipson et al. 2017 Data	Metadata
I0262	BBC	Copper Age	Spain	F	-2850	-2250	U5b3	bam	275.01	Olalde et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16270T (MT-CR): Melanoma patients (Reported) 228A (MT-CR): Low VO2max response (Reported)
I0258	BBC	Copper Age	Spain	F	-2850	-2250	H1q	bam	110.39	Olalde et al. 2018 Data	FASTA Metadata	3010A (MT-RNR2): Cyclic Vomiting Syndrome with Migraine / high altitude disease risk factor (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
DA227	IAKa	Iron Age	Kazakhstan	F	-350	-50	U5b2c	bam	11.45	de Barros Damgaard et al. 2018 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported)
DA228	MAST	Middle Ages	Kazakhstan	M	550	850	A15c	bam	24.16	de Barros Damgaard et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 4440A (MT-TM): Mitochondrial myopathy (Reported) 5650A (MT-TA): Myopathy (Cfrm) 663G (MT-RNR1): Coronary atherosclerosis risk (Reported)
RISE1	CWC	Neolithic	Poland	U	-2865	-2578	K1b1a1	<NA>	<NA>	Allentoft et al. 2015 Data	Metadata
I1976	CAIB	Copper Age	Spain	M	-2571	-2347	H3	<NA>	<NA>	Lipson et al. 2017 Data	Metadata
I2478	BBC	Copper Age	Italy	M	-2194	-1939	K1a2a	bam	251.09	Olalde et al. 2018 Data	FASTA Metadata	10398G (MT-ND3): PD protective factor / longevity / altered cell pH / metabolic syndrome / breast cancer risk / Leigh Syndrome risk / ADHD / cognitive decline / SCA2 age of onset / Fuchs endothelial corneal dystrophy (Reported / lineage L & M marker / also hg IJK) 11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 310C (MT-CR): Possible protective factor for normal tension glaucoma (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
I1843	CAIB	Copper Age	Spain	F	-3092	-2877	U5b1	<NA>	<NA>	Lipson et al. 2017 Data	Metadata
I1378	NEUk	Neolithic	Ukraine	M	-4519	-4343	U4b	bam	<NA>	Jones et al. 2017 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 15693C (MT-CYB): Possibly LVNC cardiomyopathy-associated (Reported) 195C (MT-CR): BD-associated / melanoma pts (Reported) 499A (MT-CR): Endometriosis (Reported)
I4936	BBC	Copper Age	Italy	F	-2500	-1900	K1a	bam	2.97	Olalde et al. 2018 Data	FASTA Metadata	12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 16093C (MT-CR): Cyclic Vomiting Syndrome (Reported) 9055A (MT-ATP6): PD protective factor (Reported)
DA229	IAST	Iron Age	Kazakhstan	M	-250	250	A8a1	bam	3.84	de Barros Damgaard et al. 2018 Data	FASTA Metadata	12705T (MT-CO1): Possible protective factor for normal tension glaucoma (Reported) 146C (MT-CR): Absence of Endometriosis (Reported) 4440A (MT-TM): Mitochondrial myopathy (Reported) 663G (MT-RNR1): Coronary atherosclerosis risk (Reported) 6962A (MT-CO1): Possible helper variant for 15927A (Reported)
I0585	HGW	Mesolithic	Spain	M	-5983	-5747	U5b2c	bam	<NA>	Olalde et al. 2014 Data	FASTA Metadata	11467G (MT-ND4): Altered brain pH / sCJD patients (Reported) 12308G (MT-TL2): CPEO / Stroke / CM / Breast & Renal & Prostate Cancer Risk / Altered brain pH /sCJD (Reported) 12372A (MT-ND5): Altered brain pH / sCJD patients (Reported) 13637G (MT-ND5): Possible LHON factor (Reported) 150T (MT-CR): Longevity / Cervical Carcinoma / HPV infection risk (Conflicting reports) 16192T (MT-CR): Melanoma patients (Reported) 16270T (MT-CR): Melanoma patients (Reported)
DA230	MAKa	Middle Ages	Kazakhstan	M	750	950	F1b1e	bam	837.11	de Barros Damgaard et al. 2018 Data	FASTA Metadata	16183C (MT-CR): Melanoma patients (Reported) 16189C (MT-CR): Diabetes / Cardiomyopathy /cancer risk / mtDNA copy nbr / Metabolic Syndrome / Melanoma patients (Reported) 6962A (MT-CO1): Possible helper variant for 15927A (Reported)
I1981	CAIB	Copper Age	Spain	F	-3014	-2891	J1c1	<NA>	<NA>	Lipson et al. 2017 Data	Metadata
RISE145	UNC	Bronze Age	Poland	M	-2188	-1958	H6a1b	<NA>	<NA>	Allentoft et al. 2015 Data	Metadata
RISE493	BARu	Bronze Age	Russia	M	-1531	-1427	C4a1c	<NA>	<NA>	Allentoft et al. 2015 Data	Metadata
I7673	MAIB	Middle Ages	Spain	F	785	801	W1+119	bam	50.70	Olalde et al. 2019 Data	Metadata